Baseline Demographic, Clinical History, Physical Examination, and Laboratory Characteristics for Adolescents and Adults With Sepsis, Northern Tanzania, September 2019–April 2020
| . | Total Cohort (n = 86) . | Sepsis Without Hypotension (n = 82) . | Sepsis With Hypotension (n = 4) . |
|---|---|---|---|
| Demographics | |||
| Age, median (IQR), y | 46.5 (32–60) | 46.5 (32–60) | 49.5 (40.5–69) |
| Female | 27 (31.4) | 25 (30.5) | 2 (50.0) |
| Highest level of education completed | … | … | … |
| None | 26 (30.2) | 25 (30.5) | 1 (25.0) |
| Primary | 43 (50.0) | 41 (50.0) | 2 (50.0) |
| Secondary | 10 (11.6) | 9 (11.0) | 1 (25.0) |
| University | 7 (8.1) | 7 (8.5) | 0 |
| Insured | 27 (31.4) | 26 (31.7) | 1 (25.0) |
| Clinical characteristics | |||
| Duration of illness, median (IQR), d | 5 (3–14) | 5 (3–14) | 2 (1–4.5) |
| Chief complaint by syndromea | … | … | … |
| Neurological | 36 (41.9) | 36 (43.9) | 0 |
| Fever or systemic | 21 (24.4) | 19 (23.2) | 2 (50.0) |
| Gastrointestinal | 7 (8.1) | 6 (7.3) | 1 (25.0) |
| Cardiopulmonary | 7 (8.1) | 7 (8.5) | 0 |
| Other | 15 (17.4) | 14 (17.1) | 1 (25.0) |
| Inability to walk unassisted | 62 (72.1) | 58 (70.7) | 4 (100.0) |
| Inability to drink unassisted | 31 (36.1) | 28 (34.1) | 3 (75.0) |
| Presence of chronic comorbidityb | 48 (56.5) | 45 (54.9) | 3 (75.0) |
| HIV-infected by self-report | 13 (15.3) | 12 (14.6) | 1 (25.0) |
| Health care–associated infectionc | 24 (27.9) | 21 (25.6) | 3 (75.0) |
| MUAC, median (IQR), cm | 26.0 (24.0–29.0) | 26.0 (24.0–29.0) | 26.9 (24.9–27.5) |
| Temperature, median (IQR), °C | 38.8 (38.4–39.4) | 38.9 (38.4–39.4) | 38.3 (37.9–39.2) |
| Heart rate, median (IQR), beats/min | 111 (100–122) | 109 (100–121) | 125 (116–134) |
| Respiratory rate, median (IQR), breaths/min | 26 (23–30) | 26 (23–30) | 24 (22–28) |
| Systolic blood pressure, median (IQR), mmHg | 118.5 (105–145) | 119 (107–145) | 83 (78–86) |
| Diastolic blood pressure, median (IQR), mmHg | 68 (60–82) | 68 (61–84) | 48 (43–50) |
| Hypoxiad | 26 (30.2) | 26 (31.7) | 0 |
| Altered mentatione | 21 (24.4) | 20 (24.4) | 1 (25.0) |
| Lactate, median (IQR), mmol/L | 1.5 (1.2–2.3) | 1.4 (1.1–2.2) | 3.1 (1.5–3.5) |
| . | Total Cohort (n = 86) . | Sepsis Without Hypotension (n = 82) . | Sepsis With Hypotension (n = 4) . |
|---|---|---|---|
| Demographics | |||
| Age, median (IQR), y | 46.5 (32–60) | 46.5 (32–60) | 49.5 (40.5–69) |
| Female | 27 (31.4) | 25 (30.5) | 2 (50.0) |
| Highest level of education completed | … | … | … |
| None | 26 (30.2) | 25 (30.5) | 1 (25.0) |
| Primary | 43 (50.0) | 41 (50.0) | 2 (50.0) |
| Secondary | 10 (11.6) | 9 (11.0) | 1 (25.0) |
| University | 7 (8.1) | 7 (8.5) | 0 |
| Insured | 27 (31.4) | 26 (31.7) | 1 (25.0) |
| Clinical characteristics | |||
| Duration of illness, median (IQR), d | 5 (3–14) | 5 (3–14) | 2 (1–4.5) |
| Chief complaint by syndromea | … | … | … |
| Neurological | 36 (41.9) | 36 (43.9) | 0 |
| Fever or systemic | 21 (24.4) | 19 (23.2) | 2 (50.0) |
| Gastrointestinal | 7 (8.1) | 6 (7.3) | 1 (25.0) |
| Cardiopulmonary | 7 (8.1) | 7 (8.5) | 0 |
| Other | 15 (17.4) | 14 (17.1) | 1 (25.0) |
| Inability to walk unassisted | 62 (72.1) | 58 (70.7) | 4 (100.0) |
| Inability to drink unassisted | 31 (36.1) | 28 (34.1) | 3 (75.0) |
| Presence of chronic comorbidityb | 48 (56.5) | 45 (54.9) | 3 (75.0) |
| HIV-infected by self-report | 13 (15.3) | 12 (14.6) | 1 (25.0) |
| Health care–associated infectionc | 24 (27.9) | 21 (25.6) | 3 (75.0) |
| MUAC, median (IQR), cm | 26.0 (24.0–29.0) | 26.0 (24.0–29.0) | 26.9 (24.9–27.5) |
| Temperature, median (IQR), °C | 38.8 (38.4–39.4) | 38.9 (38.4–39.4) | 38.3 (37.9–39.2) |
| Heart rate, median (IQR), beats/min | 111 (100–122) | 109 (100–121) | 125 (116–134) |
| Respiratory rate, median (IQR), breaths/min | 26 (23–30) | 26 (23–30) | 24 (22–28) |
| Systolic blood pressure, median (IQR), mmHg | 118.5 (105–145) | 119 (107–145) | 83 (78–86) |
| Diastolic blood pressure, median (IQR), mmHg | 68 (60–82) | 68 (61–84) | 48 (43–50) |
| Hypoxiad | 26 (30.2) | 26 (31.7) | 0 |
| Altered mentatione | 21 (24.4) | 20 (24.4) | 1 (25.0) |
| Lactate, median (IQR), mmol/L | 1.5 (1.2–2.3) | 1.4 (1.1–2.2) | 3.1 (1.5–3.5) |
Data are presented as No. (%) unless otherwise noted.
