Optical coherence tomography findings associated with target lesion failure (unadjusted)
| . | Event rate . | Hazard ratio (95% CI) . | P-value . |
|---|---|---|---|
| Minimal stent area, mm2 | |||
| <5.24 (median) | 81/1063 (7.6) | Reference | |
| ≥5.24 | 49/1065 (4.6) | 0.59 (0.42–0.85) | .004 |
| Minimal stent expansion, % | |||
| <79.1 (median) | 78/1063 (7.3) | Reference | |
| ≥79.1 | 52/1065 (4.9) | 0.65 (0.46–0.93) | .02 |
| Intra-stent flow area, mm2 | |||
| <5.14 (median) | 82/1061 (7.7) | Reference | |
| ≥5.14 | 48/1067 (4.5) | 0.57 (0.40–0.81) | .002 |
| Total flow area, mm2 | |||
| <5.23 (median) | 82/1058 (7.8) | Reference | |
| ≥5.23 | 48/1070 (4.5) | 0.57 (0.40–0.81) | .002 |
| Stent length, mm | |||
| <33.4 (median) | 58/1056 (5.5) | Reference | |
| ≥33.4 | 72/1072 (6.7) | 1.24 (0.88–1.76) | .22 |
| Plaque or thrombus protrusion | |||
| None | 63/1034 (6.1) | Reference | |
| Any | 67/1094 (6.1) | 1.00 (0.71–1.41) | 1.00 |
| Major | 11/147 (7.5) | 1.22 (0.64–2.31) | .55 |
| Minor | 56/947 (5.9) | 0.97 (0.67–1.39) | .85 |
| Mal-apposition | |||
| None | 48/766 (6.3) | Reference | |
| Any | 82/1362 (6.0) | 0.96 (0.67–1.37) | .83 |
| Major | 38/549 (6.9) | 1.11 (0.73–1.70) | .62 |
| Minor | 44/812 (5.4) | 0.86 (0.57–1.30) | .48 |
| Stent deformation or fracture | |||
| None | 128/2107 (6.1) | Reference | |
| Any | 2/21 (9.5) | 1.50 (0.37–6.07) | .57 |
| Proximal or distal reference disease | |||
| None | 91/1608 (5.7) | Reference | |
| Any | 39/513 (7.6) | 1.36 (0.93–1.98) | .11 |
| Focal | 24/326 (7.4) | 1.31 (0.84–2.06) | .23 |
| Diffuse | 18/210 (8.6) | 1.54 (0.93–2.55) | .10 |
| Proximal reference disease | |||
| None | 87/1674 (5.2) | Reference | |
| Any | 19/230 (8.3) | 1.63 (0.99–2.68) | .053 |
| Focal | 14/170 (8.2) | 1.62 (0.92–2.85) | .09 |
| Diffuse | 5/60 (8.3) | 1.66 (0.67–4.09) | .27 |
| Distal reference disease | |||
| None | 100/1746 (5.7) | Reference | |
| Any | 26/343 (7.6) | 1.34 (0.87–2.06) | .19 |
| Focal | 11/177 (6.2) | 1.09 (0.58–2.03) | .79 |
| Diffuse | 15/166 (9.0) | 1.60 (0.93–2.76) | .09 |
| Proximal or distal reference lipidic plaque | |||
| None | 114/1767 (6.5) | Reference | |
| Any | 16/355 (4.5) | 0.69 (0.41–1.17) | .17 |
| Proximal reference lipidic plaque | |||
| None | 100/1683 (5.9) | Reference | |
| Any | 9/238 (3.8) | 0.63 (0.32–1.25) | .19 |
| Distal reference lipidic plaque | |||
| None | 119/1950 (6.1) | Reference | |
| Any | 7/144 (4.9) | 0.79 (0.37–1.70) | .55 |
| Proximal or distal reference dissection | |||
| None | 81/1430 (5.7) | Reference | |
| Any | 49/695 (7.1) | 1.26 (0.88–1.79) | .21 |
| Major | 4/66 (6.1) | 1.06 (0.39–2.89) | .91 |
| Minor | 45/629 (7.2) | 1.28 (0.89–1.84) | .19 |
