Table 3.
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IC50 values of PARPi in different PCa parental cell lines

Cell lineOlaparib IC50 (μM)Rucaparib IC50 (μM)TalazoparibIC50 (nM)
LNCaP0.14± 0.030.47± 0.080.73± 0.09
C4-2B1.35 ± 0.233.01 ± 0.175.43 ± 1.33
PC34.12 ± 0.822.60 μM ± 0.238.45 ± 1.90
MDA-PCA-2B7.39 ± 1.631.8 ± 0.338.61 ± 2.91
22RV110.87 ± 1.892.48 ± 0.6519.25 ± 4.11
Cell lineOlaparib IC50 (μM)Rucaparib IC50 (μM)TalazoparibIC50 (nM)
LNCaP0.14± 0.030.47± 0.080.73± 0.09
C4-2B1.35 ± 0.233.01 ± 0.175.43 ± 1.33
PC34.12 ± 0.822.60 μM ± 0.238.45 ± 1.90
MDA-PCA-2B7.39 ± 1.631.8 ± 0.338.61 ± 2.91
22RV110.87 ± 1.892.48 ± 0.6519.25 ± 4.11
Table 3.
Open in new tab

IC50 values of PARPi in different PCa parental cell lines

Cell lineOlaparib IC50 (μM)Rucaparib IC50 (μM)TalazoparibIC50 (nM)
LNCaP0.14± 0.030.47± 0.080.73± 0.09
C4-2B1.35 ± 0.233.01 ± 0.175.43 ± 1.33
PC34.12 ± 0.822.60 μM ± 0.238.45 ± 1.90
MDA-PCA-2B7.39 ± 1.631.8 ± 0.338.61 ± 2.91
22RV110.87 ± 1.892.48 ± 0.6519.25 ± 4.11
Cell lineOlaparib IC50 (μM)Rucaparib IC50 (μM)TalazoparibIC50 (nM)
LNCaP0.14± 0.030.47± 0.080.73± 0.09
C4-2B1.35 ± 0.233.01 ± 0.175.43 ± 1.33
PC34.12 ± 0.822.60 μM ± 0.238.45 ± 1.90
MDA-PCA-2B7.39 ± 1.631.8 ± 0.338.61 ± 2.91
22RV110.87 ± 1.892.48 ± 0.6519.25 ± 4.11
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