Table 2. Open in new tab Summary table...

Summary of results
Fasting	BMI	Absolute	+	+	o	n/a
% Weight	Delta (Δ)	+^a	+^b	o	o^c
Plasma glucose	Absolute	+	o	o	n/a
Delta (Δ)	+^a	o^b	o^b	o^c
Serum insulin	Absolute	+	o	o	n/a
Delta (Δ)	o^a	o^b	o^b	o^c
Serum triglycerides	Absolute	+	o	↑	n/a
Delta (Δ)	o^a	o^b	o^b	o^c
HbA_1c	Absolute	+	+	o	n/a
Delta (Δ)	+^a	+^b	o^b	o^c
HOMA-IR	Absolute	+	+	↑	n/a
Delta (Δ)	+^a	o^b	o^b	o^c
Appetite VAS ratings	Absolute	o	o	o	n/a
Delta (Δ)	o^a	o^b	o^b	o^c
Hunger VAS ratings	Absolute	o	o	o	n/a
Delta (Δ)	o^a	o^b	o^b	o^c
Postprandial	Appetite VAS ratings	Absolute^d	o	o	o	n/a
Delta (Δ)^d	o^b	o^b	o^b	n/a
Fullness VAS ratings	Absolute^d	o	o	o	n/a
Delta (Δ)^d	o^b	o^b	o^b	n/a

Summary of results
Fasting	BMI	Absolute	+	+	o	n/a
% Weight	Delta (Δ)	+^a	+^b	o	o^c
Plasma glucose	Absolute	+	o	o	n/a
Delta (Δ)	+^a	o^b	o^b	o^c
Serum insulin	Absolute	+	o	o	n/a
Delta (Δ)	o^a	o^b	o^b	o^c
Serum triglycerides	Absolute	+	o	↑	n/a
Delta (Δ)	o^a	o^b	o^b	o^c
HbA_1c	Absolute	+	+	o	n/a
Delta (Δ)	+^a	+^b	o^b	o^c
HOMA-IR	Absolute	+	+	↑	n/a
Delta (Δ)	+^a	o^b	o^b	o^c
Appetite VAS ratings	Absolute	o	o	o	n/a
Delta (Δ)	o^a	o^b	o^b	o^c
Hunger VAS ratings	Absolute	o	o	o	n/a
Delta (Δ)	o^a	o^b	o^b	o^c
Postprandial	Appetite VAS ratings	Absolute^d	o	o	o	n/a
Delta (Δ)^d	o^b	o^b	o^b	n/a
Fullness VAS ratings	Absolute^d	o	o	o	n/a
Delta (Δ)^d	o^b	o^b	o^b	n/a

Table 2.

Summary table of correlational results

Summary of results
Outcome variable		LEAP2	SMM	DJBL	DJBL vs SMM	Post-DJBL explant
Fasting	BMI	Absolute	+	+	o	n/a
	% Weight	Delta (Δ)	+^a	+^b	o	o^c
	Plasma glucose	Absolute	+	o	o	n/a
	Plasma glucose	Delta (Δ)	+^a	o^b	o^b	o^c
	Serum insulin	Absolute	+	o	o	n/a
	Serum insulin	Delta (Δ)	o^a	o^b	o^b	o^c
	Serum triglycerides	Absolute	+	o	↑	n/a
	Serum triglycerides	Delta (Δ)	o^a	o^b	o^b	o^c
	HbA_1c	Absolute	+	+	o	n/a
	HbA_1c	Delta (Δ)	+^a	+^b	o^b	o^c
	HOMA-IR	Absolute	+	+	↑	n/a
	HOMA-IR	Delta (Δ)	+^a	o^b	o^b	o^c
	Appetite VAS ratings	Absolute	o	o	o	n/a
	Appetite VAS ratings	Delta (Δ)	o^a	o^b	o^b	o^c
	Hunger VAS ratings	Absolute	o	o	o	n/a
	Hunger VAS ratings	Delta (Δ)	o^a	o^b	o^b	o^c
Postprandial	Appetite VAS ratings	Absolute^d	o	o	o	n/a
	Appetite VAS ratings	Delta (Δ)^d	o^b	o^b	o^b	n/a
	Fullness VAS ratings	Absolute^d	o	o	o	n/a
	Fullness VAS ratings	Delta (Δ)^d	o^b	o^b	o^b	n/a

Summary of results
Outcome variable		LEAP2	SMM	DJBL	DJBL vs SMM	Post-DJBL explant
Fasting	BMI	Absolute	+	+	o	n/a
	% Weight	Delta (Δ)	+^a	+^b	o	o^c
	Plasma glucose	Absolute	+	o	o	n/a
	Plasma glucose	Delta (Δ)	+^a	o^b	o^b	o^c
	Serum insulin	Absolute	+	o	o	n/a
	Serum insulin	Delta (Δ)	o^a	o^b	o^b	o^c
	Serum triglycerides	Absolute	+	o	↑	n/a
	Serum triglycerides	Delta (Δ)	o^a	o^b	o^b	o^c
	HbA_1c	Absolute	+	+	o	n/a
	HbA_1c	Delta (Δ)	+^a	+^b	o^b	o^c
	HOMA-IR	Absolute	+	+	↑	n/a
	HOMA-IR	Delta (Δ)	+^a	o^b	o^b	o^c
	Appetite VAS ratings	Absolute	o	o	o	n/a
	Appetite VAS ratings	Delta (Δ)	o^a	o^b	o^b	o^c
	Hunger VAS ratings	Absolute	o	o	o	n/a
	Hunger VAS ratings	Delta (Δ)	o^a	o^b	o^b	o^c
Postprandial	Appetite VAS ratings	Absolute^d	o	o	o	n/a
	Appetite VAS ratings	Delta (Δ)^d	o^b	o^b	o^b	n/a
	Fullness VAS ratings	Absolute^d	o	o	o	n/a
	Fullness VAS ratings	Delta (Δ)^d	o^b	o^b	o^b	n/a

This table shows the correlation of absolute and changes in fasting or postprandial plasma LEAP2 with absolute and changes in BMI, plasma glucose, serum insulin, triglycerides, HbA_1c, HOMA-IR, appetite, hunger, and fullness VAS ratings for SMM and DJBL groups and the differences between groups (DJBL vs SMM) across visits. All changes expressed as delta (Δ). + indicates significant positive correlation, o indicates no correlation, ↑ indicates significantly greater correlation in DJBL vs SMM groups.

Abbreviations: BMI, body mass index; DJBL, duodenal-jejunal bypass liner; HbA_1c, glycated hemoglobin A_1c; HOMA-IR, Homeostatic Model Assessment for Insulin Resistance; iAUC, incremental area under the curve; n/a, not applicable; SMM, standard medical management; VAS, visual analogue scale.

^aΔ 104 vs −2 weeks.

^bΔ 50 vs −2 weeks.

^cΔ 104 vs 50 weeks.

^dPostprandial variables expressed as iAUC from t = 0 minutes to t = 120 minutes.

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