Table 1.

Characteristics of participants by maternal fasting plasma glucose level

Participants’ characteristicsTotal
(n = 1541)
Mean ± SD/n (%)
mFPG level (mg/dL)
Mean ± SD
P-valueamFPG level (mg/dL), Mean ± SD/n (%)
≤70 mg/dL
(n = 110)
71-94 mg/dL
(n = 1351)
≥95 mg/dL
(n = 80)
P-valueb
mFPG level (before 24 weeks of gestation) (mg/dL)81.8 ± 9.781.8 ± 9.7NA67.0 ± 3.681.5 ± 5.7107.0 ± 17.4<.0001
Gestational weeks at measurement of mFPG (weeks)11.5 ± 1.8NA.5311.5 ± 2.111.5 ± 1.711.5 ± 2.5.92
Age at delivery (years)31.9 ± 4.7NA.0732.1 ± 4.231.8 ± 4.732.8 ± 4.7.18
Educational attainment.06.13
 High school or lower488 (31.7)82.4 ± 9.930 (27.3)432 (32.0)26 (32.5)
 Junior or vocational college582 (37.8)81.8 ± 9.744 (40.0)506 (37.4)32 (40.0)
 University or higher310 (20.1)80.6 ± 8.531 (28.2)267 (19.8)12 (15.0)
 Missing161 (10.4)82.7 ± 10.85 (4.5)146 (10.8)10 (12.5)
BMI before pregnancy<.0001<.0001
 <18.5 kg/m2202 (13.1)80.6 ± 8.922 (20.0)171 (12.7)9 (11.2)
 18.5-24.9 kg/m21113 (72.2)81.4 ± 9.276 (69.1)994 (73.6)43 (53.7)
 ≥25.0 kg/m2196 (12.7)85.1 ± 12.111 (10.0)160 (11.8)25 (31.3)
 Missing30 (2.0)84.1 ± 8.71 (0.9)26 (1.9)3 (3.8)
Intake of folic acid supplements in early pregnancy.60.59
 No689 (44.7)81.8 ± 8.948 (43.6)610 (45.1)31 (38.7)
 Yes842 (54.6)81.8 ± 10.362 (56.4)732 (54.2)48 (60.0)
 Missing10 (0.7)84.9 ± 7.20 (0.0)9 (0.7)1 (1.3)
Maternal grandpaternal history of DM.14.08
 No1304 (84.6)81.6 ± 9.5102 (92.7)1139 (84.3)63 (78.8)
 Yes96 (6.2)83.4 ± 10.63 (2.7)85 (6.3)8 (10.0)
 Missing141 (9.2)82.5 ± 11.05 (4.6)127 (9.4)9 (11.2)
Maternal grandmaternal history of DM or GDM.35.42
 No1328 (86.2)81.7 ± 9.6100 (90.9)1162 (86.0)66 (82.5)
 Yes72 (4.7)83.0 ± 8.15 (4.6)62 (4.6)5 (6.3)
 Missing141 (9.1)82.5 ± 11.05 (4.5)127 (9.4)9 (11.2)
Parity.57.36
 Nullipara734 (47.6)81.8 ± 10.454 (49.1)635 (47.0)45 (56.3)
 Multipara806 (52.3)81.8 ± 8.956 (50.9)715 (52.9)35 (43.7)
 Missing1 (0.1)92.0 ± NA0 (0.0)1 (0.1)0 (0.0)
Child's sex.53.44
 Male802 (52.0)82.0 ± 9.755 (50.0)700 (51.8)47 (58.7)
 Female739 (48.0)81.7 ± 9.755 (50.0)651 (48.2)33 (41.3)
Developmental delay at the age of 2 years: across 5 domains.22.11
 No1308 (84.9)81.7 ± 9.8101 (91.8)1140 (84.4)67 (83.7)
 Yes233 (15.1)82.5 ± 8.89 (8.2)211 (15.6)13 (16.3)
Developmental delay at the age of 2 years: communication.07.33
 No1460 (94.7)81.7 ± 9.8107 (97.3)1279 (94.7)74 (92.5)
 Yes81 (5.3)83.5 ± 8.03 (2.7)72 (5.3)6 (7.5)
Developmental delay at the age of 2 years: gross motor.68.10
 No1459 (94.7)81.8 ± 9.7109 (99.1)1275 (94.4)75 (93.7)
 Yes82 (5.3)82.3 ± 8.61 (0.9)76 (5.6)5 (6.3)
Developmental delay at the age of 2 years: fine motor.80.41
 No1478 (95.9)81.8 ± 9.7108 (98.2)1292 (95.6)78 (97.5)
 Yes63 (4.1)81.5 ± 8.72 (1.8)59 (4.4)2 (2.5)
Developmental delay at the age of 2 years: problem-solving.55.40
 No1474 (95.6)81.9 ± 9.8106 (96.4)1289 (95.4)79 (98.7)
 Yes67 (4.4)81.3 ± 7.14 (3.6)62 (4.6)1 (1.3)
Developmental delay at the age of 2 years: personal-social.39.51
 No1457 (94.5)81.8 ± 9.7106 (96.4)1277 (94.5)74 (92.5)
