Table 3 Open in new tab Subgroup...

Subgroup	Total testosterone	P for interaction	Low testosterone level	P for interaction
Age group			0.279			0.955
20–40y	–31.61(–78.15, 14.93)	.168		1.47 (0.72, 3.03)	.270
40–60y	–28.90(–63.91, 6.11)	.099		1.68 (0.95, 2.97)	.073
≥60y	–69.34(–113.14, –25.54)	.004		2.07 (0.79, 5.44)	.128
BMI						0.341
<25 kg/m²	–37.90(–74.01, –1.79)	.041		3.46 (0.57, 21.05)	.164
25–30 kg/m²	–40.64(–85.89, 4.61)	.075		1.23 (0.70, 2.19)	.449
≥30 kg/m²	–45.22(–83.31, –7.12)	.023		1.97 (1.30, 2.98)	.004
Smoke			0.108			0.545
Never	–29.97(–64.51, 4.58)	.084		1.77 (1.14, 2.75)	.015
Former	–66.27(–109.97, –22.56)	.006		1.18 (0.49, 2.84)	.688
Now	–59.39(–94.24, –24.55)	.002		4.88 (2.60, 9.17)	<.0001
DM			0.39			0.626
No	–34.91(–63.25, –6.56)	.019		1.32 (0.83, 2.09)	.224
Borderline	–45.63(–89.61, –1.66)	.043		1.79 (0.48, 6.69)	.359
Yes	–46.67(–103.00, 9.66)	.098		1.97 (0.99, 3.94)	.053
Hypertension			0.287			0.476
No	–25.29(–46.80, –3.78)	.024		1.82 (1.19, 2.79)	.009
Yes	–64.94(–95.76, –34.13)	<.001		1.74 (1.00, 3.03)	.049
Hyperlipidemia			0.603			0.006
No	–27.21(–61.94, 7.51)	.116		4.63 (1.95, 11.00)	.002
Yes	–48.93(–74.30, –23.57)	<.001		1.63 (1.05, 2.54)	.033

Subgroup

Total testosterone

P for interaction

Low testosterone level

P for interaction

β (95%CI)

P value

OR (95%CI)

P value

Age group

0.279

0.955

20–40y

–31.61(–78.15, 14.93)

.168

1.47 (0.72, 3.03)

.270

40–60y

–28.90(–63.91, 6.11)

.099

1.68 (0.95, 2.97)

.073

≥60y

–69.34(–113.14, –25.54)

.004

2.07 (0.79, 5.44)

.128

BMI

0.341

<25 kg/m²

–37.90(–74.01, –1.79)

.041

3.46 (0.57, 21.05)

.164

25–30 kg/m²

–40.64(–85.89, 4.61)

.075

1.23 (0.70, 2.19)

.449

≥30 kg/m²

–45.22(–83.31, –7.12)

.023

1.97 (1.30, 2.98)

.004

Smoke

0.108

0.545

Never

–29.97(–64.51, 4.58)

.084

1.77 (1.14, 2.75)

.015

Former

–66.27(–109.97, –22.56)

.006

1.18 (0.49, 2.84)

.688

Now

–59.39(–94.24, –24.55)

.002

4.88 (2.60, 9.17)

<.0001

0.39

0.626

–34.91(–63.25, –6.56)

.019

1.32 (0.83, 2.09)

.224

Borderline

–45.63(–89.61, –1.66)

.043

1.79 (0.48, 6.69)

.359

Yes

–46.67(–103.00, 9.66)

.098

1.97 (0.99, 3.94)

.053

Hypertension

0.287

0.476

–25.29(–46.80, –3.78)

.024

1.82 (1.19, 2.79)

.009

Yes

–64.94(–95.76, –34.13)

<.001

1.74 (1.00, 3.03)

.049

Hyperlipidemia

0.603

0.006

–27.21(–61.94, 7.51)

.116

4.63 (1.95, 11.00)

.002

Yes

–48.93(–74.30, –23.57)

<.001

1.63 (1.05, 2.54)

.033

Subgroup	Total testosterone	P for interaction	Low testosterone level	P for interaction
Age group			0.279			0.955
20–40y	–31.61(–78.15, 14.93)	.168		1.47 (0.72, 3.03)	.270
40–60y	–28.90(–63.91, 6.11)	.099		1.68 (0.95, 2.97)	.073
≥60y	–69.34(–113.14, –25.54)	.004		2.07 (0.79, 5.44)	.128
BMI						0.341
<25 kg/m²	–37.90(–74.01, –1.79)	.041		3.46 (0.57, 21.05)	.164
25–30 kg/m²	–40.64(–85.89, 4.61)	.075		1.23 (0.70, 2.19)	.449
≥30 kg/m²	–45.22(–83.31, –7.12)	.023		1.97 (1.30, 2.98)	.004
Smoke			0.108			0.545
Never	–29.97(–64.51, 4.58)	.084		1.77 (1.14, 2.75)	.015
Former	–66.27(–109.97, –22.56)	.006		1.18 (0.49, 2.84)	.688
Now	–59.39(–94.24, –24.55)	.002		4.88 (2.60, 9.17)	<.0001
DM			0.39			0.626
No	–34.91(–63.25, –6.56)	.019		1.32 (0.83, 2.09)	.224
Borderline	–45.63(–89.61, –1.66)	.043		1.79 (0.48, 6.69)	.359
Yes	–46.67(–103.00, 9.66)	.098		1.97 (0.99, 3.94)	.053
Hypertension			0.287			0.476
No	–25.29(–46.80, –3.78)	.024		1.82 (1.19, 2.79)	.009
Yes	–64.94(–95.76, –34.13)	<.001		1.74 (1.00, 3.03)	.049
Hyperlipidemia			0.603			0.006
No	–27.21(–61.94, 7.51)	.116		4.63 (1.95, 11.00)	.002
Yes	–48.93(–74.30, –23.57)	<.001		1.63 (1.05, 2.54)	.033

Table 3

Open in new tab

Subgroup analysis of the association between CTI and total testosterone and low testosterone level.

