Table 4 Open in new tab Relationship...

Covariate

n (%)

Univariable HR (95% c.i.)

Univariable P

Multivariable HR (95% c.i.)

Multivariable P

Age ≥75 years

188 (30.4)

2.46 (1.83,3.31)

<0.001*

2.17 (1.58,2.97)

<0.001*

Female sex

182 (29.2)

1.27 (0.93,1.73)

0.127

–

BMI ≥25 kg/m²

426 (69.4)

0.70 (0.51,0.95)

0.023*

0.64 (0.47,0.89)

<0.007*

ASA grade >II

397 (68.2)

2.36 (1.56,3.56)

<0.001*

2.06 (1.35,3.12)

<0.001*

CVA at diagnosis

306 (49.8)

1.01 (0.75,1.36)

0.947

–

Low C3 SMI†

328 (53.4)

1.62 (1.20,2.19)

0.002*

1.20† (0.86,1.67)

0.277

Low L3 dSMI†

270 (44.2)

2.38 (1.75,3.22)

<0.001*

1.40† (0.97,2.02)

0.071

Low C3 SMD

189 (30.7)

2.02 (1.50,2.71)

<0.001*

1.84 (1.33,2.54)

<0.001*

SIG ≥2

94 (15.3)

1.68 (1.40,2.03)

<0.001*

1.63 (1.33,1.99)

<0.001*

Table 4

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Relationship between baseline clinical characteristics, CT-derived body composition analysis parameters, systemic inflammation, and overall survival in patients undergoing carotid endarterectomy for symptomatic carotid stenosis (n = 618)

Covariate	n (%)	Univariable HR (95% c.i.)	Univariable P	Multivariable HR (95% c.i.)	Multivariable P
Age ≥75 years	188 (30.4)	2.46 (1.83,3.31)	<0.001*	2.17 (1.58,2.97)	<0.001*
Female sex	182 (29.2)	1.27 (0.93,1.73)	0.127	–	–
BMI ≥25 kg/m²	426 (69.4)	0.70 (0.51,0.95)	0.023*	0.64 (0.47,0.89)	<0.007*
ASA grade >II	397 (68.2)	2.36 (1.56,3.56)	<0.001*	2.06 (1.35,3.12)	<0.001*
CVA at diagnosis	306 (49.8)	1.01 (0.75,1.36)	0.947	–	–
Low C3 SMI†	328 (53.4)	1.62 (1.20,2.19)	0.002*	1.20† (0.86,1.67)	0.277
Low L3 dSMI†	270 (44.2)	2.38 (1.75,3.22)	<0.001*	1.40† (0.97,2.02)	0.071
Low C3 SMD	189 (30.7)	2.02 (1.50,2.71)	<0.001*	1.84 (1.33,2.54)	<0.001*
SIG ≥2	94 (15.3)	1.68 (1.40,2.03)	<0.001*	1.63 (1.33,1.99)	<0.001*

Covariate	n (%)	Univariable HR (95% c.i.)	Univariable P	Multivariable HR (95% c.i.)	Multivariable P
Age ≥75 years	188 (30.4)	2.46 (1.83,3.31)	<0.001*	2.17 (1.58,2.97)	<0.001*
Female sex	182 (29.2)	1.27 (0.93,1.73)	0.127	–	–
BMI ≥25 kg/m²	426 (69.4)	0.70 (0.51,0.95)	0.023*	0.64 (0.47,0.89)	<0.007*
ASA grade >II	397 (68.2)	2.36 (1.56,3.56)	<0.001*	2.06 (1.35,3.12)	<0.001*
CVA at diagnosis	306 (49.8)	1.01 (0.75,1.36)	0.947	–	–
Low C3 SMI†	328 (53.4)	1.62 (1.20,2.19)	0.002*	1.20† (0.86,1.67)	0.277
Low L3 dSMI†	270 (44.2)	2.38 (1.75,3.22)	<0.001*	1.40† (0.97,2.02)	0.071
Low C3 SMD	189 (30.7)	2.02 (1.50,2.71)	<0.001*	1.84 (1.33,2.54)	<0.001*
SIG ≥2	94 (15.3)	1.68 (1.40,2.03)	<0.001*	1.63 (1.33,1.99)	<0.001*

HRs describe hazards of all-cause mortality during the follow-up interval generated through Cox proportional hazards analysis. For covariates with more than two subgroups, the first category was considered as the reference category. *Statistically significant. †C3 skeletal muscle index and L3 derived skeletal muscle index were modelled separately in the multivariable model to avoid multicollinearity; values reported for the other covariates in the multivariable model pertain to the model including C3 skeletal muscle index. CT, computed tomography; CVA, cerebrovascular attack; SMI, skeletal muscle index; dSMI, derived skeletal muscle index; SMD, skeletal muscle density; SIG, systemic inflammatory grade.

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