Meta-analysis results of the predictive performance results for the primary endpoint at 36 months for the three study groups in the Phase 2 analysis
| Model . | C-statistic (95% prediction interval) . | Observed:expected ratio (95% prediction interval) . |
|---|---|---|
| ICD patients | ||
| Model without CMR information: age, sex, and left ventricular ejection fraction as predictors | 0.51 (0.45, 0.58) | 1.10 (0.94, 1.29) |
| Model with CMR information: age, sex, left ventricular ejection fraction, core scar, and greyzone as predictors | 0.53 (0.46, 0.59) | 1.09 (0.93, 1.27) |
| Non-ICD patients ≤35% | ||
| Model without CMR information: age, sex, and left ventricular ejection fraction as predictors | 0.40 (0.31, 0.49) | 0.94 (0.76, 1.16) |
| Model with CMR information: age, sex, left ventricular ejection fraction, core scar, and greyzone as predictors | 0.54 (0.44, 0.63) | 0.91 (0.74, 1.12) |
| Non-ICD patients >35% | ||
| Model without CMR information: age, sex, and left ventricular ejection fraction as predictors | 0.52 (0.36, 0.67) | 0.37 (0.27, 0.50) |
| Model with CMR information: age, sex, left ventricular ejection fraction, core scar, and greyzone as predictors | 0.56 (0.42, 0.71) | 0.36 (0.27, 0.49) |
| Model . | C-statistic (95% prediction interval) . | Observed:expected ratio (95% prediction interval) . |
|---|---|---|
| ICD patients | ||
| Model without CMR information: age, sex, and left ventricular ejection fraction as predictors | 0.51 (0.45, 0.58) | 1.10 (0.94, 1.29) |
| Model with CMR information: age, sex, left ventricular ejection fraction, core scar, and greyzone as predictors | 0.53 (0.46, 0.59) | 1.09 (0.93, 1.27) |
| Non-ICD patients ≤35% | ||
| Model without CMR information: age, sex, and left ventricular ejection fraction as predictors | 0.40 (0.31, 0.49) | 0.94 (0.76, 1.16) |
| Model with CMR information: age, sex, left ventricular ejection fraction, core scar, and greyzone as predictors | 0.54 (0.44, 0.63) | 0.91 (0.74, 1.12) |
| Non-ICD patients >35% | ||
| Model without CMR information: age, sex, and left ventricular ejection fraction as predictors | 0.52 (0.36, 0.67) | 0.37 (0.27, 0.50) |
| Model with CMR information: age, sex, left ventricular ejection fraction, core scar, and greyzone as predictors | 0.56 (0.42, 0.71) | 0.36 (0.27, 0.49) |
All models are flexible parametric survival models. ICD patients, patients with left ventricular ejection fraction ≤ 35% who had received a cardioverter-defibrillator implantation for primary prevention of sudden cardiac death. Non-ICD patients ≤35%, patients who did not carry a cardioverter-defibrillator and had a left ventricular ejection fraction ≤ 35%. Non-ICD patients >35%, patients who did not carry a cardioverter-defibrillator and had a left ventricular ejection fraction > 35%.
CMR, cardiac magnetic resonance.
Meta-analysis results of the predictive performance results for the primary endpoint at 36 months for the three study groups in the Phase 2 analysis
| Model . | C-statistic (95% prediction interval) . | Observed:expected ratio (95% prediction interval) . |
|---|---|---|
| ICD patients | ||
| Model without CMR information: age, sex, and left ventricular ejection fraction as predictors | 0.51 (0.45, 0.58) | 1.10 (0.94, 1.29) |
| Model with CMR information: age, sex, left ventricular ejection fraction, core scar, and greyzone as predictors | 0.53 (0.46, 0.59) | 1.09 (0.93, 1.27) |
| Non-ICD patients ≤35% | ||
| Model without CMR information: age, sex, and left ventricular ejection fraction as predictors | 0.40 (0.31, 0.49) | 0.94 (0.76, 1.16) |
| Model with CMR information: age, sex, left ventricular ejection fraction, core scar, and greyzone as predictors | 0.54 (0.44, 0.63) | 0.91 (0.74, 1.12) |
| Non-ICD patients >35% | ||
| Model without CMR information: age, sex, and left ventricular ejection fraction as predictors | 0.52 (0.36, 0.67) | 0.37 (0.27, 0.50) |
| Model with CMR information: age, sex, left ventricular ejection fraction, core scar, and greyzone as predictors | 0.56 (0.42, 0.71) | 0.36 (0.27, 0.49) |
| Model . | C-statistic (95% prediction interval) . | Observed:expected ratio (95% prediction interval) . |
|---|---|---|
| ICD patients | ||
| Model without CMR information: age, sex, and left ventricular ejection fraction as predictors | 0.51 (0.45, 0.58) | 1.10 (0.94, 1.29) |
| Model with CMR information: age, sex, left ventricular ejection fraction, core scar, and greyzone as predictors | 0.53 (0.46, 0.59) | 1.09 (0.93, 1.27) |
| Non-ICD patients ≤35% | ||
| Model without CMR information: age, sex, and left ventricular ejection fraction as predictors | 0.40 (0.31, 0.49) | 0.94 (0.76, 1.16) |
| Model with CMR information: age, sex, left ventricular ejection fraction, core scar, and greyzone as predictors | 0.54 (0.44, 0.63) | 0.91 (0.74, 1.12) |
| Non-ICD patients >35% | ||
| Model without CMR information: age, sex, and left ventricular ejection fraction as predictors | 0.52 (0.36, 0.67) | 0.37 (0.27, 0.50) |
| Model with CMR information: age, sex, left ventricular ejection fraction, core scar, and greyzone as predictors | 0.56 (0.42, 0.71) | 0.36 (0.27, 0.49) |
All models are flexible parametric survival models. ICD patients, patients with left ventricular ejection fraction ≤ 35% who had received a cardioverter-defibrillator implantation for primary prevention of sudden cardiac death. Non-ICD patients ≤35%, patients who did not carry a cardioverter-defibrillator and had a left ventricular ejection fraction ≤ 35%. Non-ICD patients >35%, patients who did not carry a cardioverter-defibrillator and had a left ventricular ejection fraction > 35%.
CMR, cardiac magnetic resonance.
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