| Intimal | 17/264 (6.4) | 1.15 (0.68–1.94) | .60 |
| Medial | 36/460 (7.8) | 1.40 (0.94–2.07) | .10 |
| Haematoma | 7/71 (9.9) | 1.75 (0.81–3.79) | .16 |
| No haematoma | 30/398 (7.5) | 1.35 (0.89–2.05) | .16 |
| Adventitial | 0/3 (0.0) | Not applicable | .98 |
| Proximal reference dissection, any | |||
| None | 79/1579 (5.0) | Reference | |
| Any | 37/418 (8.9) | 1.80 (1.22–2.66) | .003 |
| Major | 3/34 (8.8) | 1.81 (0.57–5.72) | .32 |
| Minor | 34/384 (8.9) | 1.80 (1.21–2.69) | .004 |
| Intimal | 16/188 (8.5) | 1.74 (1.02–2.97) | .04 |
| Medial | 21/229 (9.2) | 1.86 (1.15–3.01) | .01 |
| Haematoma | 3/25 (12.0) | 2.43 (0.77–7.68) | .13 |
| No haematoma | 18/204 (8.8) | 1.79 (1.08–2.99) | .03 |
| Adventitial | 0/1 (0.0) | Not applicable | .99 |
| Distal reference dissection | |||
| None | 107/1738 (6.2) | Reference | |
| Any | 19/371 (5.1) | 0.84 (0.51–1.36) | .47 |
| Major | 1/32 (3.1) | 0.49 (0.07–3.48) | .47 |
| Minor | 18/339 (5.3) | 0.87 (0.53–1.43) | .58 |
| Intimal | 1/89 (1.1) | 0.18 (0.03–1.29) | .09 |
| Medial | 18/280 (6.4) | 1.05 (0.64–1.74) | .84 |
| Haematoma | 4/46 (8.7) | 1.42 (0.52–3.85) | .49 |
| No haematoma | 14/234 (6.0) | 0.98 (0.56–1.71) | .95 |
| Adventitial | 0/2 (0.0) | Not applicable | .98 |
| . | Event rate . | Hazard ratio (95% CI) . | P-value . |
|---|---|---|---|
| Minimal stent area, mm2 | |||
| <5.24 (median) | 81/1063 (7.6) | Reference | |
| ≥5.24 | 49/1065 (4.6) | 0.59 (0.42–0.85) | .004 |
| Minimal stent expansion, % | |||
| <79.1 (median) | 78/1063 (7.3) | Reference | |
| ≥79.1 | 52/1065 (4.9) | 0.65 (0.46–0.93) | .02 |
| Intra-stent flow area, mm2 | |||
| <5.14 (median) | 82/1061 (7.7) | Reference | |
| ≥5.14 | 48/1067 (4.5) | 0.57 (0.40–0.81) | .002 |
| Total flow area, mm2 | |||
| <5.23 (median) | 82/1058 (7.8) | Reference | |
| ≥5.23 | 48/1070 (4.5) | 0.57 (0.40–0.81) | .002 |
| Stent length, mm | |||
| <33.4 (median) | 58/1056 (5.5) | Reference | |
| ≥33.4 | 72/1072 (6.7) | 1.24 (0.88–1.76) | .22 |
| Plaque or thrombus protrusion | |||
| None | 63/1034 (6.1) | Reference | |
| Any | 67/1094 (6.1) | 1.00 (0.71–1.41) | 1.00 |
| Major | 11/147 (7.5) | 1.22 (0.64–2.31) | .55 |
| Minor | 56/947 (5.9) | 0.97 (0.67–1.39) | .85 |
| Mal-apposition | |||
| None | 48/766 (6.3) | Reference | |
| Any | 82/1362 (6.0) | 0.96 (0.67–1.37) | .83 |
| Major | 38/549 (6.9) | 1.11 (0.73–1.70) | .62 |
| Minor | 44/812 (5.4) | 0.86 (0.57–1.30) | .48 |
| Stent deformation or fracture | |||
| None | 128/2107 (6.1) | Reference | |
| Any | 2/21 (9.5) | 1.50 (0.37–6.07) | .57 |
| Proximal or distal reference disease | |||
| None | 91/1608 (5.7) | Reference | |
| Any | 39/513 (7.6) | 1.36 (0.93–1.98) | .11 |
