| . | Minimum Inhibitory Concentration,a mg/L . | EUCAST-2023, % . | ||||
|---|---|---|---|---|---|---|
| Organism/Antimicrobial Agent . | MIC50 . | MIC90 . | Range . | S . | I . | R . |
| Total Klebsiella pneumoniae complex (N = 96) | ||||||
| Amoxicillin-clavulanate | >16 | >16 | <8 to >16 | 37.5 | … | 62.5 |
| Piperacillin-tazobactam | <8 | >32 | <8 to >32 | 52.0 | … | 48.0 |
| Ceftolozane/tazobactam | 0.5 | 2 | <0.12 to >64 | 90.6 | … | 9.4 |
| Ceftazidime | 1 | >32 | <0.12 to >32 | 55.2 | 3.1 | 41.7 |
| Cefotaxime | 0.5 | >32 | <0.25 to >32 | 56.3 | 1.0 | 42.7 |
| Cefepime | 0.5 | >32 | <0.12 to >32 | 56.3 | 3.1 | 40.6 |
| Aztreonam | <1 | >16 | <1 to >16 | 56.3 | 1.0 | 42.7 |
| Ertapenem | <0.06 | 0.5 | <0.06 to >4 | 90.6 | … | 9.4 |
| Imipenem | 0.5 | 2 | <0.25 to >16 | 92.7 | 4.2 | 3.1 |
| Meropenem | <0.12 | 0.5 | <0.12 to >16 | 94.8 | 2.1 | 3.1 |
| Trimethoprim/sulfamethoxazole | <1/19 | >4/76 | <1/19 to >4/76 | 54.2 | 0.0 | 45.8 |
| Ciprofloxacin | 0.5 | >2 | <0.06 to >2 | 47.9 | 3.1 | 49.0 |
| Gentamicin | <2 | >8 | <2 to >8 | 70.8 | … | 29.2 |
| Tobramycin | <2 | >8 | <2 to >8 | 59.4 | … | 40.6 |
| Amikacin | <8 | 16 | <8 to >32 | 85.4 | … | 14.6 |
| Colistin | <2 | <2 | <2 to >4 | 94.8 | … | 5.2 |
| Non-ESBL/AmpC/carbapenemase (n = 53) | ||||||
| Amoxicillin-clavulanate | <8 | >16 | <8 to >16 | 67.9 | … | 32.1 |
| Piperacillin-tazobactam | <8 | 32 | <8 to >32 | 79.3 | … | 20.7 |
| Ceftolozane-tazobactam | 0.5 | 1 | <0.12 to 2 | 100.0 | … | 0.0 |
| Ceftazidime | 0.5 | 1 | <0.12 to 2 | 98.1 | 1.9 | 0.0 |
| Cefotaxime | <0.25 | 0.5 | <0.25 to 1 | 100.0 | 0.0 | 0.0 |
| Cefepime | <0.12 | 0.5 | <0.12 to 2 | 98.1 | 1.9 | 0.0 |
| Aztreonam | <1 | <1 | <1 | 100.0 | 0.0 | 0.0 |
| Ertapenem | <0.06 | <0.06 | <0.06 to 0.25 | 100.0 | … | 0.0 |
| Imipenem | 0.5 | 1 | <0.25 to 2 | 100.0 | 0.0 | 0.0 |
| Meropenem | <0.12 | <0.12 | <0.12 to 0.25 | 100.0 | 0.0 | 0.0 |
| Trimethoprim/sulfamethoxazole | <1/19 | >4/76 | <1/19 to >4/76 | 84.9 | 0.0 | 15.1 |
| Ciprofloxacin | <0.06 | >2 | <0.06 to 2 | 84.9 | 1.9 | 13.2 |
| Gentamicin | <2 | <2 | <2 to >8 | 98.1 | … | 1.9 |
| Tobramycin | <2 | >8 | <2 to >8 | 98.1 | … | 1.9 |
| Amikacin | <8 | <8 | <8 | 100.0 | … | 0.0 |
| Colistin | <2 | <2 | <2 to >4 | 96.2 | … | 3.8 |
| ESBL/AmpC (n = 36) | ||||||
| Amoxicillin-clavulanate | >16 | >16 | 16 to >16 | 0.0 | … | 100.0 |
| Piperacillin-tazobactam | 32 | >32 | <8 to >32 | 19.4 | … | 80.6 |
| Ceftolozane-tazobactam | 0.5 | 2 | 0.25 to >64 | 91.7 | … | 8.3 |
