Table 2. Open in new tab Disease...

Characteristic	18–64 Years	≥65 Years	≥18 Years
Severity indicators
PSI, median (IQR)	73 (53–103)	65 (42–92)	.04	111 (94–138)	107 (89–132)	.34	89 (61–114)
PSI grade IV or V	48 (35.3)	273 (26.3)	.03	64 (82.1)	621 (72.2)	.07	1006 (47.8)
Systolic BP <90 mm Hg	18 (13.2)	69 (6.7)	.01	7 (9.0)	61 (7.1)	.55	155 (7.4)
Diastolic BP ≤60 mm Hg	57 (41.9)	358 (34.5)	.09	46 (59.0)	461 (54.0)	.40	922 (43.8)
Pulse rate >100 beats/min	88 (64.7)	579 (55.8)	.05	49 (62.8)	341 (40.0)	<.0001	1057 (50.2)
SpO₂ pulse oximetry ≤90%	20 (14.7)	206 (19.9)	.15	23 (29.5)	201 (23.5)	.24	450 (21.4)
PaO₂/FiO₂ ratio <250	26 (19.1)	165 (15.9)	.34	23 (29.5)	180 (21.1)	.08	394 (18.7)
Hospitalization characteristics
Admitted to ICU/CCU	32 (23.5)	217 (20.9)	.49	18 (23.1)	189 (22.1)	.85	456 (21.7)
Duration of hospitalization, d, median (IQR)	5 (4–8)	5 (3–9)	.91	7 (4–9)	6 (4–9)	.17	5 (4–9)
Duration of ICU stay, d, median (IQR)	4.5 (3–9.5)	6 (3–11)	.26	5 (3–10)	5 (3–10)	.89	5 (3–10)
Ventilation use, any type	21 (15.4)	183 (17.7)	.52	17 (21.8)	175 (20.5)	.79	396 (18.8)
Duration of ventilation use, d, median (IQR)	7 (4–9)	5 (2–10)	.14	5 (2–7)	4 (2–10)	.66	4 (2–10)
In-hospital death	4 (2.9)	42 (4.1)	.53	6 (7.7)	61 (7.1)	.86	113 (5.4)

Characteristic

18–64 Years

≥65 Years

≥18 Years

S pneumoniae Positive
(n = 136)

S pneumoniae Negative
(n = 1037)

P Value

S pneumoniae Positive
(n = 78)

S pneumoniae Negative
(n = 854)

P Value

Total
(n = 2105)

Severity indicators

PSI, median (IQR)

73 (53–103)

65 (42–92)

.04

111 (94–138)

107 (89–132)

.34

89 (61–114)

PSI grade IV or V

48 (35.3)

273 (26.3)

.03

64 (82.1)

621 (72.2)

.07

1006 (47.8)

Systolic BP <90 mm Hg

18 (13.2)

69 (6.7)

.01

7 (9.0)

61 (7.1)

.55

155 (7.4)

Diastolic BP ≤60 mm Hg

57 (41.9)

358 (34.5)

.09

46 (59.0)

461 (54.0)

.40

922 (43.8)

Pulse rate >100 beats/min

88 (64.7)

579 (55.8)

.05

49 (62.8)

341 (40.0)

<.0001

1057 (50.2)

SpO₂ pulse oximetry ≤90%

20 (14.7)

206 (19.9)

.15

23 (29.5)

201 (23.5)

.24

450 (21.4)

PaO₂/FiO₂ ratio <250

26 (19.1)

165 (15.9)

.34

23 (29.5)

180 (21.1)

.08

394 (18.7)

Hospitalization characteristics

Admitted to ICU/CCU

32 (23.5)

217 (20.9)

.49

18 (23.1)

189 (22.1)

.85

456 (21.7)

Duration of hospitalization, d, median (IQR)

5 (4–8)

5 (3–9)

.91

7 (4–9)

6 (4–9)

.17

5 (4–9)

Duration of ICU stay, d, median (IQR)

