Hallmark gene subsets (n=16) with significant tumor versus normal sample clustering potential
Geneset . | Sil.(mean) . | Sil.(stdev) . | Sig. subsets . |
---|---|---|---|
PROTEIN_SECRETION | 0.09 | 0.12 | 1/5 |
ALLOGRAFT_REJECTION | 0.10 | 0.09 | 4/12 |
UNFOLDED_PROTEIN_RESPONSE | 0.10 | 0.03 | 1/6 |
INTERFERON_GAMMA_RESPONSE | 0.12 | 0.08 | 1/12 |
ESTROGEN_RESPONSE_EARLY | 0.13 | 0.09 | 4/12 |
REACTIVE_OXYGEN_SPECIES_PATHWAY | 0.14 | 0.11 | 0/2 |
INTERFERON_ALPHA_RESPONSE | 0.15 | 0.06 | 0/5 |
OXIDATIVE_PHOSPHORYLATION | 0.15 | 0.07 | 0/11 |
MYC_TARGETS_V1 | 0.15 | 0.07 | 0/12 |
ANDROGEN_RESPONSE | 0.15 | 0.10 | 1/6 |
PEROXISOME | 0.15 | 0.10 | 1/6 |
PANCREAS_BETA_CELLS | 0.16 | 0.02 | 0/2 |
PI3K_AKT_MTOR_SIGNALING | 0.18 | 0.11 | 0/6 |
ESTROGEN_RESPONSE_LATE | 0.18 | 0.10 | 0/12 |
COMPLEMENT | 0.20 | 0.10 | 1/12 |
MTORC1_SIGNALING | 0.20 | 0.12 | 1/12 |
TGF_BETA_SIGNALING | 0.20 | 0.06 | 0/3 |
APOPTOSIS | 0.22 | 0.09 | 0/9 |
KRAS_SIGNALING_DN | 0.22 | 0.09 | 0/12 |
UV_RESPONSE_UP | 0.22 | 0.11 | 1/9 |
HEME_METABOLISM | 0.22 | 0.08 | 0/11 |
IL6_JAK_STAT3_SIGNALING | 0.23 | 0.08 | 0/5 |
P53_PATHWAY | 0.23 | 0.07 | 0/11 |
ANGIOGENESIS | 0.23 | 0.05 | 0/2 |
MYC_TARGETS_V2 | 0.23 | 0.11 | 0/3 |
INFLAMMATORY_RESPONSE | 0.24 | 0.09 | 0/12 |
XENOBIOTIC_METABOLISM | 0.25 | 0.08 | 1/12 |
DNA_REPAIR | 0.26 | 0.06 | 0/9 |
EPITHELIAL_MESENCHYMAL_TRANSITION | 0.26 | 0.10 | 1/12 |
BILE_ACID_METABOLISM | 0.27 | 0.17 | 4/7 |
HYPOXIA | 0.27 | 0.07 | 0/11 |
TNFA_SIGNALING_VIA_NFKB | 0.28 | 0.08 | 1/12 |
APICAL_SURFACE | 0.28 | 0.08 | 0/2 |
COAGULATION | 0.29 | 0.06 | 0/8 |
GLYCOLYSIS | 0.29 | 0.10 | 0/12 |
APICAL_JUNCTION | 0.29 | 0.06 | 1/11 |
MYOGENESIS | 0.29 | 0.09 | 1/12 |
FATTY_ACID_METABOLISM | 0.29 | 0.11 | 1/9 |
ADIPOGENESIS | 0.30 | 0.06 | 0/12 |
IL2_STAT5_SIGNALING | 0.30 | 0.08 | 1/12 |
CHOLESTEROL_HOMEOSTASIS | 0.30 | 0.09 | 1/4 |
KRAS_SIGNALING_UP | 0.31 | 0.12 | 3/11 |
NOTCH_SIGNALING | 0.33 | 0.12 | 1/2 |
WNT_BETA_CATENIN_SIGNALING | 0.33 | 0.05 | 0/2 |
UV_RESPONSE_DN | 0.33 | 0.08 | 2/8 |
HEDGEHOG_SIGNALING | 0.34 | 0.00 | 0/2 |
SPERMATOGENESIS | 0.35 | 0.11 | 4/8 |
G2M_CHECKPOINT | 0.36 | 0.13 | 5/11 |
E2F_TARGETS | 0.39 | 0.12 | 8/12 |
