Multivariable logistic regression analysis: patient demographics and treatment factors for diabetes mellitus in childhood cancer survivors
| . | Model 1 . | Model 2 . | Model 3 . | Model 4 . | Model 5 . |
|---|---|---|---|---|---|
| Demographic factors | OR (95% CI) | OR (95% CI) | OR (95% CI) | OR (95% CI) | OR (95% CI) |
| Sex (female) | 1.04 (0.67-1.61) | 2.32 (0.95-5.67) | 0.96 (0.62-1.49) | 1.05 (0.67-1.66) | 2.57 (1.03-6.44) |
| Age at diagnosis (per y) | 1.01 (0.96-1.06) | 1.01 (0.96-1.06) | 1.03 (0.98-1.08) | 1.02 (0.97-1.07) | 1.02 (0.97-1.07) |
| Age at clinic visit, y (35+ vs 18-35) | 2.51 (1.52-4.16) | 4.72 (2.05-10.87) | 2.14 (1.29-3.57) | 2.15 (1.28-3.61) | 4.32 (1.84-10.15) |
| Body mass index (per point) | 1.08 (1.04-1.12) | 1.08 (1.04-1.12) | 1.09 (1.05-1.13) | 1.12 (1.08-1.16) | 1.12 (1.08-1.16) |
| Occurrence DM in family (yes vs no) | 2.19 (1.41-3.39) | 2.16 (1.39-3.35) | 2.21 (1.42-3.43) | 2.41 (1.53-3.80) | 2.38 (1.51-3.76) |
| Treatment factors | |||||
| Abdominal/Pelvic RT (yes vs no)a | — | — | 3.19 (1.81-5.63) | 4.12 (2.28-7.42) | 4.19 (2.32-7.55) |
| Total body irradiation (yes vs no) | — | — | — | 13.67 (6.72-27.82) | 14.31 (6.98-29.34) |
| Interaction | |||||
| Sex: age, y (female: 35+) | — | 0.33 (0.12-0.94) | — | — | 0.29 (0.10-0.84) |
| ANOVA (LRT) | — | P = .034 (vs model 1) | P < .001 (vs model 1) | P < .001 (vs model 3) | P = .019 (vs model 4) |
| . | Model 1 . | Model 2 . | Model 3 . | Model 4 . | Model 5 . |
|---|---|---|---|---|---|
| Demographic factors | OR (95% CI) | OR (95% CI) | OR (95% CI) | OR (95% CI) | OR (95% CI) |
| Sex (female) | 1.04 (0.67-1.61) | 2.32 (0.95-5.67) | 0.96 (0.62-1.49) | 1.05 (0.67-1.66) | 2.57 (1.03-6.44) |
| Age at diagnosis (per y) | 1.01 (0.96-1.06) | 1.01 (0.96-1.06) | 1.03 (0.98-1.08) | 1.02 (0.97-1.07) | 1.02 (0.97-1.07) |
| Age at clinic visit, y (35+ vs 18-35) | 2.51 (1.52-4.16) | 4.72 (2.05-10.87) | 2.14 (1.29-3.57) | 2.15 (1.28-3.61) | 4.32 (1.84-10.15) |
| Body mass index (per point) | 1.08 (1.04-1.12) | 1.08 (1.04-1.12) | 1.09 (1.05-1.13) | 1.12 (1.08-1.16) | 1.12 (1.08-1.16) |
| Occurrence DM in family (yes vs no) | 2.19 (1.41-3.39) | 2.16 (1.39-3.35) | 2.21 (1.42-3.43) | 2.41 (1.53-3.80) | 2.38 (1.51-3.76) |
| Treatment factors | |||||
| Abdominal/Pelvic RT (yes vs no)a | — | — | 3.19 (1.81-5.63) | 4.12 (2.28-7.42) | 4.19 (2.32-7.55) |
| Total body irradiation (yes vs no) | — | — | — | 13.67 (6.72-27.82) | 14.31 (6.98-29.34) |
| Interaction | |||||
| Sex: age, y (female: 35+) | — | 0.33 (0.12-0.94) | — | — | 0.29 (0.10-0.84) |
| ANOVA (LRT) | — | P = .034 (vs model 1) | P < .001 (vs model 1) | P < .001 (vs model 3) | P = .019 (vs model 4) |
Significant values (P < .05) are displayed in bold.
Model 1: demographic factors.
Model 2: demographic factors + interaction term between sex and age.
Model 3: demographic factors + treatment-related factors (− total body irradiation).
Model 4: demographic factors + treatment-related factors (+ total body irradiation).
Model 5: demographic factors + treatment-related factors (+ total body irradiation) + interaction term between sex and age.
Abbreviations: ANOVA, analysis of variance; DM, diabetes mellitus; LRT, likelihood ratio test; OR, odds ratio; RT, radiotherapy.
aNot including abdominal/pelvic irradiation resulting from total body irradiation.
