Table 1: Open in new tab Genetics of...

SNP	Nearest gene	Gene name	Beta^a (SE)	P-value
Trait: serum PTH (N_{discovery+validation} = 29 165)
rs6127099	CYP24A1	Cytochrome P450, family 24, subfamily A, polypeptide 1 (24-hydroxylase)	0.07 (0.003)	2.4 × 10^–72
rs4074995	RGS14	Regulator of G-protein signaling 14	0.03 (0.003)	3.3 × 10^–23
rs219779	CLDN14	Claudin 14	0.04 (0.003)	8.9 × 10^–22
rs4443100	RTDR1	Radial spoke head 14 homolog	0.02 (0.003)	4.1 × 10^–11
rs73186030	CASR	Calcium-sensing receptor	0.03 (0.004)	1.2 × 10^–9
Trait: serum FGF-23 (N = 16 224)
rs17216707	CYP24A1	Cytochrome P450, family 24, subfamily A, polypeptide 1 (24-hydroxylase)	0.054 (0.005)	3.0 × 10^–24
rs2769071	ABO	ABO blood group transferase	0.037 (0.005)	6.1 × 10^–17
rs11741640	RGS14	Regulator of G-protein signaling 14	0.039 (0.005)	1.6 × 10^–16
rs17479566	LINC01506	Long intergenic non–protein coding RNA 1506	0.031 (0.005)	2.0 × 10^–9
rs9925837	LINC01229	Long intergenic non–protein coding RNA 1229	0.035 (0.006)	5.1 × 10^–9
Trait: serum 25-hydroxyvitamin D (N = 443 734)
rs11723621	GC	Vitamin D binding protein	–0.187 (0.002)	2.9 × 10^–1689
rs117913124	CYP2R1	Cytochrome P450 2R1, vitamin D 25-hydroxylase	–0.354 (0.006)	1.7 × 10^–775
rs200454003	DHCR7/NADSYN1	7-dehydrocholesterol reductase/nicotinamide adenine dinucleotide synthetase 1	–0.087 (0.003)	2.2 × 10^–253
rs112285002	SULT2A1	Sulfotransferase 2A1	0.060 (0.003)	1.8 × 10^–110
rs6127099	CYP24A1	Cytochrome P450, family 24, subfamily A, polypeptide 1 (24-hydroxylase)	–0.037 (0.002)	9.3 × 10^–62

SNP

Nearest gene

Gene name

Beta^a (SE)

P-value

Trait: serum PTH (N_{discovery+validation} = 29 165)

rs6127099

CYP24A1

Cytochrome P450, family 24, subfamily A, polypeptide 1 (24-hydroxylase)

0.07 (0.003)

2.4 × 10^–72

rs4074995

RGS14

Regulator of G-protein signaling 14

0.03 (0.003)

3.3 × 10^–23

rs219779

CLDN14

Claudin 14

0.04 (0.003)

8.9 × 10^–22

rs4443100

RTDR1

Radial spoke head 14 homolog

0.02 (0.003)

4.1 × 10^–11

rs73186030

CASR

Calcium-sensing receptor

0.03 (0.004)

1.2 × 10^–9

Trait: serum FGF-23 (N = 16 224)

rs17216707

CYP24A1

Cytochrome P450, family 24, subfamily A, polypeptide 1 (24-hydroxylase)

0.054 (0.005)

3.0 × 10^–24

rs2769071

ABO

ABO blood group transferase

0.037 (0.005)

6.1 × 10^–17

rs11741640

RGS14

Regulator of G-protein signaling 14

0.039 (0.005)

1.6 × 10^–16

rs17479566

LINC01506

Long intergenic non–protein coding RNA 1506

0.031 (0.005)

2.0 × 10^–9

rs9925837

LINC01229

Long intergenic non–protein coding RNA 1229

0.035 (0.006)

5.1 × 10^–9

Trait: serum 25-hydroxyvitamin D (N = 443 734)

rs11723621

Vitamin D binding protein

–0.187 (0.002)

