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Ki values and inhibition types of polyphenol oxidase with different inhibitors

I (M)Ki (M)Type of inhibition% InhibitionI50
Citric acid2.0 × 10−23.25 × 10−2Competitive352.63 × 10−2
2.5 × 10−21.20 × 10−252
3.0 × 10−38.60 × 10−368
Sodium metabisulphite3.3 × 10−56.67 × 10−5Non-competitive205.05 × 10−5
1.7 × 10−42.00 × 10−555
1.0 × 10−42.23 × 10−587
Potassium cyanide1.7 × 10−512.0 × 10−6Competitive332.8 × 10−5
3.3 × 10−59.00 × 10−652
6.7 × 10−58.46 × 10−663
Glutathione3.3 × 10−56.60 × 10−5Non-competitive257.4 × 10−5
6.7 × 10−54.76 × 10−545
1.0 × 10−43.23 × 10−562
Dithiotreitol1.3 × 10−57.70 × 10−6Non-competitive201.52 × 10−5
2.0 × 10−55.64 × 10−652
3.3 × 10−55.34 × 10−670
Sodium azide3.3 × 10−55.26 × 10−5Non-competitive219.47 × 10−5
6.7 × 10−54.50 × 10−544
1.0 × 10−44.10 × 10−564
Thiourea3.3 × 10−51.57 × 10−4Competitive166.97 × 10−5
6.7 × 10−57.71 × 10−548
1.0 × 10−47.00 × 10−469
Oxalic acid6.7 × 10−51.56 × 10−4Competitive141.62 × 10−4
1.3 × 10−41.29 × 10−440
2.0 × 10−41.18 × 10−471
Sodium thiosulphite1.7 × 10−53.20 × 10−5Competitive192.61 × 10−5
2.3 × 10−51.64 × 10−544
3.3 × 10−50.64 × 10−564
Tartaric acid6.7 × 10−31.60 × 10−2Non-competitive327.83 × 10−3
8.3 × 10−39.10 × 10−353
1.0 × 10−27.10 × 10−360
β-Mercaptoethanol3.3 × 10−65.36 × 10−6Non-competitive207.61 × 10−6
6.7 × 10−64.40 × 10−644
1.0 × 10−53.50 × 10−672
Ascorbic acid3.3 × 10−57.33 × 10−5Non-competitive255.10 × 10−5
5.0 × 10−54.24 × 10−549
6.7 × 10−52.94 × 10−564
EDTA3.3 × 10−45.40 × 10−4Competitive384.54 × 10−4
5.0 × 10−43.51 × 10−455
6.7 × 10−42.70 × 10−467
l-Cysteine3.3 × 10−56.8 × 10−5Competitive385.5 × 10−5
5.0 × 10−52.8 × 10−555
6.6 × 10−51.1 × 10−576
I (M)Ki (M)Type of inhibition% InhibitionI50
Citric acid2.0 × 10−23.25 × 10−2Competitive352.63 × 10−2
2.5 × 10−21.20 × 10−252
3.0 × 10−38.60 × 10−368
Sodium metabisulphite3.3 × 10−56.67 × 10−5Non-competitive205.05 × 10−5
1.7 × 10−42.00 × 10−555
1.0 × 10−42.23 × 10−587
Potassium cyanide1.7 × 10−512.0 × 10−6Competitive332.8 × 10−5
3.3 × 10−59.00 × 10−652
6.7 × 10−58.46 × 10−663
Glutathione3.3 × 10−56.60 × 10−5Non-competitive257.4 × 10−5
6.7 × 10−54.76 × 10−545
1.0 × 10−43.23 × 10−562
Dithiotreitol1.3 × 10−57.70 × 10−6Non-competitive201.52 × 10−5
2.0 × 10−55.64 × 10−652
3.3 × 10−55.34 × 10−670
Sodium azide3.3 × 10−55.26 × 10−5Non-competitive219.47 × 10−5
6.7 × 10−54.50 × 10−544
1.0 × 10−44.10 × 10−564
Thiourea3.3 × 10−51.57 × 10−4Competitive166.97 × 10−5
6.7 × 10−57.71 × 10−548
1.0 × 10−47.00 × 10−469
Oxalic acid6.7 × 10−51.56 × 10−4Competitive141.62 × 10−4
1.3 × 10−41.29 × 10−440
2.0 × 10−41.18 × 10−471
Sodium thiosulphite1.7 × 10−53.20 × 10−5Competitive192.61 × 10−5
2.3 × 10−51.64 × 10−544
3.3 × 10−50.64 × 10−564
Tartaric acid6.7 × 10−31.60 × 10−2Non-competitive327.83 × 10−3
8.3 × 10−39.10 × 10−353
1.0 × 10−27.10 × 10−360
β-Mercaptoethanol3.3 × 10−65.36 × 10−6Non-competitive207.61 × 10−6
6.7 × 10−64.40 × 10−644
1.0 × 10−53.50 × 10−672
Ascorbic acid3.3 × 10−57.33 × 10−5Non-competitive255.10 × 10−5
5.0 × 10−54.24 × 10−549
6.7 × 10−52.94 × 10−564
EDTA3.3 × 10−45.40 × 10−4Competitive384.54 × 10−4
5.0 × 10−43.51 × 10−455
6.7 × 10−42.70 × 10−467
l-Cysteine3.3 × 10−56.8 × 10−5Competitive385.5 × 10−5
5.0 × 10−52.8 × 10−555
6.6 × 10−51.1 × 10−576
3
Open in new tab

