Table 2 Open in new tab The incidence of...

Outcome

Patient group

Sex

Proportion of patients with events

P-years (1000 years)

Incidence (per 1000 P-years)

Unadjusted IRR (95% CI)

P value

Adjusted IRR (95% CI)

P value

Any AAT

All

Male

28 781

25.1%

352.87

81.6 (80.6–82.5)

(Reference)

Female

20 222

17.6%

370.22

54.6 (53.9–55.4)

0.670 (0.658–0.682)

<0.001

0.804 (0.801–0.807)

<0.001

<65 years

Male

15 444

40.3%

134.91

114.5 (112.7–116.3)

(Reference)

Female

6001

36.1%

64.94

92.4 (90.1–94.8)

0.807 (0.784–0.832)

<0.001

0.789 (0.765–0.815)

<0.001

65–74 years

Male

9712

26.1%

114.13

85.1 (83.4–86.8)

(Reference)

Female

8402

27.9%

103.04

81.5 (79.8–83.3)

0.958 (0.931–0.987)

0.004

1.026 (0.994–1.058)

0.109

≥75 years

Male

3625

9.3%

103.82

34.9 (33.8–36.1)

(Reference)

Female

5819

8.5%

202.24

28.8 (28.0–29.5)

0.824 (0.791–0.859)

<0.001

1.045 (1.000–1.093)

0.050

AAD

All

Male

11 190

9.8%

433.09

25.8 (25.3–26.3)

(Reference)

Female

9249

8.1%

418.48

22.1 (21.6–22.5)

0.855 (0.832–0.879)

<0.001

1.195 (1.160–1.232)

<0.001

<65 years

Male

6749

17.6%

178.15

37.9 (37.0–38.8)

(Reference)

Female

3404

20.5%

77.89

43.7 (42.2–45.2)

1.154 (1.107–1.202)

<0.001

1.139 (1.089–1.190)

<0.001

65–74 years

Male

3230

8.7%

141.92

22.7 (22.0–23.5)

(Reference)

Female

3846

12.8%

123.00

31.2 (30.3–32.2)

1.374 (1.311–1.440)

<0.001

1.532 (1.457–1.611)

<0.001

≥75 years

Male

1211

3.1%

113.01

10.7 (10.1–11.3)

(Reference)

Female

1999

2.9%

217.60

9.2 (8.8–9.6)

0.857 (0.798–0.921)

<0.001

1.083 (1.003–1.169)

0.042

Cardioversion

All

Male

22 482

19.6%

385.07

58.3 (57.6–59.2)

(Reference)

Female

14 531

12.7%

398.95

36.4 (35.8–37.0)

0.624 (0.611–0.637)

<0.001

0.798 (0.780–0.816)

<0.001

<65 years

Male

11 968

31.2%

154.44

77.5 (76.1–78.9)

(Reference)

Female

3968

23.8%

76.37

52.0 (50.4–53.6)

0.670 (0.647–0.695)

<0.001

0.671 (0.646–0.697)

<0.001

65–74 years

Male

7827

21.0%

123.24

63.5 (62.1–64.9)

(Reference)

Female

6154

20.4%

114.34

53.8 (52.5–55.2)

0.847 (0.820–0.876)

<0.001

0.904 (0.872–0.937)

<0.001

≥75 years

Male

2687

6.9%

107.40

25.0 (24.1–26.0)

(Reference)

Female

4409

6.5%

208.24

21.2 (20.6–21.8)

0.846 (0.807–0.888)

<0.001

1.070 (1.016–1.126)

0.010

Catheter ablation^a

All

Male

2341

2.8%

254.71

9.2 (8.8–9.6)

(Reference)

Female

1101

1.4%

247.29

4.5 (4.2–4.7)

0.484 (0.451–0.520)

<0.001

0.888 (0.822–0.960)

0.003

<65 years

Male

1773

7.0%

92.12

19.2 (18.4–20.2)

(Reference)

Female

676

6.2%

41.20

16.4 (15.2–17.73)

0.853 (0.780–0.932)

<0.001

0.901 (0.819–0.991)

0.031

65–74 years

Male

500

1.8%

89.31

5.6 (5.1–6.1)

(Reference)

Female

377

1.7%

76.24

4.9 (4.5–5.5)

0.883 (0.773–1.010)

0.069

1.007 (0.873–1.163)

0.92394

≥75 years

Male

0.2%

73.28

0.9 (0.7–1.2)

(Reference)

Female

0.1%

129.85

0.4 (0.3–0.5)

0.398 (0.275–0.576)

<0.001

0.494 (0.333–0.734)

<0.001

Outcome

Patient group

Sex

Proportion of patients with events

P-years (1000 years)

Incidence (per 1000 P-years)

Unadjusted IRR (95% CI)

P value

Adjusted IRR (95% CI)