 Yes84 (5.5)82.7 ± 9.74 (3.6)74 (5.5)6 (7.5)
Participants’ characteristicsTotal
(n = 1541)
Mean ± SD/n (%)
mFPG level (mg/dL)
Mean ± SD
P-valueamFPG level (mg/dL), Mean ± SD/n (%)
≤70 mg/dL
(n = 110)
71-94 mg/dL
(n = 1351)
≥95 mg/dL
(n = 80)
P-valueb
mFPG level (before 24 weeks of gestation) (mg/dL)81.8 ± 9.781.8 ± 9.7NA67.0 ± 3.681.5 ± 5.7107.0 ± 17.4<.0001
Gestational weeks at measurement of mFPG (weeks)11.5 ± 1.8NA.5311.5 ± 2.111.5 ± 1.711.5 ± 2.5.92
Age at delivery (years)31.9 ± 4.7NA.0732.1 ± 4.231.8 ± 4.732.8 ± 4.7.18
Educational attainment.06.13
 High school or lower488 (31.7)82.4 ± 9.930 (27.3)432 (32.0)26 (32.5)
 Junior or vocational college582 (37.8)81.8 ± 9.744 (40.0)506 (37.4)32 (40.0)
 University or higher310 (20.1)80.6 ± 8.531 (28.2)267 (19.8)12 (15.0)
 Missing161 (10.4)82.7 ± 10.85 (4.5)146 (10.8)10 (12.5)
BMI before pregnancy<.0001<.0001
 <18.5 kg/m2202 (13.1)80.6 ± 8.922 (20.0)171 (12.7)9 (11.2)
 18.5-24.9 kg/m21113 (72.2)81.4 ± 9.276 (69.1)994 (73.6)43 (53.7)
 ≥25.0 kg/m2196 (12.7)85.1 ± 12.111 (10.0)160 (11.8)25 (31.3)
 Missing30 (2.0)84.1 ± 8.71 (0.9)26 (1.9)3 (3.8)
Intake of folic acid supplements in early pregnancy.60.59
 No689 (44.7)81.8 ± 8.948 (43.6)610 (45.1)31 (38.7)
 Yes842 (54.6)81.8 ± 10.362 (56.4)732 (54.2)48 (60.0)
 Missing10 (0.7)84.9 ± 7.20 (0.0)9 (0.7)1 (1.3)
Maternal grandpaternal history of DM.14.08
 No1304 (84.6)81.6 ± 9.5102 (92.7)1139 (84.3)63 (78.8)
 Yes96 (6.2)83.4 ± 10.63 (2.7)85 (6.3)8 (10.0)
 Missing141 (9.2)82.5 ± 11.05 (4.6)127 (9.4)9 (11.2)
Maternal grandmaternal history of DM or GDM.35.42
 No1328 (86.2)81.7 ± 9.6100 (90.9)1162 (86.0)66 (82.5)
 Yes72 (4.7)83.0 ± 8.15 (4.6)62 (4.6)5 (6.3)
 Missing141 (9.1)82.5 ± 11.05 (4.5)127 (9.4)9 (11.2)
Parity.57.36
 Nullipara734 (47.6)81.8 ± 10.454 (49.1)635 (47.0)45 (56.3)
 Multipara806 (52.3)81.8 ± 8.956 (50.9)715 (52.9)35 (43.7)
 Missing1 (0.1)92.0 ± NA0 (0.0)1 (0.1)0 (0.0)
Child's sex.53.44
 Male802 (52.0)82.0 ± 9.755 (50.0)700 (51.8)47 (58.7)
 Female739 (48.0)81.7 ± 9.755 (50.0)651 (48.2)33 (41.3)
Developmental delay at the age of 2 years: across 5 domains.22.11
 No1308 (84.9)81.7 ± 9.8101 (91.8)1140 (84.4)67 (83.7)
 Yes233 (15.1)82.5 ± 8.89 (8.2)211 (15.6)13 (16.3)
Developmental delay at the age of 2 years: communication.07.33
 No1460 (94.7)81.7 ± 9.8107 (97.3)1279 (94.7)74 (92.5)
 Yes81 (5.3)83.5 ± 8.03 (2.7)72 (5.3)6 (7.5)
Developmental delay at the age of 2 years: gross motor.68.10
 No1459 (94.7)81.8 ± 9.7109 (99.1)1275 (94.4)75 (93.7)
 Yes82 (5.3)82.3 ± 8.61 (0.9)76 (5.6)5 (6.3)
Developmental delay at the age of 2 years: fine motor.80.41
 No1478 (95.9)81.8 ± 9.7108 (98.2)1292 (95.6)78 (97.5)
 Yes63 (4.1)81.5 ± 8.72 (1.8)59 (4.4)2 (2.5)
Developmental delay at the age of 2 years: problem-solving.55.40
 No1474 (95.6)81.9 ± 9.8106 (96.4)1289 (95.4)79 (98.7)
 Yes67 (4.4)81.3 ± 7.14 (3.6)62 (4.6)1 (1.3)
Developmental delay at the age of 2 years: personal-social.39.51
 No1457 (94.5)81.8 ± 9.7106 (96.4)1277 (94.5)74 (92.5)
 Yes84 (5.5)82.7 ± 9.74 (3.6)74 (5.5)6 (7.5)

