Table 1 Open in new tab Baseline...

	Total	NSTEMI	UAP	Other cardiac	Non-cardiac	NCCP
Descriptive factors
Patient count (%)	1896	234 (12.3)	252 (13.3)	172 (9.1)	131 (6.9)	1107 (58.4)
Age, median, years	62 (52–72)	67 (57–76)	68 (59–75)	69 (58–80)	68 (57–76)	58 (49–68)
Male, %	61.1	67.9	70.2	65.1	55.0	57.6
BMI, median, kg/m²	26.9 (24.5–30.0)	26.3 (24.1–29.7)	26.1 (24.5–30.1)	27.0 (24.9–29.5)	27.8 (25.7–30.1)	27.0 (24.5–30.0)
eGFR, median, mL/min/1.73 m²	86 (71–97)	80 (67–95)	82 (66–92)	76 (60–91)	83 (63–95)	89 (77–100)
Symptoms to blood draw, median, hours	8.2 (3.5–32.0)	5.3 (2.8–22.9)	12.8 (4.2–70.8)	8.1 (3.3–32.0)	9.0 (3.8–25.9)	8.4 (3.5–30.6)
Very early presenters < 2 h, %	9.7	12.4	7.5	15.1	9.2	8.9
Early presenters < 3 h, %	21.4	27.8	16.7	22.1	14.5	21.8
Late presenters > 12 h, %	42.1	31.6	51.2	41.9	43.5	42.1
Hospital stay, median, hours	29.0 (22.0–71.0)	75.0 (63.0–122)	74.5 (46.0–137)	50.0 (24.7–97.2)	30.0 (22.0–75.6)	24.0 (19.0–31.0)
Risk factors
Hypertension, %	42.6	50.9	54.4	48.3	45.0	36.9
Hyperlipidaemia, %	20.4	21.4	29.0	18.6	21.4	28.4
Diabetes mellitus, %	11.7	14.5	22.6	9.9	14.5	8.5
Family history, %	20.1	19.2	21.4	14.0	19.1	21.0
Current smoker, %	18.5	20.5	17.5	18.0	17.6	18.4
Previous smoker, %	41.5	47.2	40.1	45.8	42.8	42.6
Medical history
Prior MI, %	20.4	24.8	31.7	27.9	20.6	15.6
Prior PCI, %	20.5	22.2	39.3	26.2	17.6	15.3
Prior CABG, %	7.8	11.1	19.8	9.9	9.9	3.7
Heart failure, %	4.4	4.7	4.0	13.4	6.9	2.8
Stroke, %	3.3	3.4	5.6	5.2	3.1	2.5
Peripheral vascular disease, %	2.3	2.6	6.3	1.7	3.1	1.3
Vital signs on admission
Systolic BP, median, mm Hg	144 (130–160)	147 (132–162)	148 (134–160)	139 (123–157)	138 (126–158)	144 (130–160)
Diastolic BP, median, mm Hg	82 (75–91)	84 (75–91)	81 (75–91)	80 (71–92)	81 (73–90)	83 (75–91)
Heart rate, median, b.p.m.	71 (63–82)	72 (63–80)	70 (62–80)	78 (65–98)	74 (64–89)	70 (63–80)
Electrocardiography
ST-segment depression, %	3.8	15.8	2.8	5.8	2.3	1.4
T-wave inversion, %	4.3	14.1	6.0	7.0	2.3	1.6
Biomarker concentrations
Troponin T (Roche), median, ng/L	7 (3–16)	48 (23–143)	9 (6–17)	15 (8–24)	8 (3–15)	5 (3–8)
Troponin I (Abbott), median, ng/L	4 (2–10)	95 (29–455)	5 (3–11)	7 (3–15)	4 (2–10)	2 (2–4)
Troponin I (Siemens), median, ng/L	6 (3–17)	154 (56–846)	8 (4–20)	10 (6–26)	6 (3–15)	4 (3–7)

