Table 4.
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Premorbid Academic Adjustment: Fixed Effect Estimates From Growth Curve Models Estimating Premorbid Academic Adjustment as a Function of Conversion Status (Converted vs Not Converted) and Clinical Covariates in 498 Youth at Clinical High Risk for Psychosis [With 95% Confidence Intervals]

Clinical Covariate
Attenuated Negative SymptomsVerbal LearningPresence of Childhood TraumaImpact of Childhood Trauma
Within-person
 Time0.30***
[0.23, 0.38]		0.30***
[0.22, 0.37]		0.29***
[0.20, 0.39]		0.31***
[0.19, 0.43]
Between-person
 Age−0.01
[−0.04, 0.01]		−0.06
[−0.08, −0.04]		−0.03
[−0.05, 0.00]		−0.01
[−0.05, 0.03]
 Sex−0.33***
[−0.52, −0.14]		−0.23*
[−0.42, −0.03]		−0.38***
[−0.57, −0.20]		−0.49***
[−0.76, −0.21]
 Conversion0.10
[−0.23, 0.43]		−0.01
[−0.03, 0.02]		0.15
[−0.27, 0.58]		0.16
[−0.28, 0.59]
 Covariate0.16***
[0.08, 0.24]		0.05***
[−0.26, 0.37]		0.47***
[0.27, 0.68]		0.03
[−0.01, 0.06]
Interactions
 Conversion × Time−0.05
[−0.28, 0.19]		−0.01
[−0.24, 0.22]		−0.02
[−0.32, 0.29]		−0.09
[−0.46, 0.28]
 Covariate × Conversion−0.13
[−0.37, 0.11]		0.03
[−0.05, 0.08]		−0.12
[−0.72, 0.49]		−0.11**,a
[−0.20, −0.02]
 Covariate × Time0.08**,a
[0.02, 0.14]		0.01
[−0.01, 0.02]		0.02
[−0.12, 0.16]		−0.01
[−0.04, 0.02]
 Covariate × Conversion × Time−0.10
[−0.27, 0.08]		−0.00
[−0.04, 0.04]		−0.08
[−0.51, 0.36]		0.01
[−0.04, 0.06]
Clinical Covariate
Attenuated Negative SymptomsVerbal LearningPresence of Childhood TraumaImpact of Childhood Trauma
Within-person
 Time0.30***
[0.23, 0.38]		0.30***
[0.22, 0.37]		0.29***
[0.20, 0.39]		0.31***
[0.19, 0.43]
Between-person
 Age−0.01
[−0.04, 0.01]		−0.06
[−0.08, −0.04]		−0.03
[−0.05, 0.00]		−0.01
[−0.05, 0.03]
 Sex−0.33***
[−0.52, −0.14]		−0.23*
[−0.42, −0.03]		−0.38***
[−0.57, −0.20]		−0.49***
[−0.76, −0.21]
 Conversion0.10
[−0.23, 0.43]		−0.01
[−0.03, 0.02]		0.15
[−0.27, 0.58]		0.16
[−0.28, 0.59]
 Covariate0.16***
[0.08, 0.24]		0.05***
[−0.26, 0.37]		0.47***
[0.27, 0.68]		0.03
[−0.01, 0.06]
Interactions
 Conversion × Time−0.05
[−0.28, 0.19]		−0.01
[−0.24, 0.22]		−0.02
[−0.32, 0.29]		−0.09
[−0.46, 0.28]
 Covariate × Conversion−0.13
[−0.37, 0.11]		0.03
[−0.05, 0.08]		−0.12
[−0.72, 0.49]		−0.11**,a
[−0.20, −0.02]
 Covariate × Time0.08**,a
[0.02, 0.14]		0.01
[−0.01, 0.02]		0.02
[−0.12, 0.16]		−0.01
[−0.04, 0.02]
 Covariate × Conversion × Time−0.10
[−0.27, 0.08]		−0.00
[−0.04, 0.04]		−0.08
[−0.51, 0.36]		0.01
[−0.04, 0.06]

Note: Bold indicates uncorrected P < .05. To minimize inflation of the Type II error rate, FDR correction was limited to tests of focal hypotheses (interactions).

aFDR-corrected P < .05.

*Uncorrected P < .05; **uncorrected P < .01; ***uncorrected P < .001.

