| All-cause mortality n = 601 . | LARS-DD (per 1 grade increase)a . | LARS-DD Grade 0/1 n = 169 . | LARS-DD Grade 2 n = 96 . | LARS-DD Grade 3 n = 336 . |
|---|---|---|---|---|
| Events/person-years | 52/643 | 37/331 | 169/1181 | |
| Incidence rate, per 1000 person-years (95% CI) | 80.88 (60.41–106.07) | 111.70 (78.65–153.96) | 143.16 (122.39–166.45) | |
| Unadjusted HR (95% CI) | 1.30 (1.12–1.52) | Reference | 1.39 (0.91–2.12) | 1.72 (1.26–2.35) |
| P-value for HR | 0.0006 | 0.13 | 0.0007 | |
| HR (95% CI) adjusted for age, sex, EuroSCORE II, eGFR, haemoglobin, NYHA Class III–IV symptoms (core model) | 1.29 (1.11–1.51) | Reference | 1.39 (0.91–2.12) | 1.69 (1.23–2.33) |
| P-value for adjusted HR | 0.001 | 0.13 | 0.001 | |
| HR (95% CI) further adjustment for LVEF, AFib, LAVI, and LV SVi (comprehensive model) | 1.28 (1.07–1.53) | Reference | 1.40 (0.91–2.14) | 1.65 (1.15–2.37) |
| P-value for adjusted HR | 0.007 | 0.13 | 0.007 |
| All-cause mortality n = 601 . | LARS-DD (per 1 grade increase)a . | LARS-DD Grade 0/1 n = 169 . | LARS-DD Grade 2 n = 96 . | LARS-DD Grade 3 n = 336 . |
|---|---|---|---|---|
| Events/person-years | 52/643 | 37/331 | 169/1181 | |
| Incidence rate, per 1000 person-years (95% CI) | 80.88 (60.41–106.07) | 111.70 (78.65–153.96) | 143.16 (122.39–166.45) | |
| Unadjusted HR (95% CI) | 1.30 (1.12–1.52) | Reference | 1.39 (0.91–2.12) | 1.72 (1.26–2.35) |
| P-value for HR | 0.0006 | 0.13 | 0.0007 | |
| HR (95% CI) adjusted for age, sex, EuroSCORE II, eGFR, haemoglobin, NYHA Class III–IV symptoms (core model) | 1.29 (1.11–1.51) | Reference | 1.39 (0.91–2.12) | 1.69 (1.23–2.33) |
| P-value for adjusted HR | 0.001 | 0.13 | 0.001 | |
| HR (95% CI) further adjustment for LVEF, AFib, LAVI, and LV SVi (comprehensive model) | 1.28 (1.07–1.53) | Reference | 1.40 (0.91–2.14) | 1.65 (1.15–2.37) |
| P-value for adjusted HR | 0.007 | 0.13 | 0.007 |
AFib, atrial fibrillation; eGFR, estimated glomerular filtration rate; HR, hazard ratio; LARS-DD, left atrial reservoir strain diastolic dysfunction; LAVI, left atrial volume indexed; LVEF, left ventricular ejection fraction; LV SVi, left ventricular stroke volume indexed; NYHA, New York Heart Association.
aPer one-grade increase above Grade 0/1.
| All-cause mortality n = 601 . | LARS-DD (per 1 grade increase)a . | LARS-DD Grade 0/1 n = 169 . | LARS-DD Grade 2 n = 96 . | LARS-DD Grade 3 n = 336 . |
|---|---|---|---|---|
| Events/person-years | 52/643 | 37/331 | 169/1181 | |
| Incidence rate, per 1000 person-years (95% CI) | 80.88 (60.41–106.07) | 111.70 (78.65–153.96) | 143.16 (122.39–166.45) | |
| Unadjusted HR (95% CI) | 1.30 (1.12–1.52) | Reference | 1.39 (0.91–2.12) | 1.72 (1.26–2.35) |
| P-value for HR | 0.0006 | 0.13 | 0.0007 | |
| HR (95% CI) adjusted for age, sex, EuroSCORE II, eGFR, haemoglobin, NYHA Class III–IV symptoms (core model) | 1.29 (1.11–1.51) | Reference | 1.39 (0.91–2.12) | 1.69 (1.23–2.33) |
| P-value for adjusted HR | 0.001 | 0.13 | 0.001 | |
| HR (95% CI) further adjustment for LVEF, AFib, LAVI, and LV SVi (comprehensive model) | 1.28 (1.07–1.53) | Reference | 1.40 (0.91–2.14) | 1.65 (1.15–2.37) |
| P-value for adjusted HR | 0.007 | 0.13 | 0.007 |
| All-cause mortality n = 601 . | LARS-DD (per 1 grade increase)a . | LARS-DD Grade 0/1 n = 169 . | LARS-DD Grade 2 n = 96 . | LARS-DD Grade 3 n = 336 . |
|---|---|---|---|---|
| Events/person-years | 52/643 | 37/331 | 169/1181 | |
| Incidence rate, per 1000 person-years (95% CI) | 80.88 (60.41–106.07) | 111.70 (78.65–153.96) | 143.16 (122.39–166.45) | |
| Unadjusted HR (95% CI) | 1.30 (1.12–1.52) | Reference | 1.39 (0.91–2.12) | 1.72 (1.26–2.35) |
| P-value for HR | 0.0006 | 0.13 | 0.0007 | |
| HR (95% CI) adjusted for age, sex, EuroSCORE II, eGFR, haemoglobin, NYHA Class III–IV symptoms (core model) | 1.29 (1.11–1.51) | Reference | 1.39 (0.91–2.12) | 1.69 (1.23–2.33) |
| P-value for adjusted HR | 0.001 | 0.13 | 0.001 | |
| HR (95% CI) further adjustment for LVEF, AFib, LAVI, and LV SVi (comprehensive model) | 1.28 (1.07–1.53) | Reference | 1.40 (0.91–2.14) | 1.65 (1.15–2.37) |
| P-value for adjusted HR | 0.007 | 0.13 | 0.007 |
AFib, atrial fibrillation; eGFR, estimated glomerular filtration rate; HR, hazard ratio; LARS-DD, left atrial reservoir strain diastolic dysfunction; LAVI, left atrial volume indexed; LVEF, left ventricular ejection fraction; LV SVi, left ventricular stroke volume indexed; NYHA, New York Heart Association.
aPer one-grade increase above Grade 0/1.
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