4.5 (3–9.5)

6 (3–11)

.26

5 (3–10)

.89

5 (3–10)

Ventilation use, any type

21 (15.4)

183 (17.7)

.52

17 (21.8)

175 (20.5)

.79

396 (18.8)

Duration of ventilation use, d, median (IQR)

7 (4–9)

5 (2–10)

.14

5 (2–7)

4 (2–10)

.66

4 (2–10)

In-hospital death

4 (2.9)

42 (4.1)

.53

6 (7.7)

61 (7.1)

.86

113 (5.4)

Characteristic	18–64 Years	≥65 Years	≥18 Years
Severity indicators
PSI, median (IQR)	73 (53–103)	65 (42–92)	.04	111 (94–138)	107 (89–132)	.34	89 (61–114)
PSI grade IV or V	48 (35.3)	273 (26.3)	.03	64 (82.1)	621 (72.2)	.07	1006 (47.8)
Systolic BP <90 mm Hg	18 (13.2)	69 (6.7)	.01	7 (9.0)	61 (7.1)	.55	155 (7.4)
Diastolic BP ≤60 mm Hg	57 (41.9)	358 (34.5)	.09	46 (59.0)	461 (54.0)	.40	922 (43.8)
Pulse rate >100 beats/min	88 (64.7)	579 (55.8)	.05	49 (62.8)	341 (40.0)	<.0001	1057 (50.2)
SpO₂ pulse oximetry ≤90%	20 (14.7)	206 (19.9)	.15	23 (29.5)	201 (23.5)	.24	450 (21.4)
PaO₂/FiO₂ ratio <250	26 (19.1)	165 (15.9)	.34	23 (29.5)	180 (21.1)	.08	394 (18.7)
Hospitalization characteristics
Admitted to ICU/CCU	32 (23.5)	217 (20.9)	.49	18 (23.1)	189 (22.1)	.85	456 (21.7)
Duration of hospitalization, d, median (IQR)	5 (4–8)	5 (3–9)	.91	7 (4–9)	6 (4–9)	.17	5 (4–9)
Duration of ICU stay, d, median (IQR)	4.5 (3–9.5)	6 (3–11)	.26	5 (3–10)	5 (3–10)	.89	5 (3–10)
Ventilation use, any type	21 (15.4)	183 (17.7)	.52	17 (21.8)	175 (20.5)	.79	396 (18.8)
Duration of ventilation use, d, median (IQR)	7 (4–9)	5 (2–10)	.14	5 (2–7)	4 (2–10)	.66	4 (2–10)
In-hospital death	4 (2.9)	42 (4.1)	.53	6 (7.7)	61 (7.1)	.86	113 (5.4)

Table 2.

Open in new tab

Disease Characteristics Among Participants Hospitalized With Radiologically Confirmed Community-Acquired Pneumonia Who Tested Positive or Negative for Streptococcus pneumoniae

