Externally validated risk equations for predicting kidney failure in patients with CKD G3–G5.
| Equation . | Variables . | Population . | Outcome . | Discrimination . | Website . |
|---|---|---|---|---|---|
| KFRE [41] | Age, sex, eGFR, ACR for 4-variable equation + calcium, phosphate, bicarbonate, albumin for 8-variable equation | >1 million patients with >10 000 events from more than 30 countries | Treated kidney failure at 2 and 5 years | 0.88–0.91 | www.kidneyfailurerisk.com; www.ckdpc.org/risk-models.html |
| KPNW [42] | Age, sex, eGFR, albuminuria, systolic BP, antihypertensive use, diabetes, diabetic complications | 39 103 patients with 1097 events from the Kaiser Permanente Health System (USA) | Kidney failure at 5 years | 0.95 | |
| Landray et al. [43] | Sex, SCr, albuminuria, phosphate | 595 patients from the CRIB and East Kent cohorts (UK) | Kidney failure | 0.91 | |
| Z6 score [44] | SCr, albumin, cystatin C, urea, haemoglobin, uACR | 7978 patients with 870 events from the German CKD study and validated in 3 additional European cohorts | Kidney failure at 5 years | 0.89–0.92 | |
| KDpredict [45] | Age, sex, eGFR, uACR/uPCR, for 4-variable equation + diabetes, cardiovascular disease for 6-variable model | 67 492 patients from Alberta Canada and validated in 17 528 patients from Denmark and 7740 patients from Scotland | Kidney failure at 2 and 5 years (and all-cause death) | 0.88–0.94 | http://kdpredict.com |
| Equation . | Variables . | Population . | Outcome . | Discrimination . | Website . |
|---|---|---|---|---|---|
| KFRE [41] | Age, sex, eGFR, ACR for 4-variable equation + calcium, phosphate, bicarbonate, albumin for 8-variable equation | >1 million patients with >10 000 events from more than 30 countries | Treated kidney failure at 2 and 5 years | 0.88–0.91 | www.kidneyfailurerisk.com; www.ckdpc.org/risk-models.html |
| KPNW [42] | Age, sex, eGFR, albuminuria, systolic BP, antihypertensive use, diabetes, diabetic complications | 39 103 patients with 1097 events from the Kaiser Permanente Health System (USA) | Kidney failure at 5 years | 0.95 | |
| Landray et al. [43] | Sex, SCr, albuminuria, phosphate | 595 patients from the CRIB and East Kent cohorts (UK) | Kidney failure | 0.91 | |
| Z6 score [44] | SCr, albumin, cystatin C, urea, haemoglobin, uACR | 7978 patients with 870 events from the German CKD study and validated in 3 additional European cohorts | Kidney failure at 5 years | 0.89–0.92 | |
| KDpredict [45] | Age, sex, eGFR, uACR/uPCR, for 4-variable equation + diabetes, cardiovascular disease for 6-variable model | 67 492 patients from Alberta Canada and validated in 17 528 patients from Denmark and 7740 patients from Scotland | Kidney failure at 2 and 5 years (and all-cause death) | 0.88–0.94 | http://kdpredict.com |
BP, blood pressure; CRIB, Chronic Renal Impairment in Birmingham; KPMW, Kaiser Permanente Northwest; SCr, serum creatinine.
Externally validated risk equations for predicting kidney failure in patients with CKD G3–G5.
| Equation . | Variables . | Population . | Outcome . | Discrimination . | Website . |
|---|---|---|---|---|---|
| KFRE [41] | Age, sex, eGFR, ACR for 4-variable equation + calcium, phosphate, bicarbonate, albumin for 8-variable equation | >1 million patients with >10 000 events from more than 30 countries | Treated kidney failure at 2 and 5 years | 0.88–0.91 | www.kidneyfailurerisk.com; www.ckdpc.org/risk-models.html |
| KPNW [42] | Age, sex, eGFR, albuminuria, systolic BP, antihypertensive use, diabetes, diabetic complications | 39 103 patients with 1097 events from the Kaiser Permanente Health System (USA) | Kidney failure at 5 years | 0.95 | |
| Landray et al. [43] | Sex, SCr, albuminuria, phosphate | 595 patients from the CRIB and East Kent cohorts (UK) | Kidney failure | 0.91 | |
| Z6 score [44] | SCr, albumin, cystatin C, urea, haemoglobin, uACR | 7978 patients with 870 events from the German CKD study and validated in 3 additional European cohorts | Kidney failure at 5 years | 0.89–0.92 | |
| KDpredict [45] | Age, sex, eGFR, uACR/uPCR, for 4-variable equation + diabetes, cardiovascular disease for 6-variable model | 67 492 patients from Alberta Canada and validated in 17 528 patients from Denmark and 7740 patients from Scotland | Kidney failure at 2 and 5 years (and all-cause death) | 0.88–0.94 | http://kdpredict.com |
| Equation . | Variables . | Population . | Outcome . | Discrimination . | Website . |
|---|---|---|---|---|---|
| KFRE [41] | Age, sex, eGFR, ACR for 4-variable equation + calcium, phosphate, bicarbonate, albumin for 8-variable equation | >1 million patients with >10 000 events from more than 30 countries | Treated kidney failure at 2 and 5 years | 0.88–0.91 | www.kidneyfailurerisk.com; www.ckdpc.org/risk-models.html |
| KPNW [42] | Age, sex, eGFR, albuminuria, systolic BP, antihypertensive use, diabetes, diabetic complications | 39 103 patients with 1097 events from the Kaiser Permanente Health System (USA) | Kidney failure at 5 years | 0.95 | |
| Landray et al. [43] | Sex, SCr, albuminuria, phosphate | 595 patients from the CRIB and East Kent cohorts (UK) | Kidney failure | 0.91 | |
| Z6 score [44] | SCr, albumin, cystatin C, urea, haemoglobin, uACR | 7978 patients with 870 events from the German CKD study and validated in 3 additional European cohorts | Kidney failure at 5 years | 0.89–0.92 | |
| KDpredict [45] | Age, sex, eGFR, uACR/uPCR, for 4-variable equation + diabetes, cardiovascular disease for 6-variable model | 67 492 patients from Alberta Canada and validated in 17 528 patients from Denmark and 7740 patients from Scotland | Kidney failure at 2 and 5 years (and all-cause death) | 0.88–0.94 | http://kdpredict.com |
BP, blood pressure; CRIB, Chronic Renal Impairment in Birmingham; KPMW, Kaiser Permanente Northwest; SCr, serum creatinine.
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