Total

NSTEMI

UAP

Other cardiac

Non-cardiac

NCCP

Descriptive factors

Patient count (%)

1896

234 (12.3)

252 (13.3)

172 (9.1)

131 (6.9)

1107 (58.4)

Age, median, years

62 (52–72)

67 (57–76)

68 (59–75)

69 (58–80)

68 (57–76)

58 (49–68)

Male, %

61.1

67.9

70.2

65.1

55.0

57.6

BMI, median, kg/m²

26.9 (24.5–30.0)

26.3 (24.1–29.7)

26.1 (24.5–30.1)

27.0 (24.9–29.5)

27.8 (25.7–30.1)

27.0 (24.5–30.0)

eGFR, median, mL/min/1.73 m²

86 (71–97)

80 (67–95)

82 (66–92)

76 (60–91)

83 (63–95)

89 (77–100)

Symptoms to blood draw, median, hours

8.2 (3.5–32.0)

5.3 (2.8–22.9)

12.8 (4.2–70.8)

8.1 (3.3–32.0)

9.0 (3.8–25.9)

8.4 (3.5–30.6)

Very early presenters < 2 h, %

9.7

12.4

7.5

15.1

9.2

8.9

Early presenters < 3 h, %

21.4

27.8

16.7

22.1

14.5

21.8

Late presenters > 12 h, %

42.1

31.6

51.2

41.9

43.5

42.1

Hospital stay, median, hours

29.0 (22.0–71.0)

75.0 (63.0–122)

74.5 (46.0–137)

50.0 (24.7–97.2)

30.0 (22.0–75.6)

24.0 (19.0–31.0)

Risk factors

Hypertension, %

42.6

50.9

54.4

48.3

45.0

36.9

Hyperlipidaemia, %

20.4

21.4

29.0

18.6

21.4

28.4

Diabetes mellitus, %

11.7

14.5

22.6

9.9

14.5

8.5

Family history, %

20.1

19.2

21.4

14.0

19.1

21.0

Current smoker, %

18.5

20.5

17.5

18.0

17.6

18.4

Previous smoker, %

41.5

47.2

40.1

45.8

42.8

42.6

Medical history

Prior MI, %

20.4

24.8

31.7

27.9

20.6

15.6

Prior PCI, %

20.5

22.2

39.3

26.2

17.6

15.3

Prior CABG, %

7.8

11.1

19.8

9.9

3.7

Heart failure, %

4.4

4.7

4.0

13.4

6.9

2.8

Stroke, %

3.3

3.4

5.6

5.2

3.1

2.5

Peripheral vascular disease, %

2.3

2.6

6.3

1.7

3.1

1.3

Vital signs on admission

Systolic BP, median, mm Hg

144 (130–160)

147 (132–162)

148 (134–160)

139 (123–157)

138 (126–158)

144 (130–160)

Diastolic BP, median, mm Hg

82 (75–91)

84 (75–91)

81 (75–91)

80 (71–92)

81 (73–90)

83 (75–91)

Heart rate, median, b.p.m.

71 (63–82)

72 (63–80)

70 (62–80)

78 (65–98)

74 (64–89)

70 (63–80)

Electrocardiography

ST-segment depression, %

3.8

15.8

2.8

5.8

2.3

1.4

T-wave inversion, %

4.3

14.1

6.0

7.0

2.3

1.6

Biomarker concentrations

Troponin T (Roche), median, ng/L

7 (3–16)

48 (23–143)

9 (6–17)

15 (8–24)

8 (3–15)

5 (3–8)

Troponin I (Abbott), median, ng/L

4 (2–10)

95 (29–455)

5 (3–11)

7 (3–15)

4 (2–10)

2 (2–4)

Troponin I (Siemens), median, ng/L

6 (3–17)

154 (56–846)

8 (4–20)

10 (6–26)

6 (3–15)

4 (3–7)

