| Parameter . | Original Pharmacokinetic Data Estimate (RSE) . | Expanded Pharmacokinetic Dataa Estimate (RSE) . |
|---|---|---|
| Ka (h−1) | 0.77 (25) | 0.982 (9.7) |
| CL/F (L/h/kg) | 4.73 (8) | 4.78 (9.6) |
| V/F (L) | 54.8 (8) | 58.1 (5.2) |
| BSVCL/F (%)—shrinkage % | 37 (16) | 55.2 (32.1)—14.5 |
| BSVV/F (%)—shrinkage % | 32 (23) | 18.9 (38.1)—20.2 |
| BSVKa (%)—shrinkage % | … | 79.4 (23.3)—34.6 |
| Correlation CL-V (%) | … | 10 |
| Additive error (mg/L) | 0.78 (91) | 1.83 (14.8) |
| Proportional error (%) | 25 (30) | 20.7 (31.4) |
| Parameter . | Original Pharmacokinetic Data Estimate (RSE) . | Expanded Pharmacokinetic Dataa Estimate (RSE) . |
|---|---|---|
| Ka (h−1) | 0.77 (25) | 0.982 (9.7) |
| CL/F (L/h/kg) | 4.73 (8) | 4.78 (9.6) |
| V/F (L) | 54.8 (8) | 58.1 (5.2) |
| BSVCL/F (%)—shrinkage % | 37 (16) | 55.2 (32.1)—14.5 |
| BSVV/F (%)—shrinkage % | 32 (23) | 18.9 (38.1)—20.2 |
| BSVKa (%)—shrinkage % | … | 79.4 (23.3)—34.6 |
| Correlation CL-V (%) | … | 10 |
| Additive error (mg/L) | 0.78 (91) | 1.83 (14.8) |
| Proportional error (%) | 25 (30) | 20.7 (31.4) |
Abbreviations: BSV, between-subject variability; CL, clearance; F, bioavailability; Ka, absorption rate constant; RSE, relative standard error; V, volume of distribution.
aExpanded pharmacokinetic data refers to the original data plus the additional new pharmacokinetic data.
| Parameter . | Original Pharmacokinetic Data Estimate (RSE) . | Expanded Pharmacokinetic Dataa Estimate (RSE) . |
|---|---|---|
| Ka (h−1) | 0.77 (25) | 0.982 (9.7) |
| CL/F (L/h/kg) | 4.73 (8) | 4.78 (9.6) |
| V/F (L) | 54.8 (8) | 58.1 (5.2) |
| BSVCL/F (%)—shrinkage % | 37 (16) | 55.2 (32.1)—14.5 |
| BSVV/F (%)—shrinkage % | 32 (23) | 18.9 (38.1)—20.2 |
| BSVKa (%)—shrinkage % | … | 79.4 (23.3)—34.6 |
| Correlation CL-V (%) | … | 10 |
| Additive error (mg/L) | 0.78 (91) | 1.83 (14.8) |
| Proportional error (%) | 25 (30) | 20.7 (31.4) |
| Parameter . | Original Pharmacokinetic Data Estimate (RSE) . | Expanded Pharmacokinetic Dataa Estimate (RSE) . |
|---|---|---|
| Ka (h−1) | 0.77 (25) | 0.982 (9.7) |
| CL/F (L/h/kg) | 4.73 (8) | 4.78 (9.6) |
| V/F (L) | 54.8 (8) | 58.1 (5.2) |
| BSVCL/F (%)—shrinkage % | 37 (16) | 55.2 (32.1)—14.5 |
| BSVV/F (%)—shrinkage % | 32 (23) | 18.9 (38.1)—20.2 |
| BSVKa (%)—shrinkage % | … | 79.4 (23.3)—34.6 |
| Correlation CL-V (%) | … | 10 |
| Additive error (mg/L) | 0.78 (91) | 1.83 (14.8) |
| Proportional error (%) | 25 (30) | 20.7 (31.4) |
Abbreviations: BSV, between-subject variability; CL, clearance; F, bioavailability; Ka, absorption rate constant; RSE, relative standard error; V, volume of distribution.
aExpanded pharmacokinetic data refers to the original data plus the additional new pharmacokinetic data.
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