| Cohort . | Sex . | Polygenic score . | Cohen's d . | P . |
|---|---|---|---|---|
| CDP | Female | Age at male pubertal hallmarks | 0.73 | 1 × 10−4 |
| Age at menarche | 1.16 | 8 × 10−10 | ||
| Male | Age at male pubertal hallmarks | 0.66 | 2 × 10−7 | |
| Age at menarche | 0.71 | 4 × 10−9 | ||
| nIHH | Female | Age at male pubertal hallmarks | 0.19 | 0.21 |
| Age at menarche | −0.02 | 0.97 | ||
| Male | Age at male pubertal hallmarks | 0.20 | 5 × 10−3 | |
| Age at menarche | 0.16 | 8 × 10−3 |
| Cohort . | Sex . | Polygenic score . | Cohen's d . | P . |
|---|---|---|---|---|
| CDP | Female | Age at male pubertal hallmarks | 0.73 | 1 × 10−4 |
| Age at menarche | 1.16 | 8 × 10−10 | ||
| Male | Age at male pubertal hallmarks | 0.66 | 2 × 10−7 | |
| Age at menarche | 0.71 | 4 × 10−9 | ||
| nIHH | Female | Age at male pubertal hallmarks | 0.19 | 0.21 |
| Age at menarche | −0.02 | 0.97 | ||
| Male | Age at male pubertal hallmarks | 0.20 | 5 × 10−3 | |
| Age at menarche | 0.16 | 8 × 10−3 |
Cohen's d of 0.2 or less was interpreted as a small difference, greater than 0.2 to less than 0.8 as a moderate difference, and 0.8 or more as a large difference.
Abbreviations: CDP, constitutional delay of puberty; nIHH, normosmic idiopathic hypogonadotropic hypogonadism.
| Cohort . | Sex . | Polygenic score . | Cohen's d . | P . |
|---|---|---|---|---|
| CDP | Female | Age at male pubertal hallmarks | 0.73 | 1 × 10−4 |
| Age at menarche | 1.16 | 8 × 10−10 | ||
| Male | Age at male pubertal hallmarks | 0.66 | 2 × 10−7 | |
| Age at menarche | 0.71 | 4 × 10−9 | ||
| nIHH | Female | Age at male pubertal hallmarks | 0.19 | 0.21 |
| Age at menarche | −0.02 | 0.97 | ||
| Male | Age at male pubertal hallmarks | 0.20 | 5 × 10−3 | |
| Age at menarche | 0.16 | 8 × 10−3 |
| Cohort . | Sex . | Polygenic score . | Cohen's d . | P . |
|---|---|---|---|---|
| CDP | Female | Age at male pubertal hallmarks | 0.73 | 1 × 10−4 |
| Age at menarche | 1.16 | 8 × 10−10 | ||
| Male | Age at male pubertal hallmarks | 0.66 | 2 × 10−7 | |
| Age at menarche | 0.71 | 4 × 10−9 | ||
| nIHH | Female | Age at male pubertal hallmarks | 0.19 | 0.21 |
| Age at menarche | −0.02 | 0.97 | ||
| Male | Age at male pubertal hallmarks | 0.20 | 5 × 10−3 | |
| Age at menarche | 0.16 | 8 × 10−3 |
Cohen's d of 0.2 or less was interpreted as a small difference, greater than 0.2 to less than 0.8 as a moderate difference, and 0.8 or more as a large difference.
Abbreviations: CDP, constitutional delay of puberty; nIHH, normosmic idiopathic hypogonadotropic hypogonadism.
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