| Focal | 24/326 (7.4) | 1.31 (0.84–2.06) | .23 |
| Diffuse | 18/210 (8.6) | 1.54 (0.93–2.55) | .10 |
| Proximal reference disease | |||
| None | 87/1674 (5.2) | Reference | |
| Any | 19/230 (8.3) | 1.63 (0.99–2.68) | .053 |
| Focal | 14/170 (8.2) | 1.62 (0.92–2.85) | .09 |
| Diffuse | 5/60 (8.3) | 1.66 (0.67–4.09) | .27 |
| Distal reference disease | |||
| None | 100/1746 (5.7) | Reference | |
| Any | 26/343 (7.6) | 1.34 (0.87–2.06) | .19 |
| Focal | 11/177 (6.2) | 1.09 (0.58–2.03) | .79 |
| Diffuse | 15/166 (9.0) | 1.60 (0.93–2.76) | .09 |
| Proximal or distal reference lipidic plaque | |||
| None | 114/1767 (6.5) | Reference | |
| Any | 16/355 (4.5) | 0.69 (0.41–1.17) | .17 |
| Proximal reference lipidic plaque | |||
| None | 100/1683 (5.9) | Reference | |
| Any | 9/238 (3.8) | 0.63 (0.32–1.25) | .19 |
| Distal reference lipidic plaque | |||
| None | 119/1950 (6.1) | Reference | |
| Any | 7/144 (4.9) | 0.79 (0.37–1.70) | .55 |
| Proximal or distal reference dissection | |||
| None | 81/1430 (5.7) | Reference | |
| Any | 49/695 (7.1) | 1.26 (0.88–1.79) | .21 |
| Major | 4/66 (6.1) | 1.06 (0.39–2.89) | .91 |
| Minor | 45/629 (7.2) | 1.28 (0.89–1.84) | .19 |
| Intimal | 17/264 (6.4) | 1.15 (0.68–1.94) | .60 |
| Medial | 36/460 (7.8) | 1.40 (0.94–2.07) | .10 |
| Haematoma | 7/71 (9.9) | 1.75 (0.81–3.79) | .16 |
| No haematoma | 30/398 (7.5) | 1.35 (0.89–2.05) | .16 |
| Adventitial | 0/3 (0.0) | Not applicable | .98 |
| Proximal reference dissection, any | |||
| None | 79/1579 (5.0) | Reference | |
| Any | 37/418 (8.9) | 1.80 (1.22–2.66) | .003 |
| Major | 3/34 (8.8) | 1.81 (0.57–5.72) | .32 |
| Minor | 34/384 (8.9) | 1.80 (1.21–2.69) | .004 |
| Intimal | 16/188 (8.5) | 1.74 (1.02–2.97) | .04 |
| Medial | 21/229 (9.2) | 1.86 (1.15–3.01) | .01 |
| Haematoma | 3/25 (12.0) | 2.43 (0.77–7.68) | .13 |
| No haematoma | 18/204 (8.8) | 1.79 (1.08–2.99) | .03 |
| Adventitial | 0/1 (0.0) | Not applicable | .99 |
| Distal reference dissection | |||
| None | 107/1738 (6.2) | Reference | |
| Any | 19/371 (5.1) | 0.84 (0.51–1.36) | .47 |
| Major | 1/32 (3.1) | 0.49 (0.07–3.48) | .47 |
| Minor | 18/339 (5.3) | 0.87 (0.53–1.43) | .58 |
| Intimal | 1/89 (1.1) | 0.18 (0.03–1.29) | .09 |
| Medial | 18/280 (6.4) | 1.05 (0.64–1.74) | .84 |
| Haematoma | 4/46 (8.7) | 1.42 (0.52–3.85) | .49 |
| No haematoma | 14/234 (6.0) | 0.98 (0.56–1.71) | .95 |
| Adventitial | 0/2 (0.0) | Not applicable | .98 |
All subcategories are compared with the reference. Outcomes are presented as number of events during 2-year follow-up/number of the patients at risk on Day 0 (Kaplan–Meier estimated event rates).
CI, confidence interval; OCT, optical coherence tomography.