| Ceftazidime | >32 | >32 | 2 to >32 | 5.6 | 0.0 | 94.4 |
| Cefotaxime | >32 | >32 | 32 to >32 | 0.0 | 0.0 | 100.0 |
| Cefepime | >32 | >32 | 0.25 to >32 | 2.8 | 2.8 | 94.4 |
| Aztreonam | >16 | >16 | 16 to >16 | 0.0 | 0.0 | 100.0 |
| Ertapenem | 0.12 | 0.5 | <0.06 to >4 | 91.7 | … | 8.3 |
| Imipenem | 0.5 | 2 | <0.25 to 4 | 97.2 | 2.8 | 0.0 |
| Meropenem | <0.12 | 0.5 | <0.12 to 0.5 | 100.0 | 0.0 | 0.0 |
| Trimethoprim/sulfamethoxazole | >4/76 | >4/76 | <1/19 to >4/76 | 11.1 | 0.0 | 88.9 |
| Ciprofloxacin | >2 | >2 | <0.06 to >2 | 2.8 | 5.6 | 91.7 |
| Gentamicin | >8 | >8 | <2 to >8 | 36.1 | … | 63.9 |
| Tobramycin | >8 | >8 | <2 to >8 | 8.3 | … | 91.7 |
| Amikacin | <8 | 16 | <8 to >32 | 66.7 | … | 33.3 |
| Colistin | <2 | <2 | <2 to >4 | 94.4 | … | 5.6 |
| Carbapenemase (n = 7) | …b | …b | ||||
| Amoxicillin-clavulanate | >16 | 0.0 | … | 100.0 | ||
| Piperacillin-tazobactam | <8 to >32 | 14.3 | … | 85.7 | ||
| Ceftolozane-tazobactam | 0.5 to >64 | 14.3 | … | 85.7 | ||
| Ceftazidime | 0.5 to >32 | 14.3 | 0.0 | 85.7 | ||
| Cefotaxime | 1 to >32 | 14.3 | 14.3 | 71.4 | ||
| Cefepime | 0.5 to >32 | 14.3 | 14.3 | 71.4 | ||
| Aztreonam | <1 to >16 | 14.3 | 14.3 | 71.4 | ||
| Ertapenem | 0.5 to >4 | 14.3 | … | 85.7 | ||
| Imipenem | <0.25 to >16 | 14.3 | 42.9 | 42.9 | ||
| Meropenem | <0.12 to >16 | 28.6 | 28.6 | 42.9 | ||
| Trimethoprim/sulfamethoxazole | <1/19 to >4/76 | 42.9 | 0.0 | 57.1 | ||
| Ciprofloxacin | 1 to >2 | 0.0 | 0.0 | 100.0 | ||
| Gentamicin | <2 to >8 | 42.9 | … | 57.1 | ||
| Tobramycin | <2 to >8 | 28.6 | … | 71.4 | ||
| Amikacin | <8 to >32 | 71.4 | … | 28.6 | ||
| Colistin | <2 to >4 | 85.7 | … | 14.3 | ||
| . | Minimum Inhibitory Concentration,a mg/L . | EUCAST-2023, % . | ||||
|---|---|---|---|---|---|---|
| Organism/Antimicrobial Agent . | MIC50 . | MIC90 . | Range . | S . | I . | R . |
| Total Klebsiella pneumoniae complex (N = 96) | ||||||
| Amoxicillin-clavulanate | >16 | >16 | <8 to >16 | 37.5 | … | 62.5 |
| Piperacillin-tazobactam | <8 | >32 | <8 to >32 | 52.0 | … | 48.0 |
| Ceftolozane/tazobactam | 0.5 | 2 | <0.12 to >64 | 90.6 | … | 9.4 |
| Ceftazidime | 1 | >32 | <0.12 to >32 | 55.2 | 3.1 | 41.7 |
| Cefotaxime | 0.5 | >32 | <0.25 to >32 | 56.3 | 1.0 | 42.7 |
| Cefepime | 0.5 | >32 | <0.12 to >32 | 56.3 | 3.1 | 40.6 |
| Aztreonam | <1 | >16 | <1 to >16 | 56.3 | 1.0 | 42.7 |
| Ertapenem | <0.06 | 0.5 | <0.06 to >4 | 90.6 | … | 9.4 |
| Imipenem | 0.5 | 2 | <0.25 to >16 | 92.7 | 4.2 | 3.1 |