Abbreviations: AVPU, Alert-Verbal-Pain-Unconscious; IQR, interquartile range; MUAC, mid-upper arm circumference.
aFever or systemic includes fever, rigors, night sweats, weight loss; Cardiopulmonary includes cough, hemoptysis, shortness of breath, chest pain; Gastrointestinal includes vomiting, vomiting of blood, abdominal pain or severe abdominal pain, diarrhea, blood in stool; Neurological includes headache, photophobia, neck stiffness, convulsions, lethargy, confusion; Other includes all other symptoms.
bPresence of chronic comorbidity was defined as those reporting a history of hypertension; diabetes mellitus; cancer; HIV; or any chronic heart, lung, liver, or kidney disease.
cHealth care–associated infection was defined as hospitalization within 90 days before onset of the presenting illness, surgery within 30 days, or prosthetic joint replacement within 1 year with symptoms at the site of joint replacement.
dHypoxia was defined as peripheral oxygen saturation <92% or use of supplemental oxygen.
eAltered mentation was defined as either V, P, or U on the AVPU scale.
Baseline Demographic, Clinical History, Physical Examination, and Laboratory Characteristics for Adolescents and Adults With Sepsis, Northern Tanzania, September 2019–April 2020
| . | Total Cohort (n = 86) . | Sepsis Without Hypotension (n = 82) . | Sepsis With Hypotension (n = 4) . |
|---|---|---|---|
| Demographics | |||
| Age, median (IQR), y | 46.5 (32–60) | 46.5 (32–60) | 49.5 (40.5–69) |
| Female | 27 (31.4) | 25 (30.5) | 2 (50.0) |
| Highest level of education completed | … | … | … |
| None | 26 (30.2) | 25 (30.5) | 1 (25.0) |
| Primary | 43 (50.0) | 41 (50.0) | 2 (50.0) |
| Secondary | 10 (11.6) | 9 (11.0) | 1 (25.0) |
| University | 7 (8.1) | 7 (8.5) | 0 |
| Insured | 27 (31.4) | 26 (31.7) | 1 (25.0) |
| Clinical characteristics | |||
| Duration of illness, median (IQR), d | 5 (3–14) | 5 (3–14) | 2 (1–4.5) |
| Chief complaint by syndromea | … | … | … |
| Neurological | 36 (41.9) | 36 (43.9) | 0 |
| Fever or systemic | 21 (24.4) | 19 (23.2) | 2 (50.0) |
| Gastrointestinal | 7 (8.1) | 6 (7.3) | 1 (25.0) |
| Cardiopulmonary | 7 (8.1) | 7 (8.5) | 0 |
| Other | 15 (17.4) | 14 (17.1) | 1 (25.0) |
| Inability to walk unassisted | 62 (72.1) | 58 (70.7) | 4 (100.0) |
| Inability to drink unassisted | 31 (36.1) | 28 (34.1) | 3 (75.0) |
| Presence of chronic comorbidityb | 48 (56.5) | 45 (54.9) | 3 (75.0) |
| HIV-infected by self-report | 13 (15.3) | 12 (14.6) | 1 (25.0) |
| Health care–associated infectionc | 24 (27.9) | 21 (25.6) | 3 (75.0) |
| MUAC, median (IQR), cm | 26.0 (24.0–29.0) | 26.0 (24.0–29.0) | 26.9 (24.9–27.5) |
| Temperature, median (IQR), °C | 38.8 (38.4–39.4) | 38.9 (38.4–39.4) | 38.3 (37.9–39.2) |
| Heart rate, median (IQR), beats/min | 111 (100–122) | 109 (100–121) | 125 (116–134) |
| Respiratory rate, median (IQR), breaths/min | 26 (23–30) | 26 (23–30) | 24 (22–28) |
| Systolic blood pressure, median (IQR), mmHg | 118.5 (105–145) | 119 (107–145) | 83 (78–86) |
| Diastolic blood pressure, median (IQR), mmHg | 68 (60–82) | 68 (61–84) | 48 (43–50) |
| Hypoxiad | 26 (30.2) | 26 (31.7) | 0 |
| Altered mentatione | 21 (24.4) | 20 (24.4) | 1 (25.0) |
| Lactate, median (IQR), mmol/L | 1.5 (1.2–2.3) | 1.4 (1.1–2.2) | 3.1 (1.5–3.5) |
