Evaluation of Surrogate Virus Neutralization assay against the WT strain using the population cut-off vs the manufacturer’s cut-off value.
| WT cutoff value, CI . | |||||
|---|---|---|---|---|---|
| Diagnostic metrics . | 27.69% . | 30.0% . | Difference . | Test statistics . | P-value . |
| Sensitivity | 100.0% (96.9%–100%) | 91.4% (84.7%–95.8%) | −8.6 | 10.00 | .002 |
| Specificity | 66.7% (9.4%–99.2%) | 66.7% (9.4%–99.2%) | 0.0 | NA | NA |
| PPV | 99.1% (95.3%–100%) | 99.1% (94.9%–100%) | 0.999 | −0.953 | .340 |
| NPV | 100.0% (15.8%–100%) | 16.7% (2.1%–48.4%) | 0.167 | −2.776 | .006 |
| WT cutoff value, CI . | |||||
|---|---|---|---|---|---|
| Diagnostic metrics . | 27.69% . | 30.0% . | Difference . | Test statistics . | P-value . |
| Sensitivity | 100.0% (96.9%–100%) | 91.4% (84.7%–95.8%) | −8.6 | 10.00 | .002 |
| Specificity | 66.7% (9.4%–99.2%) | 66.7% (9.4%–99.2%) | 0.0 | NA | NA |
| PPV | 99.1% (95.3%–100%) | 99.1% (94.9%–100%) | 0.999 | −0.953 | .340 |
| NPV | 100.0% (15.8%–100%) | 16.7% (2.1%–48.4%) | 0.167 | −2.776 | .006 |
PPV: Positive predictive value, NPV: Negative predictive value, NA: Not applicable.
Evaluation of Surrogate Virus Neutralization assay against the WT strain using the population cut-off vs the manufacturer’s cut-off value.
| WT cutoff value, CI . | |||||
|---|---|---|---|---|---|
| Diagnostic metrics . | 27.69% . | 30.0% . | Difference . | Test statistics . | P-value . |
| Sensitivity | 100.0% (96.9%–100%) | 91.4% (84.7%–95.8%) | −8.6 | 10.00 | .002 |
| Specificity | 66.7% (9.4%–99.2%) | 66.7% (9.4%–99.2%) | 0.0 | NA | NA |
| PPV | 99.1% (95.3%–100%) | 99.1% (94.9%–100%) | 0.999 | −0.953 | .340 |
| NPV | 100.0% (15.8%–100%) | 16.7% (2.1%–48.4%) | 0.167 | −2.776 | .006 |
| WT cutoff value, CI . | |||||
|---|---|---|---|---|---|
| Diagnostic metrics . | 27.69% . | 30.0% . | Difference . | Test statistics . | P-value . |
| Sensitivity | 100.0% (96.9%–100%) | 91.4% (84.7%–95.8%) | −8.6 | 10.00 | .002 |
| Specificity | 66.7% (9.4%–99.2%) | 66.7% (9.4%–99.2%) | 0.0 | NA | NA |
| PPV | 99.1% (95.3%–100%) | 99.1% (94.9%–100%) | 0.999 | −0.953 | .340 |
| NPV | 100.0% (15.8%–100%) | 16.7% (2.1%–48.4%) | 0.167 | −2.776 | .006 |
PPV: Positive predictive value, NPV: Negative predictive value, NA: Not applicable.
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