| Meropenem | <0.12 | 0.5 | <0.12 to >16 | 94.8 | 2.1 | 3.1 |
| Trimethoprim/sulfamethoxazole | <1/19 | >4/76 | <1/19 to >4/76 | 54.2 | 0.0 | 45.8 |
| Ciprofloxacin | 0.5 | >2 | <0.06 to >2 | 47.9 | 3.1 | 49.0 |
| Gentamicin | <2 | >8 | <2 to >8 | 70.8 | … | 29.2 |
| Tobramycin | <2 | >8 | <2 to >8 | 59.4 | … | 40.6 |
| Amikacin | <8 | 16 | <8 to >32 | 85.4 | … | 14.6 |
| Colistin | <2 | <2 | <2 to >4 | 94.8 | … | 5.2 |
| Non-ESBL/AmpC/carbapenemase (n = 53) | ||||||
| Amoxicillin-clavulanate | <8 | >16 | <8 to >16 | 67.9 | … | 32.1 |
| Piperacillin-tazobactam | <8 | 32 | <8 to >32 | 79.3 | … | 20.7 |
| Ceftolozane-tazobactam | 0.5 | 1 | <0.12 to 2 | 100.0 | … | 0.0 |
| Ceftazidime | 0.5 | 1 | <0.12 to 2 | 98.1 | 1.9 | 0.0 |
| Cefotaxime | <0.25 | 0.5 | <0.25 to 1 | 100.0 | 0.0 | 0.0 |
| Cefepime | <0.12 | 0.5 | <0.12 to 2 | 98.1 | 1.9 | 0.0 |
| Aztreonam | <1 | <1 | <1 | 100.0 | 0.0 | 0.0 |
| Ertapenem | <0.06 | <0.06 | <0.06 to 0.25 | 100.0 | … | 0.0 |
| Imipenem | 0.5 | 1 | <0.25 to 2 | 100.0 | 0.0 | 0.0 |
| Meropenem | <0.12 | <0.12 | <0.12 to 0.25 | 100.0 | 0.0 | 0.0 |
| Trimethoprim/sulfamethoxazole | <1/19 | >4/76 | <1/19 to >4/76 | 84.9 | 0.0 | 15.1 |
| Ciprofloxacin | <0.06 | >2 | <0.06 to 2 | 84.9 | 1.9 | 13.2 |
| Gentamicin | <2 | <2 | <2 to >8 | 98.1 | … | 1.9 |
| Tobramycin | <2 | >8 | <2 to >8 | 98.1 | … | 1.9 |
| Amikacin | <8 | <8 | <8 | 100.0 | … | 0.0 |
| Colistin | <2 | <2 | <2 to >4 | 96.2 | … | 3.8 |
| ESBL/AmpC (n = 36) | ||||||
| Amoxicillin-clavulanate | >16 | >16 | 16 to >16 | 0.0 | … | 100.0 |
| Piperacillin-tazobactam | 32 | >32 | <8 to >32 | 19.4 | … | 80.6 |
| Ceftolozane-tazobactam | 0.5 | 2 | 0.25 to >64 | 91.7 | … | 8.3 |
| Ceftazidime | >32 | >32 | 2 to >32 | 5.6 | 0.0 | 94.4 |
| Cefotaxime | >32 | >32 | 32 to >32 | 0.0 | 0.0 | 100.0 |
| Cefepime | >32 | >32 | 0.25 to >32 | 2.8 | 2.8 | 94.4 |
| Aztreonam | >16 | >16 | 16 to >16 | 0.0 | 0.0 | 100.0 |
| Ertapenem | 0.12 | 0.5 | <0.06 to >4 | 91.7 | … | 8.3 |
| Imipenem | 0.5 | 2 | <0.25 to 4 | 97.2 | 2.8 | 0.0 |
| Meropenem | <0.12 | 0.5 | <0.12 to 0.5 | 100.0 | 0.0 | 0.0 |
| Trimethoprim/sulfamethoxazole | >4/76 | >4/76 | <1/19 to >4/76 | 11.1 | 0.0 | 88.9 |
| Ciprofloxacin | >2 | >2 | <0.06 to >2 | 2.8 | 5.6 | 91.7 |
| Gentamicin | >8 | >8 | <2 to >8 | 36.1 | … | 63.9 |
| Tobramycin | >8 | >8 | <2 to >8 | 8.3 | … | 91.7 |
| Amikacin | <8 | 16 | <8 to >32 | 66.7 | … | 33.3 |
| Colistin | <2 | <2 | <2 to >4 | 94.4 | … | 5.6 |
| Carbapenemase (n = 7) | …b | …b | ||||
