Univariable and multivariable analyses of prognostic factors for overall survival after pancreatoduodenectomy for pancreatic ductal adenocarcinoma
| . | Univariable analysis . | Multivariable analysis . | ||
|---|---|---|---|---|
| HR (95% c.i.) . | P . | HR (95% c.i.) . | P . | |
| Age | ||||
| ≤Median | – | – | – | – |
| >Median | 0.89 (0.59,1.35) | 0.594 | – | – |
| Sex | ||||
| Female | – | – | – | – |
| Male | 1.10 (0.73,1.66) | 0.659 | – | – |
| BMI | 0.97 (0.92,1.02) | 0.203 | – | – |
| Tumour location | ||||
| Head | – | – | – | – |
| Uncinate process | 1.68 (1.11,2.54) | 0.014* | 1.29 (0.80,2.08) | 0.289 |
| Mesopancreas | ||||
| Normal fat | – | – | – | – |
| Fat stranding | 1.01 (0.64,1.62) | 0.953 | 0.75 (0.46,1.23) | 0.261 |
| Solid infiltration | 2.16 (1.23,3.81) | 0.007* | 1.22 (0.63,2.36) | 0.546 |
| Pathological tumour size | 1.02 (1.01,1.03) | <0.001* | 1.01 (1.00,1.03) | 0.024* |
| Lymph node status | ||||
| Negative | – | – | – | – |
| Positive | 1.99 (1.20,3.31) | 0.008* | 1.62 (0.92,2.85) | 0.096 |
| Perineural invasion | ||||
| No | – | – | – | – |
| Yes | 2.14 (1.20,3.80) | 0.010* | 1.52 (0.83,2.78) | 0.174 |
| Lymphatic invasion | ||||
| No | – | – | – | – |
| Yes | 1.43 (0.94,2.17) | 0.100 | – | – |
| Microvascular invasion | ||||
| No | – | – | – | – |
| Yes | 1.87 (1.23,2.84) | 0.003* | 1.33 (0.84,2.12) | 0.223 |
| SMV margin | ||||
| Free | – | – | – | – |
| ≤1mm | 1.10 (0.67,1.81) | 0.705 | – | – |
| Invasion | 1.53 (0.90,2.60) | 0.118 | – | – |
| SMA margin | ||||
| Free | – | – | – | – |
| ≤1mm | 1.26 (0.77,2.06) | 0.349 | 0.98 (0.58,1.63) | 0.928 |
| Invasion | 2.20 (1.31,3.70) | 0.003* | 1.31 (0.72,2.37) | 0.373 |
| . | Univariable analysis . | Multivariable analysis . | ||
|---|---|---|---|---|
| HR (95% c.i.) . | P . | HR (95% c.i.) . | P . | |
| Age | ||||
| ≤Median | – | – | – | – |
| >Median | 0.89 (0.59,1.35) | 0.594 | – | – |
| Sex | ||||
| Female | – | – | – | – |
| Male | 1.10 (0.73,1.66) | 0.659 | – | – |
| BMI | 0.97 (0.92,1.02) | 0.203 | – | – |
| Tumour location | ||||
| Head | – | – | – | – |
| Uncinate process | 1.68 (1.11,2.54) | 0.014* | 1.29 (0.80,2.08) | 0.289 |
| Mesopancreas | ||||
| Normal fat | – | – | – | – |
| Fat stranding | 1.01 (0.64,1.62) | 0.953 | 0.75 (0.46,1.23) | 0.261 |
| Solid infiltration | 2.16 (1.23,3.81) | 0.007* | 1.22 (0.63,2.36) | 0.546 |
| Pathological tumour size | 1.02 (1.01,1.03) | <0.001* | 1.01 (1.00,1.03) | 0.024* |
| Lymph node status | ||||
| Negative | – | – | – | – |
| Positive | 1.99 (1.20,3.31) | 0.008* | 1.62 (0.92,2.85) | 0.096 |
| Perineural invasion | ||||
| No | – | – | – | – |
| Yes | 2.14 (1.20,3.80) | 0.010* | 1.52 (0.83,2.78) | 0.174 |
| Lymphatic invasion | ||||
| No | – | – | – | – |
| Yes | 1.43 (0.94,2.17) | 0.100 | – | – |
| Microvascular invasion | ||||
| No | – | – | – | – |
| Yes | 1.87 (1.23,2.84) | 0.003* | 1.33 (0.84,2.12) | 0.223 |
| SMV margin | ||||
| Free | – | – | – | – |
| ≤1mm | 1.10 (0.67,1.81) | 0.705 | – | – |
| Invasion | 1.53 (0.90,2.60) | 0.118 | – | – |
| SMA margin | ||||
| Free | – | – | – | – |
| ≤1mm | 1.26 (0.77,2.06) | 0.349 | 0.98 (0.58,1.63) | 0.928 |
| Invasion | 2.20 (1.31,3.70) | 0.003* | 1.31 (0.72,2.37) | 0.373 |
*Statistically significant. BMI, body mass index; SMV, superior mesenteric vein; SMA, superior mesenteric artery.