For ANOVAs, Bonferroni's or Tukey's correction was used to obtain P-values.

Abbreviations: BMI, body mass index; DM, diabetes mellitus; GDM, gestational diabetes mellitus; mFPG, maternal fasting plasma glucose; NA, not applicable.

aObtained using correlation analysis, t-test, or ANOVA.

bObtained using ANOVA, chi-square test, or Fisher's exact test.

Table 1.

Characteristics of participants by maternal fasting plasma glucose level

Participants’ characteristicsTotal
(n = 1541)
Mean ± SD/n (%)
mFPG level (mg/dL)
Mean ± SD
P-valueamFPG level (mg/dL), Mean ± SD/n (%)
≤70 mg/dL
(n = 110)
71-94 mg/dL
(n = 1351)
≥95 mg/dL
(n = 80)
P-valueb
mFPG level (before 24 weeks of gestation) (mg/dL)81.8 ± 9.781.8 ± 9.7NA67.0 ± 3.681.5 ± 5.7107.0 ± 17.4<.0001
Gestational weeks at measurement of mFPG (weeks)11.5 ± 1.8NA.5311.5 ± 2.111.5 ± 1.711.5 ± 2.5.92
Age at delivery (years)31.9 ± 4.7NA.0732.1 ± 4.231.8 ± 4.732.8 ± 4.7.18
Educational attainment.06.13
 High school or lower488 (31.7)82.4 ± 9.930 (27.3)432 (32.0)26 (32.5)
 Junior or vocational college582 (37.8)81.8 ± 9.744 (40.0)506 (37.4)32 (40.0)
 University or higher310 (20.1)80.6 ± 8.531 (28.2)267 (19.8)12 (15.0)
 Missing161 (10.4)82.7 ± 10.85 (4.5)146 (10.8)10 (12.5)
BMI before pregnancy<.0001<.0001
 <18.5 kg/m2202 (13.1)80.6 ± 8.922 (20.0)171 (12.7)9 (11.2)
 18.5-24.9 kg/m21113 (72.2)81.4 ± 9.276 (69.1)994 (73.6)43 (53.7)
 ≥25.0 kg/m2196 (12.7)85.1 ± 12.111 (10.0)160 (11.8)25 (31.3)
 Missing30 (2.0)84.1 ± 8.71 (0.9)26 (1.9)3 (3.8)
Intake of folic acid supplements in early pregnancy.60.59
 No689 (44.7)81.8 ± 8.948 (43.6)610 (45.1)31 (38.7)
 Yes842 (54.6)81.8 ± 10.362 (56.4)732 (54.2)48 (60.0)
 Missing10 (0.7)84.9 ± 7.20 (0.0)9 (0.7)1 (1.3)
Maternal grandpaternal history of DM.14.08
 No1304 (84.6)81.6 ± 9.5102 (92.7)1139 (84.3)63 (78.8)
 Yes96 (6.2)83.4 ± 10.63 (2.7)85 (6.3)8 (10.0)
 Missing141 (9.2)82.5 ± 11.05 (4.6)127 (9.4)9 (11.2)
Maternal grandmaternal history of DM or GDM.35.42
 No1328 (86.2)81.7 ± 9.6100 (90.9)1162 (86.0)66 (82.5)
 Yes72 (4.7)83.0 ± 8.15 (4.6)62 (4.6)5 (6.3)
 Missing141 (9.1)82.5 ± 11.05 (4.5)127 (9.4)9 (11.2)
Parity.57.36
 Nullipara734 (47.6)81.8 ± 10.454 (49.1)635 (47.0)45 (56.3)
 Multipara806 (52.3)81.8 ± 8.956 (50.9)715 (52.9)35 (43.7)