| Amoxicillin-clavulanate | >16 | 0.0 | … | 100.0 | ||
| Piperacillin-tazobactam | <8 to >32 | 14.3 | … | 85.7 | ||
| Ceftolozane-tazobactam | 0.5 to >64 | 14.3 | … | 85.7 | ||
| Ceftazidime | 0.5 to >32 | 14.3 | 0.0 | 85.7 | ||
| Cefotaxime | 1 to >32 | 14.3 | 14.3 | 71.4 | ||
| Cefepime | 0.5 to >32 | 14.3 | 14.3 | 71.4 | ||
| Aztreonam | <1 to >16 | 14.3 | 14.3 | 71.4 | ||
| Ertapenem | 0.5 to >4 | 14.3 | … | 85.7 | ||
| Imipenem | <0.25 to >16 | 14.3 | 42.9 | 42.9 | ||
| Meropenem | <0.12 to >16 | 28.6 | 28.6 | 42.9 | ||
| Trimethoprim/sulfamethoxazole | <1/19 to >4/76 | 42.9 | 0.0 | 57.1 | ||
| Ciprofloxacin | 1 to >2 | 0.0 | 0.0 | 100.0 | ||
| Gentamicin | <2 to >8 | 42.9 | … | 57.1 | ||
| Tobramycin | <2 to >8 | 28.6 | … | 71.4 | ||
| Amikacin | <8 to >32 | 71.4 | … | 28.6 | ||
| Colistin | <2 to >4 | 85.7 | … | 14.3 | ||
Abbreviations: ESBL, extended-spectrum β-lactamase; I, susceptible–increase exposure; R, resistant; S, susceptible–standard dose.
aMIC50 and MIC90 refer to values that inhibit 50% and 90% of the growth of the tested bacterial isolates, respectively.
bNot applicable: number of isolates <10.
| . | Minimum Inhibitory Concentration,a mg/L . | EUCAST-2023, % . | ||||
|---|---|---|---|---|---|---|
| Organism/Antimicrobial Agent . | MIC50 . | MIC90 . | Range . | S . | I . | R . |
| Total Klebsiella pneumoniae complex (N = 96) | ||||||
| Amoxicillin-clavulanate | >16 | >16 | <8 to >16 | 37.5 | … | 62.5 |
| Piperacillin-tazobactam | <8 | >32 | <8 to >32 | 52.0 | … | 48.0 |
| Ceftolozane/tazobactam | 0.5 | 2 | <0.12 to >64 | 90.6 | … | 9.4 |
| Ceftazidime | 1 | >32 | <0.12 to >32 | 55.2 | 3.1 | 41.7 |
| Cefotaxime | 0.5 | >32 | <0.25 to >32 | 56.3 | 1.0 | 42.7 |
| Cefepime | 0.5 | >32 | <0.12 to >32 | 56.3 | 3.1 | 40.6 |
| Aztreonam | <1 | >16 | <1 to >16 | 56.3 | 1.0 | 42.7 |
| Ertapenem | <0.06 | 0.5 | <0.06 to >4 | 90.6 | … | 9.4 |
| Imipenem | 0.5 | 2 | <0.25 to >16 | 92.7 | 4.2 | 3.1 |
| Meropenem | <0.12 | 0.5 | <0.12 to >16 | 94.8 | 2.1 | 3.1 |
| Trimethoprim/sulfamethoxazole | <1/19 | >4/76 | <1/19 to >4/76 | 54.2 | 0.0 | 45.8 |
| Ciprofloxacin | 0.5 | >2 | <0.06 to >2 | 47.9 | 3.1 | 49.0 |
| Gentamicin | <2 | >8 | <2 to >8 | 70.8 | … | 29.2 |
| Tobramycin | <2 | >8 | <2 to >8 | 59.4 | … | 40.6 |
| Amikacin | <8 | 16 | <8 to >32 | 85.4 | … | 14.6 |
| Colistin | <2 | <2 | <2 to >4 | 94.8 | … | 5.2 |
| Non-ESBL/AmpC/carbapenemase (n = 53) | ||||||
| Amoxicillin-clavulanate | <8 | >16 | <8 to >16 | 67.9 | … | 32.1 |