Optical coherence tomography findings associated with target lesion failure (unadjusted)
| . | Event rate . | Hazard ratio (95% CI) . | P-value . |
|---|---|---|---|
| Minimal stent area, mm2 | |||
| <5.24 (median) | 81/1063 (7.6) | Reference | |
| ≥5.24 | 49/1065 (4.6) | 0.59 (0.42–0.85) | .004 |
| Minimal stent expansion, % | |||
| <79.1 (median) | 78/1063 (7.3) | Reference | |
| ≥79.1 | 52/1065 (4.9) | 0.65 (0.46–0.93) | .02 |
| Intra-stent flow area, mm2 | |||
| <5.14 (median) | 82/1061 (7.7) | Reference | |
| ≥5.14 | 48/1067 (4.5) | 0.57 (0.40–0.81) | .002 |
| Total flow area, mm2 | |||
| <5.23 (median) | 82/1058 (7.8) | Reference | |
| ≥5.23 | 48/1070 (4.5) | 0.57 (0.40–0.81) | .002 |
| Stent length, mm | |||
| <33.4 (median) | 58/1056 (5.5) | Reference | |
| ≥33.4 | 72/1072 (6.7) | 1.24 (0.88–1.76) | .22 |
| Plaque or thrombus protrusion | |||
| None | 63/1034 (6.1) | Reference | |
| Any | 67/1094 (6.1) | 1.00 (0.71–1.41) | 1.00 |
| Major | 11/147 (7.5) | 1.22 (0.64–2.31) | .55 |
| Minor | 56/947 (5.9) | 0.97 (0.67–1.39) | .85 |
| Mal-apposition | |||
| None | 48/766 (6.3) | Reference | |
| Any | 82/1362 (6.0) | 0.96 (0.67–1.37) | .83 |
| Major | 38/549 (6.9) | 1.11 (0.73–1.70) | .62 |
| Minor | 44/812 (5.4) | 0.86 (0.57–1.30) | .48 |
| Stent deformation or fracture | |||
| None | 128/2107 (6.1) | Reference | |
| Any | 2/21 (9.5) | 1.50 (0.37–6.07) | .57 |
| Proximal or distal reference disease | |||
| None | 91/1608 (5.7) | Reference | |
| Any | 39/513 (7.6) | 1.36 (0.93–1.98) | .11 |
| Focal | 24/326 (7.4) | 1.31 (0.84–2.06) | .23 |
| Diffuse | 18/210 (8.6) | 1.54 (0.93–2.55) | .10 |
| Proximal reference disease | |||
| None | 87/1674 (5.2) | Reference | |
| Any | 19/230 (8.3) | 1.63 (0.99–2.68) | .053 |
| Focal | 14/170 (8.2) | 1.62 (0.92–2.85) | .09 |
| Diffuse | 5/60 (8.3) | 1.66 (0.67–4.09) | .27 |
| Distal reference disease | |||
| None | 100/1746 (5.7) | Reference | |
| Any | 26/343 (7.6) | 1.34 (0.87–2.06) | .19 |
| Focal | 11/177 (6.2) | 1.09 (0.58–2.03) | .79 |
| Diffuse | 15/166 (9.0) | 1.60 (0.93–2.76) | .09 |
| Proximal or distal reference lipidic plaque | |||
| None | 114/1767 (6.5) | Reference | |
| Any | 16/355 (4.5) | 0.69 (0.41–1.17) | .17 |
| Proximal reference lipidic plaque | |||
| None | 100/1683 (5.9) | Reference | |
| Any | 9/238 (3.8) | 0.63 (0.32–1.25) | .19 |
| Distal reference lipidic plaque | |||
| None | 119/1950 (6.1) | Reference | |
| Any | 7/144 (4.9) | 0.79 (0.37–1.70) | .55 |
| Proximal or distal reference dissection | |||
| None | 81/1430 (5.7) | Reference | |
| Any | 49/695 (7.1) | 1.26 (0.88–1.79) | .21 |
| Major | 4/66 (6.1) | 1.06 (0.39–2.89) | .91 |
| Minor | 45/629 (7.2) | 1.28 (0.89–1.84) | .19 |
