| . | Training . | Internal validation . | External validation . | ||||||
|---|---|---|---|---|---|---|---|---|---|
| . | Control . | VT . | P-value . | Control . | VT . | P-value . | Control . | VT . | P-value . |
| n | 183 177 | 804 | 43 580 | 197 | 20 497 | 103 | |||
| Demographics | |||||||||
| Age (years) | 61.1 ± 17.8 | 63.4 ± 15.3 | <.001 | 62.2 ± 18.5 | 63.2 ± 16.4 | .442 | 61.3 ± 15.3 | 66.5 ± 12.7 | <.001 |
| Female (%) | 108 951 (59.5) | 244 (30.3) | <.001 | 26 887 (61.7) | 54 (27.4) | <.001 | 12 062 (58.8) | 21 (20.4) | <.001 |
| ECG measurements | |||||||||
| QRS (ms) | 100 ± 18 | 107 ± 22 | <.001 | 98 ± 17 | 107 ± 20 | <.001 | 97 ± 16 | 105 ± 21 | <.001 |
| QTc (ms) | 401 ± 38 | 409 ± 41 | <.001 | 400 ± 37 | 410 ± 40 | <.001 | 397 ± 34 | 409 ± 41 | <.001 |
| PVC burden, median (IQR) | 0.7 (0.2–3.1) | 8.9 (2.1–17.8) | <.001 | 0.6 (0.2–2.9) | 12.0 (3.4–23.5) | <.001 | 0.8 (0.2–3.5) | 9.0 (2.4–21.5) | .297 |
| PVC coupling interval (ms) | 590 ± 119 | 521 ± 106 | <.001 | 576 ± 113 | 511 ± 73 | <.001 | 585 ± 108 | 525 ± 101 | <.001 |
| HR (b.p.m.) | 74 ± 11 | 84 ± 26 | <.001 | 75 ± 11 | 81 ± 16 | <.001 | 77 ± 15 | 84 ± 50 | <.001 |
| HRV SDNN | 153 ± 48 | 160 ± 51 | .022 | 147 ± 49 | 152 ± 61 | .257 | 144 ± 51 | 161 ± 59 | .049 |
| Indication, n (%) | |||||||||
| Palpitations | 71 648 (39.1) | 216 (26.9) | <.001 | 16 981 (39.0) | 48 (24.4) | <.001 | 7194 (35.1) | 21 (20.4) | .003 |
| Atrial fibrillation | 32 499 (17.7) | 86 (10.7) | <.001 | 6869 (15.8) | 6 (3.0) | <.001 | 3239 (15.8) | 17 (16.5) | .952 |
| Syncope | 23 089 (12.6) | 59 (7.3) | <.001 | 5468 (12.5) | 19 (9.6) | .263 | 3330 (16.2) | 10 (9.7) | .097 |
| Arrhythmia | 8790 (4.8) | 47 (5.8) | .193 | 1897 (4.4) | 12 (6.1) | .309 | 1093 (5.3) | 8 (7.8) | .381 |
| Bradycardia | 6461 (3.5) | 30 (3.7) | .828 | 1721 (3.9) | 11 (5.6) | .322 | 757 (3.7) | 6 (5.8) | .378 |
| PVC | 3679 (2.0) | 114 (14.2) | <.001 | 901 (2.1) | 44 (22.3) | <.001 | 304 (1.5) | 14 (13.6) | <.001 |
| VT | 1165 (0.6) | 57 (7.1) | <.001 | 286 (0.7) | 21 (10.7) | <.001 | 111 (0.5) | 14 (13.6) | <.001 |
| Other | 35 846 (19.6) | 195 (24.3) | .001 | 9457 (21.7) | 36 (18.3) | .281 | 4469 (21.8) | 13 (12.6) | .033 |
| . | Training . | Internal validation . | External validation . | ||||||
|---|---|---|---|---|---|---|---|---|---|
| . | Control . | VT . | P-value . | Control . | VT . | P-value . | Control . | VT . | P-value . |
| n | 183 177 | 804 | 43 580 | 197 | 20 497 | 103 | |||
| Demographics | |||||||||
| Age (years) | 61.1 ± 17.8 | 63.4 ± 15.3 | <.001 | 62.2 ± 18.5 | 63.2 ± 16.4 | .442 | 61.3 ± 15.3 | 66.5 ± 12.7 | <.001 |
| Female (%) | 108 951 (59.5) | 244 (30.3) | <.001 | 26 887 (61.7) | 54 (27.4) | <.001 | 12 062 (58.8) | 21 (20.4) | <.001 |
| ECG measurements | |||||||||
| QRS (ms) | 100 ± 18 | 107 ± 22 | <.001 | 98 ± 17 | 107 ± 20 | <.001 | 97 ± 16 | 105 ± 21 | <.001 |
| QTc (ms) | 401 ± 38 | 409 ± 41 | <.001 | 400 ± 37 | 410 ± 40 | <.001 | 397 ± 34 | 409 ± 41 | <.001 |
| PVC burden, median (IQR) | 0.7 (0.2–3.1) | 8.9 (2.1–17.8) | <.001 | 0.6 (0.2–2.9) | 12.0 (3.4–23.5) | <.001 | 0.8 (0.2–3.5) | 9.0 (2.4–21.5) | .297 |