| Piperacillin-tazobactam | <8 | 32 | <8 to >32 | 79.3 | … | 20.7 |
| Ceftolozane-tazobactam | 0.5 | 1 | <0.12 to 2 | 100.0 | … | 0.0 |
| Ceftazidime | 0.5 | 1 | <0.12 to 2 | 98.1 | 1.9 | 0.0 |
| Cefotaxime | <0.25 | 0.5 | <0.25 to 1 | 100.0 | 0.0 | 0.0 |
| Cefepime | <0.12 | 0.5 | <0.12 to 2 | 98.1 | 1.9 | 0.0 |
| Aztreonam | <1 | <1 | <1 | 100.0 | 0.0 | 0.0 |
| Ertapenem | <0.06 | <0.06 | <0.06 to 0.25 | 100.0 | … | 0.0 |
| Imipenem | 0.5 | 1 | <0.25 to 2 | 100.0 | 0.0 | 0.0 |
| Meropenem | <0.12 | <0.12 | <0.12 to 0.25 | 100.0 | 0.0 | 0.0 |
| Trimethoprim/sulfamethoxazole | <1/19 | >4/76 | <1/19 to >4/76 | 84.9 | 0.0 | 15.1 |
| Ciprofloxacin | <0.06 | >2 | <0.06 to 2 | 84.9 | 1.9 | 13.2 |
| Gentamicin | <2 | <2 | <2 to >8 | 98.1 | … | 1.9 |
| Tobramycin | <2 | >8 | <2 to >8 | 98.1 | … | 1.9 |
| Amikacin | <8 | <8 | <8 | 100.0 | … | 0.0 |
| Colistin | <2 | <2 | <2 to >4 | 96.2 | … | 3.8 |
| ESBL/AmpC (n = 36) | ||||||
| Amoxicillin-clavulanate | >16 | >16 | 16 to >16 | 0.0 | … | 100.0 |
| Piperacillin-tazobactam | 32 | >32 | <8 to >32 | 19.4 | … | 80.6 |
| Ceftolozane-tazobactam | 0.5 | 2 | 0.25 to >64 | 91.7 | … | 8.3 |
| Ceftazidime | >32 | >32 | 2 to >32 | 5.6 | 0.0 | 94.4 |
| Cefotaxime | >32 | >32 | 32 to >32 | 0.0 | 0.0 | 100.0 |
| Cefepime | >32 | >32 | 0.25 to >32 | 2.8 | 2.8 | 94.4 |
| Aztreonam | >16 | >16 | 16 to >16 | 0.0 | 0.0 | 100.0 |
| Ertapenem | 0.12 | 0.5 | <0.06 to >4 | 91.7 | … | 8.3 |
| Imipenem | 0.5 | 2 | <0.25 to 4 | 97.2 | 2.8 | 0.0 |
| Meropenem | <0.12 | 0.5 | <0.12 to 0.5 | 100.0 | 0.0 | 0.0 |
| Trimethoprim/sulfamethoxazole | >4/76 | >4/76 | <1/19 to >4/76 | 11.1 | 0.0 | 88.9 |
| Ciprofloxacin | >2 | >2 | <0.06 to >2 | 2.8 | 5.6 | 91.7 |
| Gentamicin | >8 | >8 | <2 to >8 | 36.1 | … | 63.9 |
| Tobramycin | >8 | >8 | <2 to >8 | 8.3 | … | 91.7 |
| Amikacin | <8 | 16 | <8 to >32 | 66.7 | … | 33.3 |
| Colistin | <2 | <2 | <2 to >4 | 94.4 | … | 5.6 |
| Carbapenemase (n = 7) | …b | …b | ||||
| Amoxicillin-clavulanate | >16 | 0.0 | … | 100.0 | ||
| Piperacillin-tazobactam | <8 to >32 | 14.3 | … | 85.7 | ||
| Ceftolozane-tazobactam | 0.5 to >64 | 14.3 | … | 85.7 | ||
| Ceftazidime | 0.5 to >32 | 14.3 | 0.0 | 85.7 | ||
| Cefotaxime | 1 to >32 | 14.3 | 14.3 | 71.4 | ||
| Cefepime | 0.5 to >32 | 14.3 | 14.3 | 71.4 | ||
| Aztreonam | <1 to >16 | 14.3 | 14.3 | 71.4 | ||
| Ertapenem | 0.5 to >4 | 14.3 | … | 85.7 | ||
| Imipenem | <0.25 to >16 | 14.3 | 42.9 | 42.9 | ||
