Table 4 Open in new tab Associations...

Association		Cluster size	Side	Brain region	t value	MNI coordinates
Cog-CS
Acetylcholine—M1
Positive	<0.001	1148	R	STG (BA13)	5.12	55	−44	22
			R	STG (BA41)	4.73	47	−39	11
			R	MTG (BA21)	4.48	53	−35	−5
	0.026	213	R	PCC (BA29)	4.95	7	−45	15
			R	PCC (BA31)	4.07	5	−40	27
			L	PCC (BA23)	4.02	−9	−32	29
	0.001	389	R	Cerebellum—culmen	4.53	21	−50	−20
			R	Cerebellum—culmen	4.41	17	−54	−14
			R	Cerebellum—culmen	4.03	3	−56	−10
Episodic memory
Mesocorticolimbic pathway: Dopamine—D1
Negative	0.015	168	L	MFG (BA9)	4.74	−52	19	36
			L	MFG (BA46)	4.09	−50	28	27
			L	IFG (BA45)	3.55	−58	13	22
Mesocorticolimbic pathway: Dopamine—DAT
Positive	<0.001	405	R	PCC (BA31)	4.58	5	−51	28
			L	Precuneus (BA7)	4.51	−11	−63	35
			L	PCC (BA31)	4.43	−21	−62	21
Negative	0.001	354	R	ACC (BA24)	5.77	2	19	29
			L	ACC (BA32)	4.33	−4	36	23
			R	ACC (BA32)	4.01	14	18	39
	0.012	213	R	Thalamus	4.77	4	−18	18
			L	Thalamus	4.20	−2	−12	19
Nigrostriatal pathway: Dopamine—D2
Positive	0.028	173	L	Cuneus (BA23)	5.06	−15	−73	6
			L	Lingual gyrus (BA18)	4.00	−7	−71	4
			L	RSC (BA30)	3.75	1	−69	4
Acetylcholine—M1
Positive	<0.001	1159	R	IPL (BA40)	5.93	57	−44	22
			R	STG (BA22)	4.77	61	−43	10
			R	MTG (BA22)	4.31	59	−47	2
	0.035	222	L	IPL (BA40)	4.51	−65	−36	29
			L	IPL (BA40)	4.16	−53	−46	31
			L	IPL (BA40)	3.72	−59	−38	39
Negative	0.026	241	L	SFG (BA10)	4.16	−21	50	24
			L	MFG (BA10)	3.96	−11	59	13
			L	SFG (BA10)	3.87	−17	58	21
Acetylcholine—VAChT
Positive	0.017	285	L	Cuneus (BA23)	4.75	−5	−77	11
			L	Cuneus (BA18)	4.18	−5	−82	19
			L	Lingual gyrus (BA18)	3.38	−9	−67	2
	0.016	291	R	Postcentral gyrus (BA43)	4.54	53	−20	21
			R	Postcentral gyrus (BA43)	4.32	57	−6	16
			R	Postcentral gyrus (BA2)	4.10	57	−22	33

Association

Cluster size

Side

Brain region

t value

MNI coordinates

P-value

Cog-CS

Acetylcholine—M1

Positive

<0.001

1148

STG (BA13)

5.12

−44

STG (BA41)

4.73

−39

MTG (BA21)

4.48

−35

−5

0.026

213

PCC (BA29)

4.95

−45

PCC (BA31)

4.07

−40

PCC (BA23)

4.02

−9

−32

0.001

389

Cerebellum—culmen

4.53

−50

−20

Cerebellum—culmen

4.41

−54

−14

Cerebellum—culmen

4.03

−56

−10

Episodic memory

Mesocorticolimbic pathway: Dopamine—D1

Negative

0.015

168

MFG (BA9)

4.74

−52

MFG (BA46)

4.09

−50

IFG (BA45)

3.55

−58

Mesocorticolimbic pathway: Dopamine—DAT

Positive

<0.001

405

PCC (BA31)

4.58

−51

Precuneus (BA7)

4.51

−11

−63

PCC (BA31)

4.43

−21

−62

Negative

0.001

354

ACC (BA24)

5.77

ACC (BA32)

4.33

−4

ACC (BA32)

4.01

0.012

213

Thalamus

4.77

−18

Thalamus

4.20

−2

−12

Nigrostriatal pathway: Dopamine—D2

Positive

0.028

173

Cuneus (BA23)

5.06

−15

−73

Lingual gyrus (BA18)

4.00

−7

−71

RSC (BA30)

3.75

−69

Acetylcholine—M1

Positive

<0.001

1159

IPL (BA40)

5.93

−44

STG (BA22)

4.77

−43

MTG (BA22)

4.31

−47

0.035

222

IPL (BA40)

4.51

−65

−36

IPL (BA40)

4.16

−53

−46

IPL (BA40)

3.72

−59

−38

Negative

0.026

241

SFG (BA10)

4.16

−21

MFG (BA10)

3.96

−11

SFG (BA10)

3.87

−17

Acetylcholine—VAChT

Positive

0.017

285

Cuneus (BA23)