| PVC coupling interval (ms) | 590 ± 119 | 521 ± 106 | <.001 | 576 ± 113 | 511 ± 73 | <.001 | 585 ± 108 | 525 ± 101 | <.001 |
| HR (b.p.m.) | 74 ± 11 | 84 ± 26 | <.001 | 75 ± 11 | 81 ± 16 | <.001 | 77 ± 15 | 84 ± 50 | <.001 |
| HRV SDNN | 153 ± 48 | 160 ± 51 | .022 | 147 ± 49 | 152 ± 61 | .257 | 144 ± 51 | 161 ± 59 | .049 |
| Indication, n (%) | |||||||||
| Palpitations | 71 648 (39.1) | 216 (26.9) | <.001 | 16 981 (39.0) | 48 (24.4) | <.001 | 7194 (35.1) | 21 (20.4) | .003 |
| Atrial fibrillation | 32 499 (17.7) | 86 (10.7) | <.001 | 6869 (15.8) | 6 (3.0) | <.001 | 3239 (15.8) | 17 (16.5) | .952 |
| Syncope | 23 089 (12.6) | 59 (7.3) | <.001 | 5468 (12.5) | 19 (9.6) | .263 | 3330 (16.2) | 10 (9.7) | .097 |
| Arrhythmia | 8790 (4.8) | 47 (5.8) | .193 | 1897 (4.4) | 12 (6.1) | .309 | 1093 (5.3) | 8 (7.8) | .381 |
| Bradycardia | 6461 (3.5) | 30 (3.7) | .828 | 1721 (3.9) | 11 (5.6) | .322 | 757 (3.7) | 6 (5.8) | .378 |
| PVC | 3679 (2.0) | 114 (14.2) | <.001 | 901 (2.1) | 44 (22.3) | <.001 | 304 (1.5) | 14 (13.6) | <.001 |
| VT | 1165 (0.6) | 57 (7.1) | <.001 | 286 (0.7) | 21 (10.7) | <.001 | 111 (0.5) | 14 (13.6) | <.001 |
| Other | 35 846 (19.6) | 195 (24.3) | .001 | 9457 (21.7) | 36 (18.3) | .281 | 4469 (21.8) | 13 (12.6) | .033 |
HR, heart rate; HRV, heart rate variability; IQR, interquartile range; PVC, premature ventricular complex; SDNN, standard deviation of NN intervals; VT, ventricular tachycardia.
| . | Training . | Internal validation . | External validation . | ||||||
|---|---|---|---|---|---|---|---|---|---|
| . | Control . | VT . | P-value . | Control . | VT . | P-value . | Control . | VT . | P-value . |
| n | 183 177 | 804 | 43 580 | 197 | 20 497 | 103 | |||
| Demographics | |||||||||
| Age (years) | 61.1 ± 17.8 | 63.4 ± 15.3 | <.001 | 62.2 ± 18.5 | 63.2 ± 16.4 | .442 | 61.3 ± 15.3 | 66.5 ± 12.7 | <.001 |
| Female (%) | 108 951 (59.5) | 244 (30.3) | <.001 | 26 887 (61.7) | 54 (27.4) | <.001 | 12 062 (58.8) | 21 (20.4) | <.001 |
| ECG measurements | |||||||||
| QRS (ms) | 100 ± 18 | 107 ± 22 | <.001 | 98 ± 17 | 107 ± 20 | <.001 | 97 ± 16 | 105 ± 21 | <.001 |
| QTc (ms) | 401 ± 38 | 409 ± 41 | <.001 | 400 ± 37 | 410 ± 40 | <.001 | 397 ± 34 | 409 ± 41 | <.001 |
| PVC burden, median (IQR) | 0.7 (0.2–3.1) | 8.9 (2.1–17.8) | <.001 | 0.6 (0.2–2.9) | 12.0 (3.4–23.5) | <.001 | 0.8 (0.2–3.5) | 9.0 (2.4–21.5) | .297 |
| PVC coupling interval (ms) | 590 ± 119 | 521 ± 106 | <.001 | 576 ± 113 | 511 ± 73 | <.001 | 585 ± 108 | 525 ± 101 | <.001 |
| HR (b.p.m.) | 74 ± 11 | 84 ± 26 | <.001 | 75 ± 11 | 81 ± 16 | <.001 | 77 ± 15 | 84 ± 50 | <.001 |
| HRV SDNN | 153 ± 48 | 160 ± 51 | .022 | 147 ± 49 | 152 ± 61 | .257 | 144 ± 51 | 161 ± 59 | .049 |
| Indication, n (%) | |||||||||
| Palpitations | 71 648 (39.1) | 216 (26.9) | <.001 | 16 981 (39.0) | 48 (24.4) | <.001 | 7194 (35.1) | 21 (20.4) | .003 |
| Atrial fibrillation | 32 499 (17.7) | 86 (10.7) | <.001 | 6869 (15.8) | 6 (3.0) | <.001 | 3239 (15.8) | 17 (16.5) | .952 |
