Metabolic parameters of female TALLYHO/JngJ either treated or not with 4-PBA
| Mouse genotype/intervention . | Body weight at 20 weeks (g) . | Pancreas weight (g) . | Liver weight (g) . | Adipose tissue weight (g) . | Plasma cholesterol (mM) . | Plasma triglycerides (mM) . | Serum insulin (ng/mL) . |
|---|---|---|---|---|---|---|---|
| TALLYHO/JngJ sham | 43.80 ± 3.10 | 0.22 ± 0.01 | 1.51 ± 0.15 | 3.59 ± 0.82 | 3.73 ± 0.99a | 1.02 ± 0.23b | 0.90 ± 0.16c |
| TALLYHO/JngJ sham + 4-PBA | 44.14 ± 1.81 | 0.24 ± 0.07 | 2.37 ± 0.36d | 4.98 ± 0.20e | 3.29 ± 1.39f | 1.07 ± 0.12g | 0.63 ± 0.16 |
| TALLYHO/JngJ ovx | 39.94 ± 1.42 | 0.21 ± 0.02 | 2.03 ± 0.06 | 2.36 ± 0.34 | 5.40 ± 0.52 | 1.97 ± 0.26 | 0.35 ± 0.15 |
| TALLYHO/JngJ ovx + 4-PBA | 43.99 ± 1.25 | 0.21 ± 0.01 | 2.14 ± 0.06 | 3.26 ± 0.16 | 6.88 ± 0.60h | 1.21 ± 0.22 | 0.47 ± 0.15 |
| Mouse genotype/intervention . | Body weight at 20 weeks (g) . | Pancreas weight (g) . | Liver weight (g) . | Adipose tissue weight (g) . | Plasma cholesterol (mM) . | Plasma triglycerides (mM) . | Serum insulin (ng/mL) . |
|---|---|---|---|---|---|---|---|
| TALLYHO/JngJ sham | 43.80 ± 3.10 | 0.22 ± 0.01 | 1.51 ± 0.15 | 3.59 ± 0.82 | 3.73 ± 0.99a | 1.02 ± 0.23b | 0.90 ± 0.16c |
| TALLYHO/JngJ sham + 4-PBA | 44.14 ± 1.81 | 0.24 ± 0.07 | 2.37 ± 0.36d | 4.98 ± 0.20e | 3.29 ± 1.39f | 1.07 ± 0.12g | 0.63 ± 0.16 |
| TALLYHO/JngJ ovx | 39.94 ± 1.42 | 0.21 ± 0.02 | 2.03 ± 0.06 | 2.36 ± 0.34 | 5.40 ± 0.52 | 1.97 ± 0.26 | 0.35 ± 0.15 |
| TALLYHO/JngJ ovx + 4-PBA | 43.99 ± 1.25 | 0.21 ± 0.01 | 2.14 ± 0.06 | 3.26 ± 0.16 | 6.88 ± 0.60h | 1.21 ± 0.22 | 0.47 ± 0.15 |
Each average value is presented with the standard error of the mean. Abbreviation: 4-PBA, 4-phenylbutyric acid.
aP < 0.001 TALLYHO/JngJ sham vs TALLYHO/JngJ ovx + 4-PBA.
bP < .0001 TALLYHO/JngJ sham vs TALLYHO/JngJ ovx.
cP < .05 TALLYHO/JngJ sham vs TALLYHO/JngJ ovx n = 4-9/group.
dP < .05 TALLYHO/JngJ sham vs TALLYHO/JngJ sham + 4-PBA.
eP < .01 TALLYHO/JngJ sham + 4-PBA vs TALLYHO/JngJ ovx.
fP < .0001 TALLYHO/JngJ sham + 4-PBA vs TALLYHO/JngJ ovx + 4-PBA.
gP < .0001 TALLYHO/JngJ sham +4-PBA vs TALLYHO/JngJ ovx + 4-PBA.
hP < .05 TALLYHO/JngJ sham + 4-PBA vs TALLYHO/JngJ ovx + 4-PBA.
