Table 1

Outcomes of studies evaluating VT substrate ablation based on EDP targeting

 YearNo. of centreStudy designNo. of patientsCardiomyopathyLVEFSubstrate ablation strategyRF time (min)Inducibility after EDP-based substrate ablationVT-free survivalPredictors of VT recurrence
Acosta et al.1120181Prospective3776% post-MI38 ± 9S1: RV extra at VRP + 60 ms
S2: RV extra at VRP + 40 ms
+ scar dechannelling
17.4 ± 1124.3%86.5% at 6 months
Porta-Sánchez et al.1220184Prospective20Post-MI33 ± 11S1: RV pacing train 600ms
S2: RV extra at VRP + 20 ms
30.6 ± 20.420%75% at 6 months
de Riva et al.820181Prospective60Post-MI33 ± 12S1: RV pacing train 500 ms
S2: RV extra at VRP + 50 ms
15 (10–21)37%78% at 16 months
Acosta et al.1320201Prospective7063% post-MI37 ± 11S1: RV extra at VRP + 60 ms
S2: RV extra at VRP + 40ms
+ scar dechannelling
15.6 (8–23.1)28.6%75.7% at 24 monthsVT inducibility, incomplete substrate accessibility
de Riva et al.1420256Prospective130Post-MI34 (25–43)S1: RV pacing train 500 ms
S2: RV extra at VRP + 50 ms
23 (14–35)24%72% at 12 monthsLower LVEF
 YearNo. of centreStudy designNo. of patientsCardiomyopathyLVEFSubstrate ablation strategyRF time (min)Inducibility after EDP-based substrate ablationVT-free survivalPredictors of VT recurrence
Acosta et al.1120181Prospective3776% post-MI38 ± 9S1: RV extra at VRP + 60 ms
S2: RV extra at VRP + 40 ms
+ scar dechannelling
17.4 ± 1124.3%86.5% at 6 months
Porta-Sánchez et al.1220184Prospective20Post-MI33 ± 11S1: RV pacing train 600ms
S2: RV extra at VRP + 20 ms
30.6 ± 20.420%75% at 6 months
de Riva et al.820181Prospective60Post-MI33 ± 12S1: RV pacing train 500 ms
S2: RV extra at VRP + 50 ms
15 (10–21)37%78% at 16 months
Acosta et al.1320201Prospective7063% post-MI37 ± 11S1: RV extra at VRP + 60 ms
S2: RV extra at VRP + 40ms
+ scar dechannelling
15.6 (8–23.1)28.6%75.7% at 24 monthsVT inducibility, incomplete substrate accessibility
de Riva et al.1420256Prospective130Post-MI34 (25–43)S1: RV pacing train 500 ms
S2: RV extra at VRP + 50 ms
23 (14–35)24%72% at 12 monthsLower LVEF

LVEF, left ventricular ejection fraction; EDP, evoked delayed potential; MI, myocardial infarction; RF, radiofrequency; RV, right ventricle; VRP, ventricular refractory period; VT, ventricular tachycardia.

Table 1

Outcomes of studies evaluating VT substrate ablation based on EDP targeting

 YearNo. of centreStudy designNo. of patientsCardiomyopathyLVEFSubstrate ablation strategyRF time (min)Inducibility after EDP-based substrate ablationVT-free survivalPredictors of VT recurrence
Acosta et al.1120181Prospective3776% post-MI38 ± 9S1: RV extra at VRP + 60 ms
S2: RV extra at VRP + 40 ms
+ scar dechannelling
17.4 ± 1124.3%86.5% at 6 months
Porta-Sánchez et al.1220184Prospective20Post-MI33 ± 11S1: RV pacing train 600ms
S2: RV extra at VRP + 20 ms
30.6 ± 20.420%75% at 6 months
de Riva et al.820181Prospective60Post-MI33 ± 12S1: RV pacing train 500 ms
S2: RV extra at VRP + 50 ms
15 (10–21)37%78% at 16 months
Acosta et al.1320201Prospective7063% post-MI37 ± 11S1: RV extra at VRP + 60 ms
S2: RV extra at VRP + 40ms
+ scar dechannelling
15.6 (8–23.1)28.6%75.7% at 24 monthsVT inducibility, incomplete substrate accessibility
de Riva et al.1420256Prospective130Post-MI34 (25–43)S1: RV pacing train 500 ms
S2: RV extra at VRP + 50 ms
23 (14–35)24%72% at 12 monthsLower LVEF
 YearNo. of centreStudy designNo. of patientsCardiomyopathyLVEFSubstrate ablation strategyRF time (min)Inducibility after EDP-based substrate ablationVT-free survivalPredictors of VT recurrence
Acosta et al.1120181Prospective3776% post-MI38 ± 9S1: RV extra at VRP + 60 ms
S2: RV extra at VRP + 40 ms
+ scar dechannelling
17.4 ± 1124.3%86.5% at 6 months
Porta-Sánchez et al.1220184Prospective20Post-MI33 ± 11S1: RV pacing train 600ms
S2: RV extra at VRP + 20 ms
30.6 ± 20.420%75% at 6 months
de Riva et al.820181Prospective60Post-MI33 ± 12S1: RV pacing train 500 ms
S2: RV extra at VRP + 50 ms
15 (10–21)37%78% at 16 months
Acosta et al.1320201Prospective7063% post-MI37 ± 11S1: RV extra at VRP + 60 ms
S2: RV extra at VRP + 40ms
+ scar dechannelling
15.6 (8–23.1)28.6%75.7% at 24 monthsVT inducibility, incomplete substrate accessibility
de Riva et al.1420256Prospective130Post-MI34 (25–43)S1: RV pacing train 500 ms
S2: RV extra at VRP + 50 ms
23 (14–35)24%72% at 12 monthsLower LVEF

LVEF, left ventricular ejection fraction; EDP, evoked delayed potential; MI, myocardial infarction; RF, radiofrequency; RV, right ventricle; VRP, ventricular refractory period; VT, ventricular tachycardia.

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