Table 4 Open in new tab Median change in...

Table 4

Median change in bone microarchitectural parameters between baseline and time point C at distal tibia in a subgroup of patients with long-term follow-up and comparison with a control group.

Tibia	Baseline	Time C	Median % increase between baseline and time C, p	Control group	Means difference	p^*
Tb.vBMD, mgHA/cm3	88.8 ± 57.6	88.0 ± 49.8	+2.0, .021	174.7 ± 50.5	−49.6	<.001
Ct.vBMD, mgHA/cm3	788.0 ± 120.3	840.1 ± 83.0	+3.4, .049	881.6 ± 54.2	−4.7	.110
Tb.N, 1/mm	1.12 ± 0.48	1.08 ± 0.56	−0.2, .586	1.98 ± 0.42	−45.4	<.001
Tb.Th, mm	0.060 ± 0.043	0.066 ± 0.032	−6.7, .524	0.074 ± 0.017	−10.8	.209
Tb.Sp, mm	1.072 ± 0.700	1.195 ± 0.791	+1.2, .261	0.454 ± 0.125	+163.2	<.001
Tb.BV/TV, %	6.5 ± 5.3	6.7 ± 5.0	−9.9, .752	14.5 ± 4.2	−53.8	<.001
Ct.Th, mm	0.71 ± 0.34	0.89 ± 0.26	+13.8, .040	1.22 ± 0.32	−27.0	.009

Tibia	Baseline	Time C	Median % increase between baseline and time C, p	Control group	Means difference	p^*
Tb.vBMD, mgHA/cm3	88.8 ± 57.6	88.0 ± 49.8	+2.0, .021	174.7 ± 50.5	−49.6	<.001
Ct.vBMD, mgHA/cm3	788.0 ± 120.3	840.1 ± 83.0	+3.4, .049	881.6 ± 54.2	−4.7	.110
Tb.N, 1/mm	1.12 ± 0.48	1.08 ± 0.56	−0.2, .586	1.98 ± 0.42	−45.4	<.001
Tb.Th, mm	0.060 ± 0.043	0.066 ± 0.032	−6.7, .524	0.074 ± 0.017	−10.8	.209
Tb.Sp, mm	1.072 ± 0.700	1.195 ± 0.791	+1.2, .261	0.454 ± 0.125	+163.2	<.001
Tb.BV/TV, %	6.5 ± 5.3	6.7 ± 5.0	−9.9, .752	14.5 ± 4.2	−53.8	<.001
Ct.Th, mm	0.71 ± 0.34	0.89 ± 0.26	+13.8, .040	1.22 ± 0.32	−27.0	.009

Abbreviations: Tb.vBMD, trabecular density; Ct.vBMD, cortical density; Tb.N, trabecular number; Tb.Th, trabecular thickness; Tb.Sp, trabecular separation; Ct.Th, cortical thickness; Tb.BVTV, trabecular bone volume fraction.

^*Comparison between time point C in patients with TIO (subgroup analysis of 10 patients with long-term follow-up) and control group.

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