Multivariable logistic regression analysis: patient demographics and treatment factors for diabetes mellitus in childhood cancer survivors
| . | Model 1 . | Model 2 . | Model 3 . | Model 4 . | Model 5 . |
|---|---|---|---|---|---|
| Demographic factors | OR (95% CI) | OR (95% CI) | OR (95% CI) | OR (95% CI) | OR (95% CI) |
| Sex (female) | 1.04 (0.67-1.61) | 2.32 (0.95-5.67) | 0.96 (0.62-1.49) | 1.05 (0.67-1.66) | 2.57 (1.03-6.44) |
| Age at diagnosis (per y) | 1.01 (0.96-1.06) | 1.01 (0.96-1.06) | 1.03 (0.98-1.08) | 1.02 (0.97-1.07) | 1.02 (0.97-1.07) |
| Age at clinic visit, y (35+ vs 18-35) | 2.51 (1.52-4.16) | 4.72 (2.05-10.87) | 2.14 (1.29-3.57) | 2.15 (1.28-3.61) | 4.32 (1.84-10.15) |
| Body mass index (per point) | 1.08 (1.04-1.12) | 1.08 (1.04-1.12) | 1.09 (1.05-1.13) | 1.12 (1.08-1.16) | 1.12 (1.08-1.16) |
| Occurrence DM in family (yes vs no) | 2.19 (1.41-3.39) | 2.16 (1.39-3.35) | 2.21 (1.42-3.43) | 2.41 (1.53-3.80) | 2.38 (1.51-3.76) |
| Treatment factors | |||||
| Abdominal/Pelvic RT (yes vs no)a | — | — | 3.19 (1.81-5.63) | 4.12 (2.28-7.42) | 4.19 (2.32-7.55) |
| Total body irradiation (yes vs no) | — | — | — | 13.67 (6.72-27.82) | 14.31 (6.98-29.34) |
| Interaction | |||||
| Sex: age, y (female: 35+) | — | 0.33 (0.12-0.94) | — | — | 0.29 (0.10-0.84) |
| ANOVA (LRT) | — | P = .034 (vs model 1) | P < .001 (vs model 1) | P < .001 (vs model 3) | P = .019 (vs model 4) |
| . | Model 1 . | Model 2 . | Model 3 . | Model 4 . | Model 5 . |
|---|---|---|---|---|---|
| Demographic factors | OR (95% CI) | OR (95% CI) | OR (95% CI) | OR (95% CI) | OR (95% CI) |
| Sex (female) | 1.04 (0.67-1.61) | 2.32 (0.95-5.67) | 0.96 (0.62-1.49) | 1.05 (0.67-1.66) | 2.57 (1.03-6.44) |
| Age at diagnosis (per y) | 1.01 (0.96-1.06) | 1.01 (0.96-1.06) | 1.03 (0.98-1.08) | 1.02 (0.97-1.07) | 1.02 (0.97-1.07) |
| Age at clinic visit, y (35+ vs 18-35) | 2.51 (1.52-4.16) | 4.72 (2.05-10.87) | 2.14 (1.29-3.57) | 2.15 (1.28-3.61) | 4.32 (1.84-10.15) |
| Body mass index (per point) | 1.08 (1.04-1.12) | 1.08 (1.04-1.12) | 1.09 (1.05-1.13) | 1.12 (1.08-1.16) | 1.12 (1.08-1.16) |
| Occurrence DM in family (yes vs no) | 2.19 (1.41-3.39) | 2.16 (1.39-3.35) | 2.21 (1.42-3.43) | 2.41 (1.53-3.80) | 2.38 (1.51-3.76) |
| Treatment factors | |||||
| Abdominal/Pelvic RT (yes vs no)a | — | — | 3.19 (1.81-5.63) | 4.12 (2.28-7.42) | 4.19 (2.32-7.55) |
| Total body irradiation (yes vs no) | — | — | — | 13.67 (6.72-27.82) | 14.31 (6.98-29.34) |
| Interaction | |||||
| Sex: age, y (female: 35+) | — | 0.33 (0.12-0.94) | — | — | 0.29 (0.10-0.84) |
| ANOVA (LRT) | — | P = .034 (vs model 1) | P < .001 (vs model 1) | P < .001 (vs model 3) | P = .019 (vs model 4) |
Significant values (P < .05) are displayed in bold.
Model 1: demographic factors.
Model 2: demographic factors + interaction term between sex and age.
Model 3: demographic factors + treatment-related factors (− total body irradiation).
Model 4: demographic factors + treatment-related factors (+ total body irradiation).
Model 5: demographic factors + treatment-related factors (+ total body irradiation) + interaction term between sex and age.
Abbreviations: ANOVA, analysis of variance; DM, diabetes mellitus; LRT, likelihood ratio test; OR, odds ratio; RT, radiotherapy.
aNot including abdominal/pelvic irradiation resulting from total body irradiation.
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