Characteristic	18–64 Years			≥65 Years			≥18 Years
Characteristic	S pneumoniae Positive (n = 136)	S pneumoniae Negative (n = 1037)	P Value	S pneumoniae Positive (n = 78)	S pneumoniae Negative (n = 854)	P Value	Total (n = 2105)
Severity indicators
PSI, median (IQR)	73 (53–103)	65 (42–92)	.04	111 (94–138)	107 (89–132)	.34	89 (61–114)
PSI grade IV or V	48 (35.3)	273 (26.3)	.03	64 (82.1)	621 (72.2)	.07	1006 (47.8)
Systolic BP <90 mm Hg	18 (13.2)	69 (6.7)	.01	7 (9.0)	61 (7.1)	.55	155 (7.4)
Diastolic BP ≤60 mm Hg	57 (41.9)	358 (34.5)	.09	46 (59.0)	461 (54.0)	.40	922 (43.8)
Pulse rate >100 beats/min	88 (64.7)	579 (55.8)	.05	49 (62.8)	341 (40.0)	<.0001	1057 (50.2)
SpO₂ pulse oximetry ≤90%	20 (14.7)	206 (19.9)	.15	23 (29.5)	201 (23.5)	.24	450 (21.4)
PaO₂/FiO₂ ratio <250	26 (19.1)	165 (15.9)	.34	23 (29.5)	180 (21.1)	.08	394 (18.7)
Hospitalization characteristics
Admitted to ICU/CCU	32 (23.5)	217 (20.9)	.49	18 (23.1)	189 (22.1)	.85	456 (21.7)
Duration of hospitalization, d, median (IQR)	5 (4–8)	5 (3–9)	.91	7 (4–9)	6 (4–9)	.17	5 (4–9)
Duration of ICU stay, d, median (IQR)	4.5 (3–9.5)	6 (3–11)	.26	5 (3–10)	5 (3–10)	.89	5 (3–10)
Ventilation use, any type	21 (15.4)	183 (17.7)	.52	17 (21.8)	175 (20.5)	.79	396 (18.8)
Duration of ventilation use, d, median (IQR)	7 (4–9)	5 (2–10)	.14	5 (2–7)	4 (2–10)	.66	4 (2–10)
In-hospital death	4 (2.9)	42 (4.1)	.53	6 (7.7)	61 (7.1)	.86	113 (5.4)

Characteristic	18–64 Years			≥65 Years			≥18 Years
Characteristic	S pneumoniae Positive (n = 136)	S pneumoniae Negative (n = 1037)	P Value	S pneumoniae Positive (n = 78)	S pneumoniae Negative (n = 854)	P Value	Total (n = 2105)
Severity indicators
PSI, median (IQR)	73 (53–103)	65 (42–92)	.04	111 (94–138)	107 (89–132)	.34	89 (61–114)
PSI grade IV or V	48 (35.3)	273 (26.3)	.03	64 (82.1)	621 (72.2)	.07	1006 (47.8)
Systolic BP <90 mm Hg	18 (13.2)	69 (6.7)	.01	7 (9.0)	61 (7.1)	.55	155 (7.4)
Diastolic BP ≤60 mm Hg	57 (41.9)	358 (34.5)	.09	46 (59.0)	461 (54.0)	.40	922 (43.8)
Pulse rate >100 beats/min	88 (64.7)	579 (55.8)	.05	49 (62.8)	341 (40.0)	<.0001	1057 (50.2)
SpO₂ pulse oximetry ≤90%	20 (14.7)	206 (19.9)	.15	23 (29.5)	201 (23.5)	.24	450 (21.4)
PaO₂/FiO₂ ratio <250	26 (19.1)	165 (15.9)	.34	23 (29.5)	180 (21.1)	.08	394 (18.7)
Hospitalization characteristics
Admitted to ICU/CCU	32 (23.5)	217 (20.9)	.49	18 (23.1)	189 (22.1)	.85	456 (21.7)
Duration of hospitalization, d, median (IQR)	5 (4–8)	5 (3–9)	.91	7 (4–9)	6 (4–9)	.17	5 (4–9)
Duration of ICU stay, d, median (IQR)	4.5 (3–9.5)	6 (3–11)	.26	5 (3–10)	5 (3–10)	.89	5 (3–10)
Ventilation use, any type	21 (15.4)	183 (17.7)	.52	17 (21.8)	175 (20.5)	.79	396 (18.8)
Duration of ventilation use, d, median (IQR)	7 (4–9)	5 (2–10)	.14	5 (2–7)	4 (2–10)	.66	4 (2–10)
In-hospital death	4 (2.9)	42 (4.1)	.53	6 (7.7)	61 (7.1)	.86	113 (5.4)

Data are presented as No. (%) unless otherwise indicated.

Abbreviations: BP, blood pressure; ICU/CCU, intensive care unit/critical care unit; IQR, interquartile range; PaO₂/FiO₂, partial pressure of oxygen/fraction of inspired oxygen; PSI, Pneumonia Severity Index; SpO₂, saturation of peripheral oxygen.

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