MITOTIC_SPINDLE | 0.40 | 0.09 | 8/12 |
Geneset . | Sil.(mean) . | Sil.(stdev) . | Sig. subsets . |
---|---|---|---|
PROTEIN_SECRETION | 0.09 | 0.12 | 1/5 |
ALLOGRAFT_REJECTION | 0.10 | 0.09 | 4/12 |
UNFOLDED_PROTEIN_RESPONSE | 0.10 | 0.03 | 1/6 |
INTERFERON_GAMMA_RESPONSE | 0.12 | 0.08 | 1/12 |
ESTROGEN_RESPONSE_EARLY | 0.13 | 0.09 | 4/12 |
REACTIVE_OXYGEN_SPECIES_PATHWAY | 0.14 | 0.11 | 0/2 |
INTERFERON_ALPHA_RESPONSE | 0.15 | 0.06 | 0/5 |
OXIDATIVE_PHOSPHORYLATION | 0.15 | 0.07 | 0/11 |
MYC_TARGETS_V1 | 0.15 | 0.07 | 0/12 |
ANDROGEN_RESPONSE | 0.15 | 0.10 | 1/6 |
PEROXISOME | 0.15 | 0.10 | 1/6 |
PANCREAS_BETA_CELLS | 0.16 | 0.02 | 0/2 |
PI3K_AKT_MTOR_SIGNALING | 0.18 | 0.11 | 0/6 |
ESTROGEN_RESPONSE_LATE | 0.18 | 0.10 | 0/12 |
COMPLEMENT | 0.20 | 0.10 | 1/12 |
MTORC1_SIGNALING | 0.20 | 0.12 | 1/12 |
TGF_BETA_SIGNALING | 0.20 | 0.06 | 0/3 |
APOPTOSIS | 0.22 | 0.09 | 0/9 |
KRAS_SIGNALING_DN | 0.22 | 0.09 | 0/12 |
UV_RESPONSE_UP | 0.22 | 0.11 | 1/9 |
HEME_METABOLISM | 0.22 | 0.08 | 0/11 |
IL6_JAK_STAT3_SIGNALING | 0.23 | 0.08 | 0/5 |
P53_PATHWAY | 0.23 | 0.07 | 0/11 |
ANGIOGENESIS | 0.23 | 0.05 | 0/2 |
MYC_TARGETS_V2 | 0.23 | 0.11 | 0/3 |
INFLAMMATORY_RESPONSE | 0.24 | 0.09 | 0/12 |
XENOBIOTIC_METABOLISM | 0.25 | 0.08 | 1/12 |
DNA_REPAIR | 0.26 | 0.06 | 0/9 |
EPITHELIAL_MESENCHYMAL_TRANSITION | 0.26 | 0.10 | 1/12 |
BILE_ACID_METABOLISM | 0.27 | 0.17 | 4/7 |
HYPOXIA | 0.27 | 0.07 | 0/11 |
TNFA_SIGNALING_VIA_NFKB | 0.28 | 0.08 | 1/12 |
APICAL_SURFACE | 0.28 | 0.08 | 0/2 |
COAGULATION | 0.29 | 0.06 | 0/8 |
GLYCOLYSIS | 0.29 | 0.10 | 0/12 |
APICAL_JUNCTION | 0.29 | 0.06 | 1/11 |
MYOGENESIS | 0.29 | 0.09 | 1/12 |
FATTY_ACID_METABOLISM | 0.29 | 0.11 | 1/9 |
ADIPOGENESIS | 0.30 | 0.06 | 0/12 |
IL2_STAT5_SIGNALING | 0.30 | 0.08 | 1/12 |
CHOLESTEROL_HOMEOSTASIS | 0.30 | 0.09 | 1/4 |
KRAS_SIGNALING_UP | 0.31 | 0.12 | 3/11 |
NOTCH_SIGNALING | 0.33 | 0.12 | 1/2 |
WNT_BETA_CATENIN_SIGNALING | 0.33 | 0.05 | 0/2 |
UV_RESPONSE_DN | 0.33 | 0.08 | 2/8 |
HEDGEHOG_SIGNALING | 0.34 | 0.00 | 0/2 |
SPERMATOGENESIS | 0.35 | 0.11 | 4/8 |
G2M_CHECKPOINT | 0.36 | 0.13 | 5/11 |
E2F_TARGETS | 0.39 | 0.12 | 8/12 |
MITOTIC_SPINDLE | 0.40 | 0.09 | 8/12 |