4.75

−5

−77

Cuneus (BA18)

4.18

−5

−82

Lingual gyrus (BA18)

3.38

−9

−67

0.016

291

Postcentral gyrus (BA43)

4.54

−20

Postcentral gyrus (BA43)

4.32

−6

Postcentral gyrus (BA2)

4.10

−22

Association		Cluster size	Side	Brain region	t value	MNI coordinates
Cog-CS
Acetylcholine—M1
Positive	<0.001	1148	R	STG (BA13)	5.12	55	−44	22
			R	STG (BA41)	4.73	47	−39	11
			R	MTG (BA21)	4.48	53	−35	−5
	0.026	213	R	PCC (BA29)	4.95	7	−45	15
			R	PCC (BA31)	4.07	5	−40	27
			L	PCC (BA23)	4.02	−9	−32	29
	0.001	389	R	Cerebellum—culmen	4.53	21	−50	−20
			R	Cerebellum—culmen	4.41	17	−54	−14
			R	Cerebellum—culmen	4.03	3	−56	−10
Episodic memory
Mesocorticolimbic pathway: Dopamine—D1
Negative	0.015	168	L	MFG (BA9)	4.74	−52	19	36
			L	MFG (BA46)	4.09	−50	28	27
			L	IFG (BA45)	3.55	−58	13	22
Mesocorticolimbic pathway: Dopamine—DAT
Positive	<0.001	405	R	PCC (BA31)	4.58	5	−51	28
			L	Precuneus (BA7)	4.51	−11	−63	35
			L	PCC (BA31)	4.43	−21	−62	21
Negative	0.001	354	R	ACC (BA24)	5.77	2	19	29
			L	ACC (BA32)	4.33	−4	36	23
			R	ACC (BA32)	4.01	14	18	39
	0.012	213	R	Thalamus	4.77	4	−18	18
			L	Thalamus	4.20	−2	−12	19
Nigrostriatal pathway: Dopamine—D2
Positive	0.028	173	L	Cuneus (BA23)	5.06	−15	−73	6
			L	Lingual gyrus (BA18)	4.00	−7	−71	4
			L	RSC (BA30)	3.75	1	−69	4
Acetylcholine—M1
Positive	<0.001	1159	R	IPL (BA40)	5.93	57	−44	22
			R	STG (BA22)	4.77	61	−43	10
			R	MTG (BA22)	4.31	59	−47	2
	0.035	222	L	IPL (BA40)	4.51	−65	−36	29
			L	IPL (BA40)	4.16	−53	−46	31
			L	IPL (BA40)	3.72	−59	−38	39
Negative	0.026	241	L	SFG (BA10)	4.16	−21	50	24
			L	MFG (BA10)	3.96	−11	59	13
			L	SFG (BA10)	3.87	−17	58	21
Acetylcholine—VAChT
Positive	0.017	285	L	Cuneus (BA23)	4.75	−5	−77	11
			L	Cuneus (BA18)	4.18	−5	−82	19
			L	Lingual gyrus (BA18)	3.38	−9	−67	2
	0.016	291	R	Postcentral gyrus (BA43)	4.54	53	−20	21
			R	Postcentral gyrus (BA43)	4.32	57	−6	16
			R	Postcentral gyrus (BA2)	4.10	57	−22	33

Table 4

Open in new tab

Associations between neurotransmitter-enriched FC and both global cognitive and episodic memory performance

Association		Cluster size	Side	Brain region	t value	MNI coordinates
Association	P-value	Cluster size	Side	Brain region	t value	x	y	z
Cog-CS
Acetylcholine—M1
Positive	<0.001	1148	R	STG (BA13)	5.12	55	−44	22
			R	STG (BA41)	4.73	47	−39	11
			R	MTG (BA21)	4.48	53	−35	−5
	0.026	213	R	PCC (BA29)	4.95	7	−45	15
			R	PCC (BA31)	4.07	5	−40	27
			L	PCC (BA23)	4.02	−9	−32	29
	0.001	389	R	Cerebellum—culmen	4.53	21	−50	−20
			R	Cerebellum—culmen	4.41	17	−54	−14
			R	Cerebellum—culmen	4.03	3	−56	−10
Episodic memory
Mesocorticolimbic pathway: Dopamine—D1
Negative	0.015	168	L	MFG (BA9)	4.74	−52	19	36
			L	MFG (BA46)	4.09	−50	28	27
			L	IFG (BA45)	3.55	−58	13	22
Mesocorticolimbic pathway: Dopamine—DAT
Positive	<0.001	405	R	PCC (BA31)	4.58	5	−51	28
			L	Precuneus (BA7)	4.51	−11	−63	35
			L	PCC (BA31)	4.43	−21	−62	21
Negative	0.001	354	R	ACC (BA24)	5.77	2	19	29
			L	ACC (BA32)	4.33	−4	36	23
			R	ACC (BA32)	4.01	14	18	39
	0.012	213	R	Thalamus	4.77	4	−18	18
			L	Thalamus	4.20	−2	−12	19
Nigrostriatal pathway: Dopamine—D2
Positive	0.028	173	L	Cuneus (BA23)	5.06	−15	−73	6
			L	Lingual gyrus (BA18)	4.00	−7	−71	4
			L	RSC (BA30)	3.75	1	−69	4
Acetylcholine—M1
Positive	<0.001	1159	R	IPL (BA40)	5.93	57	−44	22
			R	STG (BA22)	4.77	61	−43	10
			R	MTG (BA22)	4.31	59	−47	2
	0.035	222	L	IPL (BA40)	4.51	−65	−36	29
			L	IPL (BA40)	4.16	−53	−46	31
			L	IPL (BA40)	3.72	−59	−38	39
Negative	0.026	241	L	SFG (BA10)	4.16	−21	50	24
			L	MFG (BA10)	3.96	−11	59	13
			L	SFG (BA10)	3.87	−17	58	21
Acetylcholine—VAChT
Positive	0.017	285	L	Cuneus (BA23)	4.75	−5	−77	11
			L	Cuneus (BA18)	4.18	−5	−82	19
			L	Lingual gyrus (BA18)	3.38	−9	−67	2
	0.016	291	R	Postcentral gyrus (BA43)	4.54	53	−20	21
			R	Postcentral gyrus (BA43)	4.32	57	−6	16
			R	Postcentral gyrus (BA2)	4.10	57	−22	33

