Table 2.
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Comparison of potential demographic and clinical determinants of cMyC, cTnI, and cTnT in adjusted analyses.a

 Effect (95% CI)P for comparison with cMyCb
 cMyCcTnIcTnTcTnIcTnT
Age, per year25.9 (22.0 to 29.8) %c−5.1 (−8.6 to −1.5) %−8.7 (−11.4 to −6.0) %<0.001<0.001
Male sex39.0 (33.2 to 44.7) %c53.8 (48.6 to 59.0) %57.7 (53.7 to 61.6) %<0.001<0.001
BMI, per 10 units7.2 (0.6 to 13.8) %d16.2 (10.2 to 22.3) %15.6 (11.1 to 20.1) %0.0110.022
Current smoker−2.2 (−9.5 to 5.1) %−6.3 (−13.0 to 0.3) %1.5 (−3.5 to 6.5) %0.290.37
Alcohol consumption, units per 2 weekse−0.0 (−0.3 to 0.2) %−0.1 (−0.4 to 0.1) %−0.0 (−0.2 to 0.2) %0.560.98
Coronary artery disease19.9 (9.4 to 30.5) %c21.4 (11.8 to 31.0) %−0.5 (−7.7 to 6.7) %0.79<0.001
Heart failure10.7 (−9.8 to 31.3) %17.7 (−1.0 to 36.4) %20.2 (6.1 to 34.2) %0.600.35
Stroke2.6 (−10.6 to 15.7) %5.9 (−6.1 to 17.9) %13.4 (4.4 to 22.4) %0.520.046
Diabetes mellitus5.5 (−4.0 to 14.9) %−0.9 (−9.5 to 7.7) %16.5 (10.0 to 23.0) %0.190.027
Hypertension11.3 (5.8 to 16.7) %c20.0 (15.1 to 25.0) %7.4 (3.7 to 11.1) %0.0030.18
Atrial fibrillation15.9 (3.6 to 28.2) %d18.6 (7.4 to 29.8) %14.8 (6.4 to 23.2) %0.640.85
CRP ≥3 mg/L2.4 (−4.0 to 8.8) %−1.2 (−7.1 to 4.6) %3.4 (−1.0 to 7.8) %0.300.76
Total cholesterol, per 10 mg/dL−0.0 (−0.7 to 0.7) %−0.3 (−1.0 to 0.3) %−0.7 (−1.2 to −0.2) %0.440.07
HDL cholesterol, per 10 mg/dL1.0 (−0.8 to 2.8) %4.2 (2.6 to 5.9) %2.2 (1.0 to 3.4) %0.0010.19
Triglycerides, per 10 mg/dL0.2 (−0.3 to 0.6) %0.2 (−0.2 to 0.6) %0.1 (−0.2 to 0.4) %0.860.73
eGFR, per 10 mL/min/1.73 m2−7.5 (−9.7 to −5.4) %c−2.8 (−4.8 to −0.9) %−8.0 (−9.5 to −6.6) %<0.0010.68
 Effect (95% CI)P for comparison with cMyCb
 cMyCcTnIcTnTcTnIcTnT
Age, per year25.9 (22.0 to 29.8) %c−5.1 (−8.6 to −1.5) %−8.7 (−11.4 to −6.0) %<0.001<0.001
Male sex39.0 (33.2 to 44.7) %c53.8 (48.6 to 59.0) %57.7 (53.7 to 61.6) %<0.001<0.001
BMI, per 10 units7.2 (0.6 to 13.8) %d16.2 (10.2 to 22.3) %15.6 (11.1 to 20.1) %0.0110.022
Current smoker−2.2 (−9.5 to 5.1) %−6.3 (−13.0 to 0.3) %1.5 (−3.5 to 6.5) %0.290.37
Alcohol consumption, units per 2 weekse−0.0 (−0.3 to 0.2) %−0.1 (−0.4 to 0.1) %−0.0 (−0.2 to 0.2) %0.560.98
Coronary artery disease19.9 (9.4 to 30.5) %c21.4 (11.8 to 31.0) %−0.5 (−7.7 to 6.7) %0.79<0.001
Heart failure10.7 (−9.8 to 31.3) %17.7 (−1.0 to 36.4) %20.2 (6.1 to 34.2) %0.600.35
Stroke2.6 (−10.6 to 15.7) %5.9 (−6.1 to 17.9) %13.4 (4.4 to 22.4) %0.520.046
Diabetes mellitus5.5 (−4.0 to 14.9) %−0.9 (−9.5 to 7.7) %16.5 (10.0 to 23.0) %0.190.027
Hypertension11.3 (5.8 to 16.7) %c20.0 (15.1 to 25.0) %7.4 (3.7 to 11.1) %0.0030.18
Atrial fibrillation15.9 (3.6 to 28.2) %d18.6 (7.4 to 29.8) %14.8 (6.4 to 23.2) %0.640.85
CRP ≥3 mg/L2.4 (−4.0 to 8.8) %−1.2 (−7.1 to 4.6) %3.4 (−1.0 to 7.8) %0.300.76
Total cholesterol, per 10 mg/dL−0.0 (−0.7 to 0.7) %−0.3 (−1.0 to 0.3) %−0.7 (−1.2 to −0.2) %0.440.07
HDL cholesterol, per 10 mg/dL1.0 (−0.8 to 2.8) %4.2 (2.6 to 5.9) %2.2 (1.0 to 3.4) %0.0010.19
Triglycerides, per 10 mg/dL0.2 (−0.3 to 0.6) %0.2 (−0.2 to 0.6) %0.1 (−0.2 to 0.4) %0.860.73
eGFR, per 10 mL/min/1.73 m2−7.5 (−9.7 to −5.4) %c−2.8 (−4.8 to −0.9) %−8.0 (−9.5 to −6.6) %<0.0010.68

