Table 4 Open in new tab Univariable and...

	Univariable analysis	Multivariable analysis
Age
≤Median	–	–	–	–
>Median	0.88 (0.58,1.33)	0.546	–	–
Sex
Female	–	–	–	–
Male	0.96 (0.64,1.46)	0.866	–	–
BMI	1.01 (0.96,1.06)	0.718	–	–
Tumour location
Head	–	–	–	–
Uncinate process	2.10 (1.38,3.20)	<0.001*	1.79 (1.11,2.88)	0.018*
Mesopancreas
Normal fat	–	–	–	–
Fat stranding	1.11 (0.70,1.76)	0.658	0.80 (0.49,1.30)	0.358
Solid infiltration	2.16 (1.21,3.87)	0.010*	0.84 (0.42,1.68)	0.617
Pathological tumour size	1.03 (1.02,1.04)	<0.001*	1.02 (1.01,1.04)	0.008*
Lymph node status
Negative	–	–	–	–
Positive	1.90 (1.14,3.16)	0.013*	1.57 (0.89,2.79)	0.121
Perineural invasion
No	–	–	–	–
Yes	1.84 (1.06,3.22)	0.031*	1.31 (0.73,2.36)	0.371
Lymphatic invasion
No	–	–	–	–
Yes	1.46 (0.96,2.23)	0.079	0.78 (0.44,1.40)	0.407
Microvascular invasion
No	–	–	–	–
Yes	1.66 (1.09,2.52)	0.019*	1.28 (0.72,2.28)	0.402
SMV margin
Free	–	–	–	–
≤1mm	1.13 (0.69,1.85)	0.632	–	–
Invasion	1.53 (0.90,2.62)	0.116	–	–
SMA margin
Free	–	–	–	–
≤1mm	1.48 (0.91,2.41)	0.115	1.13 (0.67,1.90)	0.644
Invasion	2.38 (1.42,4.01)	0.001*	1.46 (0.82,2.61)	0.194

Univariable analysis

Multivariable analysis

HR (95% c.i.)

Age

≤Median

–

>Median

0.88 (0.58,1.33)

0.546

–

Sex

Female

–

Male

0.96 (0.64,1.46)

0.866

–

BMI

1.01 (0.96,1.06)

0.718

–

Tumour location

Head

–

Uncinate process

2.10 (1.38,3.20)

<0.001*

1.79 (1.11,2.88)

0.018*

Mesopancreas

Normal fat

–

Fat stranding

1.11 (0.70,1.76)

0.658

0.80 (0.49,1.30)

0.358

Solid infiltration

2.16 (1.21,3.87)

0.010*

0.84 (0.42,1.68)

0.617

Pathological tumour size

1.03 (1.02,1.04)

<0.001*

1.02 (1.01,1.04)

0.008*

Lymph node status

Negative

–

Positive

1.90 (1.14,3.16)

0.013*

1.57 (0.89,2.79)

0.121

Perineural invasion

–

Yes

1.84 (1.06,3.22)

0.031*

1.31 (0.73,2.36)

0.371

Lymphatic invasion

–

Yes

1.46 (0.96,2.23)

0.079

0.78 (0.44,1.40)

0.407

Microvascular invasion

–

Yes

1.66 (1.09,2.52)

0.019*

1.28 (0.72,2.28)

0.402

SMV margin

Free

–

≤1mm

1.13 (0.69,1.85)

0.632

–

Invasion

1.53 (0.90,2.62)

0.116

–

SMA margin

Free

–

≤1mm

1.48 (0.91,2.41)

0.115

1.13 (0.67,1.90)

0.644

Invasion

2.38 (1.42,4.01)

0.001*

1.46 (0.82,2.61)

0.194

	Univariable analysis	Multivariable analysis
Age
≤Median	–	–	–	–
>Median	0.88 (0.58,1.33)	0.546	–	–
Sex
Female	–	–	–	–
Male	0.96 (0.64,1.46)	0.866	–	–
BMI	1.01 (0.96,1.06)	0.718	–	–
Tumour location
Head	–	–	–	–
Uncinate process	2.10 (1.38,3.20)	<0.001*	1.79 (1.11,2.88)	0.018*
Mesopancreas
Normal fat	–	–	–	–
Fat stranding	1.11 (0.70,1.76)	0.658	0.80 (0.49,1.30)	0.358
Solid infiltration	2.16 (1.21,3.87)	0.010*	0.84 (0.42,1.68)	0.617
Pathological tumour size	1.03 (1.02,1.04)	<0.001*	1.02 (1.01,1.04)	0.008*
Lymph node status
Negative	–	–	–	–
Positive	1.90 (1.14,3.16)	0.013*	1.57 (0.89,2.79)	0.121
Perineural invasion
No	–	–	–	–
Yes	1.84 (1.06,3.22)	0.031*	1.31 (0.73,2.36)	0.371
Lymphatic invasion
No	–	–	–	–
Yes	1.46 (0.96,2.23)	0.079	0.78 (0.44,1.40)	0.407
Microvascular invasion
No	–	–	–	–
Yes	1.66 (1.09,2.52)	0.019*	1.28 (0.72,2.28)	0.402
SMV margin
Free	–	–	–	–
≤1mm	1.13 (0.69,1.85)	0.632	–	–
Invasion	1.53 (0.90,2.62)	0.116	–	–
SMA margin
Free	–	–	–	–
≤1mm	1.48 (0.91,2.41)	0.115	1.13 (0.67,1.90)	0.644
Invasion	2.38 (1.42,4.01)	0.001*	1.46 (0.82,2.61)	0.194