P value

Any AAT

All

Male

28 781

25.1%

352.87

81.6 (80.6–82.5)

(Reference)

Female

20 222

17.6%

370.22

54.6 (53.9–55.4)

0.670 (0.658–0.682)

<0.001

0.804 (0.801–0.807)

<0.001

<65 years

Male

15 444

40.3%

134.91

114.5 (112.7–116.3)

(Reference)

Female

6001

36.1%

64.94

92.4 (90.1–94.8)

0.807 (0.784–0.832)

<0.001

0.789 (0.765–0.815)

<0.001

65–74 years

Male

9712

26.1%

114.13

85.1 (83.4–86.8)

(Reference)

Female

8402

27.9%

103.04

81.5 (79.8–83.3)

0.958 (0.931–0.987)

0.004

1.026 (0.994–1.058)

0.109

≥75 years

Male

3625

9.3%

103.82

34.9 (33.8–36.1)

(Reference)

Female

5819

8.5%

202.24

28.8 (28.0–29.5)

0.824 (0.791–0.859)

<0.001

1.045 (1.000–1.093)

0.050

AAD

All

Male

11 190

9.8%

433.09

25.8 (25.3–26.3)

(Reference)

Female

9249

8.1%

418.48

22.1 (21.6–22.5)

0.855 (0.832–0.879)

<0.001

1.195 (1.160–1.232)

<0.001

<65 years

Male

6749

17.6%

178.15

37.9 (37.0–38.8)

(Reference)

Female

3404

20.5%

77.89

43.7 (42.2–45.2)

1.154 (1.107–1.202)

<0.001

1.139 (1.089–1.190)

<0.001

65–74 years

Male

3230

8.7%

141.92

22.7 (22.0–23.5)

(Reference)

Female

3846

12.8%

123.00

31.2 (30.3–32.2)

1.374 (1.311–1.440)

<0.001

1.532 (1.457–1.611)

<0.001

≥75 years

Male

1211

3.1%

113.01

10.7 (10.1–11.3)

(Reference)

Female

1999

2.9%

217.60

9.2 (8.8–9.6)

0.857 (0.798–0.921)

<0.001

1.083 (1.003–1.169)

0.042

Cardioversion

All

Male

22 482

19.6%

385.07

58.3 (57.6–59.2)

(Reference)

Female

14 531

12.7%

398.95

36.4 (35.8–37.0)

0.624 (0.611–0.637)

<0.001

0.798 (0.780–0.816)

<0.001

<65 years

Male

11 968

31.2%

154.44

77.5 (76.1–78.9)

(Reference)

Female

3968

23.8%

76.37

52.0 (50.4–53.6)

0.670 (0.647–0.695)

<0.001

0.671 (0.646–0.697)

<0.001

65–74 years

Male

7827

21.0%

123.24

63.5 (62.1–64.9)

(Reference)

Female

6154

20.4%

114.34

53.8 (52.5–55.2)

0.847 (0.820–0.876)

<0.001

0.904 (0.872–0.937)

<0.001

≥75 years

Male

2687

6.9%

107.40

25.0 (24.1–26.0)

(Reference)

Female

4409

6.5%

208.24

21.2 (20.6–21.8)

0.846 (0.807–0.888)

<0.001

1.070 (1.016–1.126)

0.010

Catheter ablation^a

All

Male

2341

2.8%

254.71

9.2 (8.8–9.6)

(Reference)

Female

1101

1.4%

247.29

4.5 (4.2–4.7)

0.484 (0.451–0.520)

<0.001

0.888 (0.822–0.960)

0.003

<65 years

Male

1773

7.0%

92.12

19.2 (18.4–20.2)

(Reference)

Female

676

6.2%

41.20

16.4 (15.2–17.73)

0.853 (0.780–0.932)

<0.001

0.901 (0.819–0.991)

0.031

65–74 years

Male

500

1.8%

89.31

5.6 (5.1–6.1)

(Reference)

Female

377

1.7%

76.24

4.9 (4.5–5.5)

0.883 (0.773–1.010)

0.069

1.007 (0.873–1.163)

0.92394

≥75 years

Male

0.2%

73.28

0.9 (0.7–1.2)

(Reference)

Female

0.1%

129.85

0.4 (0.3–0.5)

0.398 (0.275–0.576)

<0.001

0.494 (0.333–0.734)