Abbreviations: cMyC, cardiac myosin binding protein C; cTnI, cardiac troponin I; cTnT, cardiac troponin T; CI, confidence interval; BMI, body mass index; CRP, C-reactive protein; HDL, high-density lipoprotein; eGFR, estimated glomerular filtration rate.

aAdjusted for all variables listed.

bComparison of associations with cMyC vs cTnI and cTnT.

cP < 0.001

dP < 0.05.

e1 unit of alcohol = 12 g of alcohol.

Table 2.
Open in new tab

Comparison of potential demographic and clinical determinants of cMyC, cTnI, and cTnT in adjusted analyses.a

 Effect (95% CI)P for comparison with cMyCb
 cMyCcTnIcTnTcTnIcTnT
Age, per year25.9 (22.0 to 29.8) %c−5.1 (−8.6 to −1.5) %−8.7 (−11.4 to −6.0) %<0.001<0.001
Male sex39.0 (33.2 to 44.7) %c53.8 (48.6 to 59.0) %57.7 (53.7 to 61.6) %<0.001<0.001
BMI, per 10 units7.2 (0.6 to 13.8) %d16.2 (10.2 to 22.3) %15.6 (11.1 to 20.1) %0.0110.022
Current smoker−2.2 (−9.5 to 5.1) %−6.3 (−13.0 to 0.3) %1.5 (−3.5 to 6.5) %0.290.37
Alcohol consumption, units per 2 weekse−0.0 (−0.3 to 0.2) %−0.1 (−0.4 to 0.1) %−0.0 (−0.2 to 0.2) %0.560.98
Coronary artery disease19.9 (9.4 to 30.5) %c21.4 (11.8 to 31.0) %−0.5 (−7.7 to 6.7) %0.79<0.001
Heart failure10.7 (−9.8 to 31.3) %17.7 (−1.0 to 36.4) %20.2 (6.1 to 34.2) %0.600.35
Stroke2.6 (−10.6 to 15.7) %5.9 (−6.1 to 17.9) %13.4 (4.4 to 22.4) %0.520.046
Diabetes mellitus5.5 (−4.0 to 14.9) %−0.9 (−9.5 to 7.7) %16.5 (10.0 to 23.0) %0.190.027
Hypertension11.3 (5.8 to 16.7) %c20.0 (15.1 to 25.0) %7.4 (3.7 to 11.1) %0.0030.18
Atrial fibrillation15.9 (3.6 to 28.2) %d18.6 (7.4 to 29.8) %14.8 (6.4 to 23.2) %0.640.85
CRP ≥3 mg/L2.4 (−4.0 to 8.8) %−1.2 (−7.1 to 4.6) %3.4 (−1.0 to 7.8) %0.300.76
Total cholesterol, per 10 mg/dL−0.0 (−0.7 to 0.7) %−0.3 (−1.0 to 0.3) %−0.7 (−1.2 to −0.2) %0.440.07
HDL cholesterol, per 10 mg/dL1.0 (−0.8 to 2.8) %4.2 (2.6 to 5.9) %2.2 (1.0 to 3.4) %0.0010.19
Triglycerides, per 10 mg/dL0.2 (−0.3 to 0.6) %0.2 (−0.2 to 0.6) %0.1 (−0.2 to 0.4) %0.860.73
eGFR, per 10 mL/min/1.73 m2−7.5 (−9.7 to −5.4) %c−2.8 (−4.8 to −0.9) %−8.0 (−9.5 to −6.6) %<0.0010.68