Hallmark gene subsets (n=16) with significant tumor versus normal sample clustering potential
Geneset . | Sil.(mean) . | Sil.(stdev) . | Sig. subsets . |
---|---|---|---|
PROTEIN_SECRETION | 0.09 | 0.12 | 1/5 |
ALLOGRAFT_REJECTION | 0.10 | 0.09 | 4/12 |
UNFOLDED_PROTEIN_RESPONSE | 0.10 | 0.03 | 1/6 |
INTERFERON_GAMMA_RESPONSE | 0.12 | 0.08 | 1/12 |
ESTROGEN_RESPONSE_EARLY | 0.13 | 0.09 | 4/12 |
REACTIVE_OXYGEN_SPECIES_PATHWAY | 0.14 | 0.11 | 0/2 |
INTERFERON_ALPHA_RESPONSE | 0.15 | 0.06 | 0/5 |
OXIDATIVE_PHOSPHORYLATION | 0.15 | 0.07 | 0/11 |
MYC_TARGETS_V1 | 0.15 | 0.07 | 0/12 |
ANDROGEN_RESPONSE | 0.15 | 0.10 | 1/6 |
PEROXISOME | 0.15 | 0.10 | 1/6 |
PANCREAS_BETA_CELLS | 0.16 | 0.02 | 0/2 |
PI3K_AKT_MTOR_SIGNALING | 0.18 | 0.11 | 0/6 |
ESTROGEN_RESPONSE_LATE | 0.18 | 0.10 | 0/12 |
COMPLEMENT | 0.20 | 0.10 | 1/12 |
MTORC1_SIGNALING | 0.20 | 0.12 | 1/12 |
TGF_BETA_SIGNALING | 0.20 | 0.06 | 0/3 |
APOPTOSIS | 0.22 | 0.09 | 0/9 |
KRAS_SIGNALING_DN | 0.22 | 0.09 | 0/12 |
UV_RESPONSE_UP | 0.22 | 0.11 | 1/9 |
HEME_METABOLISM | 0.22 | 0.08 | 0/11 |
IL6_JAK_STAT3_SIGNALING | 0.23 | 0.08 | 0/5 |
P53_PATHWAY | 0.23 | 0.07 | 0/11 |
ANGIOGENESIS | 0.23 | 0.05 | 0/2 |
MYC_TARGETS_V2 | 0.23 | 0.11 | 0/3 |
INFLAMMATORY_RESPONSE | 0.24 | 0.09 | 0/12 |
XENOBIOTIC_METABOLISM | 0.25 | 0.08 | 1/12 |
DNA_REPAIR | 0.26 | 0.06 | 0/9 |
EPITHELIAL_MESENCHYMAL_TRANSITION | 0.26 | 0.10 | 1/12 |
BILE_ACID_METABOLISM | 0.27 | 0.17 | 4/7 |
HYPOXIA | 0.27 | 0.07 | 0/11 |
TNFA_SIGNALING_VIA_NFKB | 0.28 | 0.08 | 1/12 |
APICAL_SURFACE | 0.28 | 0.08 | 0/2 |
COAGULATION | 0.29 | 0.06 | 0/8 |
GLYCOLYSIS | 0.29 | 0.10 | 0/12 |
APICAL_JUNCTION | 0.29 | 0.06 | 1/11 |
MYOGENESIS | 0.29 | 0.09 | 1/12 |
FATTY_ACID_METABOLISM | 0.29 | 0.11 | 1/9 |
ADIPOGENESIS | 0.30 | 0.06 | 0/12 |
IL2_STAT5_SIGNALING | 0.30 | 0.08 | 1/12 |
CHOLESTEROL_HOMEOSTASIS | 0.30 | 0.09 | 1/4 |
KRAS_SIGNALING_UP | 0.31 | 0.12 | 3/11 |
NOTCH_SIGNALING | 0.33 | 0.12 | 1/2 |
WNT_BETA_CATENIN_SIGNALING | 0.33 | 0.05 | 0/2 |
UV_RESPONSE_DN | 0.33 | 0.08 | 2/8 |
HEDGEHOG_SIGNALING | 0.34 | 0.00 | 0/2 |
SPERMATOGENESIS | 0.35 | 0.11 | 4/8 |
G2M_CHECKPOINT | 0.36 | 0.13 | 5/11 |
E2F_TARGETS | 0.39 | 0.12 | 8/12 |
MITOTIC_SPINDLE | 0.40 | 0.09 | 8/12 |
