Relationship between longitudinal bicarbonate levels and all-cause mortality in the whole cohort (whole population).
| Q SBCa . | Events, N (%) . | Person time, years . | Events for 1000 person-years . | Unadjusted, HR (95% CI) . | Sex, age, HR (95% CI)b . | BMI, albumin, SGA, HR (95% CI)b . | eGFR, K+, HR (95% CI)b . | Comorbidities, primary renal disease, HR (95% CI)b . |
|---|---|---|---|---|---|---|---|---|
| 1st | 146 (39.4) | 989.7 | 148 | 1.23 (0.97, 1.57); P = .093 | 1.27 (1, 1.62); P = .055 | 1.2 (0.94, 1.54); P = .141 | 1.22 (0.95, 1.57); P = .124 | 1.21 (0.93, 1.58); P = .158 |
| 2nd | 110 (31.4) | 1042.3 | 106 | 1 (0.78, 1.28); P = .970 | 0.99 (0.77, 1.27); P = .911 | 1.03 (0.8, 1.33); P = .806 | 1.04 (0.81, 1.33); P = .779 | 1.04 (0.81, 1.35); P = .751 |
| 3rd | 129 (33.0) | 1074.8 | 120 | 1.00 (Reference) | 1.00 (Reference) | 1.00 (Reference) | 1.00 (Reference) | 1.00 (Reference) |
| 4th | 144 (38.6) | 1030.0 | 140 | 1.17 (0.93, 1.49); P = .178 | 1.16 (0.91, 1.47); P = .225 | 1.1 (0.86, 1.4); P = .466 | 1.09 (0.85, 1.39); P = .507 | 1.08 (0.85, 1.39); P = .517 |
| Q SBCa . | Events, N (%) . | Person time, years . | Events for 1000 person-years . | Unadjusted, HR (95% CI) . | Sex, age, HR (95% CI)b . | BMI, albumin, SGA, HR (95% CI)b . | eGFR, K+, HR (95% CI)b . | Comorbidities, primary renal disease, HR (95% CI)b . |
|---|---|---|---|---|---|---|---|---|
| 1st | 146 (39.4) | 989.7 | 148 | 1.23 (0.97, 1.57); P = .093 | 1.27 (1, 1.62); P = .055 | 1.2 (0.94, 1.54); P = .141 | 1.22 (0.95, 1.57); P = .124 | 1.21 (0.93, 1.58); P = .158 |
| 2nd | 110 (31.4) | 1042.3 | 106 | 1 (0.78, 1.28); P = .970 | 0.99 (0.77, 1.27); P = .911 | 1.03 (0.8, 1.33); P = .806 | 1.04 (0.81, 1.33); P = .779 | 1.04 (0.81, 1.35); P = .751 |
| 3rd | 129 (33.0) | 1074.8 | 120 | 1.00 (Reference) | 1.00 (Reference) | 1.00 (Reference) | 1.00 (Reference) | 1.00 (Reference) |
| 4th | 144 (38.6) | 1030.0 | 140 | 1.17 (0.93, 1.49); P = .178 | 1.16 (0.91, 1.47); P = .225 | 1.1 (0.86, 1.4); P = .466 | 1.09 (0.85, 1.39); P = .507 | 1.08 (0.85, 1.39); P = .517 |
Time-dependent Cox regression model; overall study population N = 1485.
aQuartiles of serum bicarbonate; SBC, BMI, albumin, SGA, K+ and eGFR treated as time-varying covariates.
bHR and 95% CI adjusted sequentially for confounders (sex, age, BMI, SGA, eGFR, K+, comorbidities, primary renal disease).
Relationship between longitudinal bicarbonate levels and all-cause mortality in the whole cohort (whole population).
| Q SBCa . | Events, N (%) . | Person time, years . | Events for 1000 person-years . | Unadjusted, HR (95% CI) . | Sex, age, HR (95% CI)b . | BMI, albumin, SGA, HR (95% CI)b . | eGFR, K+, HR (95% CI)b . | Comorbidities, primary renal disease, HR (95% CI)b . |
|---|---|---|---|---|---|---|---|---|
| 1st | 146 (39.4) | 989.7 | 148 | 1.23 (0.97, 1.57); P = .093 | 1.27 (1, 1.62); P = .055 | 1.2 (0.94, 1.54); P = .141 | 1.22 (0.95, 1.57); P = .124 | 1.21 (0.93, 1.58); P = .158 |
| 2nd | 110 (31.4) | 1042.3 | 106 | 1 (0.78, 1.28); P = .970 | 0.99 (0.77, 1.27); P = .911 | 1.03 (0.8, 1.33); P = .806 | 1.04 (0.81, 1.33); P = .779 | 1.04 (0.81, 1.35); P = .751 |
| 3rd | 129 (33.0) | 1074.8 | 120 | 1.00 (Reference) | 1.00 (Reference) | 1.00 (Reference) | 1.00 (Reference) | 1.00 (Reference) |
| 4th | 144 (38.6) | 1030.0 | 140 | 1.17 (0.93, 1.49); P = .178 | 1.16 (0.91, 1.47); P = .225 | 1.1 (0.86, 1.4); P = .466 | 1.09 (0.85, 1.39); P = .507 | 1.08 (0.85, 1.39); P = .517 |
| Q SBCa . | Events, N (%) . | Person time, years . | Events for 1000 person-years . | Unadjusted, HR (95% CI) . | Sex, age, HR (95% CI)b . | BMI, albumin, SGA, HR (95% CI)b . | eGFR, K+, HR (95% CI)b . | Comorbidities, primary renal disease, HR (95% CI)b . |
|---|---|---|---|---|---|---|---|---|
| 1st | 146 (39.4) | 989.7 | 148 | 1.23 (0.97, 1.57); P = .093 | 1.27 (1, 1.62); P = .055 | 1.2 (0.94, 1.54); P = .141 | 1.22 (0.95, 1.57); P = .124 | 1.21 (0.93, 1.58); P = .158 |
| 2nd | 110 (31.4) | 1042.3 | 106 | 1 (0.78, 1.28); P = .970 | 0.99 (0.77, 1.27); P = .911 | 1.03 (0.8, 1.33); P = .806 | 1.04 (0.81, 1.33); P = .779 | 1.04 (0.81, 1.35); P = .751 |
| 3rd | 129 (33.0) | 1074.8 | 120 | 1.00 (Reference) | 1.00 (Reference) | 1.00 (Reference) | 1.00 (Reference) | 1.00 (Reference) |
| 4th | 144 (38.6) | 1030.0 | 140 | 1.17 (0.93, 1.49); P = .178 | 1.16 (0.91, 1.47); P = .225 | 1.1 (0.86, 1.4); P = .466 | 1.09 (0.85, 1.39); P = .507 | 1.08 (0.85, 1.39); P = .517 |
Time-dependent Cox regression model; overall study population N = 1485.
aQuartiles of serum bicarbonate; SBC, BMI, albumin, SGA, K+ and eGFR treated as time-varying covariates.
bHR and 95% CI adjusted sequentially for confounders (sex, age, BMI, SGA, eGFR, K+, comorbidities, primary renal disease).
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