2.9 × 10^–1689

rs117913124

CYP2R1

Cytochrome P450 2R1, vitamin D 25-hydroxylase

–0.354 (0.006)

1.7 × 10^–775

rs200454003

DHCR7/NADSYN1

7-dehydrocholesterol reductase/nicotinamide adenine dinucleotide synthetase 1

–0.087 (0.003)

2.2 × 10^–253

rs112285002

SULT2A1

Sulfotransferase 2A1

0.060 (0.003)

1.8 × 10^–110

rs6127099

CYP24A1

Cytochrome P450, family 24, subfamily A, polypeptide 1 (24-hydroxylase)

–0.037 (0.002)

9.3 × 10^–62

SNP	Nearest gene	Gene name	Beta^a (SE)	P-value
Trait: serum PTH (N_{discovery+validation} = 29 165)
rs6127099	CYP24A1	Cytochrome P450, family 24, subfamily A, polypeptide 1 (24-hydroxylase)	0.07 (0.003)	2.4 × 10^–72
rs4074995	RGS14	Regulator of G-protein signaling 14	0.03 (0.003)	3.3 × 10^–23
rs219779	CLDN14	Claudin 14	0.04 (0.003)	8.9 × 10^–22
rs4443100	RTDR1	Radial spoke head 14 homolog	0.02 (0.003)	4.1 × 10^–11
rs73186030	CASR	Calcium-sensing receptor	0.03 (0.004)	1.2 × 10^–9
Trait: serum FGF-23 (N = 16 224)
rs17216707	CYP24A1	Cytochrome P450, family 24, subfamily A, polypeptide 1 (24-hydroxylase)	0.054 (0.005)	3.0 × 10^–24
rs2769071	ABO	ABO blood group transferase	0.037 (0.005)	6.1 × 10^–17
rs11741640	RGS14	Regulator of G-protein signaling 14	0.039 (0.005)	1.6 × 10^–16
rs17479566	LINC01506	Long intergenic non–protein coding RNA 1506	0.031 (0.005)	2.0 × 10^–9
rs9925837	LINC01229	Long intergenic non–protein coding RNA 1229	0.035 (0.006)	5.1 × 10^–9
Trait: serum 25-hydroxyvitamin D (N = 443 734)
rs11723621	GC	Vitamin D binding protein	–0.187 (0.002)	2.9 × 10^–1689
rs117913124	CYP2R1	Cytochrome P450 2R1, vitamin D 25-hydroxylase	–0.354 (0.006)	1.7 × 10^–775
rs200454003	DHCR7/NADSYN1	7-dehydrocholesterol reductase/nicotinamide adenine dinucleotide synthetase 1	–0.087 (0.003)	2.2 × 10^–253
rs112285002	SULT2A1	Sulfotransferase 2A1	0.060 (0.003)	1.8 × 10^–110
rs6127099	CYP24A1	Cytochrome P450, family 24, subfamily A, polypeptide 1 (24-hydroxylase)	–0.037 (0.002)	9.3 × 10^–62

Table 1:

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Genetics of serum PTH, 25-hydroxyvitamin D and FGF-23 levels: top five SNPs.

