Table 1 Open in new tab Functional... | Oxford Academic

Table 1

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Functional relevance of genes in the 4-site model.

Illumina probe	Chromosome	Feature	Gene	IBD relevance	Functional role
cg17501210	6	Body	RPS6KA2	Proximity to IBD GWAS SNP (rs1819333)	Key roles include autophagy-associated mTOR pathway and proliferation³⁴
cg12054453	17	Body	VMP1	Coincides with primary transcription site for microRNA-21	Regulator of the ER and the formation of autophagosomes³⁵
cg04389058	3	Body	ARHGEF3	Differential methylation previously reported¹⁴	Roles include myeloid differentiation and binding to mTORC2³⁶
cg00382138	4	First exon	CFI	Differential methylation previously reported¹⁴	Encodes for a serine proteinase which regulates the complement cascade bridging innate and adaptive immunity³⁷

Illumina probe	Chromosome	Feature	Gene	IBD relevance	Functional role
cg17501210	6	Body	RPS6KA2	Proximity to IBD GWAS SNP (rs1819333)	Key roles include autophagy-associated mTOR pathway and proliferation³⁴
cg12054453	17	Body	VMP1	Coincides with primary transcription site for microRNA-21	Regulator of the ER and the formation of autophagosomes³⁵
cg04389058	3	Body	ARHGEF3	Differential methylation previously reported¹⁴	Roles include myeloid differentiation and binding to mTORC2³⁶
cg00382138	4	First exon	CFI	Differential methylation previously reported¹⁴	Encodes for a serine proteinase which regulates the complement cascade bridging innate and adaptive immunity³⁷

Abbreviations: ER, endoplasmic reticulum; GWAS, genome-wide association studies; IBD, inflammatory bowel disease; mTOR, mammalian target of rapamycin; SNP, single nucleotide polymorphism.

Table 1

Open in new tab

Functional relevance of genes in the 4-site model.

Illumina probe	Chromosome	Feature	Gene	IBD relevance	Functional role
cg17501210	6	Body	RPS6KA2	Proximity to IBD GWAS SNP (rs1819333)	Key roles include autophagy-associated mTOR pathway and proliferation³⁴
cg12054453	17	Body	VMP1	Coincides with primary transcription site for microRNA-21	Regulator of the ER and the formation of autophagosomes³⁵
cg04389058	3	Body	ARHGEF3	Differential methylation previously reported¹⁴	Roles include myeloid differentiation and binding to mTORC2³⁶
cg00382138	4	First exon	CFI	Differential methylation previously reported¹⁴	Encodes for a serine proteinase which regulates the complement cascade bridging innate and adaptive immunity³⁷

Illumina probe	Chromosome	Feature	Gene	IBD relevance	Functional role
cg17501210	6	Body	RPS6KA2	Proximity to IBD GWAS SNP (rs1819333)	Key roles include autophagy-associated mTOR pathway and proliferation³⁴
cg12054453	17	Body	VMP1	Coincides with primary transcription site for microRNA-21	Regulator of the ER and the formation of autophagosomes³⁵
cg04389058	3	Body	ARHGEF3	Differential methylation previously reported¹⁴	Roles include myeloid differentiation and binding to mTORC2³⁶
cg00382138	4	First exon	CFI	Differential methylation previously reported¹⁴	Encodes for a serine proteinase which regulates the complement cascade bridging innate and adaptive immunity³⁷

Abbreviations: ER, endoplasmic reticulum; GWAS, genome-wide association studies; IBD, inflammatory bowel disease; mTOR, mammalian target of rapamycin; SNP, single nucleotide polymorphism.