^aThis table gives in the comparisons all annotated genes (omitting 3UTRs, 5UTRs) in the decreasing (up-regulation) or increasing order (down-regulation) of the ratio Q, if the distance value was D >1. The comparisons were again metal-challenged CH34 cells divided by non-challenged cells, EDTA-treated CH34 cell divided by non-challenged cells, non-challenged AE104 divided by non-challenged CH34 cells, the same with metal-challenged or EDTA-treated AE104 divided by CH34 cells. For down-regulated genes, only those that were expressed in non-challenged CH34 cells (NPKM >10) were listed. The numbers following the comparison headlines indicate the total number of annotated genes that were Q >2 or Q <0.5, with D >1. The Rmet locus tags also indicate the associated replicons of these genes, Rmet_0001 to Rmet_3615 chromosome, to Rmet_5941 chromid, to Rmet_6181 pMOL30, to Rmet_6346 pMOL28 and from Rmet_6347 genes from all four replicons that were annotated in a later annotation round.