Subgroup	Total testosterone		P for interaction	Low testosterone level		P for interaction
	β (95%CI)	P value		OR (95%CI)	P value
Age group			0.279			0.955
20–40y	–31.61(–78.15, 14.93)	.168		1.47 (0.72, 3.03)	.270
40–60y	–28.90(–63.91, 6.11)	.099		1.68 (0.95, 2.97)	.073
≥60y	–69.34(–113.14, –25.54)	.004		2.07 (0.79, 5.44)	.128
BMI						0.341
<25 kg/m²	–37.90(–74.01, –1.79)	.041		3.46 (0.57, 21.05)	.164
25–30 kg/m²	–40.64(–85.89, 4.61)	.075		1.23 (0.70, 2.19)	.449
≥30 kg/m²	–45.22(–83.31, –7.12)	.023		1.97 (1.30, 2.98)	.004
Smoke			0.108			0.545
Never	–29.97(–64.51, 4.58)	.084		1.77 (1.14, 2.75)	.015
Former	–66.27(–109.97, –22.56)	.006		1.18 (0.49, 2.84)	.688
Now	–59.39(–94.24, –24.55)	.002		4.88 (2.60, 9.17)	<.0001
DM			0.39			0.626
No	–34.91(–63.25, –6.56)	.019		1.32 (0.83, 2.09)	.224
Borderline	–45.63(–89.61, –1.66)	.043		1.79 (0.48, 6.69)	.359
Yes	–46.67(–103.00, 9.66)	.098		1.97 (0.99, 3.94)	.053
Hypertension			0.287			0.476
No	–25.29(–46.80, –3.78)	.024		1.82 (1.19, 2.79)	.009
Yes	–64.94(–95.76, –34.13)	<.001		1.74 (1.00, 3.03)	.049
Hyperlipidemia			0.603			0.006
No	–27.21(–61.94, 7.51)	.116		4.63 (1.95, 11.00)	.002
Yes	–48.93(–74.30, –23.57)	<.001		1.63 (1.05, 2.54)	.033

Subgroup	Total testosterone		P for interaction	Low testosterone level		P for interaction
	β (95%CI)	P value		OR (95%CI)	P value
Age group			0.279			0.955
20–40y	–31.61(–78.15, 14.93)	.168		1.47 (0.72, 3.03)	.270
40–60y	–28.90(–63.91, 6.11)	.099		1.68 (0.95, 2.97)	.073
≥60y	–69.34(–113.14, –25.54)	.004		2.07 (0.79, 5.44)	.128
BMI						0.341
<25 kg/m²	–37.90(–74.01, –1.79)	.041		3.46 (0.57, 21.05)	.164
25–30 kg/m²	–40.64(–85.89, 4.61)	.075		1.23 (0.70, 2.19)	.449
≥30 kg/m²	–45.22(–83.31, –7.12)	.023		1.97 (1.30, 2.98)	.004
Smoke			0.108			0.545
Never	–29.97(–64.51, 4.58)	.084		1.77 (1.14, 2.75)	.015
Former	–66.27(–109.97, –22.56)	.006		1.18 (0.49, 2.84)	.688
Now	–59.39(–94.24, –24.55)	.002		4.88 (2.60, 9.17)	<.0001
DM			0.39			0.626
No	–34.91(–63.25, –6.56)	.019		1.32 (0.83, 2.09)	.224
Borderline	–45.63(–89.61, –1.66)	.043		1.79 (0.48, 6.69)	.359
Yes	–46.67(–103.00, 9.66)	.098		1.97 (0.99, 3.94)	.053
Hypertension			0.287			0.476
No	–25.29(–46.80, –3.78)	.024		1.82 (1.19, 2.79)	.009
Yes	–64.94(–95.76, –34.13)	<.001		1.74 (1.00, 3.03)	.049
Hyperlipidemia			0.603			0.006
No	–27.21(–61.94, 7.51)	.116		4.63 (1.95, 11.00)	.002
Yes	–48.93(–74.30, –23.57)	<.001		1.63 (1.05, 2.54)	.033

Abbreviations: β, effect size for linear regression; CI, confidence interval; OR, odds ratio; BMI, body mass index; UA, uric acid; HDL-c, high-density lipoprotein cholesterol; LDL-c, low-density lipoprotein cholesterol; CTI, C-reactive protein-triglyceride glucose index; PIR, poverty-to-income ratio; DM, diabetes mellitus; CVD, cardiovascular disease.

Note: Crude model: unadjusted; Model 1: adjusted for age, race, education, marital status, and PIR were adjusted; Model 2: Model 1+ LDL-c, HDL-c, UA, BMI, smoking, alcohol intake, DM, hypertension, CVD, and hyperlipidemia were adjusted).

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