Table 4.
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Premorbid Academic Adjustment: Fixed Effect Estimates From Growth Curve Models Estimating Premorbid Academic Adjustment as a Function of Conversion Status (Converted vs Not Converted) and Clinical Covariates in 498 Youth at Clinical High Risk for Psychosis [With 95% Confidence Intervals]

Clinical Covariate
Attenuated Negative SymptomsVerbal LearningPresence of Childhood TraumaImpact of Childhood Trauma
Within-person
 Time0.30***
[0.23, 0.38]		0.30***
[0.22, 0.37]		0.29***
[0.20, 0.39]		0.31***
[0.19, 0.43]
Between-person
 Age−0.01
[−0.04, 0.01]		−0.06
[−0.08, −0.04]		−0.03
[−0.05, 0.00]		−0.01
[−0.05, 0.03]
 Sex−0.33***
[−0.52, −0.14]		−0.23*
[−0.42, −0.03]		−0.38***
[−0.57, −0.20]		−0.49***
[−0.76, −0.21]
 Conversion0.10
[−0.23, 0.43]		−0.01
[−0.03, 0.02]		0.15
[−0.27, 0.58]		0.16
[−0.28, 0.59]
 Covariate0.16***
[0.08, 0.24]		0.05***
[−0.26, 0.37]		0.47***
[0.27, 0.68]		0.03
[−0.01, 0.06]
Interactions
 Conversion × Time−0.05
[−0.28, 0.19]		−0.01
[−0.24, 0.22]		−0.02
[−0.32, 0.29]		−0.09
[−0.46, 0.28]
 Covariate × Conversion−0.13
[−0.37, 0.11]		0.03
[−0.05, 0.08]		−0.12
[−0.72, 0.49]		−0.11**,a
[−0.20, −0.02]
 Covariate × Time0.08**,a
[0.02, 0.14]		0.01
[−0.01, 0.02]		0.02
[−0.12, 0.16]		−0.01
[−0.04, 0.02]
 Covariate × Conversion × Time−0.10
[−0.27, 0.08]		−0.00
[−0.04, 0.04]		−0.08
[−0.51, 0.36]		0.01
[−0.04, 0.06]
Clinical Covariate
Attenuated Negative SymptomsVerbal LearningPresence of Childhood TraumaImpact of Childhood Trauma
Within-person
 Time0.30***
[0.23, 0.38]		0.30***
[0.22, 0.37]		0.29***
[0.20, 0.39]		0.31***
[0.19, 0.43]
Between-person
 Age−0.01
[−0.04, 0.01]		−0.06
[−0.08, −0.04]		−0.03
[−0.05, 0.00]		−0.01
[−0.05, 0.03]
 Sex−0.33***
[−0.52, −0.14]		−0.23*
[−0.42, −0.03]		−0.38***
[−0.57, −0.20]		−0.49***
[−0.76, −0.21]
 Conversion0.10
[−0.23, 0.43]		−0.01
[−0.03, 0.02]		0.15
[−0.27, 0.58]		0.16
[−0.28, 0.59]
 Covariate0.16***
[0.08, 0.24]		0.05***
[−0.26, 0.37]		0.47***
[0.27, 0.68]		0.03
[−0.01, 0.06]
Interactions
 Conversion × Time−0.05
[−0.28, 0.19]		−0.01
[−0.24, 0.22]		−0.02
[−0.32, 0.29]		−0.09
[−0.46, 0.28]
 Covariate × Conversion−0.13
[−0.37, 0.11]		0.03
[−0.05, 0.08]		−0.12
[−0.72, 0.49]		−0.11**,a
[−0.20, −0.02]
 Covariate × Time0.08**,a
[0.02, 0.14]		0.01
[−0.01, 0.02]		0.02
[−0.12, 0.16]		−0.01
[−0.04, 0.02]
 Covariate × Conversion × Time−0.10
[−0.27, 0.08]		−0.00
[−0.04, 0.04]		−0.08
[−0.51, 0.36]		0.01
[−0.04, 0.06]

Note: Bold indicates uncorrected P < .05. To minimize inflation of the Type II error rate, FDR correction was limited to tests of focal hypotheses (interactions).

aFDR-corrected P < .05.

*Uncorrected P < .05; **uncorrected P < .01; ***uncorrected P < .001.

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