Geneset . | Sil.(mean) . | Sil.(stdev) . | Sig. subsets . |
---|---|---|---|
PROTEIN_SECRETION | 0.09 | 0.12 | 1/5 |
ALLOGRAFT_REJECTION | 0.10 | 0.09 | 4/12 |
UNFOLDED_PROTEIN_RESPONSE | 0.10 | 0.03 | 1/6 |
INTERFERON_GAMMA_RESPONSE | 0.12 | 0.08 | 1/12 |
ESTROGEN_RESPONSE_EARLY | 0.13 | 0.09 | 4/12 |
REACTIVE_OXYGEN_SPECIES_PATHWAY | 0.14 | 0.11 | 0/2 |
INTERFERON_ALPHA_RESPONSE | 0.15 | 0.06 | 0/5 |
OXIDATIVE_PHOSPHORYLATION | 0.15 | 0.07 | 0/11 |
MYC_TARGETS_V1 | 0.15 | 0.07 | 0/12 |
ANDROGEN_RESPONSE | 0.15 | 0.10 | 1/6 |
PEROXISOME | 0.15 | 0.10 | 1/6 |
PANCREAS_BETA_CELLS | 0.16 | 0.02 | 0/2 |
PI3K_AKT_MTOR_SIGNALING | 0.18 | 0.11 | 0/6 |
ESTROGEN_RESPONSE_LATE | 0.18 | 0.10 | 0/12 |
COMPLEMENT | 0.20 | 0.10 | 1/12 |
MTORC1_SIGNALING | 0.20 | 0.12 | 1/12 |
TGF_BETA_SIGNALING | 0.20 | 0.06 | 0/3 |
APOPTOSIS | 0.22 | 0.09 | 0/9 |
KRAS_SIGNALING_DN | 0.22 | 0.09 | 0/12 |
UV_RESPONSE_UP | 0.22 | 0.11 | 1/9 |
HEME_METABOLISM | 0.22 | 0.08 | 0/11 |
IL6_JAK_STAT3_SIGNALING | 0.23 | 0.08 | 0/5 |
P53_PATHWAY | 0.23 | 0.07 | 0/11 |
ANGIOGENESIS | 0.23 | 0.05 | 0/2 |
MYC_TARGETS_V2 | 0.23 | 0.11 | 0/3 |
INFLAMMATORY_RESPONSE | 0.24 | 0.09 | 0/12 |
XENOBIOTIC_METABOLISM | 0.25 | 0.08 | 1/12 |
DNA_REPAIR | 0.26 | 0.06 | 0/9 |
EPITHELIAL_MESENCHYMAL_TRANSITION | 0.26 | 0.10 | 1/12 |
BILE_ACID_METABOLISM | 0.27 | 0.17 | 4/7 |
HYPOXIA | 0.27 | 0.07 | 0/11 |
TNFA_SIGNALING_VIA_NFKB | 0.28 | 0.08 | 1/12 |
APICAL_SURFACE | 0.28 | 0.08 | 0/2 |
COAGULATION | 0.29 | 0.06 | 0/8 |
GLYCOLYSIS | 0.29 | 0.10 | 0/12 |
APICAL_JUNCTION | 0.29 | 0.06 | 1/11 |
MYOGENESIS | 0.29 | 0.09 | 1/12 |
FATTY_ACID_METABOLISM | 0.29 | 0.11 | 1/9 |
ADIPOGENESIS | 0.30 | 0.06 | 0/12 |
IL2_STAT5_SIGNALING | 0.30 | 0.08 | 1/12 |
CHOLESTEROL_HOMEOSTASIS | 0.30 | 0.09 | 1/4 |
KRAS_SIGNALING_UP | 0.31 | 0.12 | 3/11 |
NOTCH_SIGNALING | 0.33 | 0.12 | 1/2 |
WNT_BETA_CATENIN_SIGNALING | 0.33 | 0.05 | 0/2 |
UV_RESPONSE_DN | 0.33 | 0.08 | 2/8 |
HEDGEHOG_SIGNALING | 0.34 | 0.00 | 0/2 |
SPERMATOGENESIS | 0.35 | 0.11 | 4/8 |
G2M_CHECKPOINT | 0.36 | 0.13 | 5/11 |
E2F_TARGETS | 0.39 | 0.12 | 8/12 |
MITOTIC_SPINDLE | 0.40 | 0.09 | 8/12 |
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