Table 1 Open in new tab Description of...

Pure CI n = 69

Pure aVD n = 23

CI and aVD n = 44

CI nor aVD n = 62

P-value (CI)

P-value (aVD)

P-value (CI × aVD)

Age (years)

65.0 ± 10.3

63.9 ± 11.4

63.4 ± 11.1

57.7 ± 13.2

0.029

0.088

0.014

M:F (n)

38:31

13:10

30:14

32:30

—

SBP fall ≥ 50 mmHg (n)

1^a

—

Asystole ≥ 3 s (n)

—

Syncope last year (n; median IQR)

1 (0–4)

1 (0–1)

1 (0–2)

2 (0–4)

Latencies

T-min SBP

16.0 ± 10.1

15.9 ± 10.7

14.4 ± 7.9

19.8 ± 13.0

0.044

0.22

0.74

T-min MAP

14.0 ± 9.1

14.4 ± 8.5

12.0 ± 4.6

15.7 ± 11.2

0.10

0.39

0.57

T-min DBP

13.7 ± 9.4

15.1 ± 8.7

13.8 ± 7.3

19.2 ± 3.2

0.0082

0.41

0.40

T-min HR

7.3 ± 6.1

11.1 ± 9.2

7.5 ± 4.9

14.5 ± 14.0

0.0002

0.19

0.15

T-min TPR

18.9 ± 10.3

18.8 ± 8.6

17.2 ± 5.7

17.6 ± 11.9

0.91

0.92

0.33

T-max SV

10.6 ± 10.1

12.5 ± 6.7

10.9 ± 6.4

17.8 ± 12.7

0.013

0.16

0.12

Peak amplitudes

Delta SBP

35.0 ± 24.1

28.0 ± 16.6

39.4 ± 21.5

16.5 ± 13.8

<0.0001

0.057

0.64

Delta MAP

24.4 ± 16.5

20.1 ± 11.6

29.3 ± 15.5

10.2 ± 9.0

<0.0001

0.0038

0.54

Delta DBP

18.7 ± 12.5

16.7 ± 8.7

24.5 ± 12.5

8.1 ± 7.0

<0.0001

0.0002

0.82

Delta HR

25.2 ± 21.9

4.2 ± 4.0

23.4 ± 21.9

5.4 ± 5.8

<0.0001

0.49

0.96

Delta TPR

0.26 ± 0.33

0.40 ± 0.20

0.44 ± 0.23

0.13 ± 0.15

0.029

<0.0001

0.20

Delta SV

10.5 ± 10.5

11.6 ± 11.7

16.8 ± 12.2

4.8 ± 6.3

0.0012

0.0003

0.98

Sustained magnitude early period

SusMag_LR MAP

−43.2 ± 55.8

−29.7 ± 31.1

−58.1 + 58.6

1.1 + 34.8

<0.0001

0.0071

0.49

SusMag_LR HR

−42.6 ± 40.7

2.4 ± 30.6

−34.5 + 27.7

−1.3 + 22.6

<0.0001

0.19

0.71

SusMag_LR TPR

1.9 ± 69.2

−47.4 ± 44.6

−53.8 + 51.9

15.0 + 50.9

0.62

<0.0001

0.65

SusMag_LR SV

−11.9 ± 62.9

23.0 ± 29.4

28.5 + 51.3

−16.4 + 35.8

0.54

<0.0001

0.73

Sustained magnitude late period

Late SusMag_LR MAP

−2.4 ± 40.7

−4.8 ± 2.5

−1.0 ± 27.1

2.3 ± 32.8

0.77

0.71

0.54

Late SusMag_LR HR

−7.5 ± 28.6

27.1 ± 42.7

−6.1 ± 34.9

7.2 ± 34.7

<0.0001

0.066

0.11

Late SusMag_LR TPR

9.9 ± 69.8

−25.7 ± 44.7

−12.7 ± 61.8

14.4 ± 61.0

0.28

0.0036

0.37

Late SusMag_LR SV

−13.3 ± 57.7

−0.90 ± 22.5

12.4 ± 63.2

−22.0 ± 53.1

0.31

0.021

0.67

Table 1

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Description of cardioinhibition and arterial vasodepression in the response to carotid sinus massage