SNP	Nearest gene	Gene name	Beta^a (SE)	P-value
Trait: serum PTH (N_{discovery+validation} = 29 165)
rs6127099	CYP24A1	Cytochrome P450, family 24, subfamily A, polypeptide 1 (24-hydroxylase)	0.07 (0.003)	2.4 × 10^–72
rs4074995	RGS14	Regulator of G-protein signaling 14	0.03 (0.003)	3.3 × 10^–23
rs219779	CLDN14	Claudin 14	0.04 (0.003)	8.9 × 10^–22
rs4443100	RTDR1	Radial spoke head 14 homolog	0.02 (0.003)	4.1 × 10^–11
rs73186030	CASR	Calcium-sensing receptor	0.03 (0.004)	1.2 × 10^–9
Trait: serum FGF-23 (N = 16 224)
rs17216707	CYP24A1	Cytochrome P450, family 24, subfamily A, polypeptide 1 (24-hydroxylase)	0.054 (0.005)	3.0 × 10^–24
rs2769071	ABO	ABO blood group transferase	0.037 (0.005)	6.1 × 10^–17
rs11741640	RGS14	Regulator of G-protein signaling 14	0.039 (0.005)	1.6 × 10^–16
rs17479566	LINC01506	Long intergenic non–protein coding RNA 1506	0.031 (0.005)	2.0 × 10^–9
rs9925837	LINC01229	Long intergenic non–protein coding RNA 1229	0.035 (0.006)	5.1 × 10^–9
Trait: serum 25-hydroxyvitamin D (N = 443 734)
rs11723621	GC	Vitamin D binding protein	–0.187 (0.002)	2.9 × 10^–1689
rs117913124	CYP2R1	Cytochrome P450 2R1, vitamin D 25-hydroxylase	–0.354 (0.006)	1.7 × 10^–775
rs200454003	DHCR7/NADSYN1	7-dehydrocholesterol reductase/nicotinamide adenine dinucleotide synthetase 1	–0.087 (0.003)	2.2 × 10^–253
rs112285002	SULT2A1	Sulfotransferase 2A1	0.060 (0.003)	1.8 × 10^–110
rs6127099	CYP24A1	Cytochrome P450, family 24, subfamily A, polypeptide 1 (24-hydroxylase)	–0.037 (0.002)	9.3 × 10^–62

SNP	Nearest gene	Gene name	Beta^a (SE)	P-value
Trait: serum PTH (N_{discovery+validation} = 29 165)
rs6127099	CYP24A1	Cytochrome P450, family 24, subfamily A, polypeptide 1 (24-hydroxylase)	0.07 (0.003)	2.4 × 10^–72
rs4074995	RGS14	Regulator of G-protein signaling 14	0.03 (0.003)	3.3 × 10^–23
rs219779	CLDN14	Claudin 14	0.04 (0.003)	8.9 × 10^–22
rs4443100	RTDR1	Radial spoke head 14 homolog	0.02 (0.003)	4.1 × 10^–11
rs73186030	CASR	Calcium-sensing receptor	0.03 (0.004)	1.2 × 10^–9
Trait: serum FGF-23 (N = 16 224)
rs17216707	CYP24A1	Cytochrome P450, family 24, subfamily A, polypeptide 1 (24-hydroxylase)	0.054 (0.005)	3.0 × 10^–24
rs2769071	ABO	ABO blood group transferase	0.037 (0.005)	6.1 × 10^–17
rs11741640	RGS14	Regulator of G-protein signaling 14	0.039 (0.005)	1.6 × 10^–16
rs17479566	LINC01506	Long intergenic non–protein coding RNA 1506	0.031 (0.005)	2.0 × 10^–9
rs9925837	LINC01229	Long intergenic non–protein coding RNA 1229	0.035 (0.006)	5.1 × 10^–9
Trait: serum 25-hydroxyvitamin D (N = 443 734)
rs11723621	GC	Vitamin D binding protein	–0.187 (0.002)	2.9 × 10^–1689
rs117913124	CYP2R1	Cytochrome P450 2R1, vitamin D 25-hydroxylase	–0.354 (0.006)	1.7 × 10^–775
rs200454003	DHCR7/NADSYN1	7-dehydrocholesterol reductase/nicotinamide adenine dinucleotide synthetase 1	–0.087 (0.003)	2.2 × 10^–253
rs112285002	SULT2A1	Sulfotransferase 2A1	0.060 (0.003)	1.8 × 10^–110
rs6127099	CYP24A1	Cytochrome P450, family 24, subfamily A, polypeptide 1 (24-hydroxylase)	–0.037 (0.002)	9.3 × 10^–62

Beta estimates are interpreted as the relative difference in FGF-23 concentration per minor allele; e.g. 0.07 is a 7% higher FGF-23 concentration per additional allele.

SE, standard error.

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