The ROC analysis of HbA1c and FPG values at years −1 and −2 and the difference between each measure at years −1 and −2 for detecting the first clinic visit in the diabetes group.
| . | Events / n† . | The time point in the trajectory ‡ . | AUC (95% CI) . | P-value . | P-value . | Cutoff point § . | Sensitivity (%) . | Specificity (%) . |
|---|---|---|---|---|---|---|---|---|
| HbA1c (%) (mmol/mol) | 451 / 1,537 | Year −1 | 0.813 (0.790–0.836) | Reference | 6.501 (47.53) | 69.2 | 80.8 | |
| Year −2 | 0.728 (0.701–0.755) | <0.0001 | Reference | 6.201 (44.27) | 71.2 | 63.2 | ||
| (year −1)–(year −2) | 0.686 (0.654–0.719) | <0.0001 | 0.0824 | 0.201 (2.19) | 58.3 | 75.0 | ||
| FPG (mmol/L) | 279 / 1,035 | year − 1 | 0.680 (0.643–0.718) | Reference | 7.161 | 49.8 | 77.3 | |
| Year −2 | 0.595 (0.557–0.634) | <0.0001 | Reference | 6.717 | 49.1 | 65.2 | ||
| (year −1)–(year −2) | 0.631 (0.592–0.671) | 0.0043 | 0.2578 | 0.334 | 56.3 | 66.4 |
| . | Events / n† . | The time point in the trajectory ‡ . | AUC (95% CI) . | P-value . | P-value . | Cutoff point § . | Sensitivity (%) . | Specificity (%) . |
|---|---|---|---|---|---|---|---|---|
| HbA1c (%) (mmol/mol) | 451 / 1,537 | Year −1 | 0.813 (0.790–0.836) | Reference | 6.501 (47.53) | 69.2 | 80.8 | |
| Year −2 | 0.728 (0.701–0.755) | <0.0001 | Reference | 6.201 (44.27) | 71.2 | 63.2 | ||
| (year −1)–(year −2) | 0.686 (0.654–0.719) | <0.0001 | 0.0824 | 0.201 (2.19) | 58.3 | 75.0 | ||
| FPG (mmol/L) | 279 / 1,035 | year − 1 | 0.680 (0.643–0.718) | Reference | 7.161 | 49.8 | 77.3 | |
| Year −2 | 0.595 (0.557–0.634) | <0.0001 | Reference | 6.717 | 49.1 | 65.2 | ||
| (year −1)–(year −2) | 0.631 (0.592–0.671) | 0.0043 | 0.2578 | 0.334 | 56.3 | 66.4 |
†Individuals with missing measurements at years −1 and −2 were excluded from the analysis.
‡Year 0 was defined as the year of the first clinic visit or end of follow-up, year −1 was defined as the time point 1 year back from year 0, and year −2 was defined as the time point 2 years back from year 0.
§Cutoff points were determined by maximizing sensitivity plus specificity.
AUC, area under the ROC curve; CI, confidence interval; FPG, fasting plasma glucose; HbA1c, glycated hemoglobin.
The ROC analysis of HbA1c and FPG values at years −1 and −2 and the difference between each measure at years −1 and −2 for detecting the first clinic visit in the diabetes group.
| . | Events / n† . | The time point in the trajectory ‡ . | AUC (95% CI) . | P-value . | P-value . | Cutoff point § . | Sensitivity (%) . | Specificity (%) . |
|---|---|---|---|---|---|---|---|---|
| HbA1c (%) (mmol/mol) | 451 / 1,537 | Year −1 | 0.813 (0.790–0.836) | Reference | 6.501 (47.53) | 69.2 | 80.8 | |
| Year −2 | 0.728 (0.701–0.755) | <0.0001 | Reference | 6.201 (44.27) | 71.2 | 63.2 | ||
| (year −1)–(year −2) | 0.686 (0.654–0.719) | <0.0001 | 0.0824 | 0.201 (2.19) | 58.3 | 75.0 | ||
| FPG (mmol/L) | 279 / 1,035 | year − 1 | 0.680 (0.643–0.718) | Reference | 7.161 | 49.8 | 77.3 | |
| Year −2 | 0.595 (0.557–0.634) | <0.0001 | Reference | 6.717 | 49.1 | 65.2 | ||
| (year −1)–(year −2) | 0.631 (0.592–0.671) | 0.0043 | 0.2578 | 0.334 | 56.3 | 66.4 |
| . | Events / n† . | The time point in the trajectory ‡ . | AUC (95% CI) . | P-value . | P-value . | Cutoff point § . | Sensitivity (%) . | Specificity (%) . |
|---|---|---|---|---|---|---|---|---|
| HbA1c (%) (mmol/mol) | 451 / 1,537 | Year −1 | 0.813 (0.790–0.836) | Reference | 6.501 (47.53) | 69.2 | 80.8 | |
| Year −2 | 0.728 (0.701–0.755) | <0.0001 | Reference | 6.201 (44.27) | 71.2 | 63.2 | ||
| (year −1)–(year −2) | 0.686 (0.654–0.719) | <0.0001 | 0.0824 | 0.201 (2.19) | 58.3 | 75.0 | ||
| FPG (mmol/L) | 279 / 1,035 | year − 1 | 0.680 (0.643–0.718) | Reference | 7.161 | 49.8 | 77.3 | |
| Year −2 | 0.595 (0.557–0.634) | <0.0001 | Reference | 6.717 | 49.1 | 65.2 | ||
| (year −1)–(year −2) | 0.631 (0.592–0.671) | 0.0043 | 0.2578 | 0.334 | 56.3 | 66.4 |
†Individuals with missing measurements at years −1 and −2 were excluded from the analysis.
‡Year 0 was defined as the year of the first clinic visit or end of follow-up, year −1 was defined as the time point 1 year back from year 0, and year −2 was defined as the time point 2 years back from year 0.
§Cutoff points were determined by maximizing sensitivity plus specificity.
AUC, area under the ROC curve; CI, confidence interval; FPG, fasting plasma glucose; HbA1c, glycated hemoglobin.
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