 Missing1 (0.1)92.0 ± NA0 (0.0)1 (0.1)0 (0.0)
Child's sex.53.44
 Male802 (52.0)82.0 ± 9.755 (50.0)700 (51.8)47 (58.7)
 Female739 (48.0)81.7 ± 9.755 (50.0)651 (48.2)33 (41.3)
Developmental delay at the age of 2 years: across 5 domains.22.11
 No1308 (84.9)81.7 ± 9.8101 (91.8)1140 (84.4)67 (83.7)
 Yes233 (15.1)82.5 ± 8.89 (8.2)211 (15.6)13 (16.3)
Developmental delay at the age of 2 years: communication.07.33
 No1460 (94.7)81.7 ± 9.8107 (97.3)1279 (94.7)74 (92.5)
 Yes81 (5.3)83.5 ± 8.03 (2.7)72 (5.3)6 (7.5)
Developmental delay at the age of 2 years: gross motor.68.10
 No1459 (94.7)81.8 ± 9.7109 (99.1)1275 (94.4)75 (93.7)
 Yes82 (5.3)82.3 ± 8.61 (0.9)76 (5.6)5 (6.3)
Developmental delay at the age of 2 years: fine motor.80.41
 No1478 (95.9)81.8 ± 9.7108 (98.2)1292 (95.6)78 (97.5)
 Yes63 (4.1)81.5 ± 8.72 (1.8)59 (4.4)2 (2.5)
Developmental delay at the age of 2 years: problem-solving.55.40
 No1474 (95.6)81.9 ± 9.8106 (96.4)1289 (95.4)79 (98.7)
 Yes67 (4.4)81.3 ± 7.14 (3.6)62 (4.6)1 (1.3)
Developmental delay at the age of 2 years: personal-social.39.51
 No1457 (94.5)81.8 ± 9.7106 (96.4)1277 (94.5)74 (92.5)
 Yes84 (5.5)82.7 ± 9.74 (3.6)74 (5.5)6 (7.5)
Participants’ characteristicsTotal
(n = 1541)
Mean ± SD/n (%)
mFPG level (mg/dL)
Mean ± SD
P-valueamFPG level (mg/dL), Mean ± SD/n (%)
≤70 mg/dL
(n = 110)
71-94 mg/dL
(n = 1351)
≥95 mg/dL
(n = 80)
P-valueb
mFPG level (before 24 weeks of gestation) (mg/dL)81.8 ± 9.781.8 ± 9.7NA67.0 ± 3.681.5 ± 5.7107.0 ± 17.4<.0001
Gestational weeks at measurement of mFPG (weeks)11.5 ± 1.8NA.5311.5 ± 2.111.5 ± 1.711.5 ± 2.5.92
Age at delivery (years)31.9 ± 4.7NA.0732.1 ± 4.231.8 ± 4.732.8 ± 4.7.18
Educational attainment.06.13
 High school or lower488 (31.7)82.4 ± 9.930 (27.3)432 (32.0)26 (32.5)
 Junior or vocational college582 (37.8)81.8 ± 9.744 (40.0)506 (37.4)32 (40.0)
 University or higher310 (20.1)80.6 ± 8.531 (28.2)267 (19.8)12 (15.0)
 Missing161 (10.4)82.7 ± 10.85 (4.5)146 (10.8)10 (12.5)
BMI before pregnancy<.0001<.0001
 <18.5 kg/m2202 (13.1)80.6 ± 8.922 (20.0)171 (12.7)9 (11.2)
 18.5-24.9 kg/m21113 (72.2)81.4 ± 9.276 (69.1)994 (73.6)43 (53.7)
 ≥25.0 kg/m2196 (12.7)85.1 ± 12.111 (10.0)160 (11.8)25 (31.3)
 Missing30 (2.0)84.1 ± 8.71 (0.9)26 (1.9)3 (3.8)
Intake of folic acid supplements in early pregnancy.60.59