| Intimal | 17/264 (6.4) | 1.15 (0.68–1.94) | .60 |
| Medial | 36/460 (7.8) | 1.40 (0.94–2.07) | .10 |
| Haematoma | 7/71 (9.9) | 1.75 (0.81–3.79) | .16 |
| No haematoma | 30/398 (7.5) | 1.35 (0.89–2.05) | .16 |
| Adventitial | 0/3 (0.0) | Not applicable | .98 |
| Proximal reference dissection, any | |||
| None | 79/1579 (5.0) | Reference | |
| Any | 37/418 (8.9) | 1.80 (1.22–2.66) | .003 |
| Major | 3/34 (8.8) | 1.81 (0.57–5.72) | .32 |
| Minor | 34/384 (8.9) | 1.80 (1.21–2.69) | .004 |
| Intimal | 16/188 (8.5) | 1.74 (1.02–2.97) | .04 |
| Medial | 21/229 (9.2) | 1.86 (1.15–3.01) | .01 |
| Haematoma | 3/25 (12.0) | 2.43 (0.77–7.68) | .13 |
| No haematoma | 18/204 (8.8) | 1.79 (1.08–2.99) | .03 |
| Adventitial | 0/1 (0.0) | Not applicable | .99 |
| Distal reference dissection | |||
| None | 107/1738 (6.2) | Reference | |
| Any | 19/371 (5.1) | 0.84 (0.51–1.36) | .47 |
| Major | 1/32 (3.1) | 0.49 (0.07–3.48) | .47 |
| Minor | 18/339 (5.3) | 0.87 (0.53–1.43) | .58 |
| Intimal | 1/89 (1.1) | 0.18 (0.03–1.29) | .09 |
| Medial | 18/280 (6.4) | 1.05 (0.64–1.74) | .84 |
| Haematoma | 4/46 (8.7) | 1.42 (0.52–3.85) | .49 |
| No haematoma | 14/234 (6.0) | 0.98 (0.56–1.71) | .95 |
| Adventitial | 0/2 (0.0) | Not applicable | .98 |
| . | Event rate . | Hazard ratio (95% CI) . | P-value . |
|---|---|---|---|
| Minimal stent area, mm2 | |||
| <5.24 (median) | 81/1063 (7.6) | Reference | |
| ≥5.24 | 49/1065 (4.6) | 0.59 (0.42–0.85) | .004 |
| Minimal stent expansion, % | |||
| <79.1 (median) | 78/1063 (7.3) | Reference | |
| ≥79.1 | 52/1065 (4.9) | 0.65 (0.46–0.93) | .02 |
| Intra-stent flow area, mm2 | |||
| <5.14 (median) | 82/1061 (7.7) | Reference | |
| ≥5.14 | 48/1067 (4.5) | 0.57 (0.40–0.81) | .002 |
| Total flow area, mm2 | |||
| <5.23 (median) | 82/1058 (7.8) | Reference | |
| ≥5.23 | 48/1070 (4.5) | 0.57 (0.40–0.81) | .002 |
| Stent length, mm | |||
| <33.4 (median) | 58/1056 (5.5) | Reference | |
| ≥33.4 | 72/1072 (6.7) | 1.24 (0.88–1.76) | .22 |
| Plaque or thrombus protrusion | |||
| None | 63/1034 (6.1) | Reference | |
| Any | 67/1094 (6.1) | 1.00 (0.71–1.41) | 1.00 |
| Major | 11/147 (7.5) | 1.22 (0.64–2.31) | .55 |
| Minor | 56/947 (5.9) | 0.97 (0.67–1.39) | .85 |
| Mal-apposition | |||
| None | 48/766 (6.3) | Reference | |
| Any | 82/1362 (6.0) | 0.96 (0.67–1.37) | .83 |
| Major | 38/549 (6.9) | 1.11 (0.73–1.70) | .62 |
| Minor | 44/812 (5.4) | 0.86 (0.57–1.30) | .48 |
| Stent deformation or fracture | |||
| None | 128/2107 (6.1) | Reference | |
| Any | 2/21 (9.5) | 1.50 (0.37–6.07) | .57 |
| Proximal or distal reference disease | |||
| None | 91/1608 (5.7) | Reference | |
| Any | 39/513 (7.6) | 1.36 (0.93–1.98) | .11 |
| Focal | 24/326 (7.4) | 1.31 (0.84–2.06) | .23 |
