Table 1. Open in new tab Demographic and...

	Low Responders	High Responders	P	Test
Number	54	20
Age (year)	33.94 ± 1.922	30.59 ± 2.573	0.1584	Mann-Whitney test
Sex	Female	48.98%	65.22%	0.2169	Fisher exact test
Male	51.02%	34.78%
Ethnicity	Caucasian	78.72%	95.00%	0.1529	Fisher exact test
American Indian	21.28%	5.00%
Albumin (g/dl)	2.806 ± 0.1035	3.45 ± 0.16	0.0005	Unpaired t test
Leucocytes (cells/ml)	10109 ± 497.3	9920 ± 664.7	0.4157	Mann-Whitney test
Lymphocytes (cells/ml)	1368 ± 100.2	1845 ± 269.7	0.022	Mann-Whitney test
Neutrophils (cells/ml)	7566 ± 460.2	6866 ± 498.3	0.1804	Mann-Whitney test
Monocytes (cells/mL)	771.9 ± 66.76	839.0 ± 83.6	0.2769	Mann-Whitney test
Neutrophil/Lymphocyte Ratio	7.609 ± 0.9614	4.693 ± 0.50	0.0255	Mann-Whitney test
Time of Disease Evolution (months)	4.227 ± 0.4536	2.375 ± 0.4724	0.0118	Mann-Whitney test
Radiology	Mild/Moderate	24.00%	42.11%	0.0109	Fisher exact test
Severe	76.00%	57.89%
AFB	0/“+”	18.75%	55.00%	0.0071	Fisher exact test
“++”/“+++”	81.25%	45.00%
IFN-γ index	29.2 ± 9.2	229.3 ± 70.4	<0.0001	Mann-Whitney test
Proliferation index	7.0 ± 0.99	26.6 ± 2.9	<0.0001	Mann-Whitney test
Increase in the % of SLAMF1⁺ T cells	2.2 ± 0.50	10.9 ± 1.4	<0.0001	Mann-Whitney test

Low Responders

High Responders

Test

Number

Age (year)

33.94 ± 1.922

30.59 ± 2.573

0.1584

Mann-Whitney test

Sex

Female

48.98%

65.22%

0.2169

Fisher exact test

Male

51.02%

34.78%

Ethnicity

Caucasian

78.72%

95.00%

0.1529

Fisher exact test

American Indian

21.28%

5.00%

Albumin (g/dl)

2.806 ± 0.1035

3.45 ± 0.16

0.0005

Unpaired t test

Leucocytes (cells/ml)

10109 ± 497.3

9920 ± 664.7

0.4157

Mann-Whitney test

Lymphocytes (cells/ml)

1368 ± 100.2

1845 ± 269.7

0.022

Mann-Whitney test

Neutrophils (cells/ml)

7566 ± 460.2

6866 ± 498.3

0.1804

Mann-Whitney test

Monocytes (cells/mL)

771.9 ± 66.76

839.0 ± 83.6

0.2769

Mann-Whitney test

Neutrophil/Lymphocyte Ratio

7.609 ± 0.9614

4.693 ± 0.50

0.0255

Mann-Whitney test

Time of Disease Evolution (months)

4.227 ± 0.4536

2.375 ± 0.4724

0.0118

Mann-Whitney test

Radiology

Mild/Moderate

24.00%

42.11%

0.0109

Fisher exact test

Severe

76.00%

57.89%

AFB

0/“+”

18.75%

55.00%

0.0071

Fisher exact test

“++”/“+++”

81.25%

45.00%

IFN-γ index

29.2 ± 9.2

229.3 ± 70.4

<0.0001

Mann-Whitney test

Proliferation index

7.0 ± 0.99

26.6 ± 2.9

<0.0001

Mann-Whitney test

Increase in the % of SLAMF1⁺ T cells

2.2 ± 0.50

10.9 ± 1.4

<0.0001

Mann-Whitney test

	Low Responders	High Responders	P	Test
Number	54	20
Age (year)	33.94 ± 1.922	30.59 ± 2.573	0.1584	Mann-Whitney test
Sex	Female	48.98%	65.22%	0.2169	Fisher exact test
Male	51.02%	34.78%
Ethnicity	Caucasian	78.72%	95.00%	0.1529	Fisher exact test
American Indian	21.28%	5.00%
Albumin (g/dl)	2.806 ± 0.1035	3.45 ± 0.16	0.0005	Unpaired t test
Leucocytes (cells/ml)	10109 ± 497.3	9920 ± 664.7	0.4157	Mann-Whitney test
Lymphocytes (cells/ml)	1368 ± 100.2	1845 ± 269.7	0.022	Mann-Whitney test
Neutrophils (cells/ml)	7566 ± 460.2	6866 ± 498.3	0.1804	Mann-Whitney test
Monocytes (cells/mL)	771.9 ± 66.76	839.0 ± 83.6	0.2769	Mann-Whitney test
Neutrophil/Lymphocyte Ratio	7.609 ± 0.9614	4.693 ± 0.50	0.0255	Mann-Whitney test
Time of Disease Evolution (months)	4.227 ± 0.4536	2.375 ± 0.4724	0.0118	Mann-Whitney test
Radiology	Mild/Moderate	24.00%	42.11%	0.0109	Fisher exact test
Severe	76.00%	57.89%
AFB	0/“+”	18.75%	55.00%	0.0071	Fisher exact test
“++”/“+++”	81.25%	45.00%
IFN-γ index	29.2 ± 9.2	229.3 ± 70.4	<0.0001	Mann-Whitney test
Proliferation index	7.0 ± 0.99	26.6 ± 2.9	<0.0001	Mann-Whitney test
Increase in the % of SLAMF1⁺ T cells	2.2 ± 0.50	10.9 ± 1.4	<0.0001	Mann-Whitney test

Table 1.

