Table 2 Open in new tab Incidence event...

	Accelerometer-derived MVPA cohort
AS	Event, n	555	247	140	89	79
Incidence event rate^a	7.95 (7.31,8.64)	14.39 (12.65, 16.29)	7.97 (6.70, 9.40)	5.10 (4.10, 6.28)	4.49 (3.56, 5.60)
Adjusted incidence event rate^a,b		11.60 (10.20, 13.20)	7.82 (6.63, 9.23)	5.74 (4.67, 7.08)	5.91 (4.73, 7.39)
Adjusted incidence rate difference^a,b		Ref.	−3.78 (−1.71, −5.86)	−5.85 (−3.84, −7.82)	−5.69 (−3.59, −7.55)
Adjusted incidence rate ratio^b		Ref.	.67 (.54, .84)	.50 (.39, .63)	.51 (.40, .67)
AS-related intervention or mortality	Event, n	200	88	50	31	31
Incidence event rate^a	2.86 (2.48, 3.29)	5.11 (4.10, 6.29)	2.84 (2.11, 3.75)	1.77 (1.21, 2.52)	1.76 (1.20, 2.50)
Adjusted incidence event rate^a,b		4.37 (3.52, 5.43)	2.81 (2.13, 3.71)	1.93 (1.36, 2.75)	2.14 (1.50, 3.06)
Adjusted incidence rate difference^a,b		Ref.	−1.56 (−.25, −2.80)	−2.44 (−1.28, −3.65)	−2.23 (−.97, −3.56)
Adjusted incidence rate ratio^b		Ref.	.64 (.47, .93)	.44 (.29, .67)	.49 (.32, .73)

Accelerometer-derived MVPA cohort

Total

Q1 (0–74 min/week)

Q2 (75–167 min/week)

Q3 (168–301 min/week)

Q4 (302–2903 min/week)

Event, n

555

247

140

Incidence event rate^a

7.95 (7.31,8.64)

14.39 (12.65, 16.29)

7.97 (6.70, 9.40)

5.10 (4.10, 6.28)

4.49 (3.56, 5.60)

Adjusted incidence event rate^a,b

11.60 (10.20, 13.20)

7.82 (6.63, 9.23)

5.74 (4.67, 7.08)

5.91 (4.73, 7.39)

Adjusted incidence rate difference^a,b

Ref.

−3.78 (−1.71, −5.86)

−5.85 (−3.84, −7.82)

−5.69 (−3.59, −7.55)

Adjusted incidence rate ratio^b

Ref.

.67 (.54, .84)

.50 (.39, .63)

.51 (.40, .67)

AS-related intervention or mortality

Event, n

200

Incidence event rate^a

2.86 (2.48, 3.29)

5.11 (4.10, 6.29)

2.84 (2.11, 3.75)

1.77 (1.21, 2.52)

1.76 (1.20, 2.50)

Adjusted incidence event rate^a,b

4.37 (3.52, 5.43)

2.81 (2.13, 3.71)

1.93 (1.36, 2.75)

2.14 (1.50, 3.06)

Adjusted incidence rate difference^a,b

Ref.

−1.56 (−.25, −2.80)

−2.44 (−1.28, −3.65)

−2.23 (−.97, −3.56)

Adjusted incidence rate ratio^b

Ref.

.64 (.47, .93)

.44 (.29, .67)

.49 (.32, .73)

	Accelerometer-derived MVPA cohort
AS	Event, n	555	247	140	89	79
Incidence event rate^a	7.95 (7.31,8.64)	14.39 (12.65, 16.29)	7.97 (6.70, 9.40)	5.10 (4.10, 6.28)	4.49 (3.56, 5.60)
Adjusted incidence event rate^a,b		11.60 (10.20, 13.20)	7.82 (6.63, 9.23)	5.74 (4.67, 7.08)	5.91 (4.73, 7.39)
Adjusted incidence rate difference^a,b		Ref.	−3.78 (−1.71, −5.86)	−5.85 (−3.84, −7.82)	−5.69 (−3.59, −7.55)
Adjusted incidence rate ratio^b		Ref.	.67 (.54, .84)	.50 (.39, .63)	.51 (.40, .67)
AS-related intervention or mortality	Event, n	200	88	50	31	31
Incidence event rate^a	2.86 (2.48, 3.29)	5.11 (4.10, 6.29)	2.84 (2.11, 3.75)	1.77 (1.21, 2.52)	1.76 (1.20, 2.50)
Adjusted incidence event rate^a,b		4.37 (3.52, 5.43)	2.81 (2.13, 3.71)	1.93 (1.36, 2.75)	2.14 (1.50, 3.06)
Adjusted incidence rate difference^a,b		Ref.	−1.56 (−.25, −2.80)	−2.44 (−1.28, −3.65)	−2.23 (−.97, −3.56)
Adjusted incidence rate ratio^b		Ref.	.64 (.47, .93)	.44 (.29, .67)	.49 (.32, .73)