Table 4

Open in new tab

Univariable and multivariable analyses of prognostic factors for disease-free survival after pancreatoduodenectomy for pancreatic ductal adenocarcinoma

	Univariable analysis		Multivariable analysis
	HR (95% c.i.)	P	HR (95% c.i.)	P
Age
≤Median	–	–	–	–
>Median	0.88 (0.58,1.33)	0.546	–	–
Sex
Female	–	–	–	–
Male	0.96 (0.64,1.46)	0.866	–	–
BMI	1.01 (0.96,1.06)	0.718	–	–
Tumour location
Head	–	–	–	–
Uncinate process	2.10 (1.38,3.20)	<0.001*	1.79 (1.11,2.88)	0.018*
Mesopancreas
Normal fat	–	–	–	–
Fat stranding	1.11 (0.70,1.76)	0.658	0.80 (0.49,1.30)	0.358
Solid infiltration	2.16 (1.21,3.87)	0.010*	0.84 (0.42,1.68)	0.617
Pathological tumour size	1.03 (1.02,1.04)	<0.001*	1.02 (1.01,1.04)	0.008*
Lymph node status
Negative	–	–	–	–
Positive	1.90 (1.14,3.16)	0.013*	1.57 (0.89,2.79)	0.121
Perineural invasion
No	–	–	–	–
Yes	1.84 (1.06,3.22)	0.031*	1.31 (0.73,2.36)	0.371
Lymphatic invasion
No	–	–	–	–
Yes	1.46 (0.96,2.23)	0.079	0.78 (0.44,1.40)	0.407
Microvascular invasion
No	–	–	–	–
Yes	1.66 (1.09,2.52)	0.019*	1.28 (0.72,2.28)	0.402
SMV margin
Free	–	–	–	–
≤1mm	1.13 (0.69,1.85)	0.632	–	–
Invasion	1.53 (0.90,2.62)	0.116	–	–
SMA margin
Free	–	–	–	–
≤1mm	1.48 (0.91,2.41)	0.115	1.13 (0.67,1.90)	0.644
Invasion	2.38 (1.42,4.01)	0.001*	1.46 (0.82,2.61)	0.194

	Univariable analysis		Multivariable analysis
	HR (95% c.i.)	P	HR (95% c.i.)	P
Age
≤Median	–	–	–	–
>Median	0.88 (0.58,1.33)	0.546	–	–
Sex
Female	–	–	–	–
Male	0.96 (0.64,1.46)	0.866	–	–
BMI	1.01 (0.96,1.06)	0.718	–	–
Tumour location
Head	–	–	–	–
Uncinate process	2.10 (1.38,3.20)	<0.001*	1.79 (1.11,2.88)	0.018*
Mesopancreas
Normal fat	–	–	–	–
Fat stranding	1.11 (0.70,1.76)	0.658	0.80 (0.49,1.30)	0.358
Solid infiltration	2.16 (1.21,3.87)	0.010*	0.84 (0.42,1.68)	0.617
Pathological tumour size	1.03 (1.02,1.04)	<0.001*	1.02 (1.01,1.04)	0.008*
Lymph node status
Negative	–	–	–	–
Positive	1.90 (1.14,3.16)	0.013*	1.57 (0.89,2.79)	0.121
Perineural invasion
No	–	–	–	–
Yes	1.84 (1.06,3.22)	0.031*	1.31 (0.73,2.36)	0.371
Lymphatic invasion
No	–	–	–	–
Yes	1.46 (0.96,2.23)	0.079	0.78 (0.44,1.40)	0.407
Microvascular invasion
No	–	–	–	–
Yes	1.66 (1.09,2.52)	0.019*	1.28 (0.72,2.28)	0.402
SMV margin
Free	–	–	–	–
≤1mm	1.13 (0.69,1.85)	0.632	–	–
Invasion	1.53 (0.90,2.62)	0.116	–	–
SMA margin
Free	–	–	–	–
≤1mm	1.48 (0.91,2.41)	0.115	1.13 (0.67,1.90)	0.644
Invasion	2.38 (1.42,4.01)	0.001*	1.46 (0.82,2.61)	0.194

*Statistically significant. BMI, body mass index; SMV, superior mesenteric vein; SMA, superior mesenteric artery.

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