Continuous data synthesis of clinical and hormonal outcomes before and after treatment in 9 studies, for which raw data values were available (19, 21-24, 26, 27, 33, 34)
| Outcome . | Pretreatment (mean ± SD) . | Posttreatment (mean ± SD) . | P . | Adjusted Pa . |
|---|---|---|---|---|
| Testicular volume, mL | 0.35 ± 0.30 (n = 12) | 1.29 ± 0.81 (n = 17) | .0007 | .0049 |
| Stretched penile length, mm | 17.71 ± 5.37 (n = 24) | 36.54 ± 11.36 (n = 24) | <.0001 | .0007 |
| LH, IU/Lb | 0.05 (0.11) (n = 17) | 2.45 (3.38) (n = 12) | <.0001 | .0007 |
| FSH, IU/L | 0.30 ± 0.31 (n = 18) | 17.83 ± 18.37 (n = 15) | .0003 | .0021 |
| Testosterone, nmol/L | 0.14 ± 0.07 (n = 25) | 7.73 ± 8.89 (n = 14) | .0001 | .0007 |
| Inhibin B, pg/mL | 71.42 ± 44.64 (n = 18) | 275.00 ± 166.50 (n = 17) | <.0001 | .0007 |
| AMH, pmol/L | 694.50 ± 579.90 (n = 11) | 1067.00 ± 852.20 (n = 10) | .2516 | .8685 |
| Outcome . | Pretreatment (mean ± SD) . | Posttreatment (mean ± SD) . | P . | Adjusted Pa . |
|---|---|---|---|---|
| Testicular volume, mL | 0.35 ± 0.30 (n = 12) | 1.29 ± 0.81 (n = 17) | .0007 | .0049 |
| Stretched penile length, mm | 17.71 ± 5.37 (n = 24) | 36.54 ± 11.36 (n = 24) | <.0001 | .0007 |
| LH, IU/Lb | 0.05 (0.11) (n = 17) | 2.45 (3.38) (n = 12) | <.0001 | .0007 |
| FSH, IU/L | 0.30 ± 0.31 (n = 18) | 17.83 ± 18.37 (n = 15) | .0003 | .0021 |
| Testosterone, nmol/L | 0.14 ± 0.07 (n = 25) | 7.73 ± 8.89 (n = 14) | .0001 | .0007 |
| Inhibin B, pg/mL | 71.42 ± 44.64 (n = 18) | 275.00 ± 166.50 (n = 17) | <.0001 | .0007 |
| AMH, pmol/L | 694.50 ± 579.90 (n = 11) | 1067.00 ± 852.20 (n = 10) | .2516 | .8685 |
Data pass normality testing using the Shapiro-Wilk test and are represented by mean and SD. Sample size is shown in parentheses for each data synthesis. P values generated using an unpaired t test. Statistical significance is taken at P less than .0014.
Abbreviations: AMH, antimüllerian hormone; FSH, follicle-stimulating hormone; LH, luteinizing hormone.
aPost Bonferroni adjustment.
bNonparametric data shown as median (interquartile range).
Continuous data synthesis of clinical and hormonal outcomes before and after treatment in 9 studies, for which raw data values were available (19, 21-24, 26, 27, 33, 34)
| Outcome . | Pretreatment (mean ± SD) . | Posttreatment (mean ± SD) . | P . | Adjusted Pa . |
|---|---|---|---|---|
| Testicular volume, mL | 0.35 ± 0.30 (n = 12) | 1.29 ± 0.81 (n = 17) | .0007 | .0049 |
| Stretched penile length, mm | 17.71 ± 5.37 (n = 24) | 36.54 ± 11.36 (n = 24) | <.0001 | .0007 |
| LH, IU/Lb | 0.05 (0.11) (n = 17) | 2.45 (3.38) (n = 12) | <.0001 | .0007 |
| FSH, IU/L | 0.30 ± 0.31 (n = 18) | 17.83 ± 18.37 (n = 15) | .0003 | .0021 |
| Testosterone, nmol/L | 0.14 ± 0.07 (n = 25) | 7.73 ± 8.89 (n = 14) | .0001 | .0007 |
| Inhibin B, pg/mL | 71.42 ± 44.64 (n = 18) | 275.00 ± 166.50 (n = 17) | <.0001 | .0007 |
| AMH, pmol/L | 694.50 ± 579.90 (n = 11) | 1067.00 ± 852.20 (n = 10) | .2516 | .8685 |
| Outcome . | Pretreatment (mean ± SD) . | Posttreatment (mean ± SD) . | P . | Adjusted Pa . |
|---|---|---|---|---|
| Testicular volume, mL | 0.35 ± 0.30 (n = 12) | 1.29 ± 0.81 (n = 17) | .0007 | .0049 |
| Stretched penile length, mm | 17.71 ± 5.37 (n = 24) | 36.54 ± 11.36 (n = 24) | <.0001 | .0007 |
| LH, IU/Lb | 0.05 (0.11) (n = 17) | 2.45 (3.38) (n = 12) | <.0001 | .0007 |
| FSH, IU/L | 0.30 ± 0.31 (n = 18) | 17.83 ± 18.37 (n = 15) | .0003 | .0021 |
| Testosterone, nmol/L | 0.14 ± 0.07 (n = 25) | 7.73 ± 8.89 (n = 14) | .0001 | .0007 |
| Inhibin B, pg/mL | 71.42 ± 44.64 (n = 18) | 275.00 ± 166.50 (n = 17) | <.0001 | .0007 |
| AMH, pmol/L | 694.50 ± 579.90 (n = 11) | 1067.00 ± 852.20 (n = 10) | .2516 | .8685 |
Data pass normality testing using the Shapiro-Wilk test and are represented by mean and SD. Sample size is shown in parentheses for each data synthesis. P values generated using an unpaired t test. Statistical significance is taken at P less than .0014.
Abbreviations: AMH, antimüllerian hormone; FSH, follicle-stimulating hormone; LH, luteinizing hormone.
aPost Bonferroni adjustment.
bNonparametric data shown as median (interquartile range).
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