	Pure CI n = 69	Pure aVD n = 23	CI and aVD n = 44	CI nor aVD n = 62	P-value (CI)	P-value (aVD)	P-value (CI × aVD)
Age (years)	65.0 ± 10.3	63.9 ± 11.4	63.4 ± 11.1	57.7 ± 13.2	0.029	0.088	0.014
M:F (n)	38:31	13:10	30:14	32:30	—	—	—
SBP fall ≥ 50 mmHg (n)	17	1	13	1^a	—	—	—
Asystole ≥ 3 s (n)	8	0	6	0	—	—	—
Syncope last year (n; median IQR)	1 (0–4)	1 (0–1)	1 (0–2)	2 (0–4)
Latencies
T-min SBP	16.0 ± 10.1	15.9 ± 10.7	14.4 ± 7.9	19.8 ± 13.0	0.044	0.22	0.74
T-min MAP	14.0 ± 9.1	14.4 ± 8.5	12.0 ± 4.6	15.7 ± 11.2	0.10	0.39	0.57
T-min DBP	13.7 ± 9.4	15.1 ± 8.7	13.8 ± 7.3	19.2 ± 3.2	0.0082	0.41	0.40
T-min HR	7.3 ± 6.1	11.1 ± 9.2	7.5 ± 4.9	14.5 ± 14.0	0.0002	0.19	0.15
T-min TPR	18.9 ± 10.3	18.8 ± 8.6	17.2 ± 5.7	17.6 ± 11.9	0.91	0.92	0.33
T-max SV	10.6 ± 10.1	12.5 ± 6.7	10.9 ± 6.4	17.8 ± 12.7	0.013	0.16	0.12
Peak amplitudes
Delta SBP	35.0 ± 24.1	28.0 ± 16.6	39.4 ± 21.5	16.5 ± 13.8	<0.0001	0.057	0.64
Delta MAP	24.4 ± 16.5	20.1 ± 11.6	29.3 ± 15.5	10.2 ± 9.0	<0.0001	0.0038	0.54
Delta DBP	18.7 ± 12.5	16.7 ± 8.7	24.5 ± 12.5	8.1 ± 7.0	<0.0001	0.0002	0.82
Delta HR	25.2 ± 21.9	4.2 ± 4.0	23.4 ± 21.9	5.4 ± 5.8	<0.0001	0.49	0.96
Delta TPR	0.26 ± 0.33	0.40 ± 0.20	0.44 ± 0.23	0.13 ± 0.15	0.029	<0.0001	0.20
Delta SV	10.5 ± 10.5	11.6 ± 11.7	16.8 ± 12.2	4.8 ± 6.3	0.0012	0.0003	0.98
Sustained magnitude early period
SusMag_LR MAP	−43.2 ± 55.8	−29.7 ± 31.1	−58.1 + 58.6	1.1 + 34.8	<0.0001	0.0071	0.49
SusMag_LR HR	−42.6 ± 40.7	2.4 ± 30.6	−34.5 + 27.7	−1.3 + 22.6	<0.0001	0.19	0.71
SusMag_LR TPR	1.9 ± 69.2	−47.4 ± 44.6	−53.8 + 51.9	15.0 + 50.9	0.62	<0.0001	0.65
SusMag_LR SV	−11.9 ± 62.9	23.0 ± 29.4	28.5 + 51.3	−16.4 + 35.8	0.54	<0.0001	0.73
Sustained magnitude late period
Late SusMag_LR MAP	−2.4 ± 40.7	−4.8 ± 2.5	−1.0 ± 27.1	2.3 ± 32.8	0.77	0.71	0.54
Late SusMag_LR HR	−7.5 ± 28.6	27.1 ± 42.7	−6.1 ± 34.9	7.2 ± 34.7	<0.0001	0.066	0.11
Late SusMag_LR TPR	9.9 ± 69.8	−25.7 ± 44.7	−12.7 ± 61.8	14.4 ± 61.0	0.28	0.0036	0.37
Late SusMag_LR SV	−13.3 ± 57.7	−0.90 ± 22.5	12.4 ± 63.2	−22.0 ± 53.1	0.31	0.021	0.67

