Table 6

Overview of existing definitions in radiation oncology

Definition in (radio-) oncologyDefinitionNo. of STAR studies reporting the volumeVolumes treated (if provided)Remarks
relevant for STAR
Gross target volume (GTV)The demonstrable extent of tumour extension and location. GTV and target volume (TV) can be used interchangeable.7Median 25.1 mL
Range 6.4–88.6 mL
To date, no image or mapping technique can accurately delineate the extent of VT substrates.
Clinical target volume (CTV)Considers a volume of tissue containing subclinical malignant disease, with a certain probability of occurrence relevant to the selected therapy.5Median 34.6 mL
Range 6.75–108.7 mL
For STAR, there is no equivalent. It is advised to avoid any functioning myocardium.
Internal target volume (ITV)CTV plus a safety margin that considers uncertainties in the size, shape, and position of the CTV within the patient.12N.A.It is advised to use approaches with advanced motion management to minimize the ITV.
Planning target volume (PTV)A geometric concept introduced for treatment planning and evaluation. In the ICRU definition, the PTV is a margin around the CTV, taking into account the patient's internal and setup uncertainties.11Median 81.2
Range 3.5–345.1 mL
For STAR different margins ranging between 5 and 10 mm have been used.
Definition in (radio-) oncologyDefinitionNo. of STAR studies reporting the volumeVolumes treated (if provided)Remarks
relevant for STAR
Gross target volume (GTV)The demonstrable extent of tumour extension and location. GTV and target volume (TV) can be used interchangeable.7Median 25.1 mL
Range 6.4–88.6 mL
To date, no image or mapping technique can accurately delineate the extent of VT substrates.
Clinical target volume (CTV)Considers a volume of tissue containing subclinical malignant disease, with a certain probability of occurrence relevant to the selected therapy.5Median 34.6 mL
Range 6.75–108.7 mL
For STAR, there is no equivalent. It is advised to avoid any functioning myocardium.
Internal target volume (ITV)CTV plus a safety margin that considers uncertainties in the size, shape, and position of the CTV within the patient.12N.A.It is advised to use approaches with advanced motion management to minimize the ITV.
Planning target volume (PTV)A geometric concept introduced for treatment planning and evaluation. In the ICRU definition, the PTV is a margin around the CTV, taking into account the patient's internal and setup uncertainties.11Median 81.2
Range 3.5–345.1 mL
For STAR different margins ranging between 5 and 10 mm have been used.
Table 6

Overview of existing definitions in radiation oncology

Definition in (radio-) oncologyDefinitionNo. of STAR studies reporting the volumeVolumes treated (if provided)Remarks
relevant for STAR
Gross target volume (GTV)The demonstrable extent of tumour extension and location. GTV and target volume (TV) can be used interchangeable.7Median 25.1 mL
Range 6.4–88.6 mL
To date, no image or mapping technique can accurately delineate the extent of VT substrates.
Clinical target volume (CTV)Considers a volume of tissue containing subclinical malignant disease, with a certain probability of occurrence relevant to the selected therapy.5Median 34.6 mL
Range 6.75–108.7 mL
For STAR, there is no equivalent. It is advised to avoid any functioning myocardium.
Internal target volume (ITV)CTV plus a safety margin that considers uncertainties in the size, shape, and position of the CTV within the patient.12N.A.It is advised to use approaches with advanced motion management to minimize the ITV.
Planning target volume (PTV)A geometric concept introduced for treatment planning and evaluation. In the ICRU definition, the PTV is a margin around the CTV, taking into account the patient's internal and setup uncertainties.11Median 81.2
Range 3.5–345.1 mL
For STAR different margins ranging between 5 and 10 mm have been used.
Definition in (radio-) oncologyDefinitionNo. of STAR studies reporting the volumeVolumes treated (if provided)Remarks
relevant for STAR
Gross target volume (GTV)The demonstrable extent of tumour extension and location. GTV and target volume (TV) can be used interchangeable.7Median 25.1 mL
Range 6.4–88.6 mL
To date, no image or mapping technique can accurately delineate the extent of VT substrates.
Clinical target volume (CTV)Considers a volume of tissue containing subclinical malignant disease, with a certain probability of occurrence relevant to the selected therapy.5Median 34.6 mL
Range 6.75–108.7 mL
For STAR, there is no equivalent. It is advised to avoid any functioning myocardium.
Internal target volume (ITV)CTV plus a safety margin that considers uncertainties in the size, shape, and position of the CTV within the patient.12N.A.It is advised to use approaches with advanced motion management to minimize the ITV.
Planning target volume (PTV)A geometric concept introduced for treatment planning and evaluation. In the ICRU definition, the PTV is a margin around the CTV, taking into account the patient's internal and setup uncertainties.11Median 81.2
Range 3.5–345.1 mL
For STAR different margins ranging between 5 and 10 mm have been used.
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