Relationship between longitudinal bicarbonate levels and all-cause mortality censoring at KRT initiation (pre-KRT population).
| Q SBCa . | Events, N (%), . | Person time, years . | Events for 1000 person-years . | Unadjusted, HR (95% CI) . | Sex, age, HR (95% CI)b . | BMI, albumin, SGA, HR (95% CI)b . | eGFR, K+, HR (95% CI)b . | Comorbidities, primary renal disease, HR (95% CI)b . |
|---|---|---|---|---|---|---|---|---|
| 1st | 82 (22.8) | 683.4 | 120 | 1.52 (1.11, 2.06); P = .008 | 1.58 (1.16, 2.16); P = .004 | 1.46 (1.06, 2); P = .019 | 1.46 (1.06, 2.02); P = .022 | 1.51 (1.07, 2.11); P = .018 |
| 2nd | 70 (20.3) | 764.7 | 92 | 1.16 (0.85, 1.59); P = .346 | 1.16 (0.84, 1.59); P = .368 | 1.17 (0.85, 1.61); P = .328 | 1.17 (0.85, 1.61); P = .336 | 1.18 (0.85, 1.63); P = .334 |
| 3rd | 88 (22.9) | 853.5 | 103 | 1.00 (Reference) | 1.00 (Reference) | 1.00 (Reference) | 1.00 (Reference) | 1.00 (Reference) |
| 4th | 105 (28.5) | 823.6 | 127 | 1.35 (1, 1.82); P = .051 | 1.31 (0.97, 1.77); P = .081 | 1.22 (0.89, 1.66); P = .214 | 1.22 (0.89, 1.67); P = .222 | 1.19 (0.87, 1.63); P = .284 |
| Q SBCa . | Events, N (%), . | Person time, years . | Events for 1000 person-years . | Unadjusted, HR (95% CI) . | Sex, age, HR (95% CI)b . | BMI, albumin, SGA, HR (95% CI)b . | eGFR, K+, HR (95% CI)b . | Comorbidities, primary renal disease, HR (95% CI)b . |
|---|---|---|---|---|---|---|---|---|
| 1st | 82 (22.8) | 683.4 | 120 | 1.52 (1.11, 2.06); P = .008 | 1.58 (1.16, 2.16); P = .004 | 1.46 (1.06, 2); P = .019 | 1.46 (1.06, 2.02); P = .022 | 1.51 (1.07, 2.11); P = .018 |
| 2nd | 70 (20.3) | 764.7 | 92 | 1.16 (0.85, 1.59); P = .346 | 1.16 (0.84, 1.59); P = .368 | 1.17 (0.85, 1.61); P = .328 | 1.17 (0.85, 1.61); P = .336 | 1.18 (0.85, 1.63); P = .334 |
| 3rd | 88 (22.9) | 853.5 | 103 | 1.00 (Reference) | 1.00 (Reference) | 1.00 (Reference) | 1.00 (Reference) | 1.00 (Reference) |
| 4th | 105 (28.5) | 823.6 | 127 | 1.35 (1, 1.82); P = .051 | 1.31 (0.97, 1.77); P = .081 | 1.22 (0.89, 1.66); P = .214 | 1.22 (0.89, 1.67); P = .222 | 1.19 (0.87, 1.63); P = .284 |
Time-dependent Cox regression model; overall study population N = 1457.
aQuartiles of serum bicarbonate; SBC, BMI, albumin, SGA, K+ and eGFR treated as time-varying covariates.
bHR and 95% CI adjusted sequentially for confounders (sex, age, BMI, SGA, eGFR, K+, comorbidities, primary renal disease).
Relationship between longitudinal bicarbonate levels and all-cause mortality censoring at KRT initiation (pre-KRT population).
| Q SBCa . | Events, N (%), . | Person time, years . | Events for 1000 person-years . | Unadjusted, HR (95% CI) . | Sex, age, HR (95% CI)b . | BMI, albumin, SGA, HR (95% CI)b . | eGFR, K+, HR (95% CI)b . | Comorbidities, primary renal disease, HR (95% CI)b . |
|---|---|---|---|---|---|---|---|---|
| 1st | 82 (22.8) | 683.4 | 120 | 1.52 (1.11, 2.06); P = .008 | 1.58 (1.16, 2.16); P = .004 | 1.46 (1.06, 2); P = .019 | 1.46 (1.06, 2.02); P = .022 | 1.51 (1.07, 2.11); P = .018 |
| 2nd | 70 (20.3) | 764.7 | 92 | 1.16 (0.85, 1.59); P = .346 | 1.16 (0.84, 1.59); P = .368 | 1.17 (0.85, 1.61); P = .328 | 1.17 (0.85, 1.61); P = .336 | 1.18 (0.85, 1.63); P = .334 |
| 3rd | 88 (22.9) | 853.5 | 103 | 1.00 (Reference) | 1.00 (Reference) | 1.00 (Reference) | 1.00 (Reference) | 1.00 (Reference) |
| 4th | 105 (28.5) | 823.6 | 127 | 1.35 (1, 1.82); P = .051 | 1.31 (0.97, 1.77); P = .081 | 1.22 (0.89, 1.66); P = .214 | 1.22 (0.89, 1.67); P = .222 | 1.19 (0.87, 1.63); P = .284 |
| Q SBCa . | Events, N (%), . | Person time, years . | Events for 1000 person-years . | Unadjusted, HR (95% CI) . | Sex, age, HR (95% CI)b . | BMI, albumin, SGA, HR (95% CI)b . | eGFR, K+, HR (95% CI)b . | Comorbidities, primary renal disease, HR (95% CI)b . |
|---|---|---|---|---|---|---|---|---|
| 1st | 82 (22.8) | 683.4 | 120 | 1.52 (1.11, 2.06); P = .008 | 1.58 (1.16, 2.16); P = .004 | 1.46 (1.06, 2); P = .019 | 1.46 (1.06, 2.02); P = .022 | 1.51 (1.07, 2.11); P = .018 |
| 2nd | 70 (20.3) | 764.7 | 92 | 1.16 (0.85, 1.59); P = .346 | 1.16 (0.84, 1.59); P = .368 | 1.17 (0.85, 1.61); P = .328 | 1.17 (0.85, 1.61); P = .336 | 1.18 (0.85, 1.63); P = .334 |
| 3rd | 88 (22.9) | 853.5 | 103 | 1.00 (Reference) | 1.00 (Reference) | 1.00 (Reference) | 1.00 (Reference) | 1.00 (Reference) |
| 4th | 105 (28.5) | 823.6 | 127 | 1.35 (1, 1.82); P = .051 | 1.31 (0.97, 1.77); P = .081 | 1.22 (0.89, 1.66); P = .214 | 1.22 (0.89, 1.67); P = .222 | 1.19 (0.87, 1.63); P = .284 |
Time-dependent Cox regression model; overall study population N = 1457.
aQuartiles of serum bicarbonate; SBC, BMI, albumin, SGA, K+ and eGFR treated as time-varying covariates.
bHR and 95% CI adjusted sequentially for confounders (sex, age, BMI, SGA, eGFR, K+, comorbidities, primary renal disease).
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