Baseline demographic, clinical and radiologic characteristics of study participants, categorized by the presence or absence of the renal outcome.
| . | . | . | Renal outcome . | . | |
|---|---|---|---|---|---|
| Characteristics . | Missing values, n . | Total (N = 197) . | Absent [n = 143 (72.6%)] . | Present [n = 54 (27.4%)] . | P-valuec . |
| Demographic characteristics | |||||
| Male, n (%) | 0 | 134 (68.0) | 102 (71.3) | 32 (59.3) | .105 |
| Age (years), mean (SD) | 0 | 54.1 (14.0) | 53.9 (14.0) | 54.6 (14.0) | .750 |
| BMI (kg/m2), mean (SD) | 0 | 24.9 (5.7) | 24.8 (5.4) | 25.2 (6.5) | .675 |
| Native kidneys, n (%) | 0 | 43 (21.8) | 29 (20.3) | 14 (25.9) | .392 |
| Allograft kidneys, n (%) | 0 | 154 (78.2) | 114 (79.7) | 40 (74.1) | .392 |
| Laboratory findings | |||||
| eGFRa (ml/min/1.73 m2), mean (SD) | 0 | 54.4 (23.6) | 57.2 (20.8) | 46.9 (28.6) | .006 |
| ≥60 | 0 | 71 (36.0) | 55 (38.5) | 16 (29.6) | <.001 |
| <60–≥30 | 0 | 102 (51.8) | 80 (55.9) | 22 (40.7) | |
| <30 | 0 | 24 (12.2) | 8 (5.6) | 16 (29.6) | |
| Proteinuriab (g/24 h), mean (IQR) | 20 | 0.9 (0.06–0.47) | 0.6 (1.9) | 1.8 (3.5) | .004 |
| <0.3 | 20 | 119 (67.2) | 98 (74.8) | 21 (45.7) | |
| ≥0.3–<3.0 | 20 | 45 (25.4) | 28 (21.4) | 17 (37.0) | |
| ≥3.0 | 20 | 13 (7.3) | 5 (3.8) | 8 (17.4) | |
| Histologic findings Fibrosis level (%), mean (SD) | 1 | 28 (19) | 24 (15) | 39 (25) | <.001 |
| MRI parameters (×10−6 mm2/s), mean (SD) | |||||
| ADC cortex | 9 | 1811.0 (232.6) | 1808.3 (228.7) | 1817.6 (243.9) | .807 |
| ADC medulla | 9 | 1838.4 (248.7) | 1849.3 (237.5) | 1811.5 (275.0) | .347 |
| ΔADC | 9 | 28.0 (110.3) | 41.8 (111.9) | −6.2 (98.9) | .007 |
| T1 cortex | 3 | 1541.4 (171.6) | 1520.0 (163.2) | 1598.3 (181.8) | .004 |
| T1 medulla | 3 | 1853.5 (215.3) | 1861.5 (215.736) | 1832.3 (214.8) | .401 |
| ΔT1 | 1 | −310.5 (154.7) | −339.1 (144.7) | −234.1 (155.8) | <.001 |
| T2 cortex | 41 | 78.2 (17.5) | 77.4 (17.2) | 80.3 (18.3) | .354 |
| T2 medulla | 41 | 72.7 (17.3) | 71.7 (17.1) | 75.5 (17.8) | .236 |
| ΔT2 | 41 | 5.4 (6.5) | 5.6 (6.7) | 4.9 (6.0) | .510 |
| Follow-up duration (years) | 0 | 2.5 | 2.9 | 1.6 | <.001 |
| . | . | . | Renal outcome . | . | |
|---|---|---|---|---|---|
| Characteristics . | Missing values, n . | Total (N = 197) . | Absent [n = 143 (72.6%)] . | Present [n = 54 (27.4%)] . | P-valuec . |
| Demographic characteristics | |||||
| Male, n (%) | 0 | 134 (68.0) | 102 (71.3) | 32 (59.3) | .105 |
| Age (years), mean (SD) | 0 | 54.1 (14.0) | 53.9 (14.0) | 54.6 (14.0) | .750 |
| BMI (kg/m2), mean (SD) | 0 | 24.9 (5.7) | 24.8 (5.4) | 25.2 (6.5) | .675 |
| Native kidneys, n (%) | 0 | 43 (21.8) | 29 (20.3) | 14 (25.9) | .392 |
| Allograft kidneys, n (%) | 0 | 154 (78.2) | 114 (79.7) | 40 (74.1) | .392 |
| Laboratory findings | |||||
| eGFRa (ml/min/1.73 m2), mean (SD) | 0 | 54.4 (23.6) | 57.2 (20.8) | 46.9 (28.6) | .006 |
| ≥60 | 0 | 71 (36.0) | 55 (38.5) | 16 (29.6) | <.001 |
| <60–≥30 | 0 | 102 (51.8) | 80 (55.9) | 22 (40.7) | |
| <30 | 0 | 24 (12.2) | 8 (5.6) | 16 (29.6) | |