| . | Total Cohort (n = 86) . | Sepsis Without Hypotension (n = 82) . | Sepsis With Hypotension (n = 4) . |
|---|---|---|---|
| Demographics | |||
| Age, median (IQR), y | 46.5 (32–60) | 46.5 (32–60) | 49.5 (40.5–69) |
| Female | 27 (31.4) | 25 (30.5) | 2 (50.0) |
| Highest level of education completed | … | … | … |
| None | 26 (30.2) | 25 (30.5) | 1 (25.0) |
| Primary | 43 (50.0) | 41 (50.0) | 2 (50.0) |
| Secondary | 10 (11.6) | 9 (11.0) | 1 (25.0) |
| University | 7 (8.1) | 7 (8.5) | 0 |
| Insured | 27 (31.4) | 26 (31.7) | 1 (25.0) |
| Clinical characteristics | |||
| Duration of illness, median (IQR), d | 5 (3–14) | 5 (3–14) | 2 (1–4.5) |
| Chief complaint by syndromea | … | … | … |
| Neurological | 36 (41.9) | 36 (43.9) | 0 |
| Fever or systemic | 21 (24.4) | 19 (23.2) | 2 (50.0) |
| Gastrointestinal | 7 (8.1) | 6 (7.3) | 1 (25.0) |
| Cardiopulmonary | 7 (8.1) | 7 (8.5) | 0 |
| Other | 15 (17.4) | 14 (17.1) | 1 (25.0) |
| Inability to walk unassisted | 62 (72.1) | 58 (70.7) | 4 (100.0) |
| Inability to drink unassisted | 31 (36.1) | 28 (34.1) | 3 (75.0) |
| Presence of chronic comorbidityb | 48 (56.5) | 45 (54.9) | 3 (75.0) |
| HIV-infected by self-report | 13 (15.3) | 12 (14.6) | 1 (25.0) |
| Health care–associated infectionc | 24 (27.9) | 21 (25.6) | 3 (75.0) |
| MUAC, median (IQR), cm | 26.0 (24.0–29.0) | 26.0 (24.0–29.0) | 26.9 (24.9–27.5) |
| Temperature, median (IQR), °C | 38.8 (38.4–39.4) | 38.9 (38.4–39.4) | 38.3 (37.9–39.2) |
| Heart rate, median (IQR), beats/min | 111 (100–122) | 109 (100–121) | 125 (116–134) |
| Respiratory rate, median (IQR), breaths/min | 26 (23–30) | 26 (23–30) | 24 (22–28) |
| Systolic blood pressure, median (IQR), mmHg | 118.5 (105–145) | 119 (107–145) | 83 (78–86) |
| Diastolic blood pressure, median (IQR), mmHg | 68 (60–82) | 68 (61–84) | 48 (43–50) |
| Hypoxiad | 26 (30.2) | 26 (31.7) | 0 |
| Altered mentatione | 21 (24.4) | 20 (24.4) | 1 (25.0) |
| Lactate, median (IQR), mmol/L | 1.5 (1.2–2.3) | 1.4 (1.1–2.2) | 3.1 (1.5–3.5) |
Data are presented as No. (%) unless otherwise noted.
Abbreviations: AVPU, Alert-Verbal-Pain-Unconscious; IQR, interquartile range; MUAC, mid-upper arm circumference.
aFever or systemic includes fever, rigors, night sweats, weight loss; Cardiopulmonary includes cough, hemoptysis, shortness of breath, chest pain; Gastrointestinal includes vomiting, vomiting of blood, abdominal pain or severe abdominal pain, diarrhea, blood in stool; Neurological includes headache, photophobia, neck stiffness, convulsions, lethargy, confusion; Other includes all other symptoms.
bPresence of chronic comorbidity was defined as those reporting a history of hypertension; diabetes mellitus; cancer; HIV; or any chronic heart, lung, liver, or kidney disease.
cHealth care–associated infection was defined as hospitalization within 90 days before onset of the presenting illness, surgery within 30 days, or prosthetic joint replacement within 1 year with symptoms at the site of joint replacement.
dHypoxia was defined as peripheral oxygen saturation <92% or use of supplemental oxygen.
eAltered mentation was defined as either V, P, or U on the AVPU scale.
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