	Total	NSTEMI	UAP	Other cardiac	Non-cardiac	NCCP
Descriptive factors
Patient count (%)	1896	234 (12.3)	252 (13.3)	172 (9.1)	131 (6.9)	1107 (58.4)
Age, median, years	62 (52–72)	67 (57–76)	68 (59–75)	69 (58–80)	68 (57–76)	58 (49–68)
Male, %	61.1	67.9	70.2	65.1	55.0	57.6
BMI, median, kg/m²	26.9 (24.5–30.0)	26.3 (24.1–29.7)	26.1 (24.5–30.1)	27.0 (24.9–29.5)	27.8 (25.7–30.1)	27.0 (24.5–30.0)
eGFR, median, mL/min/1.73 m²	86 (71–97)	80 (67–95)	82 (66–92)	76 (60–91)	83 (63–95)	89 (77–100)
Symptoms to blood draw, median, hours	8.2 (3.5–32.0)	5.3 (2.8–22.9)	12.8 (4.2–70.8)	8.1 (3.3–32.0)	9.0 (3.8–25.9)	8.4 (3.5–30.6)
Very early presenters < 2 h, %	9.7	12.4	7.5	15.1	9.2	8.9
Early presenters < 3 h, %	21.4	27.8	16.7	22.1	14.5	21.8
Late presenters > 12 h, %	42.1	31.6	51.2	41.9	43.5	42.1
Hospital stay, median, hours	29.0 (22.0–71.0)	75.0 (63.0–122)	74.5 (46.0–137)	50.0 (24.7–97.2)	30.0 (22.0–75.6)	24.0 (19.0–31.0)
Risk factors
Hypertension, %	42.6	50.9	54.4	48.3	45.0	36.9
Hyperlipidaemia, %	20.4	21.4	29.0	18.6	21.4	28.4
Diabetes mellitus, %	11.7	14.5	22.6	9.9	14.5	8.5
Family history, %	20.1	19.2	21.4	14.0	19.1	21.0
Current smoker, %	18.5	20.5	17.5	18.0	17.6	18.4
Previous smoker, %	41.5	47.2	40.1	45.8	42.8	42.6
Medical history
Prior MI, %	20.4	24.8	31.7	27.9	20.6	15.6
Prior PCI, %	20.5	22.2	39.3	26.2	17.6	15.3
Prior CABG, %	7.8	11.1	19.8	9.9	9.9	3.7
Heart failure, %	4.4	4.7	4.0	13.4	6.9	2.8
Stroke, %	3.3	3.4	5.6	5.2	3.1	2.5
Peripheral vascular disease, %	2.3	2.6	6.3	1.7	3.1	1.3
Vital signs on admission
Systolic BP, median, mm Hg	144 (130–160)	147 (132–162)	148 (134–160)	139 (123–157)	138 (126–158)	144 (130–160)
Diastolic BP, median, mm Hg	82 (75–91)	84 (75–91)	81 (75–91)	80 (71–92)	81 (73–90)	83 (75–91)
Heart rate, median, b.p.m.	71 (63–82)	72 (63–80)	70 (62–80)	78 (65–98)	74 (64–89)	70 (63–80)
Electrocardiography
ST-segment depression, %	3.8	15.8	2.8	5.8	2.3	1.4
T-wave inversion, %	4.3	14.1	6.0	7.0	2.3	1.6
Biomarker concentrations
Troponin T (Roche), median, ng/L	7 (3–16)	48 (23–143)	9 (6–17)	15 (8–24)	8 (3–15)	5 (3–8)
Troponin I (Abbott), median, ng/L	4 (2–10)	95 (29–455)	5 (3–11)	7 (3–15)	4 (2–10)	2 (2–4)
Troponin I (Siemens), median, ng/L	6 (3–17)	154 (56–846)	8 (4–20)	10 (6–26)	6 (3–15)	4 (3–7)