| Proteinuriab (g/24 h), mean (IQR) | 20 | 0.9 (0.06–0.47) | 0.6 (1.9) | 1.8 (3.5) | .004 |
| <0.3 | 20 | 119 (67.2) | 98 (74.8) | 21 (45.7) | |
| ≥0.3–<3.0 | 20 | 45 (25.4) | 28 (21.4) | 17 (37.0) | |
| ≥3.0 | 20 | 13 (7.3) | 5 (3.8) | 8 (17.4) | |
| Histologic findings Fibrosis level (%), mean (SD) | 1 | 28 (19) | 24 (15) | 39 (25) | <.001 |
| MRI parameters (×10−6 mm2/s), mean (SD) | |||||
| ADC cortex | 9 | 1811.0 (232.6) | 1808.3 (228.7) | 1817.6 (243.9) | .807 |
| ADC medulla | 9 | 1838.4 (248.7) | 1849.3 (237.5) | 1811.5 (275.0) | .347 |
| ΔADC | 9 | 28.0 (110.3) | 41.8 (111.9) | −6.2 (98.9) | .007 |
| T1 cortex | 3 | 1541.4 (171.6) | 1520.0 (163.2) | 1598.3 (181.8) | .004 |
| T1 medulla | 3 | 1853.5 (215.3) | 1861.5 (215.736) | 1832.3 (214.8) | .401 |
| ΔT1 | 1 | −310.5 (154.7) | −339.1 (144.7) | −234.1 (155.8) | <.001 |
| T2 cortex | 41 | 78.2 (17.5) | 77.4 (17.2) | 80.3 (18.3) | .354 |
| T2 medulla | 41 | 72.7 (17.3) | 71.7 (17.1) | 75.5 (17.8) | .236 |
| ΔT2 | 41 | 5.4 (6.5) | 5.6 (6.7) | 4.9 (6.0) | .510 |
| Follow-up duration (years) | 0 | 2.5 | 2.9 | 1.6 | <.001 |
eGFR was calculated with the CKD-EPI 2021 equation.
Proteinuria in 24 h. In the absence of 24-h urine protein data, proteinuria was estimated using the protein:creatinine ratio.
Statistical differences between the outcome groups were assessed using Pearson chi-squared test for categorial variables and Student's t-test for continuous variable, with assessment of P-value.
Baseline demographic, clinical and radiologic characteristics of study participants, categorized by the presence or absence of the renal outcome.
| . | . | . | Renal outcome . | . | |
|---|---|---|---|---|---|
| Characteristics . | Missing values, n . | Total (N = 197) . | Absent [n = 143 (72.6%)] . | Present [n = 54 (27.4%)] . | P-valuec . |
| Demographic characteristics | |||||
| Male, n (%) | 0 | 134 (68.0) | 102 (71.3) | 32 (59.3) | .105 |
| Age (years), mean (SD) | 0 | 54.1 (14.0) | 53.9 (14.0) | 54.6 (14.0) | .750 |
| BMI (kg/m2), mean (SD) | 0 | 24.9 (5.7) | 24.8 (5.4) | 25.2 (6.5) | .675 |
| Native kidneys, n (%) | 0 | 43 (21.8) | 29 (20.3) | 14 (25.9) | .392 |
| Allograft kidneys, n (%) | 0 | 154 (78.2) | 114 (79.7) | 40 (74.1) | .392 |
| Laboratory findings | |||||
| eGFRa (ml/min/1.73 m2), mean (SD) | 0 | 54.4 (23.6) | 57.2 (20.8) | 46.9 (28.6) | .006 |
| ≥60 | 0 | 71 (36.0) | 55 (38.5) | 16 (29.6) | <.001 |
| <60–≥30 | 0 | 102 (51.8) | 80 (55.9) | 22 (40.7) | |
| <30 | 0 | 24 (12.2) | 8 (5.6) | 16 (29.6) | |
| Proteinuriab (g/24 h), mean (IQR) | 20 | 0.9 (0.06–0.47) | 0.6 (1.9) | 1.8 (3.5) | .004 |
| <0.3 | 20 | 119 (67.2) | 98 (74.8) | 21 (45.7) | |
| ≥0.3–<3.0 | 20 | 45 (25.4) | 28 (21.4) | 17 (37.0) | |
| ≥3.0 | 20 | 13 (7.3) | 5 (3.8) | 8 (17.4) | |
| Histologic findings Fibrosis level (%), mean (SD) | 1 | 28 (19) | 24 (15) | 39 (25) | <.001 |
| MRI parameters (×10−6 mm2/s), mean (SD) | |||||
| ADC cortex | 9 | 1811.0 (232.6) | 1808.3 (228.7) | 1817.6 (243.9) | .807 |