Univariable and multivariable analyses of prognostic factors for overall survival after pancreatoduodenectomy for pancreatic ductal adenocarcinoma
| . | Univariable analysis . | Multivariable analysis . | ||
|---|---|---|---|---|
| HR (95% c.i.) . | P . | HR (95% c.i.) . | P . | |
| Age | ||||
| ≤Median | – | – | – | – |
| >Median | 0.89 (0.59,1.35) | 0.594 | – | – |
| Sex | ||||
| Female | – | – | – | – |
| Male | 1.10 (0.73,1.66) | 0.659 | – | – |
| BMI | 0.97 (0.92,1.02) | 0.203 | – | – |
| Tumour location | ||||
| Head | – | – | – | – |
| Uncinate process | 1.68 (1.11,2.54) | 0.014* | 1.29 (0.80,2.08) | 0.289 |
| Mesopancreas | ||||
| Normal fat | – | – | – | – |
| Fat stranding | 1.01 (0.64,1.62) | 0.953 | 0.75 (0.46,1.23) | 0.261 |
| Solid infiltration | 2.16 (1.23,3.81) | 0.007* | 1.22 (0.63,2.36) | 0.546 |
| Pathological tumour size | 1.02 (1.01,1.03) | <0.001* | 1.01 (1.00,1.03) | 0.024* |
| Lymph node status | ||||
| Negative | – | – | – | – |
| Positive | 1.99 (1.20,3.31) | 0.008* | 1.62 (0.92,2.85) | 0.096 |
| Perineural invasion | ||||
| No | – | – | – | – |
| Yes | 2.14 (1.20,3.80) | 0.010* | 1.52 (0.83,2.78) | 0.174 |
| Lymphatic invasion | ||||
| No | – | – | – | – |
| Yes | 1.43 (0.94,2.17) | 0.100 | – | – |
| Microvascular invasion | ||||
| No | – | – | – | – |
| Yes | 1.87 (1.23,2.84) | 0.003* | 1.33 (0.84,2.12) | 0.223 |
| SMV margin | ||||
| Free | – | – | – | – |
| ≤1mm | 1.10 (0.67,1.81) | 0.705 | – | – |
| Invasion | 1.53 (0.90,2.60) | 0.118 | – | – |
| SMA margin | ||||
| Free | – | – | – | – |
| ≤1mm | 1.26 (0.77,2.06) | 0.349 | 0.98 (0.58,1.63) | 0.928 |
| Invasion | 2.20 (1.31,3.70) | 0.003* | 1.31 (0.72,2.37) | 0.373 |
| . | Univariable analysis . | Multivariable analysis . | ||
|---|---|---|---|---|
| HR (95% c.i.) . | P . | HR (95% c.i.) . | P . | |
| Age | ||||
| ≤Median | – | – | – | – |
| >Median | 0.89 (0.59,1.35) | 0.594 | – | – |
| Sex | ||||
| Female | – | – | – | – |
| Male | 1.10 (0.73,1.66) | 0.659 | – | – |
| BMI | 0.97 (0.92,1.02) | 0.203 | – | – |
| Tumour location | ||||
| Head | – | – | – | – |
| Uncinate process | 1.68 (1.11,2.54) | 0.014* | 1.29 (0.80,2.08) | 0.289 |
| Mesopancreas | ||||
| Normal fat | – | – | – | – |
| Fat stranding | 1.01 (0.64,1.62) | 0.953 | 0.75 (0.46,1.23) | 0.261 |
| Solid infiltration | 2.16 (1.23,3.81) | 0.007* | 1.22 (0.63,2.36) | 0.546 |
| Pathological tumour size | 1.02 (1.01,1.03) | <0.001* | 1.01 (1.00,1.03) | 0.024* |
| Lymph node status | ||||
| Negative | – | – | – | – |
| Positive | 1.99 (1.20,3.31) | 0.008* | 1.62 (0.92,2.85) | 0.096 |
| Perineural invasion | ||||
| No | – | – | – | – |
| Yes | 2.14 (1.20,3.80) | 0.010* | 1.52 (0.83,2.78) | 0.174 |
| Lymphatic invasion | ||||
| No | – | – | – | – |
| Yes | 1.43 (0.94,2.17) | 0.100 | – | – |
| Microvascular invasion | ||||
| No | – | – | – | – |
| Yes | 1.87 (1.23,2.84) | 0.003* | 1.33 (0.84,2.12) | 0.223 |
| SMV margin | ||||
| Free | – | – | – | – |
| ≤1mm | 1.10 (0.67,1.81) | 0.705 | – | – |
| Invasion | 1.53 (0.90,2.60) | 0.118 | – | – |
| SMA margin | ||||
| Free | – | – | – | – |
| ≤1mm | 1.26 (0.77,2.06) | 0.349 | 0.98 (0.58,1.63) | 0.928 |
| Invasion | 2.20 (1.31,3.70) | 0.003* | 1.31 (0.72,2.37) | 0.373 |
*Statistically significant. BMI, body mass index; SMV, superior mesenteric vein; SMA, superior mesenteric artery.
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