Table 3. Open in new tab Cancer in women...

Relative type

Cancer type

Observed

Expected

RR (95% CI)

P value

Self (n = 416)

Breast

5.30

2.45 (1.31-4.19)

.0033*

Ovarian

≤10

0.57

3.50 (0.42-12.66)

.11

Colon/colorectal

≤10

0.6

0 (0-6.13)

1.00

Uterine

≤10

0.93

2.16 (0.26-7.80)

.24

First degree (n = 1236 males; n = 1169 females)

Breast

26.42

1.21 (0.833-1.71)

.28

Ovarian

≤10

2.94

1.70 (0.55-3.97)

.23

Colon/colorectal

≤10

7.41

1.08 (0.47-2.13)

.71

Uterine

≤10

5.45

0.37 (0.04-1.33)

.19

Prostate

24.96

1.64 (1.18-2.23)

.0026*

Testicular

≤10

2.21

1.36 (0.28-3.97)

.49

Second degree (n = 3458 males; n = 3340 females)

Breast

127

99.58

1.28 (1.06, 1.52)

.0078*

Ovarian

12.39

0.97 (0.50-1.69)

1.00

Colon/colorectal

38.71

1.50 (1.14-1.94)

.0036*

Uterine

23.53

1.06 (0.69-1.57)

.76

Prostate

174

112.72

1.54 (1.32-1.79)

< .001*

Testicular

≤10

4.19

0.95 (0.26, 2.44)

1.00

Third degree (n = 9009 males; n = 8657 females)

Breast

230

227.36

1.01 (0.89-1.15)

.84

Ovarian

30.76

1.20 (0.85-1.66)

.24

Colon/colorectal

123

111.53

1.11 (0.92-1.33)

.24

Uterine

58.24

0.84 (0.62-1.11)

.26

Prostate

364

272.94

1.33 (1.20-1.48)

< .001*

Testicular

10.23

1.08 (0.54-1.92)

.75

Table 3.

Open in new tab

Cancer in women with POI and their first-, second-, and third-degree relatives

Relative type	Cancer type	Observed	Expected	RR (95% CI)	P value
Self (n = 416)	Breast	13	5.30	2.45 (1.31-4.19)	.0033*
	Ovarian	≤10	0.57	3.50 (0.42-12.66)	.11
	Colon/colorectal	≤10	0.6	0 (0-6.13)	1.00
	Uterine	≤10	0.93	2.16 (0.26-7.80)	.24
First degree (n = 1236 males; n = 1169 females)	Breast	32	26.42	1.21 (0.833-1.71)	.28
	Ovarian	≤10	2.94	1.70 (0.55-3.97)	.23
	Colon/colorectal	≤10	7.41	1.08 (0.47-2.13)	.71
	Uterine	≤10	5.45	0.37 (0.04-1.33)	.19
	Prostate	41	24.96	1.64 (1.18-2.23)	.0026*
	Testicular	≤10	2.21	1.36 (0.28-3.97)	.49
Second degree (n = 3458 males; n = 3340 females)	Breast	127	99.58	1.28 (1.06, 1.52)	.0078*
	Ovarian	12	12.39	0.97 (0.50-1.69)	1.00
	Colon/colorectal	58	38.71	1.50 (1.14-1.94)	.0036*
	Uterine	25	23.53	1.06 (0.69-1.57)	.76
	Prostate	174	112.72	1.54 (1.32-1.79)	< .001*
	Testicular	≤10	4.19	0.95 (0.26, 2.44)	1.00
Third degree (n = 9009 males; n = 8657 females)	Breast	230	227.36	1.01 (0.89-1.15)	.84
	Ovarian	37	30.76	1.20 (0.85-1.66)	.24
	Colon/colorectal	123	111.53	1.11 (0.92-1.33)	.24
	Uterine	49	58.24	0.84 (0.62-1.11)	.26
	Prostate	364	272.94	1.33 (1.20-1.48)	< .001*
	Testicular	11	10.23	1.08 (0.54-1.92)	.75

Relative type	Cancer type	Observed	Expected	RR (95% CI)	P value
Self (n = 416)	Breast	13	5.30	2.45 (1.31-4.19)	.0033*
	Ovarian	≤10	0.57	3.50 (0.42-12.66)	.11
	Colon/colorectal	≤10	0.6	0 (0-6.13)	1.00
	Uterine	≤10	0.93	2.16 (0.26-7.80)	.24
First degree (n = 1236 males; n = 1169 females)	Breast	32	26.42	1.21 (0.833-1.71)	.28
	Ovarian	≤10	2.94	1.70 (0.55-3.97)	.23
	Colon/colorectal	≤10	7.41	1.08 (0.47-2.13)	.71
	Uterine	≤10	5.45	0.37 (0.04-1.33)	.19
	Prostate	41	24.96	1.64 (1.18-2.23)	.0026*
	Testicular	≤10	2.21	1.36 (0.28-3.97)	.49
Second degree (n = 3458 males; n = 3340 females)	Breast	127	99.58	1.28 (1.06, 1.52)	.0078*
	Ovarian	12	12.39	0.97 (0.50-1.69)	1.00
	Colon/colorectal	58	38.71	1.50 (1.14-1.94)	.0036*
	Uterine	25	23.53	1.06 (0.69-1.57)	.76
	Prostate	174	112.72	1.54 (1.32-1.79)	< .001*
	Testicular	≤10	4.19	0.95 (0.26, 2.44)	1.00
Third degree (n = 9009 males; n = 8657 females)	Breast	230	227.36	1.01 (0.89-1.15)	.84
	Ovarian	37	30.76	1.20 (0.85-1.66)	.24
	Colon/colorectal	123	111.53	1.11 (0.92-1.33)	.24
	Uterine	49	58.24	0.84 (0.62-1.11)	.26
	Prostate	364	272.94	1.33 (1.20-1.48)	< .001*
	Testicular	11	10.23	1.08 (0.54-1.92)	.75

Abbreviations: POI, primary ovarian insufficiency; RR, relative risk.

^*Bonferroni multiple testing correction P < .012 for women and P < .017 for men.

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