Table 2

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Incidence event rate, incidence rate difference, and incidence rate ratio of aortic valve stenosis by quartiles of accelerometer-derived moderate to vigorous physical activity volume groups

		Accelerometer-derived MVPA cohort
		Total	Q1 (0–74 min/week)	Q2 (75–167 min/week)	Q3 (168–301 min/week)	Q4 (302–2903 min/week)
AS	Event, n	555	247	140	89	79
	Incidence event rate^a	7.95 (7.31,8.64)	14.39 (12.65, 16.29)	7.97 (6.70, 9.40)	5.10 (4.10, 6.28)	4.49 (3.56, 5.60)
	Adjusted incidence event rate^a,b		11.60 (10.20, 13.20)	7.82 (6.63, 9.23)	5.74 (4.67, 7.08)	5.91 (4.73, 7.39)
	Adjusted incidence rate difference^a,b		Ref.	−3.78 (−1.71, −5.86)	−5.85 (−3.84, −7.82)	−5.69 (−3.59, −7.55)
	Adjusted incidence rate ratio^b		Ref.	.67 (.54, .84)	.50 (.39, .63)	.51 (.40, .67)
AS-related intervention or mortality	Event, n	200	88	50	31	31
	Incidence event rate^a	2.86 (2.48, 3.29)	5.11 (4.10, 6.29)	2.84 (2.11, 3.75)	1.77 (1.21, 2.52)	1.76 (1.20, 2.50)
	Adjusted incidence event rate^a,b		4.37 (3.52, 5.43)	2.81 (2.13, 3.71)	1.93 (1.36, 2.75)	2.14 (1.50, 3.06)
	Adjusted incidence rate difference^a,b		Ref.	−1.56 (−.25, −2.80)	−2.44 (−1.28, −3.65)	−2.23 (−.97, −3.56)
	Adjusted incidence rate ratio^b		Ref.	.64 (.47, .93)	.44 (.29, .67)	.49 (.32, .73)

		Accelerometer-derived MVPA cohort
		Total	Q1 (0–74 min/week)	Q2 (75–167 min/week)	Q3 (168–301 min/week)	Q4 (302–2903 min/week)
AS	Event, n	555	247	140	89	79
	Incidence event rate^a	7.95 (7.31,8.64)	14.39 (12.65, 16.29)	7.97 (6.70, 9.40)	5.10 (4.10, 6.28)	4.49 (3.56, 5.60)
	Adjusted incidence event rate^a,b		11.60 (10.20, 13.20)	7.82 (6.63, 9.23)	5.74 (4.67, 7.08)	5.91 (4.73, 7.39)
	Adjusted incidence rate difference^a,b		Ref.	−3.78 (−1.71, −5.86)	−5.85 (−3.84, −7.82)	−5.69 (−3.59, −7.55)
	Adjusted incidence rate ratio^b		Ref.	.67 (.54, .84)	.50 (.39, .63)	.51 (.40, .67)
AS-related intervention or mortality	Event, n	200	88	50	31	31
	Incidence event rate^a	2.86 (2.48, 3.29)	5.11 (4.10, 6.29)	2.84 (2.11, 3.75)	1.77 (1.21, 2.52)	1.76 (1.20, 2.50)
	Adjusted incidence event rate^a,b		4.37 (3.52, 5.43)	2.81 (2.13, 3.71)	1.93 (1.36, 2.75)	2.14 (1.50, 3.06)
	Adjusted incidence rate difference^a,b		Ref.	−1.56 (−.25, −2.80)	−2.44 (−1.28, −3.65)	−2.23 (−.97, −3.56)
	Adjusted incidence rate ratio^b		Ref.	.64 (.47, .93)	.44 (.29, .67)	.49 (.32, .73)

Adjusted incidence rate difference and adjusted incidence rate ratio in bold represent statistical significance. AS, aortic valve stenosis; MVPA, moderate to vigorous physical activity.

^aPer 10 000 person-years (95% confidence interval).

^bAdjusted for age, sex, ethnicity, Townsend deprivation index, education, smoking status, alcohol intake, diet score, sleep duration, and discretionary screen time.

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