Association		Cluster size	Side	Brain region	t value	MNI coordinates
Association	P-value	Cluster size	Side	Brain region	t value	x	y	z
Cog-CS
Acetylcholine—M1
Positive	<0.001	1148	R	STG (BA13)	5.12	55	−44	22
			R	STG (BA41)	4.73	47	−39	11
			R	MTG (BA21)	4.48	53	−35	−5
	0.026	213	R	PCC (BA29)	4.95	7	−45	15
			R	PCC (BA31)	4.07	5	−40	27
			L	PCC (BA23)	4.02	−9	−32	29
	0.001	389	R	Cerebellum—culmen	4.53	21	−50	−20
			R	Cerebellum—culmen	4.41	17	−54	−14
			R	Cerebellum—culmen	4.03	3	−56	−10
Episodic memory
Mesocorticolimbic pathway: Dopamine—D1
Negative	0.015	168	L	MFG (BA9)	4.74	−52	19	36
			L	MFG (BA46)	4.09	−50	28	27
			L	IFG (BA45)	3.55	−58	13	22
Mesocorticolimbic pathway: Dopamine—DAT
Positive	<0.001	405	R	PCC (BA31)	4.58	5	−51	28
			L	Precuneus (BA7)	4.51	−11	−63	35
			L	PCC (BA31)	4.43	−21	−62	21
Negative	0.001	354	R	ACC (BA24)	5.77	2	19	29
			L	ACC (BA32)	4.33	−4	36	23
			R	ACC (BA32)	4.01	14	18	39
	0.012	213	R	Thalamus	4.77	4	−18	18
			L	Thalamus	4.20	−2	−12	19
Nigrostriatal pathway: Dopamine—D2
Positive	0.028	173	L	Cuneus (BA23)	5.06	−15	−73	6
			L	Lingual gyrus (BA18)	4.00	−7	−71	4
			L	RSC (BA30)	3.75	1	−69	4
Acetylcholine—M1
Positive	<0.001	1159	R	IPL (BA40)	5.93	57	−44	22
			R	STG (BA22)	4.77	61	−43	10
			R	MTG (BA22)	4.31	59	−47	2
	0.035	222	L	IPL (BA40)	4.51	−65	−36	29
			L	IPL (BA40)	4.16	−53	−46	31
			L	IPL (BA40)	3.72	−59	−38	39
Negative	0.026	241	L	SFG (BA10)	4.16	−21	50	24
			L	MFG (BA10)	3.96	−11	59	13
			L	SFG (BA10)	3.87	−17	58	21
Acetylcholine—VAChT
Positive	0.017	285	L	Cuneus (BA23)	4.75	−5	−77	11
			L	Cuneus (BA18)	4.18	−5	−82	19
			L	Lingual gyrus (BA18)	3.38	−9	−67	2
	0.016	291	R	Postcentral gyrus (BA43)	4.54	53	−20	21
			R	Postcentral gyrus (BA43)	4.32	57	−6	16
			R	Postcentral gyrus (BA2)	4.10	57	−22	33

ACC, anterior cingulate cortex; BA, Brodmann area; D1, D1 dopamine receptor; D2, D2 dopamine receptor; DAT, dopamine transporter; IFG, inferior frontal gyrus; IPL, inferior parietal lobule; L, left; M1, M1 muscarinic acetylcholine receptor; MFG, middle frontal gyrus; MTG, middle temporal gyrus; PCC, posterior cingulate cortex; R, right; RSC, retrosplenial cortex; SFG, superior frontal gyrus; STG, superior temporal gyrus; VAChT, vesicular acetylcholine transporter.

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