Genotype of virus clones isolated after five passages of PTV (combination) therapy using a plaque-purified virus.
| . | . | Mutations in . | |||
|---|---|---|---|---|---|
| Condition . | Number of clones . | TK (UL23) . | DP (UL30) . | Helicase (UL5) . | Primase (UL52) . |
| PTVrL | 2 | – | – | – | – |
| 3 | – | – | M355I | – | |
| PTVrH | 5 | – | – | K356N | – |
| ACV + PTVrL | 5 | ins C nts 548–553 | – | – | – |
| ACV + PTVrH | 5 | – | – | – | – |
| PFA + PTVrL | 5 | – | L702I | – | – |
| PFA + PTVrH | 5 | – | – | – | – |
| . | . | Mutations in . | |||
|---|---|---|---|---|---|
| Condition . | Number of clones . | TK (UL23) . | DP (UL30) . | Helicase (UL5) . | Primase (UL52) . |
| PTVrL | 2 | – | – | – | – |
| 3 | – | – | M355I | – | |
| PTVrH | 5 | – | – | K356N | – |
| ACV + PTVrL | 5 | ins C nts 548–553 | – | – | – |
| ACV + PTVrH | 5 | – | – | – | – |
| PFA + PTVrL | 5 | – | L702I | – | – |
| PFA + PTVrH | 5 | – | – | – | – |
- : No mutation detected, bold: novel amino acid change with an unknown effect on drug resistance, italics: known drug resistance mutations (Chibo et al. 2004, Saijo et al. 2005, Collot et al. 2016).
Genotype of virus clones isolated after five passages of PTV (combination) therapy using a plaque-purified virus.
| . | . | Mutations in . | |||
|---|---|---|---|---|---|
| Condition . | Number of clones . | TK (UL23) . | DP (UL30) . | Helicase (UL5) . | Primase (UL52) . |
| PTVrL | 2 | – | – | – | – |
| 3 | – | – | M355I | – | |
| PTVrH | 5 | – | – | K356N | – |
| ACV + PTVrL | 5 | ins C nts 548–553 | – | – | – |
| ACV + PTVrH | 5 | – | – | – | – |
| PFA + PTVrL | 5 | – | L702I | – | – |
| PFA + PTVrH | 5 | – | – | – | – |
| . | . | Mutations in . | |||
|---|---|---|---|---|---|
| Condition . | Number of clones . | TK (UL23) . | DP (UL30) . | Helicase (UL5) . | Primase (UL52) . |
| PTVrL | 2 | – | – | – | – |
| 3 | – | – | M355I | – | |
| PTVrH | 5 | – | – | K356N | – |
| ACV + PTVrL | 5 | ins C nts 548–553 | – | – | – |
| ACV + PTVrH | 5 | – | – | – | – |
| PFA + PTVrL | 5 | – | L702I | – | – |
| PFA + PTVrH | 5 | – | – | – | – |
- : No mutation detected, bold: novel amino acid change with an unknown effect on drug resistance, italics: known drug resistance mutations (Chibo et al. 2004, Saijo et al. 2005, Collot et al. 2016).
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