Odds Ratios for Ordinal Logistic Regression Model for Predicting Graded Anemia Event as Determined by Division of AIDS Criteria
| . | Univariable . | . | Multivariable . | . | ||
|---|---|---|---|---|---|---|
| Characteristic . | OR . | 95% CI . | AIC . | OR . | 95% CI . | AIC . |
| Baseline hemoglobin | 0.399 | .296–.522 | 253.6 | 0.379 | .276–.505 | 233.5 |
| Linezolid area under the time-concentration curve over 24 hours at steady state | 1.011 | 1.006–1.016 | 262.2 | 1.012 | 1.007–1.017 | |
| Duration of linezolid | 1.002 | 1.001–1.003 | 293.4 | |||
| Female sex | 1.650 | .813–3.392 | 304.4 | |||
| Age | 1.092 | 1.023–1.169 | 299.3 | |||
| Weight-for-age z score | 0.811 | .526–1.212 | 308.3 | |||
| Dose above current recommendationsa | 5.429 | 2.223–13.632 | 292.6 | |||
| . | Univariable . | . | Multivariable . | . | ||
|---|---|---|---|---|---|---|
| Characteristic . | OR . | 95% CI . | AIC . | OR . | 95% CI . | AIC . |
| Baseline hemoglobin | 0.399 | .296–.522 | 253.6 | 0.379 | .276–.505 | 233.5 |
| Linezolid area under the time-concentration curve over 24 hours at steady state | 1.011 | 1.006–1.016 | 262.2 | 1.012 | 1.007–1.017 | |
| Duration of linezolid | 1.002 | 1.001–1.003 | 293.4 | |||
| Female sex | 1.650 | .813–3.392 | 304.4 | |||
| Age | 1.092 | 1.023–1.169 | 299.3 | |||
| Weight-for-age z score | 0.811 | .526–1.212 | 308.3 | |||
| Dose above current recommendationsa | 5.429 | 2.223–13.632 | 292.6 | |||
Abbreviations: AIC, Akaike’s information criterion; CI, confidence interval; OR, odds ratio.
The empty cells under the multivariable section are for those variables not included in the final multivariable model.
aGiven dose recommendations changed after the development of the initial population pharmacokinetic model. Some of the data that were collected prior to current recommendations contained doses above what is currently recommended and were evaluated in the ordinal logistic regression model.
Odds Ratios for Ordinal Logistic Regression Model for Predicting Graded Anemia Event as Determined by Division of AIDS Criteria
| . | Univariable . | . | Multivariable . | . | ||
|---|---|---|---|---|---|---|
| Characteristic . | OR . | 95% CI . | AIC . | OR . | 95% CI . | AIC . |
| Baseline hemoglobin | 0.399 | .296–.522 | 253.6 | 0.379 | .276–.505 | 233.5 |
| Linezolid area under the time-concentration curve over 24 hours at steady state | 1.011 | 1.006–1.016 | 262.2 | 1.012 | 1.007–1.017 | |
| Duration of linezolid | 1.002 | 1.001–1.003 | 293.4 | |||
| Female sex | 1.650 | .813–3.392 | 304.4 | |||
| Age | 1.092 | 1.023–1.169 | 299.3 | |||
| Weight-for-age z score | 0.811 | .526–1.212 | 308.3 | |||
| Dose above current recommendationsa | 5.429 | 2.223–13.632 | 292.6 | |||
| . | Univariable . | . | Multivariable . | . | ||
|---|---|---|---|---|---|---|
| Characteristic . | OR . | 95% CI . | AIC . | OR . | 95% CI . | AIC . |
| Baseline hemoglobin | 0.399 | .296–.522 | 253.6 | 0.379 | .276–.505 | 233.5 |
| Linezolid area under the time-concentration curve over 24 hours at steady state | 1.011 | 1.006–1.016 | 262.2 | 1.012 | 1.007–1.017 | |
| Duration of linezolid | 1.002 | 1.001–1.003 | 293.4 | |||
| Female sex | 1.650 | .813–3.392 | 304.4 | |||
| Age | 1.092 | 1.023–1.169 | 299.3 | |||
| Weight-for-age z score | 0.811 | .526–1.212 | 308.3 | |||
| Dose above current recommendationsa | 5.429 | 2.223–13.632 | 292.6 | |||
Abbreviations: AIC, Akaike’s information criterion; CI, confidence interval; OR, odds ratio.
The empty cells under the multivariable section are for those variables not included in the final multivariable model.
aGiven dose recommendations changed after the development of the initial population pharmacokinetic model. Some of the data that were collected prior to current recommendations contained doses above what is currently recommended and were evaluated in the ordinal logistic regression model.
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