	Pure CI n = 69	Pure aVD n = 23	CI and aVD n = 44	CI nor aVD n = 62	P-value (CI)	P-value (aVD)	P-value (CI × aVD)
Age (years)	65.0 ± 10.3	63.9 ± 11.4	63.4 ± 11.1	57.7 ± 13.2	0.029	0.088	0.014
M:F (n)	38:31	13:10	30:14	32:30	—	—	—
SBP fall ≥ 50 mmHg (n)	17	1	13	1^a	—	—	—
Asystole ≥ 3 s (n)	8	0	6	0	—	—	—
Syncope last year (n; median IQR)	1 (0–4)	1 (0–1)	1 (0–2)	2 (0–4)
Latencies
T-min SBP	16.0 ± 10.1	15.9 ± 10.7	14.4 ± 7.9	19.8 ± 13.0	0.044	0.22	0.74
T-min MAP	14.0 ± 9.1	14.4 ± 8.5	12.0 ± 4.6	15.7 ± 11.2	0.10	0.39	0.57
T-min DBP	13.7 ± 9.4	15.1 ± 8.7	13.8 ± 7.3	19.2 ± 3.2	0.0082	0.41	0.40
T-min HR	7.3 ± 6.1	11.1 ± 9.2	7.5 ± 4.9	14.5 ± 14.0	0.0002	0.19	0.15
T-min TPR	18.9 ± 10.3	18.8 ± 8.6	17.2 ± 5.7	17.6 ± 11.9	0.91	0.92	0.33
T-max SV	10.6 ± 10.1	12.5 ± 6.7	10.9 ± 6.4	17.8 ± 12.7	0.013	0.16	0.12
Peak amplitudes
Delta SBP	35.0 ± 24.1	28.0 ± 16.6	39.4 ± 21.5	16.5 ± 13.8	<0.0001	0.057	0.64
Delta MAP	24.4 ± 16.5	20.1 ± 11.6	29.3 ± 15.5	10.2 ± 9.0	<0.0001	0.0038	0.54
Delta DBP	18.7 ± 12.5	16.7 ± 8.7	24.5 ± 12.5	8.1 ± 7.0	<0.0001	0.0002	0.82
Delta HR	25.2 ± 21.9	4.2 ± 4.0	23.4 ± 21.9	5.4 ± 5.8	<0.0001	0.49	0.96
Delta TPR	0.26 ± 0.33	0.40 ± 0.20	0.44 ± 0.23	0.13 ± 0.15	0.029	<0.0001	0.20
Delta SV	10.5 ± 10.5	11.6 ± 11.7	16.8 ± 12.2	4.8 ± 6.3	0.0012	0.0003	0.98
Sustained magnitude early period
SusMag_LR MAP	−43.2 ± 55.8	−29.7 ± 31.1	−58.1 + 58.6	1.1 + 34.8	<0.0001	0.0071	0.49
SusMag_LR HR	−42.6 ± 40.7	2.4 ± 30.6	−34.5 + 27.7	−1.3 + 22.6	<0.0001	0.19	0.71
SusMag_LR TPR	1.9 ± 69.2	−47.4 ± 44.6	−53.8 + 51.9	15.0 + 50.9	0.62	<0.0001	0.65
SusMag_LR SV	−11.9 ± 62.9	23.0 ± 29.4	28.5 + 51.3	−16.4 + 35.8	0.54	<0.0001	0.73
Sustained magnitude late period
Late SusMag_LR MAP	−2.4 ± 40.7	−4.8 ± 2.5	−1.0 ± 27.1	2.3 ± 32.8	0.77	0.71	0.54
Late SusMag_LR HR	−7.5 ± 28.6	27.1 ± 42.7	−6.1 ± 34.9	7.2 ± 34.7	<0.0001	0.066	0.11
Late SusMag_LR TPR	9.9 ± 69.8	−25.7 ± 44.7	−12.7 ± 61.8	14.4 ± 61.0	0.28	0.0036	0.37
Late SusMag_LR SV	−13.3 ± 57.7	−0.90 ± 22.5	12.4 ± 63.2	−22.0 ± 53.1	0.31	0.021	0.67

Local minima of HR and TPR were ‘overt’ when their amplitude was lower than 3 SD below the mean of baseline for SBP, MAP, HR, and TPR and higher for SV. Massages were divided into four combinations of presence or absence of overt peaks for HR and TPR: ‘pure CI’ means overt HR and obscure TPR; ‘overt aVD’ means obscure HR and overt TPR; ‘both CI and aVD’ means overt HR and overt TPR; and ‘CI nor aVD’ means obscure HR and obscure TPR. Logratio values are shown after multiplication by 1000 to help appreciate their relative sizes. P-values represent ANOVA with the factor CI (present or absent) and aVD (present of absent) and their interaction.

Delta, difference between period of interest and baseline period; SusMagLR, sustained magnitude in logratio units.

^aThis case represents a combination of HR and TPR decreases that were 2.5 and 2.6 SD away from the mean, so neither reached the threshold to be recognized as CI or aVD.

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