| Technique . | Single nucleotide resolution . | Portrays non-CpG sites . | DNA degradation . | Optimized for uscfDNA . |
|---|---|---|---|---|
| BS-Seq (used in this paper) | Yes | Yes | Yes | Not currently |
| 5mCAdpBS-Seq (developed in this paper) | Yes | Yes | Yes | Yes |
| Reduced representation bisulfite sequencing (RRBS) | Yes | Yes* | Yes | Not currently |
| Circulating free methylated DNA immunoprecipitation sequencing (cfMeDIP-Seq) | No | No | No | Not currently |
| Methyl-CpG binding domain protein capture sequencing (MBD-Seq) | No | No | No | Not currently |
| Enzymatic methyl sequencing (EM-Seq) | Yes | Yes | No | Not currently |
| Targeted sequencing BS | Yes | Yes* | Yes | Not currently |
| Microarray-based | Yes | No | Yes | Not currently |
| Technique . | Single nucleotide resolution . | Portrays non-CpG sites . | DNA degradation . | Optimized for uscfDNA . |
|---|---|---|---|---|
| BS-Seq (used in this paper) | Yes | Yes | Yes | Not currently |
| 5mCAdpBS-Seq (developed in this paper) | Yes | Yes | Yes | Yes |
| Reduced representation bisulfite sequencing (RRBS) | Yes | Yes* | Yes | Not currently |
| Circulating free methylated DNA immunoprecipitation sequencing (cfMeDIP-Seq) | No | No | No | Not currently |
| Methyl-CpG binding domain protein capture sequencing (MBD-Seq) | No | No | No | Not currently |
| Enzymatic methyl sequencing (EM-Seq) | Yes | Yes | No | Not currently |
| Targeted sequencing BS | Yes | Yes* | Yes | Not currently |
| Microarray-based | Yes | No | Yes | Not currently |
*Only in enriched regions.
| Technique . | Single nucleotide resolution . | Portrays non-CpG sites . | DNA degradation . | Optimized for uscfDNA . |
|---|---|---|---|---|
| BS-Seq (used in this paper) | Yes | Yes | Yes | Not currently |
| 5mCAdpBS-Seq (developed in this paper) | Yes | Yes | Yes | Yes |
| Reduced representation bisulfite sequencing (RRBS) | Yes | Yes* | Yes | Not currently |
| Circulating free methylated DNA immunoprecipitation sequencing (cfMeDIP-Seq) | No | No | No | Not currently |
| Methyl-CpG binding domain protein capture sequencing (MBD-Seq) | No | No | No | Not currently |
| Enzymatic methyl sequencing (EM-Seq) | Yes | Yes | No | Not currently |
| Targeted sequencing BS | Yes | Yes* | Yes | Not currently |
| Microarray-based | Yes | No | Yes | Not currently |
| Technique . | Single nucleotide resolution . | Portrays non-CpG sites . | DNA degradation . | Optimized for uscfDNA . |
|---|---|---|---|---|
| BS-Seq (used in this paper) | Yes | Yes | Yes | Not currently |
| 5mCAdpBS-Seq (developed in this paper) | Yes | Yes | Yes | Yes |
| Reduced representation bisulfite sequencing (RRBS) | Yes | Yes* | Yes | Not currently |
| Circulating free methylated DNA immunoprecipitation sequencing (cfMeDIP-Seq) | No | No | No | Not currently |
| Methyl-CpG binding domain protein capture sequencing (MBD-Seq) | No | No | No | Not currently |
| Enzymatic methyl sequencing (EM-Seq) | Yes | Yes | No | Not currently |
| Targeted sequencing BS | Yes | Yes* | Yes | Not currently |
| Microarray-based | Yes | No | Yes | Not currently |
*Only in enriched regions.
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