Ki values and inhibition types of polyphenol oxidase with different inhibitors

I (M)Ki (M)Type of inhibition% InhibitionI50
Citric acid2.0 × 10−23.25 × 10−2Competitive352.63 × 10−2
2.5 × 10−21.20 × 10−252
3.0 × 10−38.60 × 10−368
Sodium metabisulphite3.3 × 10−56.67 × 10−5Non-competitive205.05 × 10−5
1.7 × 10−42.00 × 10−555
1.0 × 10−42.23 × 10−587
Potassium cyanide1.7 × 10−512.0 × 10−6Competitive332.8 × 10−5
3.3 × 10−59.00 × 10−652
6.7 × 10−58.46 × 10−663
Glutathione3.3 × 10−56.60 × 10−5Non-competitive257.4 × 10−5
6.7 × 10−54.76 × 10−545
1.0 × 10−43.23 × 10−562
Dithiotreitol1.3 × 10−57.70 × 10−6Non-competitive201.52 × 10−5
2.0 × 10−55.64 × 10−652
3.3 × 10−55.34 × 10−670
Sodium azide3.3 × 10−55.26 × 10−5Non-competitive219.47 × 10−5
6.7 × 10−54.50 × 10−544
1.0 × 10−44.10 × 10−564
Thiourea3.3 × 10−51.57 × 10−4Competitive166.97 × 10−5
6.7 × 10−57.71 × 10−548
1.0 × 10−47.00 × 10−469
Oxalic acid6.7 × 10−51.56 × 10−4Competitive141.62 × 10−4
1.3 × 10−41.29 × 10−440
2.0 × 10−41.18 × 10−471
Sodium thiosulphite1.7 × 10−53.20 × 10−5Competitive192.61 × 10−5
2.3 × 10−51.64 × 10−544
3.3 × 10−50.64 × 10−564
Tartaric acid6.7 × 10−31.60 × 10−2Non-competitive327.83 × 10−3
8.3 × 10−39.10 × 10−353
1.0 × 10−27.10 × 10−360
β-Mercaptoethanol3.3 × 10−65.36 × 10−6Non-competitive207.61 × 10−6
6.7 × 10−64.40 × 10−644
1.0 × 10−53.50 × 10−672
Ascorbic acid3.3 × 10−57.33 × 10−5Non-competitive255.10 × 10−5
5.0 × 10−54.24 × 10−549
6.7 × 10−52.94 × 10−564
EDTA3.3 × 10−45.40 × 10−4Competitive384.54 × 10−4
5.0 × 10−43.51 × 10−455
6.7 × 10−42.70 × 10−467
l-Cysteine3.3 × 10−56.8 × 10−5Competitive385.5 × 10−5
5.0 × 10−52.8 × 10−555
6.6 × 10−51.1 × 10−576
I (M)Ki (M)Type of inhibition% InhibitionI50
Citric acid2.0 × 10−23.25 × 10−2Competitive352.63 × 10−2
2.5 × 10−21.20 × 10−252
3.0 × 10−38.60 × 10−368
Sodium metabisulphite3.3 × 10−56.67 × 10−5Non-competitive205.05 × 10−5
1.7 × 10−42.00 × 10−555
1.0 × 10−42.23 × 10−587
Potassium cyanide1.7 × 10−512.0 × 10−6Competitive332.8 × 10−5
3.3 × 10−59.00 × 10−652
6.7 × 10−58.46 × 10−663
Glutathione3.3 × 10−56.60 × 10−5Non-competitive257.4 × 10−5
6.7 × 10−54.76 × 10−545
1.0 × 10−43.23 × 10−562
Dithiotreitol1.3 × 10−57.70 × 10−6Non-competitive201.52 × 10−5
2.0 × 10−55.64 × 10−652
3.3 × 10−55.34 × 10−670
Sodium azide3.3 × 10−55.26 × 10−5Non-competitive219.47 × 10−5
6.7 × 10−54.50 × 10−544
1.0 × 10−44.10 × 10−564
Thiourea3.3 × 10−51.57 × 10−4Competitive166.97 × 10−5
6.7 × 10−57.71 × 10−548
1.0 × 10−47.00 × 10−469
Oxalic acid6.7 × 10−51.56 × 10−4Competitive141.62 × 10−4
1.3 × 10−41.29 × 10−440
2.0 × 10−41.18 × 10−471
Sodium thiosulphite1.7 × 10−53.20 × 10−5Competitive192.61 × 10−5
2.3 × 10−51.64 × 10−544
3.3 × 10−50.64 × 10−564
Tartaric acid6.7 × 10−31.60 × 10−2Non-competitive327.83 × 10−3
8.3 × 10−39.10 × 10−353
1.0 × 10−27.10 × 10−360
β-Mercaptoethanol3.3 × 10−65.36 × 10−6Non-competitive207.61 × 10−6
6.7 × 10−64.40 × 10−644
1.0 × 10−53.50 × 10−672
Ascorbic acid3.3 × 10−57.33 × 10−5Non-competitive255.10 × 10−5
5.0 × 10−54.24 × 10−549
6.7 × 10−52.94 × 10−564
EDTA3.3 × 10−45.40 × 10−4Competitive384.54 × 10−4
5.0 × 10−43.51 × 10−455
6.7 × 10−42.70 × 10−467
l-Cysteine3.3 × 10−56.8 × 10−5Competitive385.5 × 10−5
5.0 × 10−52.8 × 10−555
6.6 × 10−51.1 × 10−576
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