 No689 (44.7)81.8 ± 8.948 (43.6)610 (45.1)31 (38.7)
 Yes842 (54.6)81.8 ± 10.362 (56.4)732 (54.2)48 (60.0)
 Missing10 (0.7)84.9 ± 7.20 (0.0)9 (0.7)1 (1.3)
Maternal grandpaternal history of DM.14.08
 No1304 (84.6)81.6 ± 9.5102 (92.7)1139 (84.3)63 (78.8)
 Yes96 (6.2)83.4 ± 10.63 (2.7)85 (6.3)8 (10.0)
 Missing141 (9.2)82.5 ± 11.05 (4.6)127 (9.4)9 (11.2)
Maternal grandmaternal history of DM or GDM.35.42
 No1328 (86.2)81.7 ± 9.6100 (90.9)1162 (86.0)66 (82.5)
 Yes72 (4.7)83.0 ± 8.15 (4.6)62 (4.6)5 (6.3)
 Missing141 (9.1)82.5 ± 11.05 (4.5)127 (9.4)9 (11.2)
Parity.57.36
 Nullipara734 (47.6)81.8 ± 10.454 (49.1)635 (47.0)45 (56.3)
 Multipara806 (52.3)81.8 ± 8.956 (50.9)715 (52.9)35 (43.7)
 Missing1 (0.1)92.0 ± NA0 (0.0)1 (0.1)0 (0.0)
Child's sex.53.44
 Male802 (52.0)82.0 ± 9.755 (50.0)700 (51.8)47 (58.7)
 Female739 (48.0)81.7 ± 9.755 (50.0)651 (48.2)33 (41.3)
Developmental delay at the age of 2 years: across 5 domains.22.11
 No1308 (84.9)81.7 ± 9.8101 (91.8)1140 (84.4)67 (83.7)
 Yes233 (15.1)82.5 ± 8.89 (8.2)211 (15.6)13 (16.3)
Developmental delay at the age of 2 years: communication.07.33
 No1460 (94.7)81.7 ± 9.8107 (97.3)1279 (94.7)74 (92.5)
 Yes81 (5.3)83.5 ± 8.03 (2.7)72 (5.3)6 (7.5)
Developmental delay at the age of 2 years: gross motor.68.10
 No1459 (94.7)81.8 ± 9.7109 (99.1)1275 (94.4)75 (93.7)
 Yes82 (5.3)82.3 ± 8.61 (0.9)76 (5.6)5 (6.3)
Developmental delay at the age of 2 years: fine motor.80.41
 No1478 (95.9)81.8 ± 9.7108 (98.2)1292 (95.6)78 (97.5)
 Yes63 (4.1)81.5 ± 8.72 (1.8)59 (4.4)2 (2.5)
Developmental delay at the age of 2 years: problem-solving.55.40
 No1474 (95.6)81.9 ± 9.8106 (96.4)1289 (95.4)79 (98.7)
 Yes67 (4.4)81.3 ± 7.14 (3.6)62 (4.6)1 (1.3)
Developmental delay at the age of 2 years: personal-social.39.51
 No1457 (94.5)81.8 ± 9.7106 (96.4)1277 (94.5)74 (92.5)
 Yes84 (5.5)82.7 ± 9.74 (3.6)74 (5.5)6 (7.5)

For ANOVAs, Bonferroni's or Tukey's correction was used to obtain P-values.

Abbreviations: BMI, body mass index; DM, diabetes mellitus; GDM, gestational diabetes mellitus; mFPG, maternal fasting plasma glucose; NA, not applicable.

aObtained using correlation analysis, t-test, or ANOVA.

bObtained using ANOVA, chi-square test, or Fisher's exact test.

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