Frequency of total and epitope-specific CD8 T cells in the CNS of recombinant WT MHV and S510 variant-infected micea
| Virus . | No. MNC/CNS (×106) . | Frequency (%) CD8 T Cells/CNS . | Frequency (%) Native S510-Specificb . | Frequency (%) S510 Variant-Specificc . |
|---|---|---|---|---|
| rJ (n = 4) | 1.83 ± 0.43 | 13.4 ± 1.4 | 15.3 ± 1.59 | 1.55 ± 0.06d |
| rJ.SW513S (n = 8) | 1.72 ± 0.22 | 12.6 ± 3.2 | 1.04 ± 0.14 | 1.07 ± 0.16 |
| rJ.SW513R (n = 7) | 1.65 ± 0.34 | 14.5 ± 2.5 | 1.24 ± 0.36 | 4.17 ± 0.94 |
| Virus . | No. MNC/CNS (×106) . | Frequency (%) CD8 T Cells/CNS . | Frequency (%) Native S510-Specificb . | Frequency (%) S510 Variant-Specificc . |
|---|---|---|---|---|
| rJ (n = 4) | 1.83 ± 0.43 | 13.4 ± 1.4 | 15.3 ± 1.59 | 1.55 ± 0.06d |
| rJ.SW513S (n = 8) | 1.72 ± 0.22 | 12.6 ± 3.2 | 1.04 ± 0.14 | 1.07 ± 0.16 |
| rJ.SW513R (n = 7) | 1.65 ± 0.34 | 14.5 ± 2.5 | 1.24 ± 0.36 | 4.17 ± 0.94 |
Values are expressed as means ± SEM.
As measured by direct ex vivo intracellular cytokine staining assay using the native peptide S510 epitope.
As measured after ex vivo stimulation using the corresponding S510 variant epitope peptide.
Data for rJ are pooled results using each of the S510 variant epitope peptides in the ex vivo stimulation.
Frequency of total and epitope-specific CD8 T cells in the CNS of recombinant WT MHV and S510 variant-infected micea
| Virus . | No. MNC/CNS (×106) . | Frequency (%) CD8 T Cells/CNS . | Frequency (%) Native S510-Specificb . | Frequency (%) S510 Variant-Specificc . |
|---|---|---|---|---|
| rJ (n = 4) | 1.83 ± 0.43 | 13.4 ± 1.4 | 15.3 ± 1.59 | 1.55 ± 0.06d |
| rJ.SW513S (n = 8) | 1.72 ± 0.22 | 12.6 ± 3.2 | 1.04 ± 0.14 | 1.07 ± 0.16 |
| rJ.SW513R (n = 7) | 1.65 ± 0.34 | 14.5 ± 2.5 | 1.24 ± 0.36 | 4.17 ± 0.94 |
| Virus . | No. MNC/CNS (×106) . | Frequency (%) CD8 T Cells/CNS . | Frequency (%) Native S510-Specificb . | Frequency (%) S510 Variant-Specificc . |
|---|---|---|---|---|
| rJ (n = 4) | 1.83 ± 0.43 | 13.4 ± 1.4 | 15.3 ± 1.59 | 1.55 ± 0.06d |
| rJ.SW513S (n = 8) | 1.72 ± 0.22 | 12.6 ± 3.2 | 1.04 ± 0.14 | 1.07 ± 0.16 |
| rJ.SW513R (n = 7) | 1.65 ± 0.34 | 14.5 ± 2.5 | 1.24 ± 0.36 | 4.17 ± 0.94 |
Values are expressed as means ± SEM.
As measured by direct ex vivo intracellular cytokine staining assay using the native peptide S510 epitope.
As measured after ex vivo stimulation using the corresponding S510 variant epitope peptide.
Data for rJ are pooled results using each of the S510 variant epitope peptides in the ex vivo stimulation.
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