Table 1

Open in new tab

Baseline characteristics of the patients in the derivation cohort

	Total	NSTEMI	UAP	Other cardiac	Non-cardiac	NCCP
Descriptive factors
Patient count (%)	1896	234 (12.3)	252 (13.3)	172 (9.1)	131 (6.9)	1107 (58.4)
Age, median, years	62 (52–72)	67 (57–76)	68 (59–75)	69 (58–80)	68 (57–76)	58 (49–68)
Male, %	61.1	67.9	70.2	65.1	55.0	57.6
BMI, median, kg/m²	26.9 (24.5–30.0)	26.3 (24.1–29.7)	26.1 (24.5–30.1)	27.0 (24.9–29.5)	27.8 (25.7–30.1)	27.0 (24.5–30.0)
eGFR, median, mL/min/1.73 m²	86 (71–97)	80 (67–95)	82 (66–92)	76 (60–91)	83 (63–95)	89 (77–100)
Symptoms to blood draw, median, hours	8.2 (3.5–32.0)	5.3 (2.8–22.9)	12.8 (4.2–70.8)	8.1 (3.3–32.0)	9.0 (3.8–25.9)	8.4 (3.5–30.6)
Very early presenters < 2 h, %	9.7	12.4	7.5	15.1	9.2	8.9
Early presenters < 3 h, %	21.4	27.8	16.7	22.1	14.5	21.8
Late presenters > 12 h, %	42.1	31.6	51.2	41.9	43.5	42.1
Hospital stay, median, hours	29.0 (22.0–71.0)	75.0 (63.0–122)	74.5 (46.0–137)	50.0 (24.7–97.2)	30.0 (22.0–75.6)	24.0 (19.0–31.0)
Risk factors
Hypertension, %	42.6	50.9	54.4	48.3	45.0	36.9
Hyperlipidaemia, %	20.4	21.4	29.0	18.6	21.4	28.4
Diabetes mellitus, %	11.7	14.5	22.6	9.9	14.5	8.5
Family history, %	20.1	19.2	21.4	14.0	19.1	21.0
Current smoker, %	18.5	20.5	17.5	18.0	17.6	18.4
Previous smoker, %	41.5	47.2	40.1	45.8	42.8	42.6
Medical history
Prior MI, %	20.4	24.8	31.7	27.9	20.6	15.6
Prior PCI, %	20.5	22.2	39.3	26.2	17.6	15.3
Prior CABG, %	7.8	11.1	19.8	9.9	9.9	3.7
Heart failure, %	4.4	4.7	4.0	13.4	6.9	2.8
Stroke, %	3.3	3.4	5.6	5.2	3.1	2.5
Peripheral vascular disease, %	2.3	2.6	6.3	1.7	3.1	1.3
Vital signs on admission
Systolic BP, median, mm Hg	144 (130–160)	147 (132–162)	148 (134–160)	139 (123–157)	138 (126–158)	144 (130–160)
Diastolic BP, median, mm Hg	82 (75–91)	84 (75–91)	81 (75–91)	80 (71–92)	81 (73–90)	83 (75–91)
Heart rate, median, b.p.m.	71 (63–82)	72 (63–80)	70 (62–80)	78 (65–98)	74 (64–89)	70 (63–80)
Electrocardiography
ST-segment depression, %	3.8	15.8	2.8	5.8	2.3	1.4
T-wave inversion, %	4.3	14.1	6.0	7.0	2.3	1.6
Biomarker concentrations
Troponin T (Roche), median, ng/L	7 (3–16)	48 (23–143)	9 (6–17)	15 (8–24)	8 (3–15)	5 (3–8)
Troponin I (Abbott), median, ng/L	4 (2–10)	95 (29–455)	5 (3–11)	7 (3–15)	4 (2–10)	2 (2–4)
Troponin I (Siemens), median, ng/L	6 (3–17)	154 (56–846)	8 (4–20)	10 (6–26)	6 (3–15)	4 (3–7)