| ADC medulla | 9 | 1838.4 (248.7) | 1849.3 (237.5) | 1811.5 (275.0) | .347 |
| ΔADC | 9 | 28.0 (110.3) | 41.8 (111.9) | −6.2 (98.9) | .007 |
| T1 cortex | 3 | 1541.4 (171.6) | 1520.0 (163.2) | 1598.3 (181.8) | .004 |
| T1 medulla | 3 | 1853.5 (215.3) | 1861.5 (215.736) | 1832.3 (214.8) | .401 |
| ΔT1 | 1 | −310.5 (154.7) | −339.1 (144.7) | −234.1 (155.8) | <.001 |
| T2 cortex | 41 | 78.2 (17.5) | 77.4 (17.2) | 80.3 (18.3) | .354 |
| T2 medulla | 41 | 72.7 (17.3) | 71.7 (17.1) | 75.5 (17.8) | .236 |
| ΔT2 | 41 | 5.4 (6.5) | 5.6 (6.7) | 4.9 (6.0) | .510 |
| Follow-up duration (years) | 0 | 2.5 | 2.9 | 1.6 | <.001 |
| . | . | . | Renal outcome . | . | |
|---|---|---|---|---|---|
| Characteristics . | Missing values, n . | Total (N = 197) . | Absent [n = 143 (72.6%)] . | Present [n = 54 (27.4%)] . | P-valuec . |
| Demographic characteristics | |||||
| Male, n (%) | 0 | 134 (68.0) | 102 (71.3) | 32 (59.3) | .105 |
| Age (years), mean (SD) | 0 | 54.1 (14.0) | 53.9 (14.0) | 54.6 (14.0) | .750 |
| BMI (kg/m2), mean (SD) | 0 | 24.9 (5.7) | 24.8 (5.4) | 25.2 (6.5) | .675 |
| Native kidneys, n (%) | 0 | 43 (21.8) | 29 (20.3) | 14 (25.9) | .392 |
| Allograft kidneys, n (%) | 0 | 154 (78.2) | 114 (79.7) | 40 (74.1) | .392 |
| Laboratory findings | |||||
| eGFRa (ml/min/1.73 m2), mean (SD) | 0 | 54.4 (23.6) | 57.2 (20.8) | 46.9 (28.6) | .006 |
| ≥60 | 0 | 71 (36.0) | 55 (38.5) | 16 (29.6) | <.001 |
| <60–≥30 | 0 | 102 (51.8) | 80 (55.9) | 22 (40.7) | |
| <30 | 0 | 24 (12.2) | 8 (5.6) | 16 (29.6) | |
| Proteinuriab (g/24 h), mean (IQR) | 20 | 0.9 (0.06–0.47) | 0.6 (1.9) | 1.8 (3.5) | .004 |
| <0.3 | 20 | 119 (67.2) | 98 (74.8) | 21 (45.7) | |
| ≥0.3–<3.0 | 20 | 45 (25.4) | 28 (21.4) | 17 (37.0) | |
| ≥3.0 | 20 | 13 (7.3) | 5 (3.8) | 8 (17.4) | |
| Histologic findings Fibrosis level (%), mean (SD) | 1 | 28 (19) | 24 (15) | 39 (25) | <.001 |
| MRI parameters (×10−6 mm2/s), mean (SD) | |||||
| ADC cortex | 9 | 1811.0 (232.6) | 1808.3 (228.7) | 1817.6 (243.9) | .807 |
| ADC medulla | 9 | 1838.4 (248.7) | 1849.3 (237.5) | 1811.5 (275.0) | .347 |
| ΔADC | 9 | 28.0 (110.3) | 41.8 (111.9) | −6.2 (98.9) | .007 |
| T1 cortex | 3 | 1541.4 (171.6) | 1520.0 (163.2) | 1598.3 (181.8) | .004 |
| T1 medulla | 3 | 1853.5 (215.3) | 1861.5 (215.736) | 1832.3 (214.8) | .401 |
| ΔT1 | 1 | −310.5 (154.7) | −339.1 (144.7) | −234.1 (155.8) | <.001 |
| T2 cortex | 41 | 78.2 (17.5) | 77.4 (17.2) | 80.3 (18.3) | .354 |
| T2 medulla | 41 | 72.7 (17.3) | 71.7 (17.1) | 75.5 (17.8) | .236 |
| ΔT2 | 41 | 5.4 (6.5) | 5.6 (6.7) | 4.9 (6.0) | .510 |
| Follow-up duration (years) | 0 | 2.5 | 2.9 | 1.6 | <.001 |
eGFR was calculated with the CKD-EPI 2021 equation.
Proteinuria in 24 h. In the absence of 24-h urine protein data, proteinuria was estimated using the protein:creatinine ratio.
Statistical differences between the outcome groups were assessed using Pearson chi-squared test for categorial variables and Student's t-test for continuous variable, with assessment of P-value.
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