Table 1.

Metal resistance determinants in C. metalliduransa.

DeterminantOperon structure
Chromosomal determinants
hmzhmzAB↔yodB-Rmet_3014; hmzSR← (genomic island CMGI-4)
cadcdfX-Rmet_2300-Rmet_2301-cadR↔cadAC (genomic island CMGI-1)
cupcupRA↔cupC
dmedmeF-Rmet_0199←
arsarsPHC1BC2IRM← (genomic island CMGI-7)
Determinants on the chromid
znt-czc2zntA↔czcI2C2B2‘//>czcR2S2-ubiG; czcA2B2‘‘←
zni/znezniAB↔zniC; zniS↔zniR; Rmet_5324↔zneRS; zneCAB↔zneR2S2
hmvhmvCBA‘/A‘‘
hmyhmyFCB; tnpA↔hmyA
nimnimCAa-tnpB-nimA2b←
cus→cusDCBAF
cop2copD2C2B2A2↔copR2S2; (nim determinant adjacent)
chr2chrF2A2B2-Rmet_3867←
Determinants on plasmid pMOL30
czcczcM↔czcICBADRSE; czcJ-ompP-tnpBA↔flgB-czcP
ncc→nccCBa/BbA-nreB
silsilABCD←
pbrpbrD(BC)A↔pbrRTUa//→pbrUb
cop1cobWE↔copHQ;copL↔copOFGJ; copID1C1B1A1↔copR1S1N;
copKM↔copTV
Determinants on plasmid pMOL28
cnrcnrYXHCBAT
chr1chrZYPNOF1ECA1B1↔chrI-cnr determinant
DeterminantOperon structure
Chromosomal determinants
hmzhmzAB↔yodB-Rmet_3014; hmzSR← (genomic island CMGI-4)
cadcdfX-Rmet_2300-Rmet_2301-cadR↔cadAC (genomic island CMGI-1)
cupcupRA↔cupC
dmedmeF-Rmet_0199←
arsarsPHC1BC2IRM← (genomic island CMGI-7)
Determinants on the chromid
znt-czc2zntA↔czcI2C2B2‘//>czcR2S2-ubiG; czcA2B2‘‘←
zni/znezniAB↔zniC; zniS↔zniR; Rmet_5324↔zneRS; zneCAB↔zneR2S2
hmvhmvCBA‘/A‘‘
hmyhmyFCB; tnpA↔hmyA
nimnimCAa-tnpB-nimA2b←
cus→cusDCBAF
cop2copD2C2B2A2↔copR2S2; (nim determinant adjacent)
chr2chrF2A2B2-Rmet_3867←
Determinants on plasmid pMOL30
czcczcM↔czcICBADRSE; czcJ-ompP-tnpBA↔flgB-czcP
ncc→nccCBa/BbA-nreB
silsilABCD←
pbrpbrD(BC)A↔pbrRTUa//→pbrUb
cop1cobWE↔copHQ;copL↔copOFGJ; copID1C1B1A1↔copR1S1N;
copKM↔copTV
Determinants on plasmid pMOL28
cnrcnrYXHCBAT
chr1chrZYPNOF1ECA1B1↔chrI-cnr determinant

aThe determinants are listed according to their host replicon. Bold-faced gene names indicate their location on the forward strand, semicolons directly adjacent genes, double arrows „↔‘ common promoter regions and indication of the direction of transcription, single arrows direction of transcription, double slashes „//‘ separation of gene regions, in case of the ancient, interrupted czc2 gene region by 128 genes and in case of pbr by four genes. Adjacent determinants and genomic islands are also listed but the mer mercury resistance determinants were ignored. Gene names with dashes or small letters are interrupted genes.

Table 1.

Metal resistance determinants in C. metalliduransa.

DeterminantOperon structure
Chromosomal determinants
hmzhmzAB↔yodB-Rmet_3014; hmzSR← (genomic island CMGI-4)
cadcdfX-Rmet_2300-Rmet_2301-cadR↔cadAC (genomic island CMGI-1)
cupcupRA↔cupC
dmedmeF-Rmet_0199←
arsarsPHC1BC2IRM← (genomic island CMGI-7)
Determinants on the chromid
znt-czc2zntA↔czcI2C2B2‘//>czcR2S2-ubiG; czcA2B2‘‘←
zni/znezniAB↔zniC; zniS↔zniR; Rmet_5324↔zneRS; zneCAB↔zneR2S2
hmvhmvCBA‘/A‘‘
hmyhmyFCB; tnpA↔hmyA
nimnimCAa-tnpB-nimA2b←
cus→cusDCBAF
cop2copD2C2B2A2↔copR2S2; (nim determinant adjacent)
chr2chrF2A2B2-Rmet_3867←
Determinants on plasmid pMOL30
czcczcM↔czcICBADRSE; czcJ-ompP-tnpBA↔flgB-czcP
ncc→nccCBa/BbA-nreB
silsilABCD←
pbrpbrD(BC)A↔pbrRTUa//→pbrUb
cop1cobWE↔copHQ;copL↔copOFGJ; copID1C1B1A1↔copR1S1N;
copKM↔copTV
Determinants on plasmid pMOL28
cnrcnrYXHCBAT
chr1chrZYPNOF1ECA1B1↔chrI-cnr determinant
DeterminantOperon structure
Chromosomal determinants
hmzhmzAB↔yodB-Rmet_3014; hmzSR← (genomic island CMGI-4)
cadcdfX-Rmet_2300-Rmet_2301-cadR↔cadAC (genomic island CMGI-1)
cupcupRA↔cupC
dmedmeF-Rmet_0199←
arsarsPHC1BC2IRM← (genomic island CMGI-7)
Determinants on the chromid
znt-czc2zntA↔czcI2C2B2‘//>czcR2S2-ubiG; czcA2B2‘‘←
zni/znezniAB↔zniC; zniS↔zniR; Rmet_5324↔zneRS; zneCAB↔zneR2S2
hmvhmvCBA‘/A‘‘
hmyhmyFCB; tnpA↔hmyA
nimnimCAa-tnpB-nimA2b←
cus→cusDCBAF
cop2copD2C2B2A2↔copR2S2; (nim determinant adjacent)
chr2chrF2A2B2-Rmet_3867←
Determinants on plasmid pMOL30
czcczcM↔czcICBADRSE; czcJ-ompP-tnpBA↔flgB-czcP
ncc→nccCBa/BbA-nreB
silsilABCD←
pbrpbrD(BC)A↔pbrRTUa//→pbrUb
cop1cobWE↔copHQ;copL↔copOFGJ; copID1C1B1A1↔copR1S1N;
copKM↔copTV
Determinants on plasmid pMOL28
cnrcnrYXHCBAT
chr1chrZYPNOF1ECA1B1↔chrI-cnr determinant

aThe determinants are listed according to their host replicon. Bold-faced gene names indicate their location on the forward strand, semicolons directly adjacent genes, double arrows „↔‘ common promoter regions and indication of the direction of transcription, single arrows direction of transcription, double slashes „//‘ separation of gene regions, in case of the ancient, interrupted czc2 gene region by 128 genes and in case of pbr by four genes. Adjacent determinants and genomic islands are also listed but the mer mercury resistance determinants were ignored. Gene names with dashes or small letters are interrupted genes.

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