	Total	NSTEMI	UAP	Other cardiac	Non-cardiac	NCCP
Descriptive factors
Patient count (%)	1896	234 (12.3)	252 (13.3)	172 (9.1)	131 (6.9)	1107 (58.4)
Age, median, years	62 (52–72)	67 (57–76)	68 (59–75)	69 (58–80)	68 (57–76)	58 (49–68)
Male, %	61.1	67.9	70.2	65.1	55.0	57.6
BMI, median, kg/m²	26.9 (24.5–30.0)	26.3 (24.1–29.7)	26.1 (24.5–30.1)	27.0 (24.9–29.5)	27.8 (25.7–30.1)	27.0 (24.5–30.0)
eGFR, median, mL/min/1.73 m²	86 (71–97)	80 (67–95)	82 (66–92)	76 (60–91)	83 (63–95)	89 (77–100)
Symptoms to blood draw, median, hours	8.2 (3.5–32.0)	5.3 (2.8–22.9)	12.8 (4.2–70.8)	8.1 (3.3–32.0)	9.0 (3.8–25.9)	8.4 (3.5–30.6)
Very early presenters < 2 h, %	9.7	12.4	7.5	15.1	9.2	8.9
Early presenters < 3 h, %	21.4	27.8	16.7	22.1	14.5	21.8
Late presenters > 12 h, %	42.1	31.6	51.2	41.9	43.5	42.1
Hospital stay, median, hours	29.0 (22.0–71.0)	75.0 (63.0–122)	74.5 (46.0–137)	50.0 (24.7–97.2)	30.0 (22.0–75.6)	24.0 (19.0–31.0)
Risk factors
Hypertension, %	42.6	50.9	54.4	48.3	45.0	36.9
Hyperlipidaemia, %	20.4	21.4	29.0	18.6	21.4	28.4
Diabetes mellitus, %	11.7	14.5	22.6	9.9	14.5	8.5
Family history, %	20.1	19.2	21.4	14.0	19.1	21.0
Current smoker, %	18.5	20.5	17.5	18.0	17.6	18.4
Previous smoker, %	41.5	47.2	40.1	45.8	42.8	42.6
Medical history
Prior MI, %	20.4	24.8	31.7	27.9	20.6	15.6
Prior PCI, %	20.5	22.2	39.3	26.2	17.6	15.3
Prior CABG, %	7.8	11.1	19.8	9.9	9.9	3.7
Heart failure, %	4.4	4.7	4.0	13.4	6.9	2.8
Stroke, %	3.3	3.4	5.6	5.2	3.1	2.5
Peripheral vascular disease, %	2.3	2.6	6.3	1.7	3.1	1.3
Vital signs on admission
Systolic BP, median, mm Hg	144 (130–160)	147 (132–162)	148 (134–160)	139 (123–157)	138 (126–158)	144 (130–160)
Diastolic BP, median, mm Hg	82 (75–91)	84 (75–91)	81 (75–91)	80 (71–92)	81 (73–90)	83 (75–91)
Heart rate, median, b.p.m.	71 (63–82)	72 (63–80)	70 (62–80)	78 (65–98)	74 (64–89)	70 (63–80)
Electrocardiography
ST-segment depression, %	3.8	15.8	2.8	5.8	2.3	1.4
T-wave inversion, %	4.3	14.1	6.0	7.0	2.3	1.6
Biomarker concentrations
Troponin T (Roche), median, ng/L	7 (3–16)	48 (23–143)	9 (6–17)	15 (8–24)	8 (3–15)	5 (3–8)
Troponin I (Abbott), median, ng/L	4 (2–10)	95 (29–455)	5 (3–11)	7 (3–15)	4 (2–10)	2 (2–4)
Troponin I (Siemens), median, ng/L	6 (3–17)	154 (56–846)	8 (4–20)	10 (6–26)	6 (3–15)	4 (3–7)

Numbers in parentheses for continuous data are the 25th and 75th percentile.

BMI, body mass index; BP, blood pressure; CABG, coronary artery bypass graft; eGFR, estimated glomerular filtration rate; MI, myocardial infarction; NCCP, non-cardiac chest pain; NSTEMI, non-ST-elevation myocardial infarction; PCI, percutaneous coronary intervention; UAP, unstable angina pectoris.

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