 Effect (95% CI)P for comparison with cMyCb
 cMyCcTnIcTnTcTnIcTnT
Age, per year25.9 (22.0 to 29.8) %c−5.1 (−8.6 to −1.5) %−8.7 (−11.4 to −6.0) %<0.001<0.001
Male sex39.0 (33.2 to 44.7) %c53.8 (48.6 to 59.0) %57.7 (53.7 to 61.6) %<0.001<0.001
BMI, per 10 units7.2 (0.6 to 13.8) %d16.2 (10.2 to 22.3) %15.6 (11.1 to 20.1) %0.0110.022
Current smoker−2.2 (−9.5 to 5.1) %−6.3 (−13.0 to 0.3) %1.5 (−3.5 to 6.5) %0.290.37
Alcohol consumption, units per 2 weekse−0.0 (−0.3 to 0.2) %−0.1 (−0.4 to 0.1) %−0.0 (−0.2 to 0.2) %0.560.98
Coronary artery disease19.9 (9.4 to 30.5) %c21.4 (11.8 to 31.0) %−0.5 (−7.7 to 6.7) %0.79<0.001
Heart failure10.7 (−9.8 to 31.3) %17.7 (−1.0 to 36.4) %20.2 (6.1 to 34.2) %0.600.35
Stroke2.6 (−10.6 to 15.7) %5.9 (−6.1 to 17.9) %13.4 (4.4 to 22.4) %0.520.046
Diabetes mellitus5.5 (−4.0 to 14.9) %−0.9 (−9.5 to 7.7) %16.5 (10.0 to 23.0) %0.190.027
Hypertension11.3 (5.8 to 16.7) %c20.0 (15.1 to 25.0) %7.4 (3.7 to 11.1) %0.0030.18
Atrial fibrillation15.9 (3.6 to 28.2) %d18.6 (7.4 to 29.8) %14.8 (6.4 to 23.2) %0.640.85
CRP ≥3 mg/L2.4 (−4.0 to 8.8) %−1.2 (−7.1 to 4.6) %3.4 (−1.0 to 7.8) %0.300.76
Total cholesterol, per 10 mg/dL−0.0 (−0.7 to 0.7) %−0.3 (−1.0 to 0.3) %−0.7 (−1.2 to −0.2) %0.440.07
HDL cholesterol, per 10 mg/dL1.0 (−0.8 to 2.8) %4.2 (2.6 to 5.9) %2.2 (1.0 to 3.4) %0.0010.19
Triglycerides, per 10 mg/dL0.2 (−0.3 to 0.6) %0.2 (−0.2 to 0.6) %0.1 (−0.2 to 0.4) %0.860.73
eGFR, per 10 mL/min/1.73 m2−7.5 (−9.7 to −5.4) %c−2.8 (−4.8 to −0.9) %−8.0 (−9.5 to −6.6) %<0.0010.68

Abbreviations: cMyC, cardiac myosin binding protein C; cTnI, cardiac troponin I; cTnT, cardiac troponin T; CI, confidence interval; BMI, body mass index; CRP, C-reactive protein; HDL, high-density lipoprotein; eGFR, estimated glomerular filtration rate.

aAdjusted for all variables listed.

bComparison of associations with cMyC vs cTnI and cTnT.

cP < 0.001

dP < 0.05.

e1 unit of alcohol = 12 g of alcohol.

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