<0.001

Table 2

Open in new tab

The incidence of rhythm control therapies according to sex

Outcome	Patient group	Sex	N	Proportion of patients with events	P-years (1000 years)	Incidence (per 1000 P-years)	Unadjusted IRR (95% CI)	P value	Adjusted IRR (95% CI)	P value
Any AAT	All	Male	28 781	25.1%	352.87	81.6 (80.6–82.5)	(Reference)		(Reference)
		Female	20 222	17.6%	370.22	54.6 (53.9–55.4)	0.670 (0.658–0.682)	<0.001	0.804 (0.801–0.807)	<0.001
	<65 years	Male	15 444	40.3%	134.91	114.5 (112.7–116.3)	(Reference)		(Reference)
		Female	6001	36.1%	64.94	92.4 (90.1–94.8)	0.807 (0.784–0.832)	<0.001	0.789 (0.765–0.815)	<0.001
	65–74 years	Male	9712	26.1%	114.13	85.1 (83.4–86.8)	(Reference)		(Reference)
		Female	8402	27.9%	103.04	81.5 (79.8–83.3)	0.958 (0.931–0.987)	0.004	1.026 (0.994–1.058)	0.109
	≥75 years	Male	3625	9.3%	103.82	34.9 (33.8–36.1)	(Reference)		(Reference)
		Female	5819	8.5%	202.24	28.8 (28.0–29.5)	0.824 (0.791–0.859)	<0.001	1.045 (1.000–1.093)	0.050
AAD	All	Male	11 190	9.8%	433.09	25.8 (25.3–26.3)	(Reference)		(Reference)
		Female	9249	8.1%	418.48	22.1 (21.6–22.5)	0.855 (0.832–0.879)	<0.001	1.195 (1.160–1.232)	<0.001
	<65 years	Male	6749	17.6%	178.15	37.9 (37.0–38.8)	(Reference)		(Reference)
		Female	3404	20.5%	77.89	43.7 (42.2–45.2)	1.154 (1.107–1.202)	<0.001	1.139 (1.089–1.190)	<0.001
	65–74 years	Male	3230	8.7%	141.92	22.7 (22.0–23.5)	(Reference)		(Reference)
		Female	3846	12.8%	123.00	31.2 (30.3–32.2)	1.374 (1.311–1.440)	<0.001	1.532 (1.457–1.611)	<0.001
	≥75 years	Male	1211	3.1%	113.01	10.7 (10.1–11.3)	(Reference)		(Reference)
		Female	1999	2.9%	217.60	9.2 (8.8–9.6)	0.857 (0.798–0.921)	<0.001	1.083 (1.003–1.169)	0.042
Cardioversion	All	Male	22 482	19.6%	385.07	58.3 (57.6–59.2)	(Reference)		(Reference)
		Female	14 531	12.7%	398.95	36.4 (35.8–37.0)	0.624 (0.611–0.637)	<0.001	0.798 (0.780–0.816)	<0.001
	<65 years	Male	11 968	31.2%	154.44	77.5 (76.1–78.9)	(Reference)		(Reference)
		Female	3968	23.8%	76.37	52.0 (50.4–53.6)	0.670 (0.647–0.695)	<0.001	0.671 (0.646–0.697)	<0.001
	65–74 years	Male	7827	21.0%	123.24	63.5 (62.1–64.9)	(Reference)		(Reference)
		Female	6154	20.4%	114.34	53.8 (52.5–55.2)	0.847 (0.820–0.876)	<0.001	0.904 (0.872–0.937)	<0.001
	≥75 years	Male	2687	6.9%	107.40	25.0 (24.1–26.0)	(Reference)		(Reference)
		Female	4409	6.5%	208.24	21.2 (20.6–21.8)	0.846 (0.807–0.888)	<0.001	1.070 (1.016–1.126)	0.010
Catheter ablation^a	All	Male	2341	2.8%	254.71	9.2 (8.8–9.6)	(Reference)		(Reference)
		Female	1101	1.4%	247.29	4.5 (4.2–4.7)	0.484 (0.451–0.520)	<0.001	0.888 (0.822–0.960)	0.003
	<65 years	Male	1773	7.0%	92.12	19.2 (18.4–20.2)	(Reference)		(Reference)
		Female	676	6.2%	41.20	16.4 (15.2–17.73)	0.853 (0.780–0.932)	<0.001	0.901 (0.819–0.991)	0.031
	65–74 years	Male	500	1.8%	89.31	5.6 (5.1–6.1)	(Reference)		(Reference)
		Female	377	1.7%	76.24	4.9 (4.5–5.5)	0.883 (0.773–1.010)	0.069	1.007 (0.873–1.163)	0.92394
	≥75 years	Male	68	0.2%	73.28	0.9 (0.7–1.2)	(Reference)		(Reference)
		Female	48	0.1%	129.85	0.4 (0.3–0.5)	0.398 (0.275–0.576)	<0.001	0.494 (0.333–0.734)	<0.001

