Table 1

Characteristics of troponin assays used

AssayLoBLoDConcentration at 20% CVConcentration at 10% CV99th centile of the URL (plasma)Reportable measuring range
Siemens Atellica® VTLi POC hs-cTnI12 (ng/L)0.551.2 plasma, 1.6 WB2.1 plasma, 3.7 WB6.7 plasma, 8.9 WB18 (F)
27 (M)
1.2–1250
Beckman Coulter Access hs-cTnI13 (ng/L)1.72.32.35.6>10 (F)
> 20 (M)
2.3–27 027
Assessment pathway group definitions: single test risk stratification for possible early discharge requirements
Eligible for discharge if all of (a) to (e) are true. See also the Supplementary material online, Figure S1.
Siemens Atellica® VTLi POC hs-cTnI assay
  • (a) hs-cTnI < 7 ng/L,

  • (b) Normal/unchanged ECG,

  • (c) EDACS < 21,

  • (d) No red flags, and

  • (e) Symptom onset ≥3 h pre-test.

Beckman Coulter Access hs-cTnI assay
  • (a) hs-cTnI < 6 ng/L,

  • (b) Normal/unchanged ECG,

  • (c) EDACS < 21,

  • (d) No red flags, and

  • (e) Symptom onset ≥3 h pre-test blood draw.

AssayLoBLoDConcentration at 20% CVConcentration at 10% CV99th centile of the URL (plasma)Reportable measuring range
Siemens Atellica® VTLi POC hs-cTnI12 (ng/L)0.551.2 plasma, 1.6 WB2.1 plasma, 3.7 WB6.7 plasma, 8.9 WB18 (F)
27 (M)
1.2–1250
Beckman Coulter Access hs-cTnI13 (ng/L)1.72.32.35.6>10 (F)
> 20 (M)
2.3–27 027
Assessment pathway group definitions: single test risk stratification for possible early discharge requirements
Eligible for discharge if all of (a) to (e) are true. See also the Supplementary material online, Figure S1.
Siemens Atellica® VTLi POC hs-cTnI assay
  • (a) hs-cTnI < 7 ng/L,

  • (b) Normal/unchanged ECG,

  • (c) EDACS < 21,

  • (d) No red flags, and

  • (e) Symptom onset ≥3 h pre-test.

Beckman Coulter Access hs-cTnI assay
  • (a) hs-cTnI < 6 ng/L,

  • (b) Normal/unchanged ECG,

  • (c) EDACS < 21,

  • (d) No red flags, and

  • (e) Symptom onset ≥3 h pre-test blood draw.

LoB, level of blank; LoD, level of detection; CV, coefficient of variation; URL, upper reference limit; POC, point of care; F, female; M, male; WB, whole blood; ECG, electrocardiogram; EDACS, Emergency Department Assessment of Chest pain Score.

Table 1

Characteristics of troponin assays used

AssayLoBLoDConcentration at 20% CVConcentration at 10% CV99th centile of the URL (plasma)Reportable measuring range
Siemens Atellica® VTLi POC hs-cTnI12 (ng/L)0.551.2 plasma, 1.6 WB2.1 plasma, 3.7 WB6.7 plasma, 8.9 WB18 (F)
27 (M)
1.2–1250
Beckman Coulter Access hs-cTnI13 (ng/L)1.72.32.35.6>10 (F)
> 20 (M)
2.3–27 027
Assessment pathway group definitions: single test risk stratification for possible early discharge requirements
Eligible for discharge if all of (a) to (e) are true. See also the Supplementary material online, Figure S1.
Siemens Atellica® VTLi POC hs-cTnI assay
  • (a) hs-cTnI < 7 ng/L,

  • (b) Normal/unchanged ECG,

  • (c) EDACS < 21,

  • (d) No red flags, and

  • (e) Symptom onset ≥3 h pre-test.

Beckman Coulter Access hs-cTnI assay
  • (a) hs-cTnI < 6 ng/L,

  • (b) Normal/unchanged ECG,

  • (c) EDACS < 21,

  • (d) No red flags, and

  • (e) Symptom onset ≥3 h pre-test blood draw.

AssayLoBLoDConcentration at 20% CVConcentration at 10% CV99th centile of the URL (plasma)Reportable measuring range
Siemens Atellica® VTLi POC hs-cTnI12 (ng/L)0.551.2 plasma, 1.6 WB2.1 plasma, 3.7 WB6.7 plasma, 8.9 WB18 (F)
27 (M)
1.2–1250
Beckman Coulter Access hs-cTnI13 (ng/L)1.72.32.35.6>10 (F)
> 20 (M)
2.3–27 027
Assessment pathway group definitions: single test risk stratification for possible early discharge requirements
Eligible for discharge if all of (a) to (e) are true. See also the Supplementary material online, Figure S1.
Siemens Atellica® VTLi POC hs-cTnI assay
  • (a) hs-cTnI < 7 ng/L,

  • (b) Normal/unchanged ECG,

  • (c) EDACS < 21,

  • (d) No red flags, and

  • (e) Symptom onset ≥3 h pre-test.

Beckman Coulter Access hs-cTnI assay
  • (a) hs-cTnI < 6 ng/L,

  • (b) Normal/unchanged ECG,

  • (c) EDACS < 21,

  • (d) No red flags, and

  • (e) Symptom onset ≥3 h pre-test blood draw.

LoB, level of blank; LoD, level of detection; CV, coefficient of variation; URL, upper reference limit; POC, point of care; F, female; M, male; WB, whole blood; ECG, electrocardiogram; EDACS, Emergency Department Assessment of Chest pain Score.

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