Metabolic parameters of female TALLYHO/JngJ either treated or not with 4-PBA
| Mouse genotype/intervention . | Body weight at 20 weeks (g) . | Pancreas weight (g) . | Liver weight (g) . | Adipose tissue weight (g) . | Plasma cholesterol (mM) . | Plasma triglycerides (mM) . | Serum insulin (ng/mL) . |
|---|---|---|---|---|---|---|---|
| TALLYHO/JngJ sham | 43.80 ± 3.10 | 0.22 ± 0.01 | 1.51 ± 0.15 | 3.59 ± 0.82 | 3.73 ± 0.99a | 1.02 ± 0.23b | 0.90 ± 0.16c |
| TALLYHO/JngJ sham + 4-PBA | 44.14 ± 1.81 | 0.24 ± 0.07 | 2.37 ± 0.36d | 4.98 ± 0.20e | 3.29 ± 1.39f | 1.07 ± 0.12g | 0.63 ± 0.16 |
| TALLYHO/JngJ ovx | 39.94 ± 1.42 | 0.21 ± 0.02 | 2.03 ± 0.06 | 2.36 ± 0.34 | 5.40 ± 0.52 | 1.97 ± 0.26 | 0.35 ± 0.15 |
| TALLYHO/JngJ ovx + 4-PBA | 43.99 ± 1.25 | 0.21 ± 0.01 | 2.14 ± 0.06 | 3.26 ± 0.16 | 6.88 ± 0.60h | 1.21 ± 0.22 | 0.47 ± 0.15 |
| Mouse genotype/intervention . | Body weight at 20 weeks (g) . | Pancreas weight (g) . | Liver weight (g) . | Adipose tissue weight (g) . | Plasma cholesterol (mM) . | Plasma triglycerides (mM) . | Serum insulin (ng/mL) . |
|---|---|---|---|---|---|---|---|
| TALLYHO/JngJ sham | 43.80 ± 3.10 | 0.22 ± 0.01 | 1.51 ± 0.15 | 3.59 ± 0.82 | 3.73 ± 0.99a | 1.02 ± 0.23b | 0.90 ± 0.16c |
| TALLYHO/JngJ sham + 4-PBA | 44.14 ± 1.81 | 0.24 ± 0.07 | 2.37 ± 0.36d | 4.98 ± 0.20e | 3.29 ± 1.39f | 1.07 ± 0.12g | 0.63 ± 0.16 |
| TALLYHO/JngJ ovx | 39.94 ± 1.42 | 0.21 ± 0.02 | 2.03 ± 0.06 | 2.36 ± 0.34 | 5.40 ± 0.52 | 1.97 ± 0.26 | 0.35 ± 0.15 |
| TALLYHO/JngJ ovx + 4-PBA | 43.99 ± 1.25 | 0.21 ± 0.01 | 2.14 ± 0.06 | 3.26 ± 0.16 | 6.88 ± 0.60h | 1.21 ± 0.22 | 0.47 ± 0.15 |
Each average value is presented with the standard error of the mean. Abbreviation: 4-PBA, 4-phenylbutyric acid.
aP < 0.001 TALLYHO/JngJ sham vs TALLYHO/JngJ ovx + 4-PBA.
bP < .0001 TALLYHO/JngJ sham vs TALLYHO/JngJ ovx.
cP < .05 TALLYHO/JngJ sham vs TALLYHO/JngJ ovx n = 4-9/group.
dP < .05 TALLYHO/JngJ sham vs TALLYHO/JngJ sham + 4-PBA.
eP < .01 TALLYHO/JngJ sham + 4-PBA vs TALLYHO/JngJ ovx.
fP < .0001 TALLYHO/JngJ sham + 4-PBA vs TALLYHO/JngJ ovx + 4-PBA.
gP < .0001 TALLYHO/JngJ sham +4-PBA vs TALLYHO/JngJ ovx + 4-PBA.
hP < .05 TALLYHO/JngJ sham + 4-PBA vs TALLYHO/JngJ ovx + 4-PBA.
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