| Meropenem | <0.12 to >16 | 28.6 | 28.6 | 42.9 | ||
| Trimethoprim/sulfamethoxazole | <1/19 to >4/76 | 42.9 | 0.0 | 57.1 | ||
| Ciprofloxacin | 1 to >2 | 0.0 | 0.0 | 100.0 | ||
| Gentamicin | <2 to >8 | 42.9 | … | 57.1 | ||
| Tobramycin | <2 to >8 | 28.6 | … | 71.4 | ||
| Amikacin | <8 to >32 | 71.4 | … | 28.6 | ||
| Colistin | <2 to >4 | 85.7 | … | 14.3 | ||
| . | Minimum Inhibitory Concentration,a mg/L . | EUCAST-2023, % . | ||||
|---|---|---|---|---|---|---|
| Organism/Antimicrobial Agent . | MIC50 . | MIC90 . | Range . | S . | I . | R . |
| Total Klebsiella pneumoniae complex (N = 96) | ||||||
| Amoxicillin-clavulanate | >16 | >16 | <8 to >16 | 37.5 | … | 62.5 |
| Piperacillin-tazobactam | <8 | >32 | <8 to >32 | 52.0 | … | 48.0 |
| Ceftolozane/tazobactam | 0.5 | 2 | <0.12 to >64 | 90.6 | … | 9.4 |
| Ceftazidime | 1 | >32 | <0.12 to >32 | 55.2 | 3.1 | 41.7 |
| Cefotaxime | 0.5 | >32 | <0.25 to >32 | 56.3 | 1.0 | 42.7 |
| Cefepime | 0.5 | >32 | <0.12 to >32 | 56.3 | 3.1 | 40.6 |
| Aztreonam | <1 | >16 | <1 to >16 | 56.3 | 1.0 | 42.7 |
| Ertapenem | <0.06 | 0.5 | <0.06 to >4 | 90.6 | … | 9.4 |
| Imipenem | 0.5 | 2 | <0.25 to >16 | 92.7 | 4.2 | 3.1 |
| Meropenem | <0.12 | 0.5 | <0.12 to >16 | 94.8 | 2.1 | 3.1 |
| Trimethoprim/sulfamethoxazole | <1/19 | >4/76 | <1/19 to >4/76 | 54.2 | 0.0 | 45.8 |
| Ciprofloxacin | 0.5 | >2 | <0.06 to >2 | 47.9 | 3.1 | 49.0 |
| Gentamicin | <2 | >8 | <2 to >8 | 70.8 | … | 29.2 |
| Tobramycin | <2 | >8 | <2 to >8 | 59.4 | … | 40.6 |
| Amikacin | <8 | 16 | <8 to >32 | 85.4 | … | 14.6 |
| Colistin | <2 | <2 | <2 to >4 | 94.8 | … | 5.2 |
| Non-ESBL/AmpC/carbapenemase (n = 53) | ||||||
| Amoxicillin-clavulanate | <8 | >16 | <8 to >16 | 67.9 | … | 32.1 |
| Piperacillin-tazobactam | <8 | 32 | <8 to >32 | 79.3 | … | 20.7 |
| Ceftolozane-tazobactam | 0.5 | 1 | <0.12 to 2 | 100.0 | … | 0.0 |
| Ceftazidime | 0.5 | 1 | <0.12 to 2 | 98.1 | 1.9 | 0.0 |
| Cefotaxime | <0.25 | 0.5 | <0.25 to 1 | 100.0 | 0.0 | 0.0 |
| Cefepime | <0.12 | 0.5 | <0.12 to 2 | 98.1 | 1.9 | 0.0 |
| Aztreonam | <1 | <1 | <1 | 100.0 | 0.0 | 0.0 |
| Ertapenem | <0.06 | <0.06 | <0.06 to 0.25 | 100.0 | … | 0.0 |
| Imipenem | 0.5 | 1 | <0.25 to 2 | 100.0 | 0.0 | 0.0 |
| Meropenem | <0.12 | <0.12 | <0.12 to 0.25 | 100.0 | 0.0 | 0.0 |
| Trimethoprim/sulfamethoxazole | <1/19 | >4/76 | <1/19 to >4/76 | 84.9 | 0.0 | 15.1 |
| Ciprofloxacin | <0.06 | >2 | <0.06 to 2 | 84.9 | 1.9 | 13.2 |
| Gentamicin | <2 | <2 | <2 to >8 | 98.1 | … | 1.9 |
| Tobramycin | <2 | >8 | <2 to >8 | 98.1 | … | 1.9 |