| Syncope | 23 089 (12.6) | 59 (7.3) | <.001 | 5468 (12.5) | 19 (9.6) | .263 | 3330 (16.2) | 10 (9.7) | .097 |
| Arrhythmia | 8790 (4.8) | 47 (5.8) | .193 | 1897 (4.4) | 12 (6.1) | .309 | 1093 (5.3) | 8 (7.8) | .381 |
| Bradycardia | 6461 (3.5) | 30 (3.7) | .828 | 1721 (3.9) | 11 (5.6) | .322 | 757 (3.7) | 6 (5.8) | .378 |
| PVC | 3679 (2.0) | 114 (14.2) | <.001 | 901 (2.1) | 44 (22.3) | <.001 | 304 (1.5) | 14 (13.6) | <.001 |
| VT | 1165 (0.6) | 57 (7.1) | <.001 | 286 (0.7) | 21 (10.7) | <.001 | 111 (0.5) | 14 (13.6) | <.001 |
| Other | 35 846 (19.6) | 195 (24.3) | .001 | 9457 (21.7) | 36 (18.3) | .281 | 4469 (21.8) | 13 (12.6) | .033 |
| . | Training . | Internal validation . | External validation . | ||||||
|---|---|---|---|---|---|---|---|---|---|
| . | Control . | VT . | P-value . | Control . | VT . | P-value . | Control . | VT . | P-value . |
| n | 183 177 | 804 | 43 580 | 197 | 20 497 | 103 | |||
| Demographics | |||||||||
| Age (years) | 61.1 ± 17.8 | 63.4 ± 15.3 | <.001 | 62.2 ± 18.5 | 63.2 ± 16.4 | .442 | 61.3 ± 15.3 | 66.5 ± 12.7 | <.001 |
| Female (%) | 108 951 (59.5) | 244 (30.3) | <.001 | 26 887 (61.7) | 54 (27.4) | <.001 | 12 062 (58.8) | 21 (20.4) | <.001 |
| ECG measurements | |||||||||
| QRS (ms) | 100 ± 18 | 107 ± 22 | <.001 | 98 ± 17 | 107 ± 20 | <.001 | 97 ± 16 | 105 ± 21 | <.001 |
| QTc (ms) | 401 ± 38 | 409 ± 41 | <.001 | 400 ± 37 | 410 ± 40 | <.001 | 397 ± 34 | 409 ± 41 | <.001 |
| PVC burden, median (IQR) | 0.7 (0.2–3.1) | 8.9 (2.1–17.8) | <.001 | 0.6 (0.2–2.9) | 12.0 (3.4–23.5) | <.001 | 0.8 (0.2–3.5) | 9.0 (2.4–21.5) | .297 |
| PVC coupling interval (ms) | 590 ± 119 | 521 ± 106 | <.001 | 576 ± 113 | 511 ± 73 | <.001 | 585 ± 108 | 525 ± 101 | <.001 |
| HR (b.p.m.) | 74 ± 11 | 84 ± 26 | <.001 | 75 ± 11 | 81 ± 16 | <.001 | 77 ± 15 | 84 ± 50 | <.001 |
| HRV SDNN | 153 ± 48 | 160 ± 51 | .022 | 147 ± 49 | 152 ± 61 | .257 | 144 ± 51 | 161 ± 59 | .049 |
| Indication, n (%) | |||||||||
| Palpitations | 71 648 (39.1) | 216 (26.9) | <.001 | 16 981 (39.0) | 48 (24.4) | <.001 | 7194 (35.1) | 21 (20.4) | .003 |
| Atrial fibrillation | 32 499 (17.7) | 86 (10.7) | <.001 | 6869 (15.8) | 6 (3.0) | <.001 | 3239 (15.8) | 17 (16.5) | .952 |
| Syncope | 23 089 (12.6) | 59 (7.3) | <.001 | 5468 (12.5) | 19 (9.6) | .263 | 3330 (16.2) | 10 (9.7) | .097 |
| Arrhythmia | 8790 (4.8) | 47 (5.8) | .193 | 1897 (4.4) | 12 (6.1) | .309 | 1093 (5.3) | 8 (7.8) | .381 |
| Bradycardia | 6461 (3.5) | 30 (3.7) | .828 | 1721 (3.9) | 11 (5.6) | .322 | 757 (3.7) | 6 (5.8) | .378 |
| PVC | 3679 (2.0) | 114 (14.2) | <.001 | 901 (2.1) | 44 (22.3) | <.001 | 304 (1.5) | 14 (13.6) | <.001 |
| VT | 1165 (0.6) | 57 (7.1) | <.001 | 286 (0.7) | 21 (10.7) | <.001 | 111 (0.5) | 14 (13.6) | <.001 |
| Other | 35 846 (19.6) | 195 (24.3) | .001 | 9457 (21.7) | 36 (18.3) | .281 | 4469 (21.8) | 13 (12.6) | .033 |
HR, heart rate; HRV, heart rate variability; IQR, interquartile range; PVC, premature ventricular complex; SDNN, standard deviation of NN intervals; VT, ventricular tachycardia.
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