| Diffuse | 18/210 (8.6) | 1.54 (0.93–2.55) | .10 |
| Proximal reference disease | |||
| None | 87/1674 (5.2) | Reference | |
| Any | 19/230 (8.3) | 1.63 (0.99–2.68) | .053 |
| Focal | 14/170 (8.2) | 1.62 (0.92–2.85) | .09 |
| Diffuse | 5/60 (8.3) | 1.66 (0.67–4.09) | .27 |
| Distal reference disease | |||
| None | 100/1746 (5.7) | Reference | |
| Any | 26/343 (7.6) | 1.34 (0.87–2.06) | .19 |
| Focal | 11/177 (6.2) | 1.09 (0.58–2.03) | .79 |
| Diffuse | 15/166 (9.0) | 1.60 (0.93–2.76) | .09 |
| Proximal or distal reference lipidic plaque | |||
| None | 114/1767 (6.5) | Reference | |
| Any | 16/355 (4.5) | 0.69 (0.41–1.17) | .17 |
| Proximal reference lipidic plaque | |||
| None | 100/1683 (5.9) | Reference | |
| Any | 9/238 (3.8) | 0.63 (0.32–1.25) | .19 |
| Distal reference lipidic plaque | |||
| None | 119/1950 (6.1) | Reference | |
| Any | 7/144 (4.9) | 0.79 (0.37–1.70) | .55 |
| Proximal or distal reference dissection | |||
| None | 81/1430 (5.7) | Reference | |
| Any | 49/695 (7.1) | 1.26 (0.88–1.79) | .21 |
| Major | 4/66 (6.1) | 1.06 (0.39–2.89) | .91 |
| Minor | 45/629 (7.2) | 1.28 (0.89–1.84) | .19 |
| Intimal | 17/264 (6.4) | 1.15 (0.68–1.94) | .60 |
| Medial | 36/460 (7.8) | 1.40 (0.94–2.07) | .10 |
| Haematoma | 7/71 (9.9) | 1.75 (0.81–3.79) | .16 |
| No haematoma | 30/398 (7.5) | 1.35 (0.89–2.05) | .16 |
| Adventitial | 0/3 (0.0) | Not applicable | .98 |
| Proximal reference dissection, any | |||
| None | 79/1579 (5.0) | Reference | |
| Any | 37/418 (8.9) | 1.80 (1.22–2.66) | .003 |
| Major | 3/34 (8.8) | 1.81 (0.57–5.72) | .32 |
| Minor | 34/384 (8.9) | 1.80 (1.21–2.69) | .004 |
| Intimal | 16/188 (8.5) | 1.74 (1.02–2.97) | .04 |
| Medial | 21/229 (9.2) | 1.86 (1.15–3.01) | .01 |
| Haematoma | 3/25 (12.0) | 2.43 (0.77–7.68) | .13 |
| No haematoma | 18/204 (8.8) | 1.79 (1.08–2.99) | .03 |
| Adventitial | 0/1 (0.0) | Not applicable | .99 |
| Distal reference dissection | |||
| None | 107/1738 (6.2) | Reference | |
| Any | 19/371 (5.1) | 0.84 (0.51–1.36) | .47 |
| Major | 1/32 (3.1) | 0.49 (0.07–3.48) | .47 |
| Minor | 18/339 (5.3) | 0.87 (0.53–1.43) | .58 |
| Intimal | 1/89 (1.1) | 0.18 (0.03–1.29) | .09 |
| Medial | 18/280 (6.4) | 1.05 (0.64–1.74) | .84 |
| Haematoma | 4/46 (8.7) | 1.42 (0.52–3.85) | .49 |
| No haematoma | 14/234 (6.0) | 0.98 (0.56–1.71) | .95 |
| Adventitial | 0/2 (0.0) | Not applicable | .98 |
All subcategories are compared with the reference. Outcomes are presented as number of events during 2-year follow-up/number of the patients at risk on Day 0 (Kaplan–Meier estimated event rates).
CI, confidence interval; OCT, optical coherence tomography.
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