| Amikacin | <8 | <8 | <8 | 100.0 | … | 0.0 |
| Colistin | <2 | <2 | <2 to >4 | 96.2 | … | 3.8 |
| ESBL/AmpC (n = 36) | ||||||
| Amoxicillin-clavulanate | >16 | >16 | 16 to >16 | 0.0 | … | 100.0 |
| Piperacillin-tazobactam | 32 | >32 | <8 to >32 | 19.4 | … | 80.6 |
| Ceftolozane-tazobactam | 0.5 | 2 | 0.25 to >64 | 91.7 | … | 8.3 |
| Ceftazidime | >32 | >32 | 2 to >32 | 5.6 | 0.0 | 94.4 |
| Cefotaxime | >32 | >32 | 32 to >32 | 0.0 | 0.0 | 100.0 |
| Cefepime | >32 | >32 | 0.25 to >32 | 2.8 | 2.8 | 94.4 |
| Aztreonam | >16 | >16 | 16 to >16 | 0.0 | 0.0 | 100.0 |
| Ertapenem | 0.12 | 0.5 | <0.06 to >4 | 91.7 | … | 8.3 |
| Imipenem | 0.5 | 2 | <0.25 to 4 | 97.2 | 2.8 | 0.0 |
| Meropenem | <0.12 | 0.5 | <0.12 to 0.5 | 100.0 | 0.0 | 0.0 |
| Trimethoprim/sulfamethoxazole | >4/76 | >4/76 | <1/19 to >4/76 | 11.1 | 0.0 | 88.9 |
| Ciprofloxacin | >2 | >2 | <0.06 to >2 | 2.8 | 5.6 | 91.7 |
| Gentamicin | >8 | >8 | <2 to >8 | 36.1 | … | 63.9 |
| Tobramycin | >8 | >8 | <2 to >8 | 8.3 | … | 91.7 |
| Amikacin | <8 | 16 | <8 to >32 | 66.7 | … | 33.3 |
| Colistin | <2 | <2 | <2 to >4 | 94.4 | … | 5.6 |
| Carbapenemase (n = 7) | …b | …b | ||||
| Amoxicillin-clavulanate | >16 | 0.0 | … | 100.0 | ||
| Piperacillin-tazobactam | <8 to >32 | 14.3 | … | 85.7 | ||
| Ceftolozane-tazobactam | 0.5 to >64 | 14.3 | … | 85.7 | ||
| Ceftazidime | 0.5 to >32 | 14.3 | 0.0 | 85.7 | ||
| Cefotaxime | 1 to >32 | 14.3 | 14.3 | 71.4 | ||
| Cefepime | 0.5 to >32 | 14.3 | 14.3 | 71.4 | ||
| Aztreonam | <1 to >16 | 14.3 | 14.3 | 71.4 | ||
| Ertapenem | 0.5 to >4 | 14.3 | … | 85.7 | ||
| Imipenem | <0.25 to >16 | 14.3 | 42.9 | 42.9 | ||
| Meropenem | <0.12 to >16 | 28.6 | 28.6 | 42.9 | ||
| Trimethoprim/sulfamethoxazole | <1/19 to >4/76 | 42.9 | 0.0 | 57.1 | ||
| Ciprofloxacin | 1 to >2 | 0.0 | 0.0 | 100.0 | ||
| Gentamicin | <2 to >8 | 42.9 | … | 57.1 | ||
| Tobramycin | <2 to >8 | 28.6 | … | 71.4 | ||
| Amikacin | <8 to >32 | 71.4 | … | 28.6 | ||
| Colistin | <2 to >4 | 85.7 | … | 14.3 | ||
Abbreviations: ESBL, extended-spectrum β-lactamase; I, susceptible–increase exposure; R, resistant; S, susceptible–standard dose.
aMIC50 and MIC90 refer to values that inhibit 50% and 90% of the growth of the tested bacterial isolates, respectively.
bNot applicable: number of isolates <10.
This PDF is available to Subscribers Only
View Article Abstract & Purchase OptionsFor full access to this pdf, sign in to an existing account, or purchase an annual subscription.
