| Entry . | pKaH = P . | T (°C) . | Conc. = V (M) . | Z/W (mL/min) . | HPLC-UV Yield of 3 (%) . |
|---|---|---|---|---|---|
| 1 | 7.7 | 10 | 0.05 | 1.67 (Z2.0:W1.2) | 3 |
| 2 | 7.0 | −10 | 0.20 | 1.00 (Z1.6:W1.6) | 0 |
| 3 | 8.9 | 0 | 0.15 | 0.60 (Z1.2:W2.0) | 35 |
| 4 | 11.4 | 30 | 0.20 | 1.29 (Z1.8:W1.4) | 68 |
| 5 | 11.4 | 20 | 0.15 | 1.67 (Z2.0:W1.2) | 74 |
| 6 | 13.0 | −20 | 0.25 | 0.45 (Z1.0:W2.2) | 50 |
| 7 | 11.4 | −20 | 0.05 | 2.20 (Z2.2:W1.0) | 49 |
| 8 | 11.4 | 40 | 0.15 | 0.45 (Z1.0:W2.2) | 87 |
| 9 | 5.2 | 40 | 0.05 | 2.20 (Z2.2:W1.0) | 0 |
| 10 | 11.4 | 40 | 0.10 | 0.45 (Z1.0:W2.2) | 89 |
| 11 | 13.0 | 40 | 0.10 | 0.45 (Z1.0:W2.2) | 67 |
| 12 | 11.4 | 40 | 0.05 | 2.20 (Z2.2:W1.0) | 46 |
| 13 | 11.4 | 40 | 0.05 | 0.45 (Z1.0:W2.2) | 68 |
| 14 | 11.4 | −10 | 0.10 | 0.45 (Z1.0:W2.2) | 81 |
| 15 | 11.4 | 30 | 0.10 | 0.45 (Z1.0:W2.2) | 94 (92)a |
| Entry . | pKaH = P . | T (°C) . | Conc. = V (M) . | Z/W (mL/min) . | HPLC-UV Yield of 3 (%) . |
|---|---|---|---|---|---|
| 1 | 7.7 | 10 | 0.05 | 1.67 (Z2.0:W1.2) | 3 |
| 2 | 7.0 | −10 | 0.20 | 1.00 (Z1.6:W1.6) | 0 |
| 3 | 8.9 | 0 | 0.15 | 0.60 (Z1.2:W2.0) | 35 |
| 4 | 11.4 | 30 | 0.20 | 1.29 (Z1.8:W1.4) | 68 |
| 5 | 11.4 | 20 | 0.15 | 1.67 (Z2.0:W1.2) | 74 |
| 6 | 13.0 | −20 | 0.25 | 0.45 (Z1.0:W2.2) | 50 |
| 7 | 11.4 | −20 | 0.05 | 2.20 (Z2.2:W1.0) | 49 |
| 8 | 11.4 | 40 | 0.15 | 0.45 (Z1.0:W2.2) | 87 |
| 9 | 5.2 | 40 | 0.05 | 2.20 (Z2.2:W1.0) | 0 |
| 10 | 11.4 | 40 | 0.10 | 0.45 (Z1.0:W2.2) | 89 |
| 11 | 13.0 | 40 | 0.10 | 0.45 (Z1.0:W2.2) | 67 |
| 12 | 11.4 | 40 | 0.05 | 2.20 (Z2.2:W1.0) | 46 |
| 13 | 11.4 | 40 | 0.05 | 0.45 (Z1.0:W2.2) | 68 |
| 14 | 11.4 | −10 | 0.10 | 0.45 (Z1.0:W2.2) | 81 |
| 15 | 11.4 | 30 | 0.10 | 0.45 (Z1.0:W2.2) | 94 (92)a |
aIsolated yield.
| Entry . | pKaH = P . | T (°C) . | Conc. = V (M) . | Z/W (mL/min) . | HPLC-UV Yield of 3 (%) . |
|---|---|---|---|---|---|
| 1 | 7.7 | 10 | 0.05 | 1.67 (Z2.0:W1.2) | 3 |
| 2 | 7.0 | −10 | 0.20 | 1.00 (Z1.6:W1.6) | 0 |
| 3 | 8.9 | 0 | 0.15 | 0.60 (Z1.2:W2.0) | 35 |
| 4 | 11.4 | 30 | 0.20 | 1.29 (Z1.8:W1.4) | 68 |
| 5 | 11.4 | 20 | 0.15 | 1.67 (Z2.0:W1.2) | 74 |
| 6 | 13.0 | −20 | 0.25 | 0.45 (Z1.0:W2.2) | 50 |
| 7 | 11.4 | −20 | 0.05 | 2.20 (Z2.2:W1.0) | 49 |
| 8 | 11.4 | 40 | 0.15 | 0.45 (Z1.0:W2.2) | 87 |
| 9 | 5.2 | 40 | 0.05 | 2.20 (Z2.2:W1.0) | 0 |
| 10 | 11.4 | 40 | 0.10 | 0.45 (Z1.0:W2.2) | 89 |
| 11 | 13.0 | 40 | 0.10 | 0.45 (Z1.0:W2.2) | 67 |
| 12 | 11.4 | 40 | 0.05 | 2.20 (Z2.2:W1.0) | 46 |
| 13 | 11.4 | 40 | 0.05 | 0.45 (Z1.0:W2.2) | 68 |
| 14 | 11.4 | −10 | 0.10 | 0.45 (Z1.0:W2.2) | 81 |
| 15 | 11.4 | 30 | 0.10 | 0.45 (Z1.0:W2.2) | 94 (92)a |
| Entry . | pKaH = P . | T (°C) . | Conc. = V (M) . | Z/W (mL/min) . | HPLC-UV Yield of 3 (%) . |
|---|---|---|---|---|---|
| 1 | 7.7 | 10 | 0.05 | 1.67 (Z2.0:W1.2) | 3 |
| 2 | 7.0 | −10 | 0.20 | 1.00 (Z1.6:W1.6) | 0 |
| 3 | 8.9 | 0 | 0.15 | 0.60 (Z1.2:W2.0) | 35 |
| 4 | 11.4 | 30 | 0.20 | 1.29 (Z1.8:W1.4) | 68 |
| 5 | 11.4 | 20 | 0.15 | 1.67 (Z2.0:W1.2) | 74 |
| 6 | 13.0 | −20 | 0.25 | 0.45 (Z1.0:W2.2) | 50 |
| 7 | 11.4 | −20 | 0.05 | 2.20 (Z2.2:W1.0) | 49 |
| 8 | 11.4 | 40 | 0.15 | 0.45 (Z1.0:W2.2) | 87 |
| 9 | 5.2 | 40 | 0.05 | 2.20 (Z2.2:W1.0) | 0 |
| 10 | 11.4 | 40 | 0.10 | 0.45 (Z1.0:W2.2) | 89 |
| 11 | 13.0 | 40 | 0.10 | 0.45 (Z1.0:W2.2) | 67 |
| 12 | 11.4 | 40 | 0.05 | 2.20 (Z2.2:W1.0) | 46 |
| 13 | 11.4 | 40 | 0.05 | 0.45 (Z1.0:W2.2) | 68 |
| 14 | 11.4 | −10 | 0.10 | 0.45 (Z1.0:W2.2) | 81 |
| 15 | 11.4 | 30 | 0.10 | 0.45 (Z1.0:W2.2) | 94 (92)a |
aIsolated yield.
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