Relationship between longitudinal bicarbonate levels and all-cause mortality in the transition-CKD population.
| Q SBCa . | Events, N (%) . | Person time, years . | Events for 1000 person-years . | Unadjusted, HR (95% CI) . | Sex, age, HR (95% CI)b . | BMI, albumin, SGA, HR (95% CI)b . | eGFR, K+, HR (95% CI)b . | Comorbidities, primary renal disease, HR (95% CI)b . |
|---|---|---|---|---|---|---|---|---|
| 1st | 60 (39.0) | 474.0 | 127 | 0.82 (0.54, 1.23); P = .336 | 0.84 (0.56, 1.26); P = .391 | 0.86 (0.57, 1.29); P = .458 | 0.87 (0.58, 1.32); P = .514 | 0.88 (0.57, 1.36); P = .572 |
| 2nd | 39 (28.9) | 489.4 | 80 | 0.76 (0.5, 1.15); P = .188 | 0.74 (0.49, 1.13); P = .161 | 0.85 (0.56, 1.29); P = .451 | 0.86 (0.57, 1.31); P = .485 | 0.9 (0.59, 1.39); P = .640 |
| 3rd | 40 (36.0) | 386.1 | 104 | 1.00 (Reference) | 1.00 (Reference) | 1.00 (Reference) | 1.00 (Reference) | 1.00 (Reference) |
| 4th | 38 (37.3) | 355.7 | 107 | 1.05 (0.71, 1.55); P = .819 | 1.05 (0.71, 1.57); P = .791 | 0.92 (0.61, 1.39); P = .687 | 0.89 (0.59, 1.36); P = .601 | 0.92 (0.61, 1.38); P = .685 |
| Q SBCa . | Events, N (%) . | Person time, years . | Events for 1000 person-years . | Unadjusted, HR (95% CI) . | Sex, age, HR (95% CI)b . | BMI, albumin, SGA, HR (95% CI)b . | eGFR, K+, HR (95% CI)b . | Comorbidities, primary renal disease, HR (95% CI)b . |
|---|---|---|---|---|---|---|---|---|
| 1st | 60 (39.0) | 474.0 | 127 | 0.82 (0.54, 1.23); P = .336 | 0.84 (0.56, 1.26); P = .391 | 0.86 (0.57, 1.29); P = .458 | 0.87 (0.58, 1.32); P = .514 | 0.88 (0.57, 1.36); P = .572 |
| 2nd | 39 (28.9) | 489.4 | 80 | 0.76 (0.5, 1.15); P = .188 | 0.74 (0.49, 1.13); P = .161 | 0.85 (0.56, 1.29); P = .451 | 0.86 (0.57, 1.31); P = .485 | 0.9 (0.59, 1.39); P = .640 |
| 3rd | 40 (36.0) | 386.1 | 104 | 1.00 (Reference) | 1.00 (Reference) | 1.00 (Reference) | 1.00 (Reference) | 1.00 (Reference) |
| 4th | 38 (37.3) | 355.7 | 107 | 1.05 (0.71, 1.55); P = .819 | 1.05 (0.71, 1.57); P = .791 | 0.92 (0.61, 1.39); P = .687 | 0.89 (0.59, 1.36); P = .601 | 0.92 (0.61, 1.38); P = .685 |
Time-dependent Cox regression model; overall study population N = 502.
aQuartiles of serum bicarbonate; SBC, BMI, albumin, SGA, K+ and eGFR treated as time-varying covariates.
bHR and 95% CI adjusted sequentially for confounders (sex, age, BMI, SGA, eGFR, K+, comorbidities, primary renal disease).
Relationship between longitudinal bicarbonate levels and all-cause mortality in the transition-CKD population.
| Q SBCa . | Events, N (%) . | Person time, years . | Events for 1000 person-years . | Unadjusted, HR (95% CI) . | Sex, age, HR (95% CI)b . | BMI, albumin, SGA, HR (95% CI)b . | eGFR, K+, HR (95% CI)b . | Comorbidities, primary renal disease, HR (95% CI)b . |
|---|---|---|---|---|---|---|---|---|
| 1st | 60 (39.0) | 474.0 | 127 | 0.82 (0.54, 1.23); P = .336 | 0.84 (0.56, 1.26); P = .391 | 0.86 (0.57, 1.29); P = .458 | 0.87 (0.58, 1.32); P = .514 | 0.88 (0.57, 1.36); P = .572 |
| 2nd | 39 (28.9) | 489.4 | 80 | 0.76 (0.5, 1.15); P = .188 | 0.74 (0.49, 1.13); P = .161 | 0.85 (0.56, 1.29); P = .451 | 0.86 (0.57, 1.31); P = .485 | 0.9 (0.59, 1.39); P = .640 |
| 3rd | 40 (36.0) | 386.1 | 104 | 1.00 (Reference) | 1.00 (Reference) | 1.00 (Reference) | 1.00 (Reference) | 1.00 (Reference) |
| 4th | 38 (37.3) | 355.7 | 107 | 1.05 (0.71, 1.55); P = .819 | 1.05 (0.71, 1.57); P = .791 | 0.92 (0.61, 1.39); P = .687 | 0.89 (0.59, 1.36); P = .601 | 0.92 (0.61, 1.38); P = .685 |
| Q SBCa . | Events, N (%) . | Person time, years . | Events for 1000 person-years . | Unadjusted, HR (95% CI) . | Sex, age, HR (95% CI)b . | BMI, albumin, SGA, HR (95% CI)b . | eGFR, K+, HR (95% CI)b . | Comorbidities, primary renal disease, HR (95% CI)b . |
|---|---|---|---|---|---|---|---|---|
| 1st | 60 (39.0) | 474.0 | 127 | 0.82 (0.54, 1.23); P = .336 | 0.84 (0.56, 1.26); P = .391 | 0.86 (0.57, 1.29); P = .458 | 0.87 (0.58, 1.32); P = .514 | 0.88 (0.57, 1.36); P = .572 |
| 2nd | 39 (28.9) | 489.4 | 80 | 0.76 (0.5, 1.15); P = .188 | 0.74 (0.49, 1.13); P = .161 | 0.85 (0.56, 1.29); P = .451 | 0.86 (0.57, 1.31); P = .485 | 0.9 (0.59, 1.39); P = .640 |
| 3rd | 40 (36.0) | 386.1 | 104 | 1.00 (Reference) | 1.00 (Reference) | 1.00 (Reference) | 1.00 (Reference) | 1.00 (Reference) |
| 4th | 38 (37.3) | 355.7 | 107 | 1.05 (0.71, 1.55); P = .819 | 1.05 (0.71, 1.57); P = .791 | 0.92 (0.61, 1.39); P = .687 | 0.89 (0.59, 1.36); P = .601 | 0.92 (0.61, 1.38); P = .685 |
Time-dependent Cox regression model; overall study population N = 502.
aQuartiles of serum bicarbonate; SBC, BMI, albumin, SGA, K+ and eGFR treated as time-varying covariates.
bHR and 95% CI adjusted sequentially for confounders (sex, age, BMI, SGA, eGFR, K+, comorbidities, primary renal disease).
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