Outcome	Patient group	Sex	N	Proportion of patients with events	P-years (1000 years)	Incidence (per 1000 P-years)	Unadjusted IRR (95% CI)	P value	Adjusted IRR (95% CI)	P value
Any AAT	All	Male	28 781	25.1%	352.87	81.6 (80.6–82.5)	(Reference)		(Reference)
		Female	20 222	17.6%	370.22	54.6 (53.9–55.4)	0.670 (0.658–0.682)	<0.001	0.804 (0.801–0.807)	<0.001
	<65 years	Male	15 444	40.3%	134.91	114.5 (112.7–116.3)	(Reference)		(Reference)
		Female	6001	36.1%	64.94	92.4 (90.1–94.8)	0.807 (0.784–0.832)	<0.001	0.789 (0.765–0.815)	<0.001
	65–74 years	Male	9712	26.1%	114.13	85.1 (83.4–86.8)	(Reference)		(Reference)
		Female	8402	27.9%	103.04	81.5 (79.8–83.3)	0.958 (0.931–0.987)	0.004	1.026 (0.994–1.058)	0.109
	≥75 years	Male	3625	9.3%	103.82	34.9 (33.8–36.1)	(Reference)		(Reference)
		Female	5819	8.5%	202.24	28.8 (28.0–29.5)	0.824 (0.791–0.859)	<0.001	1.045 (1.000–1.093)	0.050
AAD	All	Male	11 190	9.8%	433.09	25.8 (25.3–26.3)	(Reference)		(Reference)
		Female	9249	8.1%	418.48	22.1 (21.6–22.5)	0.855 (0.832–0.879)	<0.001	1.195 (1.160–1.232)	<0.001
	<65 years	Male	6749	17.6%	178.15	37.9 (37.0–38.8)	(Reference)		(Reference)
		Female	3404	20.5%	77.89	43.7 (42.2–45.2)	1.154 (1.107–1.202)	<0.001	1.139 (1.089–1.190)	<0.001
	65–74 years	Male	3230	8.7%	141.92	22.7 (22.0–23.5)	(Reference)		(Reference)
		Female	3846	12.8%	123.00	31.2 (30.3–32.2)	1.374 (1.311–1.440)	<0.001	1.532 (1.457–1.611)	<0.001
	≥75 years	Male	1211	3.1%	113.01	10.7 (10.1–11.3)	(Reference)		(Reference)
		Female	1999	2.9%	217.60	9.2 (8.8–9.6)	0.857 (0.798–0.921)	<0.001	1.083 (1.003–1.169)	0.042
Cardioversion	All	Male	22 482	19.6%	385.07	58.3 (57.6–59.2)	(Reference)		(Reference)
		Female	14 531	12.7%	398.95	36.4 (35.8–37.0)	0.624 (0.611–0.637)	<0.001	0.798 (0.780–0.816)	<0.001
	<65 years	Male	11 968	31.2%	154.44	77.5 (76.1–78.9)	(Reference)		(Reference)
		Female	3968	23.8%	76.37	52.0 (50.4–53.6)	0.670 (0.647–0.695)	<0.001	0.671 (0.646–0.697)	<0.001
	65–74 years	Male	7827	21.0%	123.24	63.5 (62.1–64.9)	(Reference)		(Reference)
		Female	6154	20.4%	114.34	53.8 (52.5–55.2)	0.847 (0.820–0.876)	<0.001	0.904 (0.872–0.937)	<0.001
	≥75 years	Male	2687	6.9%	107.40	25.0 (24.1–26.0)	(Reference)		(Reference)
		Female	4409	6.5%	208.24	21.2 (20.6–21.8)	0.846 (0.807–0.888)	<0.001	1.070 (1.016–1.126)	0.010
Catheter ablation^a	All	Male	2341	2.8%	254.71	9.2 (8.8–9.6)	(Reference)		(Reference)
		Female	1101	1.4%	247.29	4.5 (4.2–4.7)	0.484 (0.451–0.520)	<0.001	0.888 (0.822–0.960)	0.003
	<65 years	Male	1773	7.0%	92.12	19.2 (18.4–20.2)	(Reference)		(Reference)
		Female	676	6.2%	41.20	16.4 (15.2–17.73)	0.853 (0.780–0.932)	<0.001	0.901 (0.819–0.991)	0.031
	65–74 years	Male	500	1.8%	89.31	5.6 (5.1–6.1)	(Reference)		(Reference)
		Female	377	1.7%	76.24	4.9 (4.5–5.5)	0.883 (0.773–1.010)	0.069	1.007 (0.873–1.163)	0.92394
	≥75 years	Male	68	0.2%	73.28	0.9 (0.7–1.2)	(Reference)		(Reference)
		Female	48	0.1%	129.85	0.4 (0.3–0.5)	0.398 (0.275–0.576)	<0.001	0.494 (0.333–0.734)	<0.001

AAD, antiarrhythmic drugs; AAT, antiarrhythmic therapy; CI, confidence interval; IRR, incidence rate ratio.

^aPatients entering the cohort from 2011 onwards.

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