Open in new tab

Demographic and clinical parameters of TB patients.

		Low Responders	High Responders	P	Test
Number		54	20
Age (year)		33.94 ± 1.922	30.59 ± 2.573	0.1584	Mann-Whitney test
Sex	Female	48.98%	65.22%	0.2169	Fisher exact test
Sex	Male	51.02%	34.78%	0.2169	Fisher exact test
Ethnicity	Caucasian	78.72%	95.00%	0.1529	Fisher exact test
Ethnicity	American Indian	21.28%	5.00%	0.1529	Fisher exact test
Albumin (g/dl)		2.806 ± 0.1035	3.45 ± 0.16	0.0005	Unpaired t test
Leucocytes (cells/ml)		10109 ± 497.3	9920 ± 664.7	0.4157	Mann-Whitney test
Lymphocytes (cells/ml)		1368 ± 100.2	1845 ± 269.7	0.022	Mann-Whitney test
Neutrophils (cells/ml)		7566 ± 460.2	6866 ± 498.3	0.1804	Mann-Whitney test
Monocytes (cells/mL)		771.9 ± 66.76	839.0 ± 83.6	0.2769	Mann-Whitney test
Neutrophil/Lymphocyte Ratio		7.609 ± 0.9614	4.693 ± 0.50	0.0255	Mann-Whitney test
Time of Disease Evolution (months)		4.227 ± 0.4536	2.375 ± 0.4724	0.0118	Mann-Whitney test
Radiology	Mild/Moderate	24.00%	42.11%	0.0109	Fisher exact test
Radiology	Severe	76.00%	57.89%	0.0109	Fisher exact test
AFB	0/“+”	18.75%	55.00%	0.0071	Fisher exact test
AFB	“++”/“+++”	81.25%	45.00%	0.0071	Fisher exact test
IFN-γ index		29.2 ± 9.2	229.3 ± 70.4	<0.0001	Mann-Whitney test
Proliferation index		7.0 ± 0.99	26.6 ± 2.9	<0.0001	Mann-Whitney test
Increase in the % of SLAMF1⁺ T cells		2.2 ± 0.50	10.9 ± 1.4	<0.0001	Mann-Whitney test

		Low Responders	High Responders	P	Test
Number		54	20
Age (year)		33.94 ± 1.922	30.59 ± 2.573	0.1584	Mann-Whitney test
Sex	Female	48.98%	65.22%	0.2169	Fisher exact test
Sex	Male	51.02%	34.78%	0.2169	Fisher exact test
Ethnicity	Caucasian	78.72%	95.00%	0.1529	Fisher exact test
Ethnicity	American Indian	21.28%	5.00%	0.1529	Fisher exact test
Albumin (g/dl)		2.806 ± 0.1035	3.45 ± 0.16	0.0005	Unpaired t test
Leucocytes (cells/ml)		10109 ± 497.3	9920 ± 664.7	0.4157	Mann-Whitney test
Lymphocytes (cells/ml)		1368 ± 100.2	1845 ± 269.7	0.022	Mann-Whitney test
Neutrophils (cells/ml)		7566 ± 460.2	6866 ± 498.3	0.1804	Mann-Whitney test
Monocytes (cells/mL)		771.9 ± 66.76	839.0 ± 83.6	0.2769	Mann-Whitney test
Neutrophil/Lymphocyte Ratio		7.609 ± 0.9614	4.693 ± 0.50	0.0255	Mann-Whitney test
Time of Disease Evolution (months)		4.227 ± 0.4536	2.375 ± 0.4724	0.0118	Mann-Whitney test
Radiology	Mild/Moderate	24.00%	42.11%	0.0109	Fisher exact test
Radiology	Severe	76.00%	57.89%	0.0109	Fisher exact test
AFB	0/“+”	18.75%	55.00%	0.0071	Fisher exact test
AFB	“++”/“+++”	81.25%	45.00%	0.0071	Fisher exact test
IFN-γ index		29.2 ± 9.2	229.3 ± 70.4	<0.0001	Mann-Whitney test
Proliferation index		7.0 ± 0.99	26.6 ± 2.9	<0.0001	Mann-Whitney test
Increase in the % of SLAMF1⁺ T cells		2.2 ± 0.50	10.9 ± 1.4	<0.0001	Mann-Whitney test

Immunological classification of TB patients as High and Low Responders (HR and LR) was performed according to the IFN-γ index; proliferation index and increase in the percentage of SLAMF1⁺ T cells in response to Mtb-Ag stimulation. Clinical symptoms analyzed in TB patients previous to hospital admission to establish the time (months) of disease evolution were: weight loss, night sweats, symptoms of malaise or weakness, persistent fever, presence of cough, history of shortness of breath, and hemoptysis. Radiological lesions: “mild” corresponds to patients with a single lobe involved and without visible cavities; “moderate” relates to patients presenting unilateral involvement of two or more lobes with cavities, if present, reaching a total diameter no greater than 4 cm; “severe” corresponds to bilateral disease with massive affectation and multiple cavities. Acid-Fast Bacilli (AFB) in sputum smear represent: AFB-, 0 bacilli count; AFB +, 1–9 bacilli/100 fields; AFB + +, 1–9 bacilli/10 fields; AFB + + + , 1–9 bacilli/field. Continuous data are